Clinical trials: Post Operative Pain, open to volunteers
Apical Periodontitis, Post Operative Pain, Acute
Post-operative Pain and Apical Healing After Root Canal (re)Treatment With Laser-activated Irrigation Versus Sonic or no Activation
When a tooth's nerve dies, inflammation can develop at the tip of the tooth's root. Root canal treatment is carried out to allow this inflammation to heal.
- Trial name
- NCT07883486
- Testing
- sonically activated irrigation, laser activated irrigation, conventional needle irrigation
- Where
- 2 sites in Belgium
- Volunteers
- 183 people
- Sponsor
- University Ghent
Hip Fractures (ICD-10 72.01-72.2), Post Operative Analgesia
Suzetrigine (Journavx) as Multimodal Therapy for Pain Management in Adults Undergoing Surgery for Hip Fracture
The goal of this clinical trial is to learn whether suzetrigine (Journavx®), when added to standard multimodal pain management, can reduce opioid use while providing adequate pain control in adults undergoing surgery for an acute…
- Trial name
- STRIDE-HIP (NCT07905404)
- Testing
- Suzetrigine (Journavx)
- Where
- United States
- Volunteers
- 79 people
- Sponsor
- Beth Israel Deaconess Medical Center
Pain, Acute, Pain, Chronic
Butyrate and Taurine for Chronic Postsurgical Pain in Adult Cardiac Surgical Patients
This study is a single-center, phase II, randomized, placebo-controlled, Bayesian-designed, double-blinded trial Goal and Questions: The primary goal is to evaluate if a combination of taurine and butyrate can reduce chronic…
- Conditions
- Pain, Acute, Pain, Chronic, Chronic Post Operative Pain
- Trial name
- NCT07144033
- Testing
- Butyrate and Taurine
- Where
- Hong Kong
- Volunteers
- 216 people
- Sponsor
- Chinese University of Hong Kong
Ventral Hernia, Ventral Incisional Hernia
The IMPACT Study: Personalized Physical Therapy for Better Recovery and a Stronger Core After Hernia Surgery
Ventral hernia repair is among the most common operations performed in the United States each year, yet the great majority of patients receive no structured rehabilitation for the persistent pain, weakness, and functional loss…
- Conditions
- Ventral Hernia, Ventral Incisional Hernia, Post Operative Pain
- Trial name
- IMPACT (NCT07145099)
- Testing
- PT Group, Usual Care
- Where
- United States
- Volunteers
- 60 people
- Sponsor
- Thomas Jefferson University
Surgery, Pain, Post Operative
Comparing Analgesic Regimen Effectiveness and Safety for Surgery for Kids Trial
This trial is being completed to compare two commonly used options to treat pain after discharge from surgery. Participants that undergo tonsil removal, gallbladder removal, and knee scope will be eligible to enroll.
- Trial name
- CARES for Kids (NCT06671002)
- Testing
- NSAID, Opioid, Acetaminophen
- Where
- 9 sites in United States
- Volunteers
- 900 people
- Sponsor
- University of Michigan
Breast Cancer, Post Operative Pain
Perioperative Mirogabalin for Pain Relief After Modified Radical Mastectomy
This study aims to evaluate whether perioperative mirogabalin can reduce postoperative pain and morphine consumption in female patients undergoing modified radical mastectomy for breast cancer.
