Clinical trials: Post Prostatectomy
Posterior Bladder Wall Reconstruction, Anterior Bladder Wall Reconstruction
A Technique Improves Urinary Continence in Patients Undergoing Laparoscopic Radical Prostatectomy
Laparoscopic radical prostatectomy (LRP) is the main treatment method for early prostate cancer, and postoperative urinary incontinence is one of the main complications after LRP.
- Conditions
- Posterior Bladder Wall Reconstruction, Anterior Bladder Wall Reconstruction, Anterior Bladder Wall Suspension
- Trial name
- NCT06754488
- Testing
- Posterior Reconstruction, anterior suspension
- Where
- China
- Volunteers
- 120 people
- Sponsor
- Suzhou Municipal Hospital
Prostate Cancer
Prostate Radiation Therapy or Short-Term Androgen Deprivation Therapy and Pelvic Lymph Node Radiation Therapy With or Without Prostate Radiation Therapy in Treating Patients With a Rising Prostate Specific Antigen (PSA) After Surgery for Prostate Cancer
RATIONALE: Radiation therapy uses high-energy x-rays to kill tumor cells. Androgens can cause the growth of prostate cancer cells.
- Trial name
- NCT00567580
- Testing
- PBRT, PLNRT, AA
- Where
- 460 sites in United States, Canada and 2 more
- Volunteers
- 1,792 people
- Sponsor
- Radiation Therapy Oncology Group
Prostate Cancer
A Study of a Pelvic Floor Muscle Exercise Program Before and After Radical Prostatectomy
The researchers are doing this study to find out if a PFME program to reduce urinary incontinence after radical prostatectomy is feasible for people with prostate cancer.
- Trial name
- NCT06671782
- Testing
- Kegel exercises, Pelvic Floor Muscle Exercise Program with biofeedback, Questionnaires
- Where
- 7 sites in United States
- Volunteers
- 32 people
- Sponsor
- Memorial Sloan Kettering Cancer Center
Erectile Dysfunction
On Demand Versus Daily Sildenafil for Patients Undergoing Radical Prostatectomy
Viagra (Sildenafil citrate) is an orally active selective inhibitor of cyclic guanosine monophosphate (cGMP)-specific phosphodiesterase type 5 (PDE5) which is used for the treatment of erectile dysfunction (ED).
- Trial name
- URO2010 (NCT01315262)
- Testing
- Sildenafil
- Where
- Italy
- Volunteers
- 200 people
- Sponsor
- Università Vita-Salute San Raffaele
Prostate Carcinoma
Prostate Resection After Microwave Ablation (PRAMA)
This phase I trial tests the safety of magnetic resonance imaging (MRI)/ ultrasound (US) fusion guided transperineal targeted microwave ablation (TMA) before a radical prostatectomy (RP) and how well it works in treating patients…
- Trial name
- NCT06128525
- Testing
- Biospecimen Collection, Microwave Ablation, Multiparametric Magnetic Resonance Imaging
- Where
- United States
- Volunteers
- 1 people
- Sponsor
- University of Southern California
Prostate Cancer, Sexual Dysfunction and Infertility
Hormone Therapy in Treating Patients With Prostate Cancer
RATIONALE: Male hormones can stimulate the growth of prostate cancer cells. Hormone therapy using flutamide and finasteride may fight prostate cancer by reducing the production of male hormones.
- Trial name
- NCT00003323
- Testing
- finasteride, flutamide, quality-of-life assessment
- Where
- 43 sites in United States
- Volunteers
- 101 people
- Sponsor
- Alliance for Clinical Trials in Oncology
Prostate Cancer Surgery
Suturing Techniques for Vesico-urethral Anastomosis
Radical prostatectomy (RP) is the most common curative treatment for prostate cancer (PCa).Vesicourethral anastomosis (VUA) is a crucial step and either a conventional interrupted (IS) or a running (RS) suture is employed during…
- Trial name
- NCT06670924
- Testing
- Running suture for vesico-urethral anastomosis in open radical prostatectomy, interrupted suture for vesico-urethral anastomosis in open radical prostatectomy
- Where
- Turkey (Türkiye)
- Volunteers
- 70 people
- Sponsor
- Kartal City Hospital
Erectile Dysfunction
Low Intensity Shock Wave Therapy (LI-ESWT) for Erectile Dysfunction in Post Radical Prostatectomy Patients Not Responding to PDE5 Inhibitors (LI-ESWT)
Low intensity shock waves (LISW) have been proven in animal studies to induce local growth of new blood vessels. The investigators hypothesized that LISW therapy could improve the symptoms of patients with erectile dysfunction…
- Trial name
- LI-ESWT (NCT01317680)
- Testing
- Omnispec model ED1000
- Where
- Israel
- Volunteers
- 60 people
- Sponsor
- Rambam Health Care Campus
Prostate Cancer, Erectile Dysfunction
A Yoga Program for Patients Undergoing Prostate Cancer Surgery
Men with localized prostate cancer (PCa) are often treated with surgery, a treatment that is associated with high rates of side effects such as erectile dysfunction (ED) and urinary incontinence (UI) which impact quality of life.
- Conditions
- Prostate Cancer, Erectile Dysfunction, Urinary Incontinence
- Trial name
- NCT05929300
- Testing
- Yoga, Usual Care
- Where
- United States
- Sponsor
- VA Office of Research and Development
Prostate Cancer, Quality of Life
Clinical and Quality of Life Outcomes After Open or Robotic-Assisted Laparoscopic Radical Prostatectomy
The goal of the study is to look at surgical recovery and quality of life for men who have an open versus robotic-assisted laparoscopic radical prostatectomy (RP). RP is a procedure that removes the prostate gland.
