Clinical trials: Positron-Emission Tomography
Post Traumatic Stress Disorder
A Pilot Study of Deep Brain Stimulation of the Amygdala for Treatment-Refractory Combat Post-Traumatic Stress Disorder
The purpose of this study is to determine whether deep brain stimulation of the basolateral nucleus (BLn) of the amygdala, on both sides of the brain, can safely reduce symptoms of post-traumatic stress disorder (PTSD) in combat…
- Trial name
- ADIP (NCT01658748)
- Testing
- Week 0 Medtronic 3387 electrodes/Activa PC amygdala DBS, Week 12 Medtronic 3387 electrodes/Activa PC amygdala DBS
- Where
- United States
- Sponsor
- US Department of Veterans Affairs
Acute Myocardial Infarction
68 Ga-NODAGA-E[c(RGDγK)]2: Positron Emission Tomography Tracer for Imaging of Myocardial Angiogenesis
The aim is to examine the expression of αvβ3 integrin using a novel selective radiotracer in patients with myocardial infarction and investigate if it is a suitable tool for predicting myocardial recovery and thus prognosis.
- Trial name
- NCT03445884
- Testing
- 68Ga-NODAGA-E[c(RGDyK)]2
- Where
- Denmark
- Volunteers
- 42 people, healthy volunteers welcome
- Sponsor
- Copenhagen University Hospital, Rigshospitalet
68Ga-FAPI, Ovarian Cancer
Clinical Application of 68Ga-FAPI PET Imaging in Detection of Ovarian Cancer Recurrence
This is a prospective study to investigate the potential efficacy of 68Ga-FAPI PET/CT for recurrence detection of epithelial ovarian cancer in comparison with 18F-FDG PET/CT.
- Conditions
- 68Ga-FAPI, Ovarian Cancer, Epithelial Ovarian Cancer, Positron Emission Tomography
- Trial name
- NCT05856409
- Testing
- 68Ga-FAPI
- Where
- China
- Volunteers
- 20 people
- Sponsor
- RenJi Hospital
Cancer
Study of Kinetics, Dosimetry & Safety of [18F]F-AraG, a Positron Emission Tomography Imaging Tracer in Healthy Humans
The goal of this study is to visualize biodistribution of a PET tracer called [18F]F-AraG through time in healthy human volunteers.
- Trial name
- NCT02323893
- Testing
- [18F]F-AraG
- Where
- United States
- Volunteers
- 6 people, healthy volunteers welcome
- Sponsor
- CellSight Technologies, Inc.
Lung Cancer, Colorectal Cancer
Evaluation of 89Zr-DFO-nimotuzumab for Non-invasive Imaging of EGFR+ Cancers by Positron Emission Tomography (PET)
Over-expression of Epidermal Growth Factor Receptor (EGFR) on cells occurs in all aggressive cancers of epithelial origin. Existing tests for monitoring EGFR expression are invasive and not reliable.
- Trial name
- NCT04235114
- Testing
- 50 mg 89Zr-DFO-Nimotuzumab, 1 mg 89Zr-DFO-Nimotuzumab
- Where
- Canada
- Volunteers
- 14 people
- Sponsor
- University of Saskatchewan
Irritable Bowel Syndrome
Pilot Study of the Physiological Effects of an Integrative Medicine Approach in Irritable Bowel Syndrome
Although underutilized, what is emerging as one of the best ways of evaluating inflammation in the body, particularly in difficult to observe regions, is through the use of Fluorodeoxyglucose (FDG) positron emission tomography…
- Trial name
- IBS (NCT03370614)
- Testing
- IBS Group, Healthy Control Group
- Where
- 2 sites in United States
- Volunteers
- 50 people, healthy volunteers welcome
- Sponsor
- Thomas Jefferson University
Congenital Hyperinsulinism, Insulinoma
Fluorodopa F 18 in Congenital Hyperinsulinism and Insulinoma
Low blood sugars are known to cause brain damage in newborn babies. One of the most common causes of low blood sugars persisting beyond the new born period is a condition called congenital hyperinsulinism (HI).
- Trial name
- NCT02021604
- Testing
- Fluorodopa F 18
- Where
- United States
- Volunteers
- 250 people
- Sponsor
- Cook Children's Health Care System
Cancer
[18F]FAraG PET Imaging for Analysis of Biodistribution in Cancer Patients Expected to Undergo Immunotherapy and/or Radiation Therapy
This is a Phase 1 study is to visualize biodistribution of a PET tracer called [18F]F-AraG (VisAcT) in cancer patients expected to undergo immunotherapy and/or radiation therapy.
- Trial name
- NCT03142204
- Testing
- [18F]F-AraG
- Where
- United States
- Volunteers
- 30 people
- Sponsor
- CellSight Technologies, Inc.
Healthy Volunteers
A Phase I Study in Healthy Volunteers to Assess Dosimetry and Safety Following Injection of BMS747158 at Stress
The purpose of this clinical research study is to learn the biodistribution of injection of BMS747158 at stress and assess the safety of two doses of BMS747158
- Trial name
- NCT00707538
- Testing
- BMS747158
- Where
- 2 sites in United States
- Volunteers
- 12 people, healthy volunteers welcome
- Sponsor
- Lantheus Medical Imaging
Healthy
Positron-Emission Tomography With Vesicular Monoamine Transporter Ligand ([18F]-DTBZ) In Healthy Elderly And Young Subjects
A total 25 healthy subjects will be included in this study. Subjects between 20 and 80 years of age may be eligible for this study. Candidates are screened with a medical history and physical examination, and blood test.
