Clinical trials: Polyuria
Diabetes Insipidus
Copeptin After a Subcutaneous Stimulation With Glucagon in Adults
This study is to evaluate copeptin values after the subcutaneous injection of glucagon in adults (healthy volunteers and patients with diabetes insipidus or primary polydipsia).
- Trial name
- Glucacop (NCT04550520)
- Testing
- Glucagon
- Where
- Switzerland
- Volunteers
- 42 people, healthy volunteers welcome
- Sponsor
- University Hospital, Basel, Switzerland
Nocturia, Polyuria
Food and Salt Handling in Diuresis
Understanding the impact of food/nutrients on body fluid metabolism is important for improving diagnosis and treatment of nocturia, polyuria in relation to lifestyle interventions.
- Trial name
- NCT04526340
- Testing
- Blood sample, Bio-impedance measurement (BIA), Ingestion of testing nutrient/food capsules
- Where
- Belgium
- Volunteers
- 21 people, healthy volunteers welcome
- Sponsor
- University Hospital, Ghent
Nocturia
Bioavailability of [14C]-SK-1404 ADME & IV Microtracer Study
The primary objectives of the study are: To determine the absolute bioavailability of SK-1404 To assess the mass balance recovery after a single oral (PO) dose of carbon-14 (14C)-SK-1404 To provide plasma, urine and faecal…
- Trial name
- NCT02878096
- Testing
- [14C]-SK-1404
- Where
- United Kingdom
- Volunteers
- 6 people, healthy volunteers welcome
- Sponsor
- Sanwa Kagaku Kenkyusho Co., Ltd.
Nocturia, Pelvic Organ Prolapse
Severe Pelvic Organ Prolapse and Post-Obstructive Diuresis (SOPPO) Pilot Study
In our experience, women with severe pelvic organ prolapse (POP) frequently have bothersome nocturia. The International Continence Society (ICS) defines nocturia as "having to wake at night one or more times to void." Though some…
- Trial name
- SOPPO (NCT02060331)
- Where
- United States
- Volunteers
- healthy volunteers welcome
- Sponsor
- Loyola University
Polyuria-polydipsia Syndrome, Arginine Vasopressin Deficiency
Mannitol-induced Release of Copeptin in Healthy Adults and Patients With Polyuria-Polydipsia Syndrome (MARS Study)
The aims of this study are to investigate whether mannitol stimulates copeptin (part 1: proof-of-concept) and whether the copeptin levels upon mannitol infusion differ in primary polydipsia and arginine vasopressin deficiency…
- Conditions
- Polyuria-polydipsia Syndrome, Arginine Vasopressin Deficiency, Primary Polydipsia
- Trial name
- MARS (NCT06542198)
- Testing
- Mannitol Infusion (blinded), Mannitol Infusion (open label)
- Where
- Switzerland
- Volunteers
- 42 people, healthy volunteers welcome
- Sponsor
- University Hospital, Basel, Switzerland
Healthy, Polyuria-polydipsia Syndrome
Copeptin After Arginine Infusion in Polyuria-Polydipsia Syndrome
the purpose of the study is to investigate whether arginine infusion is a new tool to differentiate patients with diabetes insipidus, primary polydipsia and healthy subjects.
- Trial name
- NCT01879137
- Where
- Switzerland
- Volunteers
- 60 people, healthy volunteers welcome
- Sponsor
- University Hospital, Basel, Switzerland
Total Body Water, Nocturnal Polyuria
Watershift - Pilot Study
The aim of this pilot was to study how body water behaves between the different internal water pools of the human body, what the role and influence of the interstitium is and what the effect is of body position on the…
- Trial name
- WATERSHIFT (NCT04520477)
- Testing
- Bio Impedance assesement (BIA), Blood and salava sample, Ingestion of deuterated water
- Where
- Belgium
- Volunteers
- 19 people, healthy volunteers welcome
- Sponsor
- University Hospital, Ghent
Polyuria, Polydipsia
Copeptin in Differentiation of Polyuria and Polydipsia
The differential diagnosis of patients with polyuria/ polydipsia is often complex, but important for the therapeutic strategy. Challenging is in particular the clinical differentiation between patients with a partial Diabetes…
- Trial name
- NCT01056887
- Where
- Germany
- Volunteers
- 50 people, healthy volunteers welcome
- Sponsor
- University of Wuerzburg
Polyuria-polydipsia Syndrome
Copeptin After an Oral Stimulation With Macimorelin in Healthy Volunteers
This study investigates stimulation of the posterior pituitary gland by oral Macimorelin (a ghrelin receptor Agonist) to be a novel diagnostic test in the polyuria-polydipsia syndrome.
- Trial name
- Macicop (NCT03844217)
- Testing
- Macimorelin 0.5mg/kg body weight, Macimorelin 0.75mg/kg body weight
- Where
- Switzerland
- Volunteers
- 28 people, healthy volunteers welcome
- Sponsor
- University Hospital, Basel, Switzerland
Arginine Vasopressin Deficiency, Primary Polydipsia
Plasma Copeptin in Response to Oral Urea in Healthy Adults and Patients With Polyuria-polydipsia Syndrome
The aim of this study is to investigate whether oral urea stimulates copeptin release and, if so, whether it may provide a novel diagnostic test in the differentiation between AVP-D (Arginine vasopressin deficiency) and PP…
- Trial name
- URANOS (NCT05890690)
- Testing
- Urea
- Where
- Switzerland
- Volunteers
- 48 people, healthy volunteers welcome
- Sponsor
- University Hospital, Basel, Switzerland