Clinical trials: Post Concussive Syndrome, open to volunteers
Post-Concussion Syndrome, COVID Long-Haul
Percutaneous Electrical Nerve Field Stimulation (PENFS) in Patients With Post Concussion Syndrome (PCS)
The purpose of this study is to test the effect of Auricular Percutaneous Electrical Nerve Field Stimulation (a Neurostim device) on children with pain and Post Concussion symptoms.
- Conditions
- Post-Concussion Syndrome, COVID Long-Haul, COVID-19
- Trial name
- NCT04978571
- Testing
- percutaneous electrical nerve-field stimulation, PENFS, percutaneous electrical nerve-field stimulation, PENFS (COVID active device)
- Where
- United States
- Volunteers
- 125 people
- Sponsor
- Children's Hospital of Orange County
Chronic Traumatic Encephalopathy
Post-Concussion Syndrome in Professional Athletes: A Multidisciplinary Study
to examine the relationship between repeated concussions and late decline of brain function. In addition, all participants agreeing to participate in the study will be asked to will their brains to The Krembil Neuroscience Centre…
- Trial name
- NCT03218332
- Testing
- Biomarkers for detecting possible CTE invivo
- Where
- Canada
- Volunteers
- 150 people, healthy volunteers welcome
- Sponsor
- University Health Network, Toronto
Persistent Post-concussive Symptoms
Transcutaneous Auricular Vagus Nerve Stimulation for Persistent Post-concussion Symptoms
Persistent post-concussive symptoms (PPCS) affect a significant proportion of individuals following a concussion, leading to debilitating impacts on their quality of life and work capacity.
- Trial name
- taVNS-PPCS (NCT07017257)
- Testing
- Active taVNS
- Where
- Belgium
- Volunteers
- 48 people
- Sponsor
- University of Liege
Transcranial Direct Current Stimulation, Post-Concussion Syndrome
Effects of tDCS for Enhancing Cognitive Function in Individuals With Persistent Post-Concussion Syndrome
Globally, 10 million new traumatic brain injury (TBI) cases are estimated annually, with mild traumatic brain injury (mTBI) accounting for 75-90% of all TBI cases.
- Conditions
- Transcranial Direct Current Stimulation, Post-Concussion Syndrome, Functional Magnetic Resonance Imaging, Magnetic Resonance Spectroscopy
- Trial name
- NCT06376500
- Testing
- tDCS with cognitive training programme
- Where
- Hong Kong
- Volunteers
- 40 people
- Sponsor
- The Hong Kong Polytechnic University
Concussion (Diagnosis), Concussion Post Syndrome
Female Concussion Head Cooling
This research is being done to examine the benefits of a 28 day head cooling intervention on cognition, inflammation of the brain, sleep quality, menstrual symptom interaction, and mood in acutely concussed females.
- Conditions
- Concussion (Diagnosis), Concussion Post Syndrome, Concussion, Mild
- Trial name
- NCT07303933
- Testing
- Brain Cooling
- Where
- United States
- Volunteers
- 32 people
- Sponsor
- Penn State University
Post Concussion Syndrome
Effects of Vestibular Rehabilitation and Routine Physical Therapy in Athletes With Post Concussion Syndrome
This randomized controlled trial with a parallel design was conducted over six months at Ghurki Trust Teaching Hospital to compare the effects of Vestibular Rehabilitation and Routine Physical Therapy on stability, kinesiophobia…
- Trial name
- PCS BESS IPRRS (NCT07401706)
- Testing
- Intervention 1, Control Arm (Conventional Therapy)
- Volunteers
- 34 people
- Sponsor
- Lahore University of Biological and Applied Sciences
Persistent Post-concussive Symptoms, Post Traumatic Headache
SPINEPASS: SPINE Self-management Techniques for Persistent Headache After Concussion: Physical Therapy Targeting Autonomic and Dura Mater Function.
This is a prospective randomized controlled trial comparing two different physical therapy approaches to the treatment of posttraumatic headache with autonomic symptoms.