- Trial name
- NCT00578123
- Testing
- Quality of Life Questionnaires
- Where
- United States
- Volunteers
- 959 people
- Sponsor
- Memorial Sloan Kettering Cancer Center
Prostate Cancer
SAKK 08/15 - PROMET - Salvage Radiotherapy +/- Metformin for Patients With Prostate Cancer After Prostatectomy
The main objective of the trial is to explore the efficacy of salvage radiotherapy (SRT) plus metformin compared to SRT in the endpoint of time to progression after prostatectomy failure.
- Trial name
- NCT02945813
- Testing
- Metformin, Salvage Radiotherapy SRT
- Where
- 27 sites in France, Germany and 1 more
- Volunteers
- 112 people
- Sponsor
- Swiss Cancer Institute
Prostate Cancer
The Effect of Combined General/Epidural Anesthesia Versus General Anesthesia on Diaphragmatic Function
The aim of this study was to investigate whether robot assisted laparoscopic radical prostatectomy give rise to the impairment of diaphragmatic function postoperatively, and whether combined general/epidural anesthesia could…
- Trial name
- NCT01547416
- Testing
- epidural 250mL of 0.2% ropivacaine and 2 μg/mL of fentanyl, 5 mL/hr continuous infusion and 0.5 mL bolus dose, no epidural drug administered
- Where
- South Korea
- Volunteers
- 50 people
- Sponsor
- Yonsei University
Prostate Cancer
Adjuvant Curcumin to Assess Recurrence Free Survival in Patients Who Have Had a Radical Prostatectomy
This is a prospective study to determine if the adjuvant use of Curcumin improves recurrence-free survival.
- Trial name
- NCT02064673
- Testing
- Curcumin
- Where
- United States
- Volunteers
- 650 people
- Sponsor
- yair lotan
Prostate Cancer
Prostatectomy Adaptive Radiation Therapy (ART)
This study will ultimately aim to evaluate the side effects of treatment by asking 20 subjects to receive post-operative radiotherapy for prostate cancer with the treatment plan adapted after the first week of treatment to…
- Trial name
- NCT02034955
- Testing
- Post-operative Adaptive Radiation Therapy
- Where
- Canada
- Volunteers
- 21 people
- Sponsor
- University Health Network, Toronto
Impotence, Prostatic Neoplasms
Can Hyperbaric Oxygen Improve Erectile Function Following Surgery for Prostate Cancer
The purpose of this study is to determine if adding hyperbaric oxygen therapy, a therapy that delivers oxygen under slight pressure, to a drug treatment of PDE5I (such as Viagra, Levitra, Cialis)for men following surgery for…
- Trial name
- HBOT (NCT00906269)
- Testing
- Sildenafil therapy plus post-NSRRP HBO2T
- Where
- United States
- Volunteers
- 100 people
- Sponsor
- Hartford Hospital
Urologic Cancer, Biochemical Recurrence of Malignant Neoplasm of Prostate
SRT in Combination With Pembrolizumab in Patients With Recurrent Prostate Cancer After Radical Prostatectomy
To evaluate the efficacy and safety of a pembrolizumab therapy of pembrolizumab in combination with standard salvage radiation therapy (SRT) in patients with biochemical recurrence (BCR) of prostate-specific antigen (PSA)…
- Trial name
- Pembro-SRT (NCT04931979)
- Testing
- Pembrolizumab Injection [Keytruda], Salvage Radiation Therapy (SRT)
- Where
- Germany
- Volunteers
- 49 people
- Sponsor
- Prof. Dr. med. Christian Gratzke
Prostate Cancer, DNA
Dynamics of Androgen Receptor Genomics and Transcriptomics After Neoadjuvant Androgen Ablation
Rationale: Understanding the mechanisms of enzalutamide as an androgen receptor inhibitor in early prostate cancer could lead to improved patient selection for treatment.
- Conditions
- Prostate Cancer, DNA, Androgen Receptor Abnormal
- Trial name
- DARANA (NCT03297385)
- Testing
- Enzalutamide
- Volunteers
- 50 people
- Sponsor
- The Netherlands Cancer Institute
Prostate Cancer (Post Prostatectomy), Urinary Incontinence (UI)
The Effect of Pelvic Floor Muscle Exercises After Radical Prostatectomy
Cancer, a major public health problem worldwide, was one of the leading causes of mortality in 2020, accounting for approximately 10 million deaths.
- Trial name
- NCT07045415
- Testing
- Pelvic Floor Muscle Exercises.
- Where
- Turkey (Türkiye)
- Volunteers
- 10 people
- Sponsor
- KTO Karatay University
Prostate Cancer
A Salvage Trial of AR Inhibition With ADT and Apalutamide With Radiation Therapy Followed by Docetaxel in Men With PSA Recurrent Prostate Cancer After Radical Prostatectomy (STARTAR)
The purpose of this study is to describe the rate of 3-year progression free survival in men with recurrent PSA-only disease after prostatectomy, who receive combined apalutamide (ARN-509) and standard ADT with salvage radiation…
- Trial name
- NCT03311555
- Testing
- Apalutamide, Androgen deprivation, Salvage radiation therapy
- Where
- 5 sites in United States
- Volunteers
- 39 people
- Sponsor
- Andrew J. Armstrong, MD
Urinary Catheter-Related Discomfort
Urethral Catheter Immobilization Device to Reduce Catheter-Related Discomfort
This is a randomized controlled study to determine the efficacy and safety of a patented urethral catheter support device designed to reduce discomfort associated with urethral catheter mobility in males.
- Trial name
- NCT03341468
- Testing
- Urethral catheter immobilization
- Where
- United States
- Sponsor
- Massachusetts General Hospital