- Trial name
- NCT07880821
- Testing
- Mirogabalin
- Volunteers
- 50 people
- Sponsor
- Cairo University
Pain, Post Operative Analgesia
The Impact of Perioperative Lidocaine Infusions on Enhanced Recovery After Non-Cardiac Surgery
The goal of this single-center, pragmatic, randomized, blinded, placebo-controlled trial is to evaluate the impact of intravenous (IV) lidocaine within the existing Enhanced Recovery After Surgery (ERAS)program on outcomes in…
- Conditions
- Pain, Post Operative Analgesia, Opioid Consumption, Postoperative
- Trial name
- IMPALA ERAS (NCT07224711)
- Testing
- Lidocaine HCl 0.8% in D5W, Dextrose 5% in water
- Where
- United States
- Volunteers
- 2,290 people
- Sponsor
- Vanderbilt University Medical Center
Post-operative Pain, Periapical Inflammation
Modulation of Periapical Inflammation Following Nano-sized Intracanal Medication. A Randomized Controlled Clinical Trial
The main cause of endodontic disorders is microbial infection. From the infected pulp tissue, microorganisms can penetrate into the deeper layers of root dentine and propagate a periapical tissue through the apical foramen and…
- Trial name
- Nano-Chitosan (NCT07571837)
- Testing
- Nanochitosan paste, Nano-calcium hydroxide paste, Calcium hydroxide paste
- Where
- Egypt
- Volunteers
- 63 people
- Sponsor
- Al-Azhar University
Chronic Postsurgical Pain, Chronic Post-surgical Pain
Prevention of Postsurgical Chronic Pain in Children and Adolescents (PREVENDOL)
Chronic postsurgical pain is a health problem with a great societal impact: approximately 20% of all children and adolescents undergoing surgery will develop chronic pain.
- Conditions
- Chronic Postsurgical Pain, Chronic Post-surgical Pain, Chronic Postoperative Pain, Chronic Post-operative Pain
- Trial name
- NCT06638437
- Testing
- Cognitive-behavioral therapy
- Where
- 3 sites in Spain
- Volunteers
- 125 people
- Sponsor
- University Rovira i Virgili
Post Operative Pain, Thoracic Surgery
Comparative Study Between Erector Spinae Plane Block Versus Combined Pectoralis and Serratus Interfascial Plane Blocks for Post-operative Analgesia After Thoracic Surgery.
The aim of this study is to evaluate the effect of combined pectoralis II and serratus interfascial plane blocks in comparison with erector spinae plane block on post-operative analgesia after thoracic surgeries.
- Trial name
- NCT07855549
- Testing
- Erector spinae plane block, Combined pectoralis and serratus anterior plane blocks
- Where
- Egypt
- Volunteers
- 66 people
- Sponsor
- Minia University
Post Operative Pain, Laparoscopic Hysterectomy
Preoperative Acetazolamide
The goal of this randomized study looks at whether giving patients a medicine called acetazolamide (also called Diamox) before they have laparoscopic hysterectomy may decrease postoperative pain.
- Conditions
- Post Operative Pain, Laparoscopic Hysterectomy, Referred Pain
- Trial name
- NCT07101250
- Testing
- Acetazolamide 500 MG Extended Release Oral Capsule
- Where
- United States
- Volunteers
- 100 people
- Sponsor
- Prisma Health-Upstate
Cataract, Cataract (Post-operative Cataract Surgery Follow-up)
Randomized Controlled Trial of the STEIN Protocol: A Neuroplastic Pain Education and Guided Breathing Intervention During Awake Cataract Surgery
This randomized controlled trial evaluates whether a standardized perioperative neuroplastic intervention: the STEIN Protocol (Strategies and Techniques for Enhancing Integration and Neuroplasticity), consisting of pain…
- Trial name
- SLin (NCT07715591)
- Testing
- Music and Guided Imagery, Control, Music Only
- Where
- United States
- Volunteers
- 300 people
- Sponsor
- University of California, Los Angeles
Post Operative Pain, Opioid Use
Serratus vs ESP Block for Postoperative Pain in Unilateral Breast Surgery
This prospective, randomized, assessor-blinded trial compares serratus posterior superior intercostal plane block (SPSIPB) and erector spinae plane block (ESPB) for postoperative analgesia in unilateral breast surgery.
- Trial name
- NCT07541040
- Testing
- Serratus Posterior Superior Intercostal Plane Block
- Where
- Turkey (Türkiye)
- Volunteers
- 54 people
- Sponsor
- Engin Çetin
Symptomatic Irreversible Pulpitis and Post Operative Pain
Laser-Assisted vs Conventional Total Pulpotomy in Symptomatic Irreversible Pulpitis
his randomized controlled clinical trial will compare laser-assisted total pulpotomy with conventional total pulpotomy in permanent molar teeth diagnosed with symptomatic irreversible pulpitis.