- Trial name
- SPINEPASS (NCT06882239)
- Testing
- SPINEPASS Physical Therapy, Standard Physical Therapy
- Where
- United States
- Volunteers
- 120 people
- Sponsor
- The University of Queensland
Mild Traumatic Brain Injury
Quetiapine to Reduce Post Concussive Syndrome After Mild Traumatic Brain Injury (mTBI)
A two site, 2-arm, Phase III randomized pragmatic clinical trial evaluating the effectiveness of quetiapine monotherapy in comparison to Treatment As Usual (TAU) medication management for symptoms experienced by veterans…
- Trial name
- NCT06333990
- Testing
- Quetiapine Fumarate, TAU
- Where
- 2 sites in United States
- Volunteers
- 146 people
- Sponsor
- Foundation for Advancing Veterans' Health Research
Concussions, Mild Traumatic Brain Injury, Concussion
Mindfulness-Based Intervention for Pediatric Mild Traumatic Brain Injury
Formal MBIs, such as Mindfulness-Based Stress Reduction (MBSR), have been shown to increase resiliency and teach affect regulation.
- Conditions
- Concussions, Mild Traumatic Brain Injury, Concussion, Concussion Mild
- Trial name
- MBI-4-mTBI (NCT07272941)
- Testing
- Mindfulness Based Intervention (MBI)
- Where
- 5 sites in Canada
- Volunteers
- 362 people
- Sponsor
- Children's Hospital of Eastern Ontario
Patients With Persistent Post-concussion Symptoms
Electroencephalography Markers of Brain Stimulation in Post-Concussion Patients
In this randomized, sham-controlled, two-group, parallel, single-session study, the investigators aim to identify EEG biomarkers associated with cerebellar transcranial direct current stimulation (tDCS) in patients with…
- Trial name
- Stim-PPCS (NCT07895797)
- Testing
- tDCS 8 channels
- Where
- Belgium
- Volunteers
- 38 people
- Sponsor
- University of Liege
Brain Concussion, Brain Trauma
Remotely Supervised tDCS+ for Complex Attention in mTBI (Cognetric)
The proposed study will evaluate a new approach to cognitive rehabilitation of mTBI using a brain stimulation technique called "Remotely Supervised Transcranial Direct Current Stimulation combined with Cognitive Training"…
- Conditions
- Brain Concussion, Brain Trauma, Attention Concentration Difficulty, Brain Injuries
- Trial name
- COGNETRIC (NCT06413173)
- Testing
- Active tDCS and Cognitive Training Intervention
- Where
- 2 sites in United States
- Volunteers
- 160 people
- Sponsor
- United States Naval Medical Center, San Diego
Post-Concussion Syndrome
Interest of the 7 Tesla MRI in the Diagnosis of Post-concussion Syndromes Among Patients With Mild Traumatic Brain Injury
We aimed to conduct a prospective longitudinal interventionnal monocentric study to assess the ability of seven tesla MRI to detect diffuses axonal lesions in patients presenting a post concussional syndrom (PCS) at seven days…
- Trial name
- SPIN (NCT04982562)
- Testing
- 7T MRI
- Where
- France
- Volunteers
- 100 people
- Sponsor
- Poitiers University Hospital
Mild Traumatic Brain Injury, Concussion, Mild
Facilitating Access to Specialty Treatment
The goal of this hybrid implementation-effectiveness study is to evaluate the effectiveness (hastened recovery times) and feasibility (fidelity in connecting to concussion specialty care) of a novel mobile health intervention…
- Conditions
- Mild Traumatic Brain Injury, Concussion, Mild, Concussion, Severe, Concussion, Intermediate
- Trial name
- NCT05741411
- Testing
- RPM-assisted specialist access
- Where
- United States
- Volunteers
- 210 people
- Sponsor
- Children's Hospital of Philadelphia
Brain Concussion, Mild Traumatic Brain Injury
Get Going After concussIonN Lite
Background: Concussion affects around 25 000 people each year in Denmark. A large research initiative (GAIN 2.0) has been established, and the current study is a part of this initiative. Aims: 1.
