Clinical trials: Poorly Controlled Diabetes Mellitus
Type 2 Diabetes Mellitus
Stepping-down Approach in Patients With Chronic Poorly-controlled Diabetes on Advanced Insulin Therapy?
In traditional step-up approach, the patients with poorly-controlled type 2 diabetes are instructed to take up to 4 insulin injections daily or multiple daily injections (MDI) as the most advanced therapy.
- Trial name
- NCT02846233
- Testing
- GLP1 receptor agonist, basal insulin, SGLT2 inhibitor
- Where
- United States
- Volunteers
- 22 people
- Sponsor
- University of California, San Francisco
Diabetes Mellitus Type 2
A Clinical Trial Assessing The Impact Of Inhaled Insulin On Glucose Control In Patients With Type 2 Diabetes Mellitus
To assess the impact on glucose control by inhaled insulin in patients with type 2 diabetes who are not well controlled on 2 or more oral anti-diabetic agents
- Trial name
- NCT00282971
- Testing
- Inhaled Insulin (Exubera), Standard of Care
- Where
- 64 sites in Canada, France and 5 more
- Volunteers
- 354 people
- Sponsor
- Pfizer
Diabetes Mellitus, Type 2
Comparison of Thrice Daily Biphasic Human Insulin With Basal Bolus Regimen in Type 2 Diabetes Mellitus Patients
It is a proven fact that Basal Bolus insulin regimen is the near- physiological regimen \& Thrice daily Biphasic Insulin Aspart is a comparable alternative for glycemic control in type 2 diabetes mellitus patients.
- Trial name
- NCT01039532
- Where
- India
- Volunteers
- 50 people
- Sponsor
- Post Graduate Institute of Medical Education and Research, Chandigarh
Type 1 Diabetes
Lunch Time Insulin Injection by School Nurse for Poorly Controlled Diabetes
We hypothesize that checking blood sugar and taking long and short acting insulin before lunch at school may improve overall blood sugar control, grades, and decreases school absences in children and teens with poorly controlled…
- Trial name
- NCT00340613
- Testing
- glargine insulin
- Where
- United States
- Volunteers
- 36 people
- Sponsor
- Baylor College of Medicine
Diabetes, Sleep Apnea
CPAP in Diabetes Type 2 Patients With Sleep Apnea
Aim: To assess if six months of treatment with CPAP associated with conventional drug therapy, contribute to improved glycemic control in patients with type 2 diabetes and sleep apnea-hypopnea syndrome SAHS)
- Trial name
- DM-SAHS (NCT01801150)
- Testing
- CPAP nasal treatment
- Where
- Spain
- Volunteers
- 61 people
- Sponsor
- Hospital Universitario La Paz
Type 1 Diabetes
Applying the "New Authority" Model in the Treatment of Poorly Controlled Diabetic Adolescents and Their Families
It is presumed that families of poorly controlled diabetic adolescents (type 1) would benefit from parents' counselling, guided by "the New Authority" model.
- Trial name
- NCT02093676
- Testing
- experimental protocol treatment "The New Authority"
- Where
- Israel
- Volunteers
- 40 people
- Sponsor
- Sheba Medical Center
Type 2 Diabetes Mellitus
Incretin Based Therapy for Poorly Controlled Type 2 Diabetic Patients
Type 2 diabetes patients have been proved to have decreased of glucagon-like peptide-1 (GLP-1) levels. Incretin based therapy is associated with improved glycemic control by boosting GLP-1 levels .
- Trial name
- IBCT2 (NCT02026024)
- Where
- Taiwan
- Volunteers
- 10 people
- Sponsor
- Chang Gung Memorial Hospital
Closed Loop, Diabetes Mellitus, Type 1
Diabeloop for Teens
An open-label, three-centers, controlled, randomized, and crossover study containing 14 days of baseline period with standard of care (SOC) therapy followed by two-sessions of 4-weeks home study phase with Diabeloop closed-loop…
- Conditions
- Closed Loop, Diabetes Mellitus, Type 1, Adolescents (12 to 17 Years Old)
- Trial name
- DBL4T (NCT04725591)
- Testing
- Dexcom G6 Continuous Glucose Monitoring, MEDISAFE WITH External Insulin Pump, Diabeloop Software (Model predictive control)
- Where
- 3 sites in Belgium, France and 1 more
- Volunteers
- 49 people
- Sponsor
- Centre d'Etudes et de Recherche pour l'Intensification du Traitement du Diabète
Type2 Diabetes
Head-to-head Comparison of Empagliflozin and Dapagliflozin
This open-labeled, prospective, observational, 3-year, clinical study was conducted to compare the effectiveness and safety between empagliflozin (25 mg once daily) and dapagliflozin (10 mg once daily) in patients with…
- Trial name
- NCT03748810
- Testing
- Empagliflozin, Dapagliflozin
- Where
- South Korea
- Volunteers
- 600 people
- Sponsor
- Chungbuk National University Hospital
Hypertension
A Study of the Effects of 6R-BH4 on Blood Pressure in Subjects With Poorly Controlled Systemic Hypertension
The purpose of this study is to determine whether 6R-BH4 (sapropterin dihydrochloride) is safe and effective in the treatment of poorly controlled hypertension in the presence or absence of type 2 diabetes.
