Clinical trials: Post Prostatectomy
Prostate Cancer
Salvage Moderate Hypofractionated Versus Ultrahypofractionated Radiotherapy for Biochemical Recurrence After Radical Prostatectomy in Prostate Cancer
This study is the first prospective, randomized phase III clinical trial designed to evaluate whether ultrahypofractionated radiotherapy is non-inferior to conventionally moderately hypofractionated radiotherapy in terms of…
- Trial name
- NCT07500701
- Testing
- Moderate hypofractionated radiotherapy (Moderate-hypoRT), Ultra-hypofractionated radiotherapy (Ultra-hypoRT)
- Where
- South Korea
- Volunteers
- 270 people
- Sponsor
- Samsung Medical Center
Prostate Cancer
Randomized Phase II Study of Salvage XRT + ADT +/- Abiraterone and Apalutamide for Rising PSA After RP (FORMULA-509)
This research study is comparing two different combinations of androgen deprivation therapy (ADT) used together with radiation as a treatment for rising PSA after radical prostatectomy (prostate cancer).
- Trial name
- NCT03141671
- Testing
- GnRH, Bicalutamide, Salvage radiation
- Where
- 8 sites in United States
- Volunteers
- 345 people
- Sponsor
- Dana-Farber Cancer Institute
Prostate Cancer
Docetaxel, Radiation Therapy, and Prednisone in Treating Patients Who Have Undergone Surgery For Prostate Cancer
RATIONALE: Drugs used in chemotherapy, such as docetaxel and prednisone, work in different ways to stop the growth of tumor cells, either by killing the cells or by stopping them from dividing.
- Trial name
- NCT00348816
- Testing
- docetaxel, prednisone, Radical prostatectomy
- Where
- United States
- Volunteers
- 21 people
- Sponsor
- The University of Texas Health Science Center at San Antonio
Urinary Incontinence
Efficacy of Electrical Pudendal Nerve Stimulation for Patients With Post Prostatectomy Urinary Incontinence
The purpose of this study is to determine whether electrical pudendal nerve stimulation is more effective than pelvic floor muscle training plus transanal electrical stimulation in treating post prostatectomy Incontinence.
- Trial name
- NCT02599831
- Testing
- Electrical pudendal nerve stimulation, PFM training, Transanal ES
- Where
- China
- Volunteers
- 96 people
- Sponsor
- Shanghai Institute of Acupuncture, Moxibustion and Meridian
Recurrent Prostate Cancer
Peptide-specific Vaccination in HLA-A*02 Positive Patients With Biochemical Recurrence After Radical Prostatectomy
The study evaluates the prostate-specific antigen (PSA) response in HLA-A*02 positive patients with biochemical recurrence after radical prostatectomy treated with a prostate-specific peptide vaccine in combination with different…
- Trial name
- NCT02452307
- Testing
- Peptide vaccine, Montanide ISA-51, Granulocyte macrophage colony stimulating factor (GM-CSF)
- Volunteers
- 36 people
- Sponsor
- University Hospital Tuebingen
Prostate Cancer
Impact of Abdominal Incompetence on Urinary Incontinence After Prostatectomy (PROSTABDO)
the aim of this study is assess deep abdominal wall (ultrasonography of transversus abdominis muscle) before prostatectomy, and look at one year post surgery if patient with several incontinence are the same who have dysfunction…
- Trial name
- PROSTABDO (NCT05432687)
- Testing
- evaluation of deep abdominal wall before surgery
- Where
- France
- Volunteers
- 80 people
- Sponsor
- Centre Hospitalier Universitaire de Besancon
Prostate Cancer (Post Prostatectomy), Perioperative Anesthetic
Effects of Rectal Indomethacin Suppository on Postoperative CRBD in Patients Undergoing LRP
The postoperative incidence of catheter-related bladder discomfort (CRBD) ranges from 47% to 95%. It increases postoperative pain and agitation, thus requiring early intervention.
- Conditions
- Prostate Cancer (Post Prostatectomy), Perioperative Anesthetic, Catheter-related Bladder Discomfort (CRBD)
- Trial name
- NCT07607990
- Testing
- Indomethacin suppository
- Where
- China
- Volunteers
- 130 people
- Sponsor
- Zhejiang University
Prostate Cancer
Pneumatic Compression and Post-induction Hypotension
The purpose of this study is to evaluate the effect of pneumatic compression on post-induction hypotension in elderly patients undergoing robot assisted laparoscopic prostatectomy.
- Trial name
- NCT05343689
- Testing
- Pneumatic compression
- Where
- South Korea
- Volunteers
- 100 people
- Sponsor
- Asan Medical Center
Myocard Injury After Non Cardiac Surgery, Robotic Assisted Laparoscopic Radical Prostatectomy
PERIOPERATIVE MYOCARDIAL DAMAGE IN ROBOT-ASSISTED SURGERY
Our study aimed to identify myocardial damage during or after robotic-assisted radical prostatectomy by measuring high-sensitive Troponin I levels, which are the most sensitive and effective according to the AHA/ACC guideline.
- Trial name
- NCT06502340
- Testing
- high sensitive troponin I
- Where
- Turkey (Türkiye)
- Volunteers
- 75 people, healthy volunteers welcome
- Sponsor
- Ankara City Hospital Bilkent
Prostate Carcinoma
Testing the Addition of Darolutamide to Hormonal Therapy (Androgen Deprivation Therapy [ADT]) After Surgery for Men With High-Risk Prostate Cancer, The ERADICATE Study
This phase III trial compares the effect of adding darolutamide to ADT versus ADT alone after surgery for the treatment of high-risk prostate cancer. ADT reduces testosterone levels in the blood.