- Conditions
- Brain Concussion, Mild Traumatic Brain Injury, Commotio Cerebri
- Trial name
- GAIN Lite (NCT05233475)
- Testing
- Enhanced usual care (EUC), Get Going after concussIoN Lite
- Where
- Denmark
- Volunteers
- 100 people
- Sponsor
- University of Aarhus
Post Concussion Syndrome
GyroStim for Post Concussion Syndrome
The goal of this study is to evaluate the efficacy of using sensorimotor multi-axis automated rotational therapy (SMART) to help treat post concussion syndrome (PCS) in adults.
- Trial name
- NCT07527663
- Testing
- Sensorimotor Multi-axis Automated Rotational Therapy (SMART) utilizing GyroStim device, Physical therapy and speech therapy/cognitive rehabilitation therapy
- Where
- United States
- Volunteers
- 128 people
- Sponsor
- Neuroscience Group
Concussion, Brain, Brain Injury Traumatic Mild
Concussion Health Improvement Program
More than 1 million U.S. youth sustain a concussion each year, and up to 30% report persistent post-concussive symptoms (PPCS) lasting 1 month or more.
- Trial name
- CHIP (NCT06036147)
- Testing
- Concussion-focused cognitive behavioral therapy, Parent skills training, Care management
- Where
- United States
- Volunteers
- 304 people
- Sponsor
- Seattle Children's Hospital
Autonomic Nervous System Disease, Concussive Injury
Randomized Controlled Trial of Treatment to Optimize Heart Rate Variability for Persistent Post-Concussion Symptoms
Many combat veterans (c-Vs), service members (SMs) and civilians with mild traumatic brain injury (mTBI, also termed concussion) suffer from persistent post-concussion symptoms (PPCS) that degrade physical and cognitive…
- Conditions
- Autonomic Nervous System Disease, Concussive Injury, Mild Traumatic Brain Injury, Post Traumatic Stress Disorder
- Trial name
- NCT07071350
- Testing
- HRV Coherence Ratio, NSI, Pittsburgh Sleep Quality Index (PSQI)
- Where
- United States
- Volunteers
- 148 people
- Sponsor
- Virginia Commonwealth University
Traumatic Brain Injury, PTSD - Post Traumatic Stress Disorder
HBOT Effects on First Responders' Cognition and Well-Being
The goal of this study is to examine changes in cognitive functioning and post-concussive symptoms following hyperbaric oxygen therapy (HBOT) in current and former first responders with a history of traumatic brain injury.
- Conditions
- Traumatic Brain Injury, PTSD - Post Traumatic Stress Disorder, Anxiety, Depression
- Trial name
- NCT07852728
- Testing
- Hyperbaric Oxygen Therapy (HBOT)
- Where
- United States
- Volunteers
- 54 people
- Sponsor
- Summit Hyperbarics and Wellness
Brain Concussion, Mild Traumatic Brain Injury
Repetitive Transcranial Magnetic Stimulation for Post-concussion Headaches
This study aims to examine the long-term effect of repetitive transcranial magnetic stimulation (rTMS), a non-invasive brain stimulation technique, on chronic headaches following mild traumatic brain injury (mTBI).
- Conditions
- Brain Concussion, Mild Traumatic Brain Injury, Headache, Post-Concussion Symptoms
- Trial name
- NCT06112093
- Testing
- Repetitive Transcranial Magnetic Stimulation
- Where
- United States
- Volunteers
- 60 people, healthy volunteers welcome
- Sponsor
- State University of New York - Upstate Medical University
Traumatic Brain Injury (TBI) Patients, Post Concussive Symptoms
Hyperbaric Oxygen Therapy for Veterans With TBI and PCS: A Biomarker Study
The goal of this study is to examine changes in blood biomarkers following hyperbaric oxygen therapy (HBOT) in military veterans with traumatic brain injury and persistent post-concussive symptoms.
- Conditions
- Traumatic Brain Injury (TBI) Patients, Post Concussive Symptoms, PTSD
- Trial name
- NCT07849465
- Testing
- Hyperbaric Oxygen Therapy (HBOT)
- Where
- United States
- Volunteers
- 34 people
- Sponsor
- Summit Hyperbarics and Wellness