Clinical trials: Poor Memory
Mild Cognitive Impairment (MCI), Subjective Cognitive Decline (SCD)
Effect of Accelerated Neuromodulation of Anterior Cingulate Cortex to Enhance Cognition in Older Adults With Mild Memory Problems
The goal of this clinical trial is to test whether an accelerated deep Transcranial Magnetic Stimulation (dTMS) protocol in combination with cognitive training can improve cognitive abilities in older adults with Subjective…
- Trial name
- NACC-EC (NCT07212504)
- Testing
- Active Brainsway H7-Coil Deep TMS System
- Where
- Canada
- Volunteers
- 30 people
- Sponsor
- Rotman Research Institute at Baycrest
Memory Deficits, Mood Change
The Effects of Microbiological Spectrum Changes to Improve Cognitive Health in Aging Population
The goal of this project is to develop probiotic dietary supplements intended for the elderly, which can modify the composition of the intestinal microbiota typically occurring in the aging population.
- Conditions
- Memory Deficits, Mood Change, Gut Health, Aging Problems
- Trial name
- CleverAgeBiota (NCT05051501)
- Testing
- Probiotics C2P
- Where
- 2 sites in Czechia
- Volunteers
- 90 people, healthy volunteers welcome
- Sponsor
- National Institute of Mental Health, Czech Republic
Mild Cognitive Impairment
Evaluating a Digital Memory Notebook App to Improve Functional Independence
This study will investigate the efficacy of a smart home / digital memory notebook (DMN) partnership that will allow for real-time intervention and thereby facilitate acquisition and use of the DMN to support everyday…
- Trial name
- NCT03453554
- Testing
- Digital Notebook app, Smart Home Prompting
- Where
- United States
- Volunteers
- 30 people
- Sponsor
- Washington State University
Mild Cognitive Impairment (MCI)
Aging Stereotypes and Prodromal Alzheimer's Disease
Because of the lengthening of life expectancy, more and more people are concerned with the effects of aging on their mental faculties (e.g., memory decline) and with the possibility of getting Alzheimer's Disease (AD) or other…
- Trial name
- AGING (NCT03138018)
- Testing
- Diagnosis of MCI versus No MCI (SCI or healthy patient)
- Where
- France
- Volunteers
- 130 people
- Sponsor
- Assistance Publique Hopitaux De Marseille
Mild Cognitive Impairment, Memory Impairment
IHT for Mild Cognitive Impairment
This phase I clinical trial will examine the safety and efficacy of intermittent hypoxia training (IHT) for up to 12 weeks to treat subjects with mild cognitive impairment (MCI).
- Trial name
- NCT05495087
- Testing
- IHT Treatment
- Where
- United States
- Volunteers
- 66 people
- Sponsor
- University of North Texas Health Science Center
Organic Memory Impairment
Attenuation of Corticosteroid Induced Hippocampal Changes
The purpose of the study is to determine if an investigational drug called memantine,used here as add-on therapy, is associated with improvements in memory, mood and asthma symptoms.
- Trial name
- NCT01656187
- Testing
- Memantine 10 mg capsule
- Where
- United States
- Volunteers
- 46 people
- Sponsor
- University of Texas Southwestern Medical Center
Sleep Disorder, Circadian Dysregulation
NIA_Improving Function and Well-being by Improving Patient Memory: Transdiagnostic Sleep and Circadian Treatment
Mental illness is often chronic, severe, and difficult to treat. Though there has been significant progress towards establishing effective and efficient interventions for psychological health problems, many individuals do not…
- Conditions
- Sleep Disorder, Circadian Dysregulation, Memory Impairment
- Trial name
- NCT05986604
- Testing
- Memory Support Intervention, Transdiagnostic Intervention for Sleep and Circadian Dysfunction
- Where
- United States
- Volunteers
- 178 people, healthy volunteers welcome
- Sponsor
- University of California, Berkeley
Ruptured Aneurysm, Memory Deficits
Memory Training in Aneurysmal Subarachnoid Hemorrhage Patients
The study aim is to determine if periodic online cognitive exercises (Lumosity) improve memory function in ruptured cerebral aneurysm patients with disabling baseline memory deficits within the first 24 months after rupture.