- Trial name
- LASERPULP (NCT07850258)
- Testing
- Conventional Total Pulpotomy, Laser-Assisted Total Pulpotomy
- Where
- Turkey (Türkiye)
- Volunteers
- 70 people, healthy volunteers welcome
- Sponsor
- meliksahgunduz
Pain, Acute Post-Operative, Dexmedetomidine
Esmolol Versus Dexmedetomidine for Opioid-sparing in Laparoscopic Gynecological Surgery
The aim of this study is to investigate and compare the effects of a continuous infusion of low-dose esmolol and dexmedetomidine versus placebo on intraoperative and postoperative opioid consumption and analgesic efficacy in…
- Conditions
- Pain, Acute Post-Operative, Dexmedetomidine, Analgesia, Esmolol
- Trial name
- NCT07846722
- Testing
- Esmolol hydrochloride, Dexmedetomidine, Normal (0.9%) saline
- Where
- Greece
- Volunteers
- 90 people
- Sponsor
- Vasiliki Samartzi
Post-operative Pain, DIEP Flap Breast Reconstruction
Suzetrigine Post DIEP
This research study is being conducted to see whether adding suzetrigine (Journavx), an FDA-approved non-opioid pain medication, to the standard Enhanced Recovery After Surgery (ERAS) pain management protocol can improve pain…
- Conditions
- Post-operative Pain, DIEP Flap Breast Reconstruction, DIEP Flap, Opioid
- Trial name
- NCT07839715
- Testing
- Suzetrigine Group
- Volunteers
- 198 people
- Sponsor
- Vanderbilt University Medical Center
Post Operative Pain
Erector Spinae Plane Block Versus Rectus Sheath Block for Postoperative Analgesia After Supraumbilical Surgery
Objectives: To compare the effectiveness of erector spinae plane block (ESPB) and rectus sheath block (RSB) in providing postoperative analgesia after supraumbilical surgery in adult patients and their impact on the patient's…
- Trial name
- NCT05179928
- Testing
- Erector Spinae Plane Block (ESPB), Rectus Sheath Block (RSB)
- Where
- Egypt
- Volunteers
- 60 people
- Sponsor
- Damanhour Teaching Hospital
Post Operative Pain
Rhomboid Intercostal Block Versus Retrolaminar Block for Postoperative Analgesia After Thoracoscopic Sympathectomy
Background: Although thoracoscopic sympathectomy is made via small incisions, it is associated with severe postoperative pain. Both Rhomboid intercostal block (RIB) and Retrolaminar block (RLB) are recent techniques used for pain…
- Trial name
- NCT06653803
- Testing
- Rhomboid Intercostal Block (RIB), Retrolaminar Block (RLB)
- Where
- Egypt
- Volunteers
- 60 people
- Sponsor
- Damanhour Teaching Hospital
Post Operative Pain, Acute, Periodontitis
The Effect of Dexamethasone on Short Term Patient Response: IV vs Oral Administration
Possible participants will be scheduled to have 2 gum flap surgeries done on 2 similar surgical sites in the mouth. The study looks at two different ways of giving dexamethasone, a medication used to reduce inflammation.
- Trial name
- NCT07832110
- Testing
- Dexamethasone IV injection, Dexamethasone Capsule
- Where
- United States
- Volunteers
- 40 people
- Sponsor
- The University of Texas Health Science Center at San Antonio
Back Pain, Surgery-Complications
Analgesic Requirement for Post-Operative Pain Control in TLIP Interbody Fusion
The goal of this clinical trail is to to compare the efficacy of thoracolumbar interfascial plane block with Exparel vs with standard of care 0.25% Bupivacaine HCl in patients undergoing 1-3 level elective transforaminal lumbar…
- Conditions
- Back Pain, Surgery-Complications, Narcotic Use, Physical Stress
- Trial name
- NCT06350981
- Testing
- Exparel, Bupivacain
- Where
- United States
- Volunteers
- 76 people
- Sponsor
- Foundation for Orthopaedic Research and Education