Clinical trials: Post Traumatic Stress Disorders
Major Depressive Disorder, Post-Traumatic Stress Disorder
Examination of Glutamate and mGluR5 in Psychiatric Disorders
This research study is designed to look at the involvement of the glutamate system in depression. Each subject will undergo a screening appointment to determine study eligibility.
- Conditions
- Major Depressive Disorder, Post-Traumatic Stress Disorder, Bipolar Disorder
- Trial name
- NCT02727972
- Testing
- Cognitive Testing, MRI, PET
- Where
- United States
- Volunteers
- 180 people, healthy volunteers welcome
- Sponsor
- Yale University
Post-Traumatic Stress Disorder
Study of Eye Movement Desensitization and Reprocessing (EMDR) Working Mechanism
EMDR (Eye Movement Desensitization and Reprocessing) is an exposure-based procedure for the treatment of patients with post-traumatic stress disorder (PTSD).
- Trial name
- NCT01209377
- Testing
- standard, fixed, no focus
- Where
- Germany
- Volunteers
- 192 people, healthy volunteers welcome
- Sponsor
- Technical University of Munich
PTSD - Post Traumatic Stress Disorder, Depression/Anxiety
An Integrative, Digital Health Approach to Veteran-Centered PTSD Care
The goal of this study is to test the effectiveness of a stress self-management mobile health system (smartphone app + wearable sensor) alongside an intense physical cycling intervention to reduce symptoms of stress in a veteran…
- Trial name
- NCT06993012
- Testing
- Mobile Health Stress Self Management System, Intensive Cycling Activity
- Where
- United States
- Volunteers
- 37 people, healthy volunteers welcome
- Sponsor
- Texas A&M University
Posttraumatic Growth, Posttraumatic Stress Disorder
Stress, Adjustment And Growth In Children With Cancer And Their Parents
This proposal examines trauma and growth responses in the childhood cancer experience. It addresses a number of gaps and unanswered questions in the literature, while integrating several distinct but related lines of research.
- Trial name
- NCT01044160
- Where
- United States
- Volunteers
- 663 people, healthy volunteers welcome
- Sponsor
- St. Jude Children's Research Hospital
Post-Traumatic Stress Disorder
Resilience and Modification of Brain Control Network Following November 13
This is a multiwave longitudinal neuroimaging study in a cohort of direct survivors of 11/13 Paris terrorist attacks. Both structural and functional brain imaging data will be collected at 8-12 months, 3 years, and 6 years after…
- Trial name
- REMEMBER (NCT02810197)
- Testing
- Psychopathological assessment, Neuropsychological assessment, Functional magnetic resonance imaging (fMRI)
- Where
- France
- Volunteers
- 216 people, healthy volunteers welcome
- Sponsor
- Institut National de la Santé Et de la Recherche Médicale, France
Post Traumatic Stress Disorder
A Correlation Between Hair Cortisol Levels and the Development of Post Traumatic Stress Disorder (PTSD)
This observational study follows subjects who have been exposed to a traumatic event and are at risk of developing PTSD symptoms.
- Trial name
- NCT02033395
- Where
- Israel
- Volunteers
- 60 people, healthy volunteers welcome
- Sponsor
- Sheba Medical Center
Posttraumatic Stress Disorder
The Role of Expectations in the Development of Intrusive Memories
In the experimental study, the well-established trauma film paradigm will be used to investigate the impact of expectations on the development of intrusive memories as a hallmark symptom of PTSD.
- Trial name
- NCT03950869
- Testing
- Positive Expectation Manipulation, Negative Expectation Manipulation
- Where
- Germany
- Volunteers
- 90 people, healthy volunteers welcome
- Sponsor
- Philipps University Marburg
Posttraumatic Stress Disorder
The Effect of Oxytocin on Fear Memory Consolidation Novel Intervention to Prevent Posttraumatic Stress Disorder (PTSD)
The purpose of the study is to learn how differences in learning under mildly-stressful circumstances may be changed by taking oxytocin. Oxytocin is a hormone made naturally in the body.
- Trial name
- NCT01466127
- Testing
- Oxytocin
- Where
- United States
- Volunteers
- 60 people, healthy volunteers welcome
- Sponsor
- Massachusetts General Hospital
PTSD, Intrusive Memories
Estradiol and Intrusive Memories
The aim of the current project is to investigate the impact of 3mg of oral estradiol valerate on the formation of intrusive memories after analog trauma.
- Conditions
- PTSD, Intrusive Memories, Intrusion Symptom, Trauma
- Trial name
- EstraMemo (NCT07419594)
- Testing
- Estradiol Valerate
- Where
- Germany
- Volunteers
- 273 people, healthy volunteers welcome
- Sponsor
- Charite University, Berlin, Germany
HIV Prevention, PTSD and Substance Use Disorder
Preventing HIV Among Native Americans Through the Treatment PTSD & Substance Use
Investigators will conduct a two-arm, comparative effectiveness randomized controlled trial of two culturally adapted, empirically based programs (EBP) - Narrative Exposure Therapy (NET) vs.
- Trial name
- NCT03112369
- Testing
- Narrative Exposure Therapy (NET), Motivational Interviewing w/Skills Training (MIST)
- Where
- United States
- Volunteers
- 125 people, healthy volunteers welcome
- Sponsor
- University of Washington
Work Related Stress
Somatic Psychoeducational Intervention
The goal of this clinical trial is to explore possible benefits and mechanisms through which the Somatic Psychoeducational Intervention can improve health and wellness.
- Trial name
- NCT06580119
- Testing
- Somatic Psychoeducational Intervention
- Where
- United States
- Volunteers
- 30 people, healthy volunteers welcome
- Sponsor
- University of Florida
Psychological Trauma, Historical, Nutrition
Nutrition for Trauma Community Survey
The survey will help investigators learn everything about how people view and respond to trauma from a holistic perspective through body (nutrition), mind (mental health rejuvenation and renewal), and spirit (faith-based) lens.
- Conditions
- Psychological Trauma, Historical, Nutrition, PTSD - Post Traumatic Stress Disorder
- Trial name
- N4T (NCT06864637)
- Where
- United States
- Volunteers
- 20 people, healthy volunteers welcome
- Sponsor
- True Paleo Inc.
Depression, Anxiety
Perinatal Mental Health Study (PMHS) India
The purpose of this observational study is to improve understanding of mental disorders among perinatal women in India.
- Conditions
- Depression, Anxiety, Suicidal Ideation, Somatization
- Trial name
- PMHS (NCT05485701)
- Testing
- Screening tools for common mental disorders
- Where
- 2 sites in India
- Volunteers
- 2,332 people, healthy volunteers welcome
- Sponsor
- University of Oxford
Post Traumatic Stress Disorder
Department of Defense PTSD Adaptive Platform Trial - Intervention B - Vilazodone
This is a Phase 2 randomized, double-blinded, placebo-controlled study that will evaluate multiple potential pharmacotherapeutic interventions for PTSD utilizing an adaptive platform trial design.
- Trial name
- NCT05948579
- Testing
- Intervention B Vilazodone Hydrochloride (HCl)
- Volunteers
- 200 people, healthy volunteers welcome
- Sponsor
- Global Coalition for Adaptive Research
Post-Traumatic Stress Disorder
Risperidone in the Treatment of PTSD in Women Survivors of Domestic Abuse and Rape Trauma
This medical study is an assessment of clinical response in women with Posttraumatic Stress Disorder (PTSD) due to domestic violence or rape trauma when treated with risperidone.
- Trial name
- NCT00208182
- Testing
- Risperidone
- Where
- United States
- Volunteers
- 20 people, healthy volunteers welcome
- Sponsor
- Creighton University
MDD, Bipolar Disorder
Evaluation of Generalization Paradigm Patterns Among Different Psychiatric Disorders
Learning includes the ability to generalize to new situations and respond to similar, yet not identical stimuli. In previous work, focused on stimulus generalization in healthy volunteers, tones that were negatively reinforced…
- Conditions
- MDD, Bipolar Disorder, Schizophrenia Disorder, Anxiety Disorder (Panic Disorder or GAD)
- Trial name
- NCT01501812
- Testing
- Generalization pattern
- Where
- Israel
- Volunteers
- 180 people, healthy volunteers welcome
- Sponsor
- Shalvata Mental Health Center
Posttraumatic Stress Disorder, Pregnancy Related
Online Intervention to Promote Resilience to Traumatic Stress During Pregnancy
The investigators will design, construct, and pilot a prototype of a trauma-informed online intervention, which will be called "SunnysideFlex," that functionally integrates a web-based intervention targeting skills to decrease…
- Trial name
- NCT04992767
- Testing
- Sunnyside, SunnysideFlex
- Where
- United States
- Volunteers
- 31 people, healthy volunteers welcome
- Sponsor
- University of Illinois Chicago
Posttraumatic Stress Disorder, Cardiovascular Diseases
NightWare and Cardiovascular Health in Adults With PTSD
The purpose of this study is to determine whether NightWare therapeutic intervention improves biomarkers of vascular aging and autonomic function in adults with nightmares related to PTSD.
- Conditions
- Posttraumatic Stress Disorder, Cardiovascular Diseases, Autonomic Dysfunction, Vascular Stiffness
- Trial name
- NCT05365607
- Testing
- NightWare
- Where
- 2 sites in United States
- Volunteers
- 40 people, healthy volunteers welcome
- Sponsor
- University of Colorado, Denver
Mental Health, Depression
Designing a