- Conditions
- Ruptured Aneurysm, Memory Deficits, Subarachnoid Hemorrhage
- Trial name
- MASH (NCT02864940)
- Testing
- Lumosity, Crossword puzzle
- Where
- United States
- Volunteers
- 38 people
- Sponsor
- Rush University Medical Center
Memory Loss
Efficacy of Cognitive Training in Subjective Memory Impairment
This study evaluates the efficacy of cognitive training in subjects with subjective memory impairment. The first group will receive cognitive training and lifestyle modification in combination, the second group will receive only…
- Trial name
- NCT02555774
- Testing
- cognitive training, lifestyle modification
- Where
- South Korea
- Volunteers
- 65 people
- Sponsor
- Asan Medical Center
Multiple Sclerosis, Progressive, Cognition - Other
Treating New Learning and Memory Deficits in Progressive Multiple Sclerosis (MS)
This study is a double-blind placebo-controlled randomized clinical trial (RCT) to provide Class I evidence in support of or in refute of the efficacy of the modified Story Memory Technique (mSMT) in persons with progressive MS…
- Conditions
- Multiple Sclerosis, Progressive, Cognition - Other, Memory Impairment
- Trial name
- NCT02301247
- Testing
- Memory retraining exercises
- Where
- United States
- Volunteers
- 32 people
- Sponsor
- Kessler Foundation
Cognitive Change, Mood
Turmeric for Memory Impairment and Cognition
The objective of the study is to test the capacity of acute and chronic supplementations of Turmipure GOLD® to improve cognitive performance in healthy aging
- Conditions
- Cognitive Change, Mood, Stress
- Trial name
- TURMEMIC (NCT04860050)
- Testing
- Turmipure Gold®
- Where
- Ireland
- Volunteers
- 568 people, healthy volunteers welcome
- Sponsor
- Givaudan France Naturals
Memory Impairment
The Effects of Minocycline in Humans
To determine minocycline's effects on cognitive performance and measures of mood in abstinent cocaine users. Minocycline is a tetracycline derivative antibiotic that also inhibits microglia activation and the release of…
- Trial name
- NCT02193269
- Testing
- Sugar pill, Minocycline
- Where
- United States
- Volunteers
- 10 people
- Sponsor
- Yale University
Epilepsy, Generalized, Memory Impairment
Exercise for Memory Rehabilitation in Epilepsy
The purpose of this study is to determine how effective a 6-week exercise program is for improving memory compared to a no-intervention control group, investigate the brain changes that may be responsible for memory improvements…
- Trial name
- EMemRE (NCT04959019)
- Testing
- Supervised combined endurance and resistance training (CERT), Delayed supervised combined endurance and resistance training (CERT)
- Where
- United States
- Volunteers
- 71 people
- Sponsor
- University of Alabama at Birmingham
Traumatic Brain Injury, Memory Deficits
Multicenter Evaluation of Memory Remediation After TBI With Donepezil
This is a four-site, randomized, parallel design, double-blind, placebo-controlled, 10-week trial of donepezil 10 mg daily for verbal memory problems among adults with TBI in the subacute or chronic recovery period.
- Trial name
- MEMRI-TBI-D (NCT02255799)
- Testing
- Donepezil
- Where
- 4 sites in United States
- Volunteers
- 75 people
- Sponsor
- Baylor College of Medicine
Traumatic Brain Injury
Brain Training to Enhance Frontal Lobe Reasoning
This study is being done to improve the ability to diagnose and to achieve higher-levels of functional recovery in soldiers and civilians who have suffered either mild Traumatic Brain Injury (TBIs) or moderate-to-severe TBIs at…
- Trial name
- NCT01552473
- Testing
- Brain Training Program 1, Brain Training Program 2
- Where
- United States
- Volunteers
- 108 people
- Sponsor
- The University of Texas at Dallas
Mild Cognitive Impairment, Cognitive Impairment
SNIFF - Combo INI+EMPA Trial
The proposed pilot study will provide safety and efficacy preliminary data regarding singular and combined effects of two therapeutic approaches, intranasal insulin and treatment with the sodium-glucose cotransporter type 2…
- Conditions
- Mild Cognitive Impairment, Cognitive Impairment, Alzheimer Disease
- Trial name
- NCT05081219
- Testing
- Insulin (Humulin® R U-100), Empagliflozin 10 MG, Aptar Pharma CPS Intranasal Delivery Device
- Where
- United States
- Volunteers
- 47 people, healthy volunteers welcome
- Sponsor
- Wake Forest University Health Sciences
Mild Cognitive Impairment
An Observational Study for Analysis of Mortality in Participants Who Participated in Previous 3 Studies of Galantamine
The purpose of the study is to collect data of patients who were randomized (assignment of study medication by chance) and treated in 3 previous studies of galantamine (CR003145, CR002014 and CR005947) for the treatment of mild…
- Trial name
- NCT00297414
- Testing
- No intervention
- Where
- 144 sites in United States, Argentina and 14 more
- Volunteers
- 1,083 people
- Sponsor
- Johnson & Johnson Pharmaceutical Research & Development, L.L.C.
Depression, Mild Cognitive Impairment
Combination Treatment Study for Memory Impairment and Depression
Patients presenting with depression (DEP) and cognitive impairment (CI), represent a unique, understudied population that is difficult to diagnose, treat and estimate prognosis.
- Trial name
- DEP-CI (NCT01658228)
- Testing
- Donepezil, Citalopram, Venlafaxine
- Where
- 2 sites in United States
- Volunteers
- 86 people
- Sponsor
- New York State Psychiatric Institute
Mild Cognitive Impairment, Memory Impairment
Enhancing Frontal Lobes Plasticity in Mild Cognitive Impairment
More than 5 million people live with Alzheimer's dementia (AD) in North America. No effective treatment exists yet probably because by the time AD has developed it is too late to intervene.
- Trial name
- PAS-MCI (NCT04583215)
- Testing
- Paired Associative Stimulation (PAS)
- Where
- Canada
- Volunteers
- 150 people, healthy volunteers welcome
- Sponsor
- Centre for Addiction and Mental Health
Alzheimer's Disease
Chronic Electrical Stimulation of Hypothalamus/Fornix in Alzheimer's Disease
Alzheimer's Disease (AD) is the most common cause of dementia for which no treatment has shown consistent efficacy to stop or slow down the disease.
- Trial name
- NCT00888056
- Testing
- Bilateral chronic electrical stimulation of the hypothalamus/fornix
- Where
- France
- Volunteers
- 5 people
- Sponsor
- Centre Hospitalier Universitaire de Nice