Clinical trials: Population Study
Healthy Volunteer
A Study to Investigate the Effects of Rifampicin on the Pharmacokinetics of Aleglitazar in Healthy Volunteers
This open-label, fixed-sequence, three-period, single group study will evaluate the effects of rifampicin on the pharmacokinetics of aleglitazar in healthy volunteers.
- Trial name
- NCT01679639
- Testing
- aleglitazar, rifampicin
- Where
- United Kingdom
- Volunteers
- 24 people, healthy volunteers welcome
- Sponsor
- Hoffmann-La Roche
Cervical Intraepithelial Neoplasia, Cervical Cancer
Chinese Cancer Prevention Study(CHICAPS)
The purpose of this study is to develop and implement a community based preventive healthcare model using cervical cancer screening as the target medical intervention.
- Conditions
- Cervical Intraepithelial Neoplasia, Cervical Cancer, Cervical Neoplasm, Cervical Dysplasia
- Trial name
- CHICAPS (NCT01524003)
- Testing
- cryotherapy, Colposcopy
- Where
- China
- Volunteers
- 8,382 people, healthy volunteers welcome
- Sponsor
- Preventive Oncology International, Inc.
Health Adult Subjects, Exposure Occupational
French Military Firefighters to Assess Relationships Between Exposome and Health.
The aim of the study is to describe professional exposures and health events among French military firefighters (both active-duty personnel and veterans) and identify potential relationships between the exposome (the total…
- Conditions
- Health Adult Subjects, Exposure Occupational, Health Behavior, Risky, Occupational Health
- Trial name
- COMITEX-BSPP (NCT07270627)
- Where
- France
- Volunteers
- 1,811 people, healthy volunteers welcome
- Sponsor
- Direction Centrale du Service de Santé des Armées
Hepatic Impairment, Healthy
A Study to Evaluate Pharmacokinetics and Safety of Tegoprazan in Subjects With Hepatic Impairment and Healthy Controls
The main purpose of this study is to compare the pharmacokinetic and safety of tegoprazan following single oral dose in subjects with hepatic impairment versus healthy control.
- Trial name
- NCT04494269
- Testing
- Tegoprazan 50mg
- Where
- 3 sites in South Korea
- Volunteers
- 28 people, healthy volunteers welcome
- Sponsor
- HK inno.N Corporation
Athletic Performance, Decision Making
Critical Thinking Tactical Training in University Futsal Players
This study examined the effects of a tactical training program based on critical thinking (TPCT) on the tactical efficiency and decision-making performance of university futsal players.
- Trial name
- TPCT-FUTSAL (NCT07279753)
- Testing
- Tactical Program Critical Thinking
- Where
- Colombia
- Volunteers
- 13 people, healthy volunteers welcome
- Sponsor
- Federal University of Vicosa
Hypertension, African Americans
Giving a Low Carbohydrate Diet to Overcome Hypertension
This study will test the preliminary efficacy of adding a very low carbohydrate dietary intervention to the evidence-based DPP-GLB on blood pressure reductions for lower-income AA men and women in a community-based clinic.
- Conditions
- Hypertension, African Americans, Diet, Carbohydrate-Restricted, Risk Reduction Behavior
- Trial name
- GLOH (NCT04230928)
- Testing
- Very low carbohydrate diet, Standard DPP-GLB diet, Standard DPP-GLB program modules
- Where
- United States
- Volunteers
- 64 people, healthy volunteers welcome
- Sponsor
- Baylor Research Institute
Mild Cognitive Impairment (MCI), Parkinsons Disease (PD)
Study to Investigate Vagus Nerve Stimulation to Augment Executive Function in Healthy and Cognitively Impaired Populations
This study plans to learn more about how stimulating the vagus nerve through gentle electrical stimulation applied to the ear can affect decision-making, problem-solving, and other thinking abilities.
- Conditions
- Mild Cognitive Impairment (MCI), Parkinsons Disease (PD), Healthy Adult
- Trial name
- NCT07424365
- Testing
- transcutaneous auricular vagus nerve stimulation
- Where
- United States
- Volunteers
- 80 people, healthy volunteers welcome
- Sponsor
- University of Colorado, Denver
Atherosclerosis, Intermittent Claudication
Does the Reduction of Total Body Iron Storage (TBIS) Alter Mortality in a Population of Patients With Advanced PVD?
Veterans Affairs Cooperative Study #410, The Iron and Atherosclerosis Trial, FeAST, a 24-hospital prospective randomized single-blinded clinical trial of graded iron reduction was conducted between May 1, 1999 and April 30, 2005…
- Conditions
- Atherosclerosis, Intermittent Claudication, Peripheral Vascular Diseases
- Trial name
- FeAST (NCT00032357)
- Testing
- Ferritin reduction to 25 ng/ml by phlebotomy
- Where
- 24 sites in United States, Puerto Rico
- Volunteers
- 1,277 people, healthy volunteers welcome
- Sponsor
- US Department of Veterans Affairs
QT Effects in Healthy Volunteers
Effect of a Single Oral Dose of Moxidectin on the Cardiac QT Interval of Healthy Volunteers
This study will investigate the effect of a single oral dose of moxidectin on the QT interval associated with moxidectin plasma concentrations.
- Trial name
- NCT03012828
- Testing
- Moxidectin
- Where
- United States
- Volunteers
- 60 people, healthy volunteers welcome
- Sponsor
- Medicines Development for Global Health
ALS
Spinal Interneuron Excitability in ALS
Amyotrophic lateral sclerosis (ALS) is due to neurodegeneration of upper and lower motor neurons, leading to muscle atrophy, paralysis and death.