- Trial name
- NCT00325962
- Testing
- 6R-BH4 (sapropterin dihydrochloride)
- Where
- 24 sites in United States
- Volunteers
- 84 people
- Sponsor
- BioMarin Pharmaceutical
Type 2 Diabetes Mellitus
Glimepiride, Alogliptin and Alogliptin+Pioglitazone Combination
This trial is a three-armed, open label, random assignment trial. The research subjects are patients who are first starting their treatment or patients who have failed with the metformin treatment and are changing their…
- Trial name
- NCT04470310
- Testing
- Glimepiride, Alogliptin 25Mg Tab, Alogliptin-Pioglitazone 25 Mg-15 Mg Oral Tablet
- Volunteers
- 99 people
- Sponsor
- Seoul National University Hospital
Type 2 Diabetes Mellitus
Impact of Web-based Care Management for Poorly Controlled Type 2 Diabetes Mellitus: a Randomized, Controlled Trial
Between October 1 and November 30, 2011, participants will be enrolled in this study comparing the use of MyLink web-based care with usual CPS care. Patients age 18- 74 with HbA1c ≥ 9% in the last 12 months will be identified.
- Trial name
- NCT01960062
- Testing
- Diabetes software and device
- Where
- United States
- Sponsor
- Kaiser Permanente
Gastric Ultrasound, Gastric Ultrasound in Chronic Opioid Use (≥2 Weeks)
Does Pre-operative Gastric Ultrasound Influence Anaesthetic Decision-Making in Chronic Pain Patients? A Prospective Observational Cohort.
Gastric POCUS has been validated and shown to be an accurate diagnostic tool in both healthy individuals and medically complex patient populations.
- Conditions
- Gastric Ultrasound, Gastric Ultrasound in Chronic Opioid Use (≥2 Weeks), Gastric Ultrasound in Poorly Controlled Acute-on-chronic Pain, Gastric Ultrasound in Acute Opioid Administration Within 24 Hours Prior to the Procedure
- Trial name
- NCT07537582
- Where
- United Arab Emirates
- Volunteers
- 140 people
- Sponsor
- Danat Al Emarat Hospital
Diabetes Mellitus
Electronic Decision Support for Intervention in Poorly Controlled Type 2 Diabetes
To determine the impact of an electronic decision support tool on physician decision making and patient outcomes for the treatment of poorly controlled diabetes mellitus. Primary endpoint will measure change in hemoglobin A1c.
- Trial name
- PATH (NCT02924207)
- Testing
- PATH electronic decision support tool
- Where
- United States
- Volunteers
- 77 people, healthy volunteers welcome
- Sponsor
- St Elizabeth Healthcare
Type 2 Diabetes Mellitus
Efficacy and Safety of SHR3824 in Combination With Metformin in Subjects With Type 2 Diabetes
The purpose of this study is to obtain information on efficacy and safety of SHR3824 with metformin over 24 weeks and 52 weeks in metformin monotherapy poorly glycemic controlled chinese Type 2 Diabetes.
- Trial name
- NCT04390295
- Testing
- SHR3824, metformin
- Where
- China
- Volunteers
- 450 people
- Sponsor
- Jiangsu HengRui Medicine Co., Ltd.
Type 2 Diabetes
The Breakfast Study
The investigators conducted an acceptability, feasibility, preliminary effectiveness trial of a 4-month, online, very low-carbohydrate breakfast-focused program in 120 adults with type 2 diabetes.
- Trial name
- NCT05986097
- Testing
- Breakfast
- Where
- United States
- Volunteers
- 119 people
- Sponsor
- University of Michigan
Diabetes Mellitus, Type 1
Type 1 Diabetes Telemedicine
At the conclusion of this project, investigators will have assessed the effectiveness of home-based telemedicine for improving multiple important clinical and patient-centered outcomes in a high-risk pediatric cohort with T1D.
- Trial name
- NCT03374462
- Testing
- Telemedicine Intervention
- Where
- United States
- Volunteers
- 59 people
- Sponsor
- University of California, Davis
Diabetes Mellitus, Type 2
LANTUSTITR: Insulin Glargine in Type 2 Diabetes Mellitus
The rationale of the study is to determine: the first dose and the titration of basal insulin the exact daily time administration of basal insulin in poorly controlled type II diabetic patients.
- Trial name
- NCT00349986
- Testing
- Insuline glargine
- Where
- Hungary
- Volunteers
- 4 people
- Sponsor
- Sanofi
Diabetes Mellitus, Type 2
This Study Is To Determine If Inhaled Insulin Is Effective In Treating Type 2 Diabetes Mellitus
This study is to determine if inhaled insulin is effective in treating type 2 diabetes mellitus.
- Trial name
- NCT00418522
- Testing
- Insulin glargine, Inhaled Insulin (Exubera)
- Where
- 73 sites in United States, Puerto Rico
- Volunteers
- 413 people
- Sponsor
- Pfizer
Type 2 Diabetes Mellitus, Hypoglycemia
Bedtime Insulins and Oral Antihyperglycemic Drugs in Type 2 Diabetes
The maintenance of nearly normal glycemic levels reduces the risk of diabetic complications, but is difficult to achieve, despite the administration of escalating doses of oral antidiabetic drugs, such as metformin…
- Trial name
- NCT00641407
- Testing
- NPL insulin, Insulin glargine
- Where
- Italy
- Volunteers
- 100 people
- Sponsor
- University of Campania Luigi Vanvitelli