Clinical trials: Polytrauma
Polytrauma, Coagulation Disorder
Comparison of Viscoelastic Measurement by ROTEM® Delta and ClotPro® in Trauma Patients.
The purpose of the study is to describe the differences and interchangeability in measurements of viscoelastic tests of coagulation by two different devices in adult trauma patients.
- Trial name
- ROTCLOT (NCT04107818)
- Where
- Czechia
- Volunteers
- 108 people
- Sponsor
- Masaryk University
Stroke, Acquired Brain Injury
Machine Learning to Predict Factors Affecting Rehabilitation Length of Stay and Healthcare Costs for Neurological Rehabilitation
The aim of this retrospective study is to ascertain total direct costs, rehabilitation length of stay (RLOS) and factors associated with RLOS for neurological inpatient rehabilitation at the tertiary care hospital.
- Conditions
- Stroke, Acquired Brain Injury, Traumatic Brain Injury, Brain Tumor
- Trial name
- NCT06704997
- Where
- Singapore
- Volunteers
- 10,000 people
- Sponsor
- Tan Tock Seng Hospital
Critical Illness, Intensive Care Patients
IMMUNOREA - Immunological and Inflammatory Determinants Associated With the Prognosis of Intensive Care Patients
This is a prospective observational physiopathological study aimed at evaluating the immunological and inflammatory determinants associated with the prognosis of patients admitted to intensive care units (ICU).
- Conditions
- Critical Illness, Intensive Care Patients, Critical Illness Requiring Intensive Care - Sepsis, Critical Illness Requiring Intensive Care - Acute Brain Injury
- Trial name
- IMMUNOREA (NCT07345169)
- Where
- France
- Volunteers
- 540 people
- Sponsor
- Assistance Publique - Hôpitaux de Paris
Polytrauma, Regional Anaesthesia
BLOCK-TRAUMA Study
This prospective cohort study will evaluate the association between the overall burden of regional anesthesia and early clinical outcomes in adult patients with polytrauma.
- Conditions
- Polytrauma, Regional Anaesthesia, Nerve Block, Acute Pain
- Trial name
- BLOCK-TRAUMA (NCT07702071)
- Where
- Ukraine
- Volunteers
- 500 people
- Sponsor
- Ukrainian Society of Regional Anesthesia and Pain Therapy
Multiple Trauma, Polytrauma
Development and Internal Validation of a Multimodal Prediction Score for Early Hemodynamic Deterioration in Adult Polytrauma Patients
Severe traumatic injury involving multiple body regions (polytrauma) carries a high risk of rapid bleeding, tissue hypoperfusion, and circulatory collapse.
- Conditions
- Multiple Trauma, Polytrauma, Hemodynamic Instability, Traumatic Shock
- Trial name
- NCT07850427
- Volunteers
- 300 people
- Sponsor
- Assiut University
Spinal Cord Injuries, Polytrauma
Reduction of Opioid Dose Using Conditioning & Open-Label Placebo (COLP) in Intensive Rehabilitation
The use of conditioning open-label placebo (COLP) will be studied as a dose extension method to lower opioid dosage in patients with spinal cord injury, polytrauma, and burn injury.
- Conditions
- Spinal Cord Injuries, Polytrauma, Burn Injury, Pain Management
- Trial name
- COLP (NCT03906721)
- Testing
- Oxycodone, Essential Oil
- Where
- United States
- Volunteers
- 20 people
- Sponsor
- Spaulding Rehabilitation Hospital
Patients Undergoing Esophagectomy, Patients With Severe Polytrauma
Evolution of the Lymphocyte Phenotype in Patients With Infection in Intensive Care Unit
Patients admitted for polytrauma, severe neurological injury, post-operative monitoring or sepsis/septic shock present with significant inflammation, leading to immunoparalysis, which is responsible for infection, particularly…
- Conditions
- Patients Undergoing Esophagectomy, Patients With Severe Polytrauma, Patients With Severe Neurological Lesion, Patients With Abdominal Infection
- Trial name
- REAPHEN (NCT06415474)
- Testing
- Lymphocyte Phenotyping Procedure
- Where
- France
- Volunteers
- 38 people
- Sponsor
- University Hospital, Brest
Polytrauma, Polytrauma Patients
Polytrauma Patients and Non-technical Skills
The study aims to examine the experience of anaesthesia residents in approching polytrauma patients at different stages of their training using a phenomenological approach.
- Conditions
- Polytrauma, Polytrauma Patients, Non-technical Skills
- Trial name
- NCT07550244
- Testing
- Questions
- Where
- Turkey (Türkiye)
- Volunteers
- 16 people
- Sponsor
- Antalya Training and Research Hospital
Polytrauma
Prognostic Value of Capillary Lactatemia in Potentially Severe Polytrauma Patients
Nowadays, the tools available to assess the severity of a polytrauma patient in the pre-hospital setting (vital parameters, shock index, MGAP score, Vittel criteria) have their limitations and are sometimes subjective.
- Trial name
- CLAT (NCT06969404)
- Testing
- capillary blood sampling
- Where
- 3 sites in France
- Volunteers
- 550 people
- Sponsor
- Centre Hospitalier Universitaire de Nice
Polytrauma Patients
Evaluation of Patients Suffering From Polytrauma Admitted to the ICU
The primary objective of this study is to assess the number of polytrauma patients admitted to the Intensive Care Unit. In addition, we aim to describe their clinical characteristics, therapeutic management, and clinical outcomes.
