Clinical trials: Post Prostatectomy
Robotic-assisted Radical Prostatectomy
Can the Prophylactic Administration of Tranexamic Acid Reduce Blood Loss After Robotic-assisted Radical Prostatectomy?
The prophylactic administration of tranexamic acid reduces blood loss during procedures at high risk of perioperative bleeding. Several studies in neurosurgery, cardiac surgery, and orthopedics confirm this finding.
- Trial name
- RARPEX (NCT04319614)
- Testing
- Tranexamic Acid Injectable Product
- Where
- Czechia
- Volunteers
- 200 people
- Sponsor
- University Hospital Hradec Kralove
Prostate Cancer
Adjuvant Docetaxel-Zoledronic Acid in High-risk Early Prostate Cancer Following Prostatectomy.
Radical prostatectomy is used to treat early prostate cancer in otherwise well men, but is followed by later cancer relapse in 1 in 4 cases.
- Trial name
- NCT00258765
- Testing
- Zoledronic Acid, Docetaxel
- Where
- Australia
- Volunteers
- 1 people
- Sponsor
- Novartis Pharmaceuticals
Postpartum Bladder Dysfunction, Post-prostatectomy Bladder Dysfunction
Exploring Clinical Utility of Wearables for the Bladder in Pelvic Health Physical Therapy Clinics
Pelvic health physical therapy (PHPT) is an evidence-based intervention for bladder dysfunction (BD) and pelvic floor disorders (PFD) in men postprostatectomy, and postpartum women.
- Conditions
- Postpartum Bladder Dysfunction, Post-prostatectomy Bladder Dysfunction, Bladder Dysfunction
- Trial name
- ClinicWeB (NCT07451106)
- Testing
- DFree Non-Invasive Bladder Ultrasound, Perifit Kegel Exerciser, Exit interview
- Where
- United States
- Volunteers
- 25 people
- Sponsor
- University of California, San Francisco
Recurrent Prostate Cancer
Trial of Ultrahypofractionated Focal Salvage Radiotherapy for Isolated Prostate Bed Recurrence After Radical Prostatectomy
The main objective of the trial is to explore the efficacy and safety of combining short-term androgen deprivation therapy (ADT) over 6 months to focal ultrahypofractionated salvage radiotherapy (SRT) delivered in 5 fractions to…
- Trial name
- HypoFocal SRT (NCT05746806)
- Testing
- Ultrahypofractionated salvage radiotherapy to a local recurrence after radical prostatectomy, Androgen deprivation therapy
- Where
- 5 sites in Switzerland
- Volunteers
- 36 people
- Sponsor
- Insel Gruppe AG, University Hospital Bern
Prostate Cancer (Adenocarcinoma)
Robot-Assisted Radical Prostatectomy: the HOOD Technique Versus Standard Anterior Reconstruction
This prospective, non-randomized cohort study included consecutive patients undergoing robotic-assisted laparoscopic radical prostatectomy (RARP) between January 2024 and January 2026 following ethics committee approval.
- Trial name
- NCT07417475
- Testing
- Prostatectomy with anterior-posterior renconstruciton, Prostatectomy with HOOD techinque
- Where
- Turkey (Türkiye)
- Volunteers
- 200 people
- Sponsor
- Araz Musaev
Anesthesia
Intrathecal Additives to Prevent Post Spinal Shivering in Transurethral Prostatectomy
Spinal anesthesia is the technique of choice in transurethral prostatectomy.However,one of the common complications of spinal anesthesia is shivering which is even exaggerated in patients undergoing transurethral…
- Trial name
- NCT04178512
- Testing
- Drug:dexamethasone in group Dexamethasone,fentanyl in group Fentanyl,normal saline 0.9%in group Control
- Volunteers
- 51 people
- Sponsor
- Zagazig University
Prostate Cancer
Archive Prostate. Observational Study of Patients Who Underwent Radical Prostatectomy Surgery
This is a single-center, observational, prospective study on quality of life and disease status of patients who underwent radical prostatectomy.
- Trial name
- NCT06154499
- Testing
- Radical prostatectomy
- Where
- Italy
- Volunteers
- 1,784 people
- Sponsor
- IRCCS San Raffaele
Prostate Cancer, Cancer Recurrence
PSMA-PET Guided Hypofractionated Salvage Prostate Bed Radiotherapy
After radical prostatectomy approximately 15-40% of men develop a biochemical recurrence (BR) within 5 years. The standard treatment of post-prostatectomy BR is salvage external beam radiation therapy (sEBRT).
- Trial name
- PERYTON (NCT04642027)
- Testing
- Conventional sEBRT, Hypofractionated sEBRT
- Where
- 13 sites in Netherlands
- Volunteers
- 538 people
- Sponsor
- University Medical Center Groningen
Delirium, Neurocognitive Disorders
Patient-reported Outcome Measures After Post-anesthesia Care Unit Delirium
To assess self-reported cognitive function and health-related quality of life in patients with and without early postoperative delirium
- Trial name
- NCT04168268
- Where
- Germany
- Volunteers
- 222 people
- Sponsor
- Universitätsklinikum Hamburg-Eppendorf
Prostate Cancer
Effects of IAS in Men With Localized Biochemical Relapsed Prostate Cancer
This study was a prospective analysis in men with localized prostate cancer who had rising Prostate Specific Antigen (PSA) levels after definitive treatment with surgery or radiation.
- Trial name
- IAS (NCT00223665)
- Testing
- Flutamide, Leuprolide Acetate
- Where
- United States
- Volunteers
- 102 people
- Sponsor
- University of Washington
Prostate Cancer
R-Flurbiprofen in Treating Patients With Localized Prostate Cancer at Risk of Recurrence
RATIONALE: Drugs used in chemotherapy use different ways to stop tumor cells from dividing so they stop growing or die. R-flurbiprofen may be effective in delaying the recurrence of localized prostate cancer.
