Clinical trials: Polyphenols
Healthy
Polyphenol Bioavailability From Chocolate
Dark chocolate is one of the richest sources of polyphenols though it has been hypothesised that the bioavailability of epicatechin from milk chocolate was reduced compared to dark.
- Trial name
- NCT00492713
- Testing
- dark chocolate, Milk chocolate 1, Milk chocolate 2
- Where
- Switzerland
- Volunteers
- 18 people, healthy volunteers welcome
- Sponsor
- Société des Produits Nestlé (SPN)
Vaginal Microbiome, Gut Microbiome
The Effect Cranberry-Based Products on the Female Microbiome
The overall objective of this clinical trial is to compare the effects of a cranberry-based product to a placebo-control product on vaginal and GI microbiome outcomes and associated participant reported outcomes in generally…
- Conditions
- Vaginal Microbiome, Gut Microbiome, Gut Health
- Trial name
- NCT07109713
- Testing
- Active
- Where
- United States
- Volunteers
- 60 people, healthy volunteers welcome
- Sponsor
- Ocean Spray Cranberries, Inc.
Healthy
Effect of Blueberries on Vascular Function in Healthy Men
Scientific question to be addressed: To determine the effects of acute blueberry ingestion on vascular function and blood pressure in humans Hypothesis: Acute consumption of blueberry induces an improvement in blood pressure and…
- Trial name
- NCT01292954
- Testing
- Blueberries
- Where
- United Kingdom
- Volunteers
- 10 people, healthy volunteers welcome
- Sponsor
- University of Reading
Hypercholesterolemia, Healthy
Effects of Dietary Antioxidants to Prevent Cardiovascular Disease
Background \& Aims: The role of red wine in cardiovascular risk prevention has been documented by several epidemiological studies in patients and normocholesterolemic healthy individuals.
- Trial name
- RWTAC (NCT02409537)
- Testing
- red wine, resveratrol
- Volunteers
- 37 people, healthy volunteers welcome
- Sponsor
- Aeromedical Center, Thessaloniki
Glycemic Index
Safety and Efficacy of a Single Dose of a Polyphenol-enriched Brown Seaweed Powder in Human
The primary endpoint of this trial will be to evaluate the safety of a single administration in human of a dose of 500 mg of a polyphenol-rich algal powder when taken 30 minutes before a test meal.
- Trial name
- ICAST (NCT00936754)
- Testing
- Brown seaweed powder
- Where
- Canada
- Volunteers
- 23 people, healthy volunteers welcome
- Sponsor
- innoVactiv Inc.
Healthy
Absorption, Metabolism and Excretion of Apigenin and Apigenin Glycosides
Probe dietary intervention study in healthy young adult males to evaluate the concentration of apigenin derived metabolites in plasma and urine after single acute intakes of different apigenin-containing test materials.
- Trial name
- NCT03526081
- Testing
- Chamomile Tea, Parsley based drink, Parsley Yogurt
- Where
- 2 sites in United States
- Volunteers
- 17 people, healthy volunteers welcome
- Sponsor
- University of California, Davis
Postprandial, Hyperglycemia, Postprandial
Postprandial Response to Different Jams
The aim of this study is to investigate the effects of an acute intake of three different types of strawberry jam, differing in the carbohydrates and antioxidants content, on postprandial glucose metabolism, lipid profile…
- Conditions
- Postprandial, Hyperglycemia, Postprandial, Feeding Behaviors, Antioxidant
- Trial name
- NCT01684332
- Testing
- Strawberry Jam
- Where
- Spain
- Volunteers
- 16 people, healthy volunteers welcome
- Sponsor
- Clinica Universidad de Navarra, Universidad de Navarra
Healthy
Bioavailability of the Polyphenols Contained in a Red Grape Extract-based Drink and Their Metabolic Effects
Randomized placebo-controlled crossover study during which participants undergo two different experimental days. The participants consume a red grape based- drink (polyphenols: 300 mg/100 ml and sugar: 9.8g/100 ml) or a placebo…
- Trial name
- BIOP (NCT02865278)
- Testing
- Standard meal
- Volunteers
- 10 people, healthy volunteers welcome
- Sponsor
- Federico II University
Healthy Nutrition
Bioavailability and Bioactivity of Orange Polyphenols
This study will provide a greater insight into the relationship between orange consumption and health (particularly gut health) and could be used to help with the development of novel food products.
- Trial name
- ORANGUT (NCT06430138)
- Testing
- 300ml Orange Juice
- Where
- United Kingdom
- Volunteers
- 20 people, healthy volunteers welcome
- Sponsor
- University of Ulster
Healthy, Biological Availability
Nutritional Intervention With Table Olives in Healthy Volunteers
Olives and olive oil are typical components of the Mediterranean diet being part of its cultural and gastronomic heritage. Since ancient times, olives have been used either for both, oil extraction or whole fruit consumption as…
- Conditions
- Healthy, Biological Availability, Nutritional Intervention, Functional Food
- Trial name
- BIOLIVA (NCT03886597)
- Testing
- Table Olives
- Where
- Spain
- Volunteers
- 58 people, healthy volunteers welcome
- Sponsor
- Fundació Institut de Recerca de l'Hospital de la Santa Creu i Sant Pau
Dysbiosis
Prebiotic Effects of a Polyphenol-rich Food Product
The specific aim for this project will be to investigate a cranberry beverage as a means to restore balance in terms of the relative proportions of the various bacteria that inhabit the large intestine.