- Trial name
- Polytrauma ICU (NCT07482267)
- Where
- Belgium
- Volunteers
- 417 people
- Sponsor
- Jessa Hospital
Polytrauma, Resuscitation, Trauma Patients
Pv-aCO₂ Gap-Guided Resuscitation in Adult Polytrauma Patients: A Prospective Randomized Controlled Trial
dult patients with multiple traumatic injuries admitted to the ICU from the operating room, emergency department, or hospital wards who meet the study criteria will be included after obtaining informed consent from the patient or…
- Trial name
- NCT07480655
- Testing
- Veno-arterial Carbondioxide gap, Conventional resuscitation end points
- Where
- Pakistan
- Volunteers
- 60 people
- Sponsor
- Pakistan Institute of Medical Sciences
Delirium, Cognitive Impairment
Illuminating Neuropsychological Dysfunction and Systemic Inflammatory Mechanisms Gleaned After Hospitalization in Trauma-ICU Study
Cognitive skills are essential to live independently, manage finances, maintain employment, and function in society. Loss of these cognitive skills puts a tremendous burden on society as seen with dementias, Alzheimer's disease…
- Conditions
- Delirium, Cognitive Impairment, Alzheimer; Early Onset, Trauma
- Trial name
- INSIGHT-ICU (NCT03098459)
- Testing
- Non-interventional observational prospective cohort study
- Where
- United States
- Volunteers
- 432 people
- Sponsor
- Vanderbilt University Medical Center
Exanguination, Polytrauma
Abdominal Aortic Junction Tourniquet (AAJT-S) for Non-compressible Torso Haemorrhage in the Prehospital and Emergency Room Setting
This study seeks to evaluate the feasibility of a Abdominal Aortic Balloon Occlusion of the Aorta (AAJT-S) in exanguinating trauma patients with non-compressible truncal haemorrhage in the emergency room and the pre-hospital…
- Conditions
- Exanguination, Polytrauma, NCTH
- Trial name
- NCT07274150
- Where
- Austria
- Volunteers
- 50 people
- Sponsor
- Medical University of Graz
Polytrauma Patients
Correlation Between Inferior Vena Cava Collapsibility Index and Serum Lactate in Poly-trauma Patients
Polytrauma is defined as the presence of multiple traumatic injuries that may cause systemic physiological derangements and life-threatening conditions.
- Trial name
- NCT07255456
- Testing
- Abdominal ultrasound and Serum Lactate Level
- Where
- Egypt
- Volunteers
- 126 people
- Sponsor
- Farid Esmael Haridy Mohamed
Spinal Cord Injuries, Polytrauma
Conditioning & Open-Label Placebo (COLP) for Opioid Management in Intensive Inpatient Rehabilitation
The use of the conditioning open-label placebo (COLP) paradigm will be studied as a dose extension method to lower opioid dosage in patients with spinal cord injury, polytrauma, and burn injury.
- Conditions
- Spinal Cord Injuries, Polytrauma, Burns
- Trial name
- NCT05351333
- Where
- United States
- Volunteers
- 66 people
- Sponsor
- Spaulding Rehabilitation Hospital
Polytrauma
Inflammatory Markers in Trauma Patient Outcomes
It is unknown whether early modulation of inflammatory cytokines is associated with improved patient outcomes, reduced narcotic requirements in orthopaedic patient population, and improved patient subjective pain after hospital…
- Trial name
- NCT03671746
- Testing
- Ketorolac, Saline Solution
- Where
- United States
- Volunteers
- 70 people
- Sponsor
- Arun Aneja
Exanguination, NCTH
Abdominal Aortic Junction Tourniquet (AAJT-S) for Non-compressible Torso Haemorrhage
This study seeks to evaluate the feasibility of a Abdominal Aortic Balloon Occlusion of the Aorta (AAJT-S) in exanguinating trauma patients with non-compressible truncal haemorrhage in the emergency room and the pre-hospital…
- Conditions
- Exanguination, NCTH, Polytrauma
- Trial name
- NCT06622317
- Where
- Austria
- Volunteers
- 10 people
- Sponsor
- Medical University of Graz
Hemorrhage, Shock, Traumatic
The AT-REBOA Target Trial
Temporary aortic occlusion can limit haemorrhage, can help to maintain perfusion to the heart and brain, and may be associated with improved survival.
- Conditions
- Hemorrhage, Shock, Traumatic, Cardiac Arrest Due to Trauma, Polytrauma
- Trial name
- AT-REBOA (NCT06312436)
- Testing
- Resuscitative Endovascular Balloon Occlusion of the Aorta (REBOA)
- Where
- 2 sites in Austria
- Volunteers
- 44 people
- Sponsor
- Medical University of Graz
Polytrauma Patients
Predictive Value of Revised Trauma Score(RTS)and Glasgow Coma Scale (GCS)of Mortality in Patients with Multiple Trauma.
This study aims to assess the efficacy of RTS and GCS in predicating the mortality among multiple trauma patients admitted to emergency departments at Assiut university hospital.Which score is better in predicting mortality in…
- Trial name
- NCT06737874
- Volunteers
- 100 people
- Sponsor
- Assiut University
Augmented Renal Clearance, Critical Illness
Incidence and Associated Risk Factors of ARC in the Trauma Critically Ill Older Than 50 Years Old
This single-center prospective cohort study conducted at the adult trauma ICU of the Montreal General Hospital (MGH) affiliated with the McGill University Health Centre (MUHC) aims to determine the incidence and associated risk…
- Conditions
- Augmented Renal Clearance, Critical Illness, Polytrauma, Traumatic Brain Injury
- Trial name
- NCT04766944
- Testing
- No intervention
- Where
- Canada
- Volunteers
- healthy volunteers welcome
- Sponsor
- McGill University Health Centre/Research Institute of the McGill University Health Centre