- Trial name
- NCT00045123
- Testing
- tarenflurbil, adjuvant therapy
- Where
- 58 sites in United States
- Sponsor
- Myrexis Inc.
Prostatic Neoplasms, Prostate-Specific Antigen
Prognostic Study of Prostate Cancer Via Dynamic Change of PSA in Peritoneal Drainage Fluid After Radical Prostatectomy
This study investigates the prognostic value of dynamic changes in Prostate-Specific Antigen (PSA) levels found in the peritoneal drainage fluid after radical prostatectomy.
- Trial name
- NCT06608225
- Where
- China
- Volunteers
- 100 people
- Sponsor
- Shanghai General Hospital, Shanghai Jiao Tong University School of Medicine
Pain
Does the TAP Block Work Better Than the TFP Block for Relieving Pain
Regional anesthetics, nerve blocks, and interfascial blocks are becoming more common in many types of surgery to help with pain after surgery.
- Trial name
- Tapblock (NCT06975735)
- Testing
- TAP Plane Block, TFP Block
- Where
- Turkey (Türkiye)
- Volunteers
- 108 people, healthy volunteers welcome
- Sponsor
- TC Erciyes University
Erectile Dysfunction Following Radical Prostatectomy
Low-Intensity Extracorporeal Shockwave Therapy for Penile Rehabilitation in Post-Radical Prostatectomy Patients
Radical prostatectomy (RP) is one of the curative treatment modalities for localized or locally advanced prostate cancer. Urinary incontinence and erectile dysfunction (ED) are two most common complications after RP.
- Trial name
- NCT06076850
- Testing
- Low-Intensity Extracorporeal Shockwave Therapy (LiEWST) - Active
- Where
- Malaysia
- Volunteers
- 70 people
- Sponsor
- Hospital Pengajar Universiti Putra Malaysia
Prostate Cancer, Erectile Dysfunction Following Radical Prostatectomy
Human Amnion Membrane Allograft and Early Return of Erectile Function After Radical Prostatectomy
The purpose of this research study is to evaluate if placing a dehydrated human amnion chorion membrane (dHACM) over the nerves after removal of the prostate during surgery (radical prostatectomy) will allow an earlier recovery…
- Trial name
- HAMMER (NCT05842057)
- Testing
- BioDFence G3 Placental Tissue Membrane, Robot-Assisted Radical Prostatectomy
- Where
- United States
- Volunteers
- 118 people
- Sponsor
- University of Miami
Radical Prostatectomy, Robotic Radical Prostatectomy
Continence Post Retzius-Sparing Versus Standard Robot-Assisted Radical Prostatectomy
To compare the short term (three month) continence rates using versius robotic system between the Retzius-sparing and the standard RARP within three month from removal of catheter.
- Conditions
- Radical Prostatectomy, Robotic Radical Prostatectomy, Retzius-sparing Robot-assisted Radical Prostatectomy With "Sandwich" Technique of Total Urethral Reconstruction
- Trial name
- Continence (NCT07899268)
- Testing
- Procedure: Retzius-Sparing Robot-Assisted Radical Prostatectomy (RS-RARP), Standard Robot-Assisted Radical Prostatectomy (S-RARP)
- Where
- Egypt
- Volunteers
- 88 people
- Sponsor
- Armed Forces College of Medicine, Cairo, Egypt
Urinary Incontinence, Stress
Fundación IVO Registry for Patients Undergoing Sling or Artificial Urinary Sphincter After Prostate Cancer Treatment
Stress urinary incontinence is a significant potential source of morbidity after radical prostatectomy or radiation therapy for prostate cancer. At present, artificial urinary sphincter remains the preferred therapeutic option.
- Trial name
- NCT02901392
- Testing
- AMS-800, ADVANCE/ADVANCEXP, VIRTUE
- Where
- Spain
- Volunteers
- 400 people
- Sponsor
- Fundación Instituto Valenciano de Oncología
Recovery, Post Prostatectomy
Effects of Exercise Prior to Radical Prostatectomy
This pilot study will explore the metabolic and psychological effects of High-Intensity Interval Training (HIIT) exercise as well as its impact on patient recovery from radical prostatectomy.
- Trial name
- NCT07746414
- Testing
- High-intensity interval training (HIIT) exercise
- Where
- United States
- Volunteers
- 20 people
- Sponsor
- Yale University
Prostate Cancer
Docetaxel Compared With Observation in Treating Patients Who Have Undergone Radical Prostatectomy for Prostate Cancer
RATIONALE: Drugs used in chemotherapy, such as docetaxel, work in different ways to stop the growth of tumor cells, either by killing the cells or by stopping them from dividing.
- Trial name
- NCT00376792
- Testing
- docetaxel, active surveillance, adjuvant therapy
- Where
- 8 sites in Denmark, Finland and 3 more
- Volunteers
- 396 people
- Sponsor
- Scandinavian Prostate Cancer Group
Benign Prostatic Hyperplasia
Serum Copeptin as a Predictor of the Risk of Hyponatremia After Transurethral Prostatectomy
Hyponatremic hypovolemia is a frequent complication of transurethral resection of the prostate gland (TURP). Copeptin has been established as is a surrogate marker of vasopressin and is measured useful for thea clinical…
- Trial name
- NCT03912766
- Testing
- serum copeptin
- Where
- Poland
- Volunteers
- 43 people
- Sponsor
- Medical University of Lodz