- Trial name
- SpineBioMark (NCT02429492)
- Testing
- Electrophysiology
- Where
- France
- Volunteers
- 101 people, healthy volunteers welcome
- Sponsor
- Institut National de la Santé Et de la Recherche Médicale, France
Plasmodium Falciparum Malaria, Plasmodium Vivax Malaria
Targeting High Risk Populations With Enhanced Reactive Case Detection in Southern Lao Peoples Democratic Republic
This study assesses the effectiveness and feasibility of enhanced reactive case detection (RACD) targeting high-risk villages and forest workers for reducing Plasmodium falciparum and Plasmodium vivax transmission in southern Lao…
- Trial name
- COMBAT (NCT04416945)
- Testing
- Household Reactive Case Detection, RACD of cases' co-workers/co-travelers, Case Management and Follow-up
- Where
- Laos
- Volunteers
- healthy volunteers welcome
- Sponsor
- University of California, San Francisco
Pregnancy
Effect of a Dairy Product for Pregnant and Lactating Women on the Composition of Human Milk
Vulnerable populations, who have deficient diets, may produce human milk (HML) that is not adequate in all nutrients, and this will have consequences on the growth and development of the child.
- Trial name
- NCT07173881
- Testing
- Fortified powder milk
- Where
- 2 sites in Argentina
- Volunteers
- 20 people, healthy volunteers welcome
- Sponsor
- Instituto de Desarrollo e Investigaciones Pediátricas Prof. Dr. Fernando E. Viteri
Intrahepatic Cholestasis of Pregnancy, Genetic Mutation
Bile Acids Metabolism and Genetic Mutation Profile in the Intrahepatic Cholestasis of Pregnacy in Indian Population
Intrahepatic cholestasis of pregnancy (ICP) is a disorder characterized by itching, elevated fasting serum bile acids ≥10μmol/L (and elevated serum transaminases), with increased risks of perinatal complications, including…
- Conditions
- Intrahepatic Cholestasis of Pregnancy, Genetic Mutation, Health Related Quality of Life
- Trial name
- ICP (NCT05691036)
- Where
- India
- Volunteers
- 150 people, healthy volunteers welcome
- Sponsor
- Post Graduate Institute of Medical Education and Research, Chandigarh
Tobacco Use Disorder
Project 3, Study 2: Extended Exposure to Low Nicotine Content Cigarettes in People With Current Affective Disorders
This study will examine extended exposure to cigarettes varying in nicotine content among disadvantaged women. Adults with affective disorders are at increased risk for smoking, nicotine dependence, and using high nicotine yield…
- Trial name
- NCT02232737
- Testing
- Very low nicotine content cigarettes
- Where
- 2 sites in United States
- Volunteers
- 775 people, healthy volunteers welcome
- Sponsor
- Brown University
Healthy Volunteers
Study Comparing Pharmacokinetics, Safety and Immunogenicity of CT-P6 and US-licensed Herceptin
This is a double-blind, two-arm, parallel-group, single-dose study.
- Trial name
- NCT02665637
- Testing
- Trastuzumab
- Where
- United States
- Volunteers
- 70 people, healthy volunteers welcome
- Sponsor
- Celltrion
Alzheimer's Disease
Dose-ranging Safety and Tolerability Study in Subjects ≥60 Years of Age
The study determined the safety of CNP520 in healthy elderly over 3 months. Data relevant for Pharmacokinetic/Pharmacodynamic modeling were obtained in order to define the target dose in subsequent efficacy studies.
- Trial name
- NCT02576639
- Testing
- CNP520
- Where
- 11 sites in United States, Belgium and 3 more
- Volunteers
- 124 people, healthy volunteers welcome
- Sponsor
- Novartis Pharmaceuticals
Mild Moderate, or Severe Renal Impairment
An Open-label, Parallel-group Study to Determine the Pharmacokinetics of a Single Dose of AFQ056 in Subjects With Renal Impairment Compared to Healthy Subjects
The aim of this study was to characterize the pharmacokinetics and safety of AFQ056 in subjects with a different degree of renal impairment.
- Trial name
- NCT01442259
- Testing
- AFQ056
- Where
- Germany
- Volunteers
- 48 people, healthy volunteers welcome
- Sponsor
- Novartis Pharmaceuticals
Multiple Sclerosis
EPID Multiple Sclerosis Pregnancy Study
Multiple Sclerosis (MS) is the most common chronic neurologic disability in young adult females in their childbearing ages. Little evidence is available regarding the association between exposure to IFN-beta (β) products and…
- Trial name
- NCT02749396
- Testing
- Betaseron (Interferon beta-1b, BAY86-5046), Bayer HealthCare AG, Extavia (interferon beta-1b), Novartis Pharma AG, Rebif (interferon beta-1a), Merck Serono Europe Ltd
- Where
- Finland
- Volunteers
- 2,089 people, healthy volunteers welcome
- Sponsor
- Bayer
Healthy
A Study to Assess the Safety, Tolerability and Pharmacokinetics of Modified-Release Formulations of AZD1446 After Oral Single and Repeated Doses
The purpose of this study is to assess safety, tolerability and pharmacokinetics of AZD1446 in young and elderly healthy Japanese volunteers.
- Trial name
- NCT01199315
- Testing
- AZD1446
- Where
- Japan
- Volunteers
- 24 people, healthy volunteers welcome
- Sponsor
- AstraZeneca
Hepatic Impairment
A Phase I Study to Assess the Pharmacokinetics of Olorofim in Subjects With Hepatic Impairment
A single oral dose study to investigate the PK and safety of olorofim in mild and moderately hepatically impaired subjects compared to subjects with normal hepatic function.
- Trial name
- NCT04752540
- Testing
- Olorofim
- Where
- 2 sites in United States
- Volunteers
- 32 people, healthy volunteers welcome
- Sponsor
- F2G Biotech GmbH
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