Clinical trials: Poor Ovarian Response
Infertility
Effect of Dehydroepiandrosterone Administration in Patients With Poor Ovarian Response According to the Bologna Criteria
Women with low ovarian reserve typically respond less well to the drugs used to stimulate the ovary during IVF treatment and produce fewer eggs and, as a result, are less likely to fall pregnant either naturally or after…
- Trial name
- NCT02132559
- Testing
- DHEA
- Where
- China
- Volunteers
- 386 people, healthy volunteers welcome
- Sponsor
- Chinese Medical Association
Premature Ovarian Insufficiency, Infertility, Female
Ovarian PRP (Platelet Rich Plasma) Injection for Follicular Activation
The primary objective is to investigate the efficacy, defined as an increase in oocyte numbers upon ovarian stimulation, and safety of a single intra-ovarian PRP injection vs.
- Conditions
- Premature Ovarian Insufficiency, Infertility, Female, Sterility, Female, PRP
- Trial name
- OPIF (NCT05279560)
- Testing
- autologous PRP (platelet rich plasma), Saline solution (NaCL) Injection
- Where
- Germany
- Volunteers
- 114 people
- Sponsor
- University of Luebeck
Infertility
Extended High Dose Letrozole Regimen Versus Short Low Dose Letrozole Regimen as an Adjuvant to GnRH Antagonist Protocol in the Management of Poor Responders Undergoing IVF-ET
The aim of this randomized controlled trial is to compare the efficacy of extended high dose letrozole regimen (5 mg /day for the first 5 days of cycle and 2.5 mg/day for the subsequent 3 days ) with short low dose letrozole…
- Trial name
- NCT01219153
- Testing
- Extended high dose letrozole regimen /GnRH antagonist protocol, Short low dose letrozole regimen /GnRH antagonist protocol
- Where
- Egypt
- Volunteers
- 136 people
- Sponsor
- Cairo University
Ovarian Stimulation, Reproductive Techniques, Assisted
The Effect of Dual Trigger for Final Oocyte Maturation on IVF/ICSI Outcomes in Patients With Suboptimal Ovarian Response
Recently, in patients with a suboptimal ovarian response, a study of the role of adding a single dose of GnRH agonist to a standard dose of hCG to initiate final oocyte maturation has also been studied. Griffin et al.
- Trial name
- NCT04549649
- Testing
- Dual triggering
- Where
- Iran
- Volunteers
- 52 people, healthy volunteers welcome
- Sponsor
- Royan Institute
Infertility
Protocols for Improved in Vitro Fertilization (IVF) Outcomes
Many infertile patients have a decreased chance of becoming pregnant when using in vitro fertilization (IVF). For these patients, many different treatments are available, but none of them have been shown to be better than the…
- Trial name
- NCT00334243
- Testing
- Microflare protocol for IVF, Antagonist protocol for IVF, Demi-halt protocol for IVF
- Where
- United States
- Volunteers
- 2 people
- Sponsor
- University of California, San Francisco
Infertility
Autologous Platelet-rich Plasma to Improve Responsiveness and Embryo Quality in Patients With Poor Ovarian Response
This study was a prospective randomized controlled trial. Patients with POR who were aged <40 years and underwent IVF/ICSI with assisted ovulation induction at our hospital were enrolled in the study.
- Trial name
- NCT05105724
- Testing
- PRP
- Where
- China
- Volunteers
- 50 people
- Sponsor
- Nanjing University
Infertility,Female
Recombinant LH Supplementation Timing Strategies (From Day 1 or Day 6) to a Standard GnRH Agonist Long Protocol in Subsequent COS Cycle of Older Patients With Unexpected Poor or Suboptimal Ovarian Response
A randomized, controlled, pilot study, for Patients ≥ 35 years and < 40 years old with sufficient ovarian reserve parameters (AFC≥ 5), but showed an unexpected poor or suboptimal ovarian response(defined as ≤ 9 retrieved oocytes…
- Trial name
- NCT04178135
- Testing
- rLH
- Where
- 2 sites in China
- Volunteers
- 100 people, healthy volunteers welcome
- Sponsor
- Reproductive & Genetic Hospital of CITIC-Xiangya
Poor Ovarian Response, Ovarian Reactivation
Proteomic and Biological Characterisation of Plasma for the Study of Changes Following Ovarian Reactivation Treatment
The samples used in PRGF treatments owe their effectiveness to the handling, concentration, and preservation of their components, which explains why samples obtained with different platelet-rich plasma preparation systems may…
- Trial name
- NCT07376460
- Testing
- Platelet Rich Plasma + BMDSCs mobilization
- Where
- Spain
- Volunteers
- 10 people
- Sponsor
- Instituto Valenciano de Infertilidad, IVI Alicante
Ovarian Response
Human Chorionic Gonadotropin (hCG) Priming Prior to Controlled Ovarian Hyperstimulation (COH) in Poor Responder In Vitro Fertilization (IVF) Patients
There is a decline in androgen concentration with ovarian aging. Also, ovarian response to COH in IVF cycles diminishes with ovarian aging.