- Trial name
- NCT03659240
- Testing
- Cranberry beverage
- Where
- United States
- Volunteers
- 25 people, healthy volunteers welcome
- Sponsor
- Iowa State University
Emotional Eating, Overweight or Obesity
Efficacy of Satisens® in Reducing Emotional Eating
This study evaluates the efficacy of Satisens®, a dietary supplement composed of plant extracts, in reducing emotional eating and sweet cravings in healthy adults.
- Conditions
- Emotional Eating, Overweight or Obesity, Hormonal Changes, Neurotransmitter Agents
- Trial name
- Satisens (NCT07079046)
- Testing
- Intervention 1: Satisens®
- Where
- Spain
- Volunteers
- 84 people, healthy volunteers welcome
- Sponsor
- José Enrique de la Rubia Ortí, Ph
Intervention
Intervention Effect of TP and AOB-w on Acrylamide Exposure in Chinese Adolescents
A double-blind randomized controlled trial (RCT) was conducted in current human study. This study aims to investigate the intervention effect of AOB-w on the short-term exposure and toxicokinetics of acrylamide, a dietary…
- Trial name
- NCT03118167
- Testing
- Tea polyphenols, AOB-w, Acrylamide (Potato Chips)
- Volunteers
- 110 people, healthy volunteers welcome
- Sponsor
- Zhejiang University
Overweight, Obesity
Effects of Red Beetroot Juice on High-Fat Meal-Induced Endothelial Dysfunction and Cardiometabolic Disturbances
Aside from aging, numerous factors increase the risk for developing cardiovascular disease (CVD) including diet and nutrition. High-fat meal consumption induces postprandial vascular endothelial dysfunction and other…
- Conditions
- Overweight, Obesity, Aging, Menopause
- Trial name
- NCT02949115
- Testing
- 70 mL red beetroot juice, 70 mL red beetroot juice without nitrate
- Where
- United States
- Volunteers
- 15 people, healthy volunteers welcome
- Sponsor
- Colorado State University
Absorption and Metabolism, Effect on Vascular Function
Absorption and Metabolism of Olive Leaf Extract and Its Effect on Vascular Reactivity and Cytokine Concentrations
The purpose of this study is to determine how olive leaf is absorbed and metabolised and also whether it has any effect on the elasticity of blood vessels and the immune system.
- Conditions
- Absorption and Metabolism, Effect on Vascular Function, Effect on Cytokine Concentrations
- Trial name
- NCT01479699
- Testing
- Olive leaf extract capsules
- Where
- United Kingdom
- Volunteers
- 18 people, healthy volunteers welcome
- Sponsor
- University of Reading
Iron-deficiency
Effect of Polyphenols on Absorption of Iron From Sodium Iron Chlorophyllin
Polyphenols present in tea are known to inhibit the absorption of non heme iron. The inhibiting effect of tea on non-heme iron absorption is attributed to the flavonoids present in tea.
- Trial name
- polySIC (NCT04849832)
- Testing
- SIC, SIC + tea, FeSO4
- Where
- Switzerland
- Volunteers
- 40 people, healthy volunteers welcome
- Sponsor
- Swiss Federal Institute of Technology
Blood Iron Isotope Enrichment
Impact of Bean Polyphenols and Phytic Acid on Iron Absorption
Recently isolated low PA varieties (lpa) in wheat, rice, maize, barley and beans might have the potential to alleviate iron bioavailability problems associated with PA.
- Trial name
- NCT01472484
- Testing
- 586/8x87 white, 586/8x87 brown, BAT 881
- Where
- Switzerland
- Volunteers
- 20 people, healthy volunteers welcome
- Sponsor
- Swiss Federal Institute of Technology
Presbycusis, Frailty Syndrome
Study of the Association Between Presbycusis With the Incidence of Frailty
The objective of the project is to establish the association between presbycusis and the incidence of frailty in humans in order to establish hearing loss with age as another index for the diagnosis of frailty; As well as…
- Conditions
- Presbycusis, Frailty Syndrome, Oxidative Stress
- Trial name
- NCT04360109
- Where
- Spain
- Volunteers
- 300 people, healthy volunteers welcome
- Sponsor
- Universidad Europea de Madrid
Insulin Resistance
The Effect of Tea on Vascular Function and Insulin Sensitivity
The aim of this research is to explore changes in peripheral/cerebrovascular function and insulin sensitivity after a 7-day combination of physical activity reduction (-50% steps per day) and overfeeding (+50% kcal per day…
- Trial name
- NCT02777853
- Testing
- Green tea
- Where
- United Kingdom
- Volunteers
- 12 people, healthy volunteers welcome
- Sponsor
- Liverpool John Moores University
Microbiota, Cognitive Function
Effect of Tomato Paste Consumption on the Microbiota-gut-brain Axis in Healthy Adults
Tomatoes and tomato-based products could play an important role in modulating microbiota-gut-brain axis (MGBA) interactions due to their high content of fiber and phytochemicals.
- Conditions
- Microbiota, Cognitive Function, Healthy Lifestyle
- Trial name
- MITOS (NCT05891977)
- Testing
- Intervention A - Tomato paste, Intervention B - Control
- Where
- Spain
- Volunteers
- 47 people, healthy volunteers welcome
- Sponsor
- University of Barcelona