- Trial name
- NCT04484818
- Testing
- Darolutamide, Goserelin Acetate, Leuprolide Acetate
- Where
- 115 sites in United States
- Volunteers
- 27 people
- Sponsor
- ECOG-ACRIN Cancer Research Group
Lymphocele After Surgical Procedure
MICHL-trial: Impact of Peritoneal Bladder Flap in RARP Patients on Lymphoceles
A two-armed prospective randomised, controlled, single-centre trial on 1080 patients with prostate cancer who underwent robot-assisted radical prostatectomy with bilateral pelvic lymph node dissection was carried out.
- Trial name
- NCT06284135
- Testing
- Michl-stitch
- Where
- Germany
- Volunteers
- 1,080 people
- Sponsor
- Martini-Klinik am UKE GmbH
Cancer of Prostate
Radiotherapy Combined With a LHRH (Ant)Agonist Versus Apalutamide in Patients With Biochemical Recurrence After RP
This is a phase II randomized, open-label study comparing salvage radiotherapy in combination with 6 months of androgen-deprivation therapy (ADT) with LHRH agonist or antagonist (arm A) versus anti-androgen therapy (AAT) with…
- Trial name
- SAVE (NCT03899077)
- Testing
- Apalutamide, Leuprorelin Acetate 45Mg Powder for Injection Suspension Vial, Goserelin Acetate 10.8 MG Subcutaneous Implant
- Where
- 9 sites in Belgium
- Volunteers
- 202 people
- Sponsor
- Cancer Research Antwerp
Urinary Incontinence
ProACT Therapy for the Treatment of Stress Urinary Incontinence in Males
The purpose of the study is to evaluate the safety and effectiveness of a minimally invasive surgical procedure in up to 109 male patients.
- Trial name
- ProACT (NCT00277095)
- Testing
- ProACT (Adjustable Continence Therapy)
- Where
- 10 sites in United States, Canada and 1 more
- Volunteers
- 123 people, healthy volunteers welcome
- Sponsor
- Uromedica
Prostate Cancer, Cancer Recurrence
PSMA-PET Guided Hypofractionated Salvage Prostate Bed Radiotherapy
After radical prostatectomy approximately 15-40% of men develop a biochemical recurrence (BR) within 5 years. The standard treatment of post-prostatectomy BR is salvage external beam radiation therapy (sEBRT).
- Trial name
- PERYTON (NCT04642027)
- Testing
- Conventional sEBRT, Hypofractionated sEBRT
- Where
- 13 sites in Netherlands
- Volunteers
- 538 people
- Sponsor
- University Medical Center Groningen
Prostate Cancer, Post Prostatectomy Incontinence
Anatomical and Functional Differences Between Continent and Incontinent Men Post Radical Prostatectomy
One out of every six men will be diagnosed with prostate cancer and post prostatectomy up to 75% report urinary incontinence. There are many hypotheses about the exact cause of post prostatectomy stress incontinence (PPI).
- Trial name
- NCT01832831
- Where
- 2 sites in United States
- Volunteers
- 24 people, healthy volunteers welcome
- Sponsor
- University of Michigan
Urinary Incontinence, Erectile Dysfunction
Effectiveness of Physiotherapy to Treat the Urinary Incontinence and Erectile Dysfunction Post Retropubic Prostatectomy
The prostate cancer is the most common parenchymal neoplasia in men over 45 years old. Radical prostatectomy is curative treatment is most used today.
- Trial name
- NCT02226237
- Testing
- group of pelvic floor exercises, anal electrostimulation group
- Where
- Brazil
- Volunteers
- 237 people
- Sponsor
- Barretos Cancer Hospital
Prostatic Neoplasms
Adjuvant Apalutamide in Subjects With High-risk Localized or Locally Advanced Prostate Cancer After Radical Prostatectomy
The primary objective of this trial is to determine if adjuvant apalutamide in prostate cancer patients at high risk of developing subsequent metastatic disease results in prolonged biochemically recurrence-free survival after…
- Trial name
- ADAM (NCT04295447)
- Testing
- Standard of care, Apalutamide 60Mg Tab
- Where
- 21 sites in Austria, Germany
- Volunteers
- 190 people
- Sponsor
- Universität Münster
Prostate Cancer Patients Undergoing Radical Prostatectomy
Advanced Pelvic Floor Training Program for Prostate Cancer Surgery
Radical prostatectomy is a common and effective treatment for prostate cancer but is associated with urinary incontinence that can persist for several months after surgery and significantly reduce quality of life.
- Trial name
- AFPX (NCT02233608)
- Testing
- Advanced Pelvic Floor Muscle Exercise (APFX)
- Where
- Canada
- Volunteers
- 88 people
- Sponsor
- University of Guelph-Humber
Urinary Incontinence, Radical Prostatectomy
Mechanical Nerve Stimulation in the Treatment of Post Prostatectomy Incontinence
During transcutaneous mechanical nerve stimulation in spinal cord injured men an increase in pressure was observed in the external urethral sphincter along with an increase in bladder capacity.
- Trial name
- NCT01540656
- Testing
- Transcutaneous mechanical nerve stimulation (TMNS) (FERTI CARE)
- Where
- 2 sites in Denmark
- Volunteers
- 39 people
- Sponsor
- Copenhagen University Hospital at Herlev
Erectile Dysfunction Following Radical Prostatectomy
Efficacy of RestoreX Penile Traction Therapy In Preserving Erectile Function Post-Prostatectomy
Evaluate the efficacy of the RestoreX penile traction device in preserving erectile function in men undergoing robotic-assisted prostatectomy.
- Trial name
- NCT05244486
- Testing
- RestoreX 1-6 months (randomized phase), RestoreX 6-9 months (open label phase)
- Where
- 4 sites in United States
- Volunteers
- 200 people
- Sponsor
- Charitable Union for the Research and Education of Peyronie's Disease