- Trial name
- APPE (NCT00870025)
- Testing
- human chorionic gonadotropin
- Where
- Spain
- Volunteers
- 60 people
- Sponsor
- IVI Madrid
Ovarian Function at Advanced Reproductive Age
Co Enzyme Q10 Improves IVF Outcome in With Advanced Reproductive Age
The goal of the investigators research is to explore energy production of the ovarian follicle in older reproductive age women at the time of oocyte retrieval.
- Trial name
- NCT01659788
- Testing
- Coenzyme Q10 concomitant treatment
- Where
- Israel
- Volunteers
- 100 people, healthy volunteers welcome
- Sponsor
- Hadassah Medical Organization
In Vitro Fertilization, Poor Ovarian Response
Impact of Melatonin on IVF/ICSI Outcomes in Prospective Poor Responders
The purpose of this study is to investigate the impact of melatonin administration on in vitro fertilization (IVF/ICSI) outcomes namely the total number and quality of the oocytes and embryos in the prospective poor responders.
- Trial name
- NCT02993588
- Testing
- Melatonin
- Where
- 2 sites in Egypt
- Volunteers
- 100 people
- Sponsor
- Assiut University
Female Infertility
Clomiphene Citrate in Combination With Gonadotropins for Ovarian Stimulation in Women With Poor Ovarian Response.
Coadministration of various drugs used for ovarian stimulation can increase the efficiency of IVF especially in poor responders.
- Trial name
- NCT02237755
- Testing
- Clomiphene citrate, Gonadotropins
- Volunteers
- 50 people, healthy volunteers welcome
- Sponsor
- University of Athens
Infertility
Delayed Embryo Transfer in Poor Responders
Poor ovarian response indicates inadequate ovarian response to ovarian stimulation. In the current study the investigators will attempt to compare antagonist and short protocols regarding oocyte as well as embryo quantity and…
- Trial name
- NCT02431689
- Testing
- IVF/ICSI
- Where
- 3 sites in Egypt
- Volunteers
- 400 people
- Sponsor
- Cairo University
Poor Ovarian Response, Infertility, Female
Menstrual Blood Stem Cells in Poor Ovarian Responders
In this controlled trial, poor ovarian responder women will be treated with transplantation of autologous menstrual blood stem cells.
- Trial name
- NCT05703308
- Testing
- Autologous Menstrual Blood Stem Cells
- Where
- Iran
- Volunteers
- 180 people
- Sponsor
- Avicenna Research Institute
Ovarian Response
Androgens for Poor Responders in In Vitro Fertilization
it has been shown that androgens in non human primates may favour follicular growth in the ovaries when animals are treated with gonadotropins which are the hormones used in patients receiving treatment with in vitro…
- Trial name
- NCT00693108
- Testing
- Transdermal testosterone
- Where
- Spain
- Sponsor
- Hospital Clinic of Barcelona
Proteome
Comparison of Endometrial Protein Profile in Spontaneous Versus Stimulated Menstrual Cycles in Poor Responders
Evaluation of endometrial protein profile in spontaneous and stimulated menstrual cycles
- Trial name
- NCT06804174
- Testing
- use of gonadotropins
- Where
- Slovenia
- Volunteers
- 15 people
- Sponsor
- University Medical Centre Ljubljana
Ovarian Stimulation
Dehydroepiandrosterone Supplementation for Poor Responder Patients During in Vitro Fertilization Treatment
The aim of this study was to evaluate the effect of dehydroepiandrosterone supplementation on in vitro fertilization performance and outcome among poor-responder patient.
- Trial name
- NCT01145144
- Testing
- dehydroepiandrosterone crystalline fine powder
- Where
- 2 sites in Israel
- Sponsor
- Meir Medical Center
Infertility, Female
Clinical Trial to Assess the Effect of Testosterone in Patients With Poor Ovarian Response (TESTOPRIM)
Trial to determine the absolute and relative efficacy of two follicular preparation regimens with transdermal testosterone during the cycle (s) prior to the initiation of COS (controlled ovarian stimulation) in patients diagnosed…
- Trial name
- TESTOPRIM (NCT03378713)
- Testing
- GROUP 1: Long testosterone, GROUP 2: Short testosterone, GROUP 3: Control
- Where
- Spain
- Volunteers
- 63 people
- Sponsor
- Instituto de Investigacion Sanitaria La Fe
Poor Response to Ovulation Induction, Infertility, Female
Autologous Platelet Rich Plasma Intraovarian Infusion for Poor Responders
Autologous platelet rich plasma (PRP) intraovarian infusion may improve ovarian response to controlled ovarian stimulation as well as the hormonal profile of poor ovarian response infertile women subjected to intracytoplasmic…
- Conditions
- Poor Response to Ovulation Induction, Infertility, Female, Ovarian Insufficiency, Ovarian Failure
- Trial name
- PRPPOR (NCT05181748)
- Testing
- Autologous platelet rich plasma
- Where
- Greece
- Volunteers
- 100 people, healthy volunteers welcome
- Sponsor
- Genesis Athens Clinic
Infertility
Effect of Testosterone Pretreatment in POR
This study compared the therapeutic effect of 4- and 6-week TTG application before controlled ovarian hyperstimulation (COH) in POR.
- Trial name
- NCT04602143
- Testing
- Testosterone gel
- Where
- Vietnam
- Volunteers
- 165 people
- Sponsor
- Hanoi Medical University