Clinical trials: Poor Ovarian Reserve
Low Ovarian Reserve, Poor Ovarian Response
Ovulation Trigger Strategies in Low Ovarian Reserve (TRIGGERBEST)
This study aims to compare different ovulation triggering strategies in women with low ovarian reserve undergoing fresh in vitro fertilization (IVF) cycles.
- Trial name
- TRIGGERBEST (NCT07816562)
- Testing
- Human chorionic gonadotropin (hCG), Follitropin delta, Triptorelin
- Where
- Spain
- Volunteers
- 126 people
- Sponsor
- Fundación para la Investigación del Hospital Clínico de Valencia
Poor Ovarian Reserve, Infertility (IVF Patients)
Drospirenone-Primed Ovarian Stimulation Versus GnRH Antagonist Protocol in Poor Ovarian Responders Undergoing Freeze-All IVF/ICSI
Participants will: Take either drospirenone (a daily pill) or the standard daily injection during their ovarian stimulation cycle, alongside their regular fertility hormone injections Undergo egg retrieval, with all resulting…
- Trial name
- PPOS (NCT07736261)
- Testing
- Drospirenone drug, Cetrorelix 0.25 mg
- Where
- Egypt
- Volunteers
- 100 people
- Sponsor
- Ahmed Saad
Low Ovarian Reserve, Poor Response to Ovulation Induction Poseidon Type IV
Follicular Flushing Using Double Lumen Needle Versus Direct Aspiration in Low Prognosis Patients According to the POSEIDON Criteria
This is a prospective, randomized, controlled clinical trial designed to evaluate whether follicular flushing increases the number of cumulus-oocyte complexes (COCs) retrieved compared to single aspiration in patients with poor…
- Conditions
- Low Ovarian Reserve, Poor Response to Ovulation Induction Poseidon Type IV, Poor Response to Ovulation Induction
- Trial name
- FLUSHING (NCT07270081)
- Testing
- follicular flushing, follicular aspiration
- Where
- Spain
- Volunteers
- 40 people
- Sponsor
- Instituto Bernabeu
Poor Ovarian Reserve, Platelet Derived Growth Factor
The Role of Ovarian PRP Therapy in Poseidon Poor Responders Women Undergoing ICSI Cycle
Objective : This study aims to evaluate the impact of ovarian PRP therapy compared to control in Poseidon females undergoing ICSI cycles.
- Trial name
- PRP (NCT07199868)
- Testing
- During early-mid follicular phase, using TV-US guidance and conscious sedation, 1.5 ml of PRP was injected into each ovary's subcortical layer using a 17-gauge ovum pick-up needle.
- Where
- 2 sites in Iraq
- Volunteers
- 102 people, healthy volunteers welcome
- Sponsor
- Karbala University
Infertility, Poor Ovarian Reserve
Ovarian PRP Injections for Improved Embryo Quality Using Embryo Quality Score
Patients will have ovarian PRP treatments and embryo development will be observed using time-lapse imaging and AI software.
- Conditions
- Infertility, Poor Ovarian Reserve, Embryo Growth Disorder, in Vitro Fertilization
- Trial name
- NCT07020546
- Testing
- Ovarian Platelet-rich plasma (PRP) injections
- Where
- United States
- Volunteers
- 180 people, healthy volunteers welcome
- Sponsor
- Generation Next Fertility
Ovarian Reserve, Poor Responders
Controlled Ovarian Stimulation Versus Modified Natural Cycles in Poor Responders
This is a prospective, randomized, single center, phase 4 controlled trial. The study will compare the efficacy of two different strategies for the management of predicted poor response patients under stimulation for IVF/ICSI: up…
- Conditions
- Ovarian Reserve, Poor Responders, IVF
- Trial name
- MONACO (NCT04487925)
- Testing
- A single Gonadotropin-Releasing Hormone (GnRH) antagonist corifollitropin alfa (CFA) stimulation, Up to three modified natural cycles with Follitropin beta.
- Where
- Belgium
- Volunteers
- 208 people
- Sponsor
- University Hospital, Ghent
Poor Ovarian Reserve
Growth Hormone For Poor Ovarian Reserve Patients in ICSI Trials
Effect of Growth Hormone Adjuvant Therapy on ICSI Trials For Poor ovarian Reserve Patients
- Trial name
- NCT05602090
- Testing
- 4 IU of recombinant GH (Somatotropin )
- Where
- Egypt
- Volunteers
- 120 people, healthy volunteers welcome
- Sponsor
- Beni-Suef University
Poor Ovarian Reserve
Autologous Intraovarian Platelet Rich Plasma Treatment in Women With Poor Ovarian Response
Reproductive age women diagnosed with poor ovarian response (POR) based on Bologna criteria with a history of at least two prior failed ICSI cycle will be recruited for the study.
- Trial name
- NCT04797377
- Testing
- Autologous ovarian PRP injection
- Where
- Bulgaria
- Volunteers
- 66 people
- Sponsor
- Nadezhda Women's Health Hospital
Poor Ovarian Reserve
Dual Trigger in the Final Oocyte Maturation in Poor Ovarian Responders
This is a randomized controlled clinical trial to investigate the effect of dual trigger (hCG and GnRH agonist) on the final oocyte maturation compared to the standard hCG trigger in patients with poor ovarian reserve seeking…
- Trial name
- NCT04224818
- Testing
- Dual trigger, hCG (standard)
- Where
- Lebanon
- Volunteers
- 140 people, healthy volunteers welcome
- Sponsor
- American University of Beirut Medical Center
Poor Ovarian Reserve
Effect of Growth Hormone Injection on the IVF/ICSI Outcome of Patients With Poor Ovarian Reserve.
Declined fertility and ovarian reserve in older women are associated with lower density of Growth hormone (GH) receptors and dysregulation in GH secretion.
- Trial name
- NCT04588844
- Testing
- Polyethylene Glycol Recombinant Human Somatropin
- Volunteers
- 200 people
- Sponsor
- Shandong University
GH, Poor Ovarian Reserve Based on POSEIDON
To Explore the Effect of GH on Outcomes of IVF and Telomerase Activity of Granulosa Cells in Women With POR
It is still a big difficult clinical problem for patients with poor ovarian reserve undergoing in vitro fertilization. The decrease in both quality and quantity of egg are the main cause for poor clinical prognosis.
- Trial name
- NCT04384744
- Testing
- growth hormone
- Volunteers
- 40 people
- Sponsor
- Guangzhou First People's Hospital
Infertility, Ovarian Aging
Dehydroepiandrosterone (DHEA) Intervention To Treat Ovarian Aging
To test the hypothesis that supplementation of DHEA for at least twelve weeks prior to and during ovarian stimulation increases oocyte quantity (number of oocytes retrieved) and oocyte quality (clinical pregnancy rates and…
- Conditions
- Infertility, Ovarian Aging, Diminished Ovarian Reserve (DOR), Predicted Poor-responders
- Trial name
- DITTO (NCT01572025)
- Testing
- Dehydroepiandrosterone
- Where
- United Kingdom
- Volunteers
- 60 people
- Sponsor
- University of Nottingham
Low Ovarian Reserve, Poor Quality Oocytes
Improving the Reproductive Outcome of Poor Quality Ova by Injection of Autologous Somatic Mitochondria
A prospective randomized controlled trial (RCT) to determine the effect of injecting an autologous somatic mitochondria concentrate, together with the spermatozoon during ICSI, into oocytes of older and or poor prognosis in vitro…
- Trial name
- NCT01631578
- Testing
- Injection of an autologous mitochondria to the oocyte.
- Where
- Israel
- Sponsor
- Hadassah Medical Organization
Infertility, Poor Ovarian Reserve
Growth Hormone for Poor Responders in in Vitro Fertilization (IVF)
The purpose of this study is to determine if growth hormone given 4 weeks before as well as during a cycle of in vitro fertilization will improve outcomes in women who have had previous failure with IVF treatment cycles using…
- Trial name
- NCT01204840
- Testing
- Growth Hormone, Patch protocol
- Where
- Canada
- Volunteers
- 38 people, healthy volunteers welcome
- Sponsor
- Ottawa Fertility Centre
Low Ovarian Reserve, Poor Responders to Gonadotropihins Treatment
Can Dormant Perimenopausal Ovarian Follicles Become FSH Responsive?
The purpose of this study to obtain ovarian cortical fragments from perimenopausal patients, who undergo pelvic organ surgery and test whether treatment with PTEN inhibitor and PI3K activating peptide would induce these fragments…
- Trial name
- NCT01201226
- Testing
- Removal of half an ovary
- Where
- Israel
- Volunteers
- 10 people, healthy volunteers welcome
- Sponsor
- The Baruch Padeh Medical Center, Poriya