Clinical trials: Post Pulmonary Resection
Pneumothorax and Air Leak, Pneumothorax
Urine Bag Usage Versus Chest Drain Clamping After Lung Resection Surgeries
Investigators will compare two different approaches of postoperative drainage after the standard water-seal drain has been used efficiently; one is by using urine bag and check it get blown by the leaked air, two is by using…
- Conditions
- Pneumothorax and Air Leak, Pneumothorax, Pleura Injury, Pleural Effusion
- Trial name
- NCT05230420
- Testing
- Clamping, Urine bag
- Where
- 4 sites in Egypt, Italy and 1 more
- Volunteers
- 160 people
- Sponsor
- Al-Quds University
Non-Small Cell Lung Cancer
Analysis of RATS, VATS and Open Lung Resections After Neoadjuvant Chemo-immunotherapy in Patients Performed in Five Referred Centers
The study is a retrospective observational study. The study is designed to be multicentric and international and it will analyze medical records from selected patients diagnosed with locally advanced and resectable NSCLC who…
- Trial name
- IMMUNORATS (NCT06626243)
- Where
- 6 sites in United States, Italy
- Volunteers
- 140 people
- Sponsor
- Scientific Institute San Raffaele
Non-Small Cell Lung Cancer
A Multicenter Prospective Study to Assess the Effects of Adjuvant Icotinib in EGFRm Stage I NSCLC With High-risk of Disease Recurrence After Complete Resection
This is a multicenter single arm study, with an aim to assess the effects of adjuvant icotinib among EGFR mutant stage I lung adenocarcinoma patients, who have high-risk pathological features of recurrence.
- Trial name
- NCT05514314
- Testing
- Icotinib
- Volunteers
- 90 people
- Sponsor
- Wu Nan
Stage IB Lung Non-Small Cell Carcinoma AJCC v7, Stage II Lung Non-Small Cell Cancer AJCC v7
Nivolumab After Surgery and Chemotherapy in Treating Patients With Stage IB-IIIA Non-small Cell Lung Cancer (An ALCHEMIST Treatment Trial)
This phase III ALCHEMIST treatment trial studies how well nivolumab after surgery and chemotherapy work in treating patients with stage IB-IIIA non-small cell lung cancer.
- Conditions
- Stage IB Lung Non-Small Cell Carcinoma AJCC v7, Stage II Lung Non-Small Cell Cancer AJCC v7, Stage IIIA Lung Non-Small Cell Cancer AJCC v7
- Trial name
- ANVIL (NCT02595944)
- Testing
- Biospecimen Collection, Computed Tomography, Echocardiography Test
- Where
- 884 sites in United States
- Volunteers
- 903 people
- Sponsor
- National Cancer Institute (NCI)
Pulmonary Rehabilitation, Lung Cancer
Lung Resection and Pulmonary Rehabilitation
Lung cancer is the most common cancer in the world and surgical resection remains the gold standard curative treatment in early stage non-small cell lung cancer.
- Trial name
- NCT04722393
- Testing
- Exercise
- Where
- Turkey (Türkiye)
- Volunteers
- 66 people
- Sponsor
- Izmir Katip Celebi University
Non-small Cell Lung Cancer, Surgery
Anesthesia and Non-small Cell Lung Cancer Recurrence
There has been ongoing debate about the relationship between cancer recurrence and anesthetic management. Therefore, the investigators will test the hypothesis that the recurrence free survival (RFS) after curative resection of…
- Conditions
- Non-small Cell Lung Cancer, Surgery, Anesthesia
- Trial name
- GASTIVA (NCT06330038)
- Testing
- Propofol, Inhaled anesthetics
- Where
- South Korea
- Volunteers
- 5,384 people
- Sponsor
- Samsung Medical Center
Non-Small Cell Lung Cancer, Adjuvant Therapy
Adjuvant Immune Checkpoint Inhibitor Versus Observation After Neoadjuvant Immunochemotherapy and Surgery in High-Risk NSCLC
This multicenter, randomized, open-label, phase II trial is designed to evaluate the efficacy and safety of adjuvant sintilimab in patients with completely resected non-small cell lung cancer who remain at high risk of recurrence…
- Conditions
- Non-Small Cell Lung Cancer, Adjuvant Therapy, Immune Checkpoint Inhibitors
- Trial name
- RICA (NCT07748325)
- Testing
- Sintilimab
- Where
- 2 sites in China
- Volunteers
- 100 people
- Sponsor
- Sichuan University
NSCLC Stage IV
Primary Tumor Resection With EGFR TKI for Stage IV NSCLC
Our project is going to enroll patients with stage IV NSCLC with EGFR mutation and evaluate whether primary tumor resection after receiving the afatinib can prolong survival.
- Trial name
- NCT05215548
- Testing
- therapeutic thoracic surgery, Afatinib
- Where
- 2 sites in Taiwan
- Volunteers
- 100 people
- Sponsor
- National Taiwan University Hospital
Non-Small Cell Lung Cancer, Lung Neoplasms
McMaster Catheterization for Thoracoscopic Surgery Study
It is common practice to insert a Foley catheter into the bladder to drain urine during and after a lung resection. Recently, there has been increasing interest in the potential risks associated with this catheterization…
- Conditions
- Non-Small Cell Lung Cancer, Lung Neoplasms, Metastatic Lung Cancer, Urinary Retention
- Trial name
- UCATh (NCT02640326)
- Testing
- No Foley Urinary Catheter, Standard of care Foley urinary catheter insertion
- Where
- Canada
- Sponsor
- McMaster University
Postoperative Pulmonary Complications (PPCs), Preoperative Functional Status
Physical Function Before Surgery and Lung Complications After Lung Surgery
This study will examine whether patients' ability to perform everyday physical activities before lung surgery is related to their risk of developing lung complications after surgery.
- Trial name
- NCT07853430
- Testing
- Preoperative Functional Status Assessment
- Volunteers
- 450 people
- Sponsor
- Aerospace Center Hospital
Lung Cancer Patient
Low (-4) vs Physiologic (-8) Pressure Digital Continuous Suction After Lung Resection
The goal of this clinical trial is to learn whether using a lower negative pressure (-4 cmH₂O) on a digital chest drainage device after lung resection reduces the time a chest tube must stay in place compared with the commonly…
- Trial name
- Suction48 (NCT07527702)
- Testing
- Low-pressure digital suction (-4 cmH₂O)
- Where
- South Korea
- Volunteers
- 160 people
- Sponsor
- Seoul National University Hospital
Lung Neoplasms, Non-Small Cell Lung Cancer
Osimertinib With or Without Primary Lung Tumor Resection for EGFR-Mutant Oligometastatic Non-Small Cell Lung Cancer
Osimertinib is a standard first-line treatment for patients with metastatic non-small cell lung cancer harboring an epidermal growth factor receptor exon 19 deletion or exon 21 L858R mutation.
- Trial name
- PTR-2 (NCT07738172)
- Testing
- Primary Tumor Resection, Osimertinib
- Where
- Taiwan
- Volunteers
- 154 people
- Sponsor
- National Taiwan University Hospital
Surgery-Complications, Respiratory Complication
Dexmedetomidine Infusion and Postoperative Lung Aeration After Thoracic Surgery
This will be a randomized, placebo-controlled, double-blinded, pilot trial with two parallel groups (1:1 ratio) receiving either dexmedetomidine (initial bolus of 1 mcg/kg over 30 min after induction, followed by an infusion rate…
- Conditions
- Surgery-Complications, Respiratory Complication, Lung Injury, Acute
- Trial name
- NCT06502002
- Testing
- Dexmedetomidine Hydrochloride
- Where
- United States
- Volunteers
- 100 people
- Sponsor
- Brigham and Women's Hospital
Focus on Developing a Deep Learning Model to Predict the Recurrence Risk of Stage IA Invasive Lung Adenocarcinoma After Sub-lobar Resection
Deep Learning Model to Predict the Recurrence of Stage IA Invasive Lung Adenocarcinoma After Sub-lobar Resection
This study aims to develop a deep learning model based on noncontrast CT images to predict the recurrence risk of stage IA invasive lung adenocarcinoma after sub-lobar resection，which can serve as potential tool to assist…
- Trial name
- DL-Rec-ILA (NCT06659601)
- Where
- China
- Volunteers
- 9 people
- Sponsor
- First Affiliated Hospital of Chongqing Medical University
Lung Cancer
Effect of Dexmedetomidine on the Inflammatory Response After One-lung Ventilation
The postoperative inflammatory response is significant in lung resection surgery because of major operation and one-lung ventilation.
- Trial name
- NCT04007341
- Testing
- Dexmedetomidine
- Where
- South Korea
- Volunteers
- 40 people
- Sponsor
- Seoul St. Mary's Hospital
Lung Surgery, Chest Tube Removal
Patient Reported Outcomes Targeting Early Chest Tube Removal (PROTECTR) Study
This study is a single centre, prospective clinical trial evaluating the safety and feasibility of implementing a same day chest tube removal protocol in patients undergoing Video Assisted Thoracic Surgery (VATS) anatomical…
- Conditions
- Lung Surgery, Chest Tube Removal, Enhanced Recovery After Surgery (ERAS)
- Trial name
- PROTECTR (NCT06444854)
- Testing
- early chest tube removal
- Where
- Canada
- Volunteers
- 130 people
- Sponsor
- London Health Sciences Centre Research Institute OR Lawson Research Institute of St. Joseph's
Non-small- Cell Lung Cancer
Study of S-588410 After Adjuvant Chemotherapy for Completely Resected Non-small- Cell Lung Cancer
In this clinical study, the investigators evaluate the efficacy and safety of S-588410 in patients who underwent an adjuvant chemotherapy after the complete resection of non-small-cell lung cancer.
- Trial name
- NCT02410369
- Testing
- S-588410
- Where
- Japan
- Volunteers
- 60 people
- Sponsor
- Tokyo University
Pulmonary Neoplasm
Impact of Different Lung Isolation Devices on Pharyngolaryngeal Injuries After Pulmonary Resection
The goal of this clinical trial is to assess the impact of laryngeal mask combined with visual bronchial blocker on pharyngolaryngeal injury after pulmonary resection in patients with pulmonary nodules.
- Trial name
- PLIAP (NCT07117539)
- Testing
- visual bronchial blocker (VBB), double-lumen endotracheal tube (DLT)
- Where
- 3 sites in China
- Volunteers
- 270 people
- Sponsor
- Tingting Li
Non-small Cell Lung Cancer
Study of Split-course Chemoradiotherapy For Postoperative Locoregional Recurrence Of Non-small Cell Lung Cancer
This Phase II randomized study is to determine the efficacy of split-course irradiation with concurrent chemotherapy in locoregional recurrence of non-small cell lung cancer after surgical resection
- Trial name
- NCT03006575
- Testing
- split-course radiotherapy, concurrent chemotherapy
- Where
- China
- Volunteers
- 57 people
- Sponsor
- Sun Yat-sen University
Lung Cancer, Atrial Fibrillation
Determining the True Incidence of Atrial Fibrillation Before and After Lung Resection
Lung resections for pulmonary malignancies offer the best chance of survival for patients, but these procedures carry a significant burden of post-operative morbidity and mortality.
- Conditions
- Lung Cancer, Atrial Fibrillation, Stroke
- Trial name
- Lung-AF (NCT02547168)
- Testing
- iRhythm ZIO XT patch
- Where
- Canada
- Volunteers
- 27 people
- Sponsor
- McMaster University