Clinical trials: Polyunsaturated Fatty Acids
Tobacco Use in Childbirth, Smoking Cessation
Fish Oil to Reduce Tobacco Use iN Expectant Mothers Study
The purpose of this feasibility study is to obtain pilot data in preparation for an upcoming R01 submission. The goals of that submission will be to conduct a clinical trial of n-3 LCPUFAs for smoking cessation in pregnant women.
- Conditions
- Tobacco Use in Childbirth, Smoking Cessation, Pregnancy Related
- Trial name
- FORTUNE (NCT03077724)
- Testing
- Fish oil
- Where
- United States
- Volunteers
- 28 people, healthy volunteers welcome
- Sponsor
- Vanderbilt University Medical Center
Pregnancy
Effect of Mother's Supplementation Omega-3 in the Dynamics of Fetal Ductus Arteriosus: a Randomized Clinical Trial.
The effect of anti-inflammatory substances on the dynamics of the fetal ductus arteriosus is well documented, but the anti-inflammatory property of polyunsaturated fatty acid omega-3 about changing this dynamic is not…
- Trial name
- NCT02565290
- Testing
- Omega 3, Soy Oil
- Where
- Brazil
- Volunteers
- 74 people, healthy volunteers welcome
- Sponsor
- Instituto de Cardiologia do Rio Grande do Sul
Child Obesity, Insulin Resistance
Supplementation With PUFA´s in Obese Children
Introduction. Insulin resistance (IR) accompanies practically half of children with obesity. This alteration is the border between what can be reversible or permanent.
- Conditions
- Child Obesity, Insulin Resistance, Metabolic Complication
- Trial name
- PUFA (NCT05488223)
- Testing
- AGPI ω-3 (Triple Strength Fish Oil®), AGPI ω-3 + MUFA (avocado oil), MUFA (avocado oil) (1.8g)
- Where
- Mexico
- Volunteers
- 133 people, healthy volunteers welcome
- Sponsor
- Hospital Infantil de Mexico Federico Gomez
Obesity
Alpha and Omega of Lifestyle Therapy
The study aims to investigate the effects of double-blinded, randomized placebo-controlled n3-fatty acid supplementation (1000 mg day-1) and 13 weeks of resistance training on muscle function/biology and systemic health in…
- Trial name
- Alpha&Omega (NCT04279951)
- Testing
- Resistance exercise, Omega-3
- Where
- Norway
- Volunteers
- 150 people, healthy volunteers welcome
- Sponsor
- Inland Norway University of Applied Sciences
Healthy
Effect of Vitamin B12 and n-3 Polyunsaturated Fatty Acids on Plasma Homocysteine
Vitamin B12and n-3 polyunsaturated fatty acids (PUFA) decrease blood homocysteine (Hcy) concentration. However, the combined effect of these nutrients on Hcy and ferritin, and C-reactive protein is limited and inconclusive.
- Trial name
- NCT01762072
- Testing
- Fish oil, vitaminB12
- Where
- China
- Volunteers
- 30 people, healthy volunteers welcome
- Sponsor
- Zhejiang University
Brain Health, Brain Function
Effect of Fish Oil on Athlete's Executive Function
The goal of this study is to determine the impact of long chain omega-3 PUFA (Polyunsaturated fatty acids) supplementation on executive function in collegiate athletes in a randomized, double-blind, placebo-controlled trial
- Conditions
- Brain Health, Brain Function, Brain Development
- Trial name
- NCT04570995
- Testing
- Fish Oil, Safflower Oil
- Where
- United States
- Volunteers
- 22 people, healthy volunteers welcome
- Sponsor
- Wake Forest University Health Sciences
Healthy Diet
Impacts of Omega-3-PUFA Enriched Chicken-meat and Eggs in Healthy Humans
Eating oily fish containing long chain seafood-derived omega-3 polyunsaturated fatty acids (PUFAs) protects against heart attacks and strokes.
- Trial name
- NCT04127409
- Testing
- Control Chicken-meat, Control Eggs, Omega-3-PUFA Enriched Chicken-meat
- Where
- Ireland
- Volunteers
- 160 people, healthy volunteers welcome
- Sponsor
- Alice Stanton
Tobacco Dependence
Preventing Tobacco Relapse With Omega-3s Trial
Almost 12% of women report smoking during pregnancy. Smoking during pregnancy is associated with adverse fetal outcomes and up to 35-75% of women quit smoking during their pregnancy.
- Trial name
- PRO-3 (NCT03113370)
- Testing
- Fish Oil
- Volunteers
- healthy volunteers welcome
- Sponsor
- Vanderbilt University Medical Center
Healthy
Does Consuming Modified Plant Seed Oil Containing Fish Oil Fatty Acids Act in the Same Way as Consuming Fish Oil?
Fish oil and oily fish contain omega 3 long chain polyunsaturated fatty acids known to be beneficial to health. Many people consume little, despite UK government recommendations to eat at least one portion of oily fish per week.
- Trial name
- NCT03477045
- Testing
- Single dose fish oil, Repeated dose fish oil, single dose Camelina seed oil
- Where
- United Kingdom
- Volunteers
- 31 people, healthy volunteers welcome
- Sponsor
- University of Southampton
Allergies
Does Omega-3 Fatty Acid Supplementation in Pregnancy and During Lactation Protect the Child From Allergic Disease?
The incidence of allergic diseases has increased and a relation between allergy and dietary fatty acids has been proposed. Modulation of the maternal immune function during pregnancy may have an impact on future clinical outcomes…
- Trial name
- NCT00892684
- Testing
- Omega-3 long chain polyunsaturated fatty acids
- Where
- Sweden
- Volunteers
- 146 people, healthy volunteers welcome
- Sponsor
- Linkoeping University
Premature
Effect of Docosahexaenoic Acid (DHA)-Enriched Human Milk in Premature Newborns
Several recent publications showed a reduction in the level of DHA and/or an increase in the arachidonic acid (AA)/DHA ratio in the milk of mother.
- Trial name
- DHARMA (NCT01062373)
- Testing
- Supplementation of lactating mothers who has delivered prematurely with DHA
- Where
- France
- Volunteers
- 2 people, healthy volunteers welcome
- Sponsor
- Institut National de la Santé Et de la Recherche Médicale, France
Postmenopause, Premenopause
Marine n-3 Polyunsaturated Fatty Acids in Pre- and Postmenopausal Women
The study is a randomised placebo controlled double-blinded clinical trial where a group of healthy pre- and postmenopausal women is randomised to the intake of fish oil capsules or placebo oil capsules for 12 weeks.
- Trial name
- NCT00901589
- Testing
- marine n-3 polyunsaturated fatty acids, thistle oil
- Where
- Denmark
- Volunteers
- 92 people, healthy volunteers welcome
- Sponsor
- Aalborg University Hospital
Atopic Dermatitis
The Role of Filaggrin and FADS Genes on the Concentrations of PUFA Towards Its Effect on Atopic Dermatitis in Infants
The incidence of atopic dermatitis has increased dramatically in this years. Atopic dermatitis occurs due to complex interactions between genetic and environmental factors.
- Trial name
- FLG-FADSgen (NCT02401178)
- Where
- Indonesia
- Volunteers
- 400 people, healthy volunteers welcome
- Sponsor
- Universitas Indonesia
Healthy
Effect of an Alpha-linolenic Acid-rich Supplement on Ketogenesis and Plasma Fatty Acids
Background: As the main alternative fuel to glucose for the brain, increased plasma ketones could potentially help compensate for brain glucose hypometabolism occurring during aging.
- Trial name
- NCT02410161
- Testing
- alpha-linolenic acid-rich supplement
- Volunteers
- 20 people, healthy volunteers welcome
- Sponsor
- Université de Sherbrooke
Tobacco Dependence, Nicotine Dependence
Studying the Effects of Administration of Polyunsaturated Fatty Acids (PUFAS) of Omega-3 Series in Nicotine Dependence
Nicotine dependence may prolong the exposure to toxic substances that cause various diseases. The Central Nervous System (CNS) is consisted by a large amount of Polyunsaturated Fatty Acids (PUFAS) from omega-3 serie.
- Trial name
- NCT01735279
- Testing
- Omega 3
- Where
- Brazil
- Volunteers
- 58 people, healthy volunteers welcome
- Sponsor
- Federal University of São Paulo
Nasopharyngeal Carcinoma (NPC), Radiation-induced Oral Mucositis
Pre-Radiotherapy n-6/n-3 Fatty Acid Ratio Predicts Severe Oral Mucositis in Nasopharyngeal Carcinoma
The goal of this clinical trial is to learn if the balance of omega-6 and omega-3 fats in red blood cells can predict severe mouth sores caused by radiation therapy in people with locally advanced nasopharyngeal carcinoma (a type…
- Conditions
- Nasopharyngeal Carcinoma (NPC), Radiation-induced Oral Mucositis, Head and Neck Neoplasms
- Trial name
- NCT07920250
- Testing
- Toripalimab (240mg day1, Q3W*3cycle), Cisplatin (80 mg/m2), Nab-paclitaxel
- Where
- China
- Volunteers
- 210 people, healthy volunteers welcome
- Sponsor
- Affiliated Hospital of Guangdong Medical University
Fatty Acid Status
Polyunsaturated Fatty Acids in Child Nutrition
Primary objective of this study is to examine the effects of 2 different approaches of dietary strategies to optimise fatty acid composition in complementary food on infant's fatty acid status and its consequences on cognitive…
- Trial name
- PINGU (NCT01487889)
- Testing
- Fatty acid composition of complementary food
- Where
- Germany
- Volunteers
- 214 people, healthy volunteers welcome
- Sponsor
- Research Institute of Child Nutrition, Dortmund
Healthy, Omega 3
Observing Metabolism of EPA With Consideration of Genetics And Sex
The goal of this clinical study is to learn how fast EPA is converted to other molecules, including DHA, with consideration of biological sex and genetics in healthy humans.
- Conditions
- Healthy, Omega 3, Metabolism, Lipids
- Trial name
- OMEGA (NCT06975241)
- Testing
- EPA 2.4g/day
- Where
- Canada
- Volunteers
- 64 people, healthy volunteers welcome
- Sponsor
- University of Toronto