- Trial name
- NCT01838785
- Testing
- 18F-DTBZ AV-133
- Volunteers
- 25 people, healthy volunteers welcome
- Sponsor
- Chang Gung Memorial Hospital
B Cell Malignancies, B-cell Leukemia
Bispecific CAR T Cells for B-cell Malignancies (BaseCAR-01 Trial)
This study is to provide locally produced, bispecific CD19 CD20 CAR T cells to patients with B-cell lymphoma/leukemia who have no access to commercial CAR T cells or who have relapsed thereafter.
- Conditions
- B Cell Malignancies, B-cell Leukemia, B Cell Lymphoma, Bispecific Chimeric Antigen Receptor (CAR) T Cells
- Trial name
- BaseCAR-01 (NCT07166549)
- Testing
- Experimental Intervention
- Where
- Switzerland
- Volunteers
- 12 people
- Sponsor
- University Hospital, Basel, Switzerland
Giant Cell Arteritis, Large Vessel Giant Cell Arteriitis
Longitudinal Imaging in Patients With Large Vessel Vasculitis to Predict Further Disease Course
Longitudinal imaging in patients with large vessel vasculitis to predict further disease course
- Trial name
- NCT04204876
- Testing
- Magnet Resonance Imaging (MRI), PET/CT analysis
- Where
- Switzerland
- Volunteers
- 40 people
- Sponsor
- University Hospital, Basel, Switzerland
Melanoma (Skin)
PET and CT Scans to Evaluate Patients With Stage III or Stage IV Melanoma
RATIONALE: Diagnostic procedures may improve the ability to detect metastatic melanoma and to determine the extent of disease. PURPOSE: Phase II trial to evaluate the effectiveness of PET and CT scans to detect metastatic disease…
- Trial name
- NCT00004152
- Testing
- iodinated contrast dye, computed tomography, positron emission tomography
- Where
- United States
- Sponsor
- Memorial Sloan Kettering Cancer Center
Biliary Tract Cancer
A Phase II Trial of Preoperative Chemotherapy for Biliary Tract Cancer (BTC) With Node Metastasis
To evaluate the efficacy and the safety of preoperative chemotherapy with Gemcitabine/ Cisplatin /S-1 for biliary tract cancers with lymph node metastasis by FDG-PET.
- Trial name
- NCT01821248
- Testing
- Gemcitabine, Cisplatin, S-1
- Where
- Japan
- Volunteers
- 25 people
- Sponsor
- Kansai Hepatobiliary Oncology Group
Metastatic Cancer, Unresectable Solid Tumor
CSB-321 Ph 1 in Immunotherapy for the Treatment of Cancer
Single-center with the option to expand to multi-center, international, open label, non-randomized, multiple-dose, multi-cohort study, in participants with metastatic or unresectable cancer.
- Trial name
- NCT07057349
- Testing
- [18F]CSB-321
- Where
- United States
- Volunteers
- 40 people
- Sponsor
- Cytosite Biopharma Inc.
Prostate Cancer
Diagnostic Performance of PSMA PET/CT for Pre-operative Lymph Node Assessment in Intermediate and High-risk Non-metastasic Prostate Cancer (PREOP-PSMA ).
In France, prostate cancer is the most common cancer in men over 50 years of age (nearly 50,000 new cases per year) and is the second most common cause of cancer death in men (approximately 9,000 deaths per year).
- Trial name
- PREOP-PSMA (NCT04745871)
- Testing
- PSMA PET/CT
- Where
- France
- Volunteers
- 112 people
- Sponsor
- University Hospital, Brest
Prostate Cancer (Adenocarcinoma), Adenocarcinoma of the Prostate
RYZ711 Diagnostic Platform Study
This is a Phase 1/2 multicenter, multi-cohort imaging study to evaluate the safety, tolerability, and diagnostic performance of RYZ711 positron emission tomography/computed tomography (PET/CT) in men with histologically confirmed…
- Conditions
- Prostate Cancer (Adenocarcinoma), Adenocarcinoma of the Prostate, Metastatic Castration-resistant Prostate Cancer (mCRPC), Metastatic Hormone-Sensitive Prostate Cancer (mHSPC)
- Trial name
- NCT07862582
- Testing
- RYZ711, PSMA PET/CT
- Where
- United States
- Volunteers
- 116 people
- Sponsor
- RayzeBio, Inc.
Neurodegenerative Diseases
Study on the Application of ¹⁸F-FCOB04, a MAO-B Targeted PET Imaging Agent, in Neurodegenerative Diseases
In this clinical trial, we intend to perform 18F-FCOB04 PET imaging in patients with neurodegenerative diseases to observe the brain uptake of this tracer.We will investigate the distinct imaging patterns of brain MAO-B…
- Trial name
- NCT07470710
- Testing
- 18F-FCOB04
- Volunteers
- 40 people, healthy volunteers welcome
- Sponsor
- Peking Union Medical College Hospital
Oral Cancer, Oropharyngeal Cancer
uPAR PET/CT for Staging Advanced and Localised Oral and Oropharyngeal Cancer
uPAR PET/CT for Staging Advanced and Localised oral and oropharyngeal cancer
- Conditions
- Oral Cancer, Oropharyngeal Cancer, Neoplasms, Head and Neck Neoplasms
- Trial name
- NCT02960724
- Testing
- 68Ga-NOTA-AE105 PET/CT
- Where
- Denmark
- Volunteers
- 90 people
- Sponsor
- Copenhagen University Hospital, Rigshospitalet
Sarcoma
FAZA PET/MRI Sarcoma
This is a dual arm, single centre, investigator initiated study to investigate the use of FAZA-PET in combination with MRI. FAZA is an investigational radiotracer used in PET scans.
- Trial name
- NCT03418818
- Testing
- 18F-FAZA, Pimonidazole
- Where
- Canada
- Volunteers
- 70 people
- Sponsor
- University Health Network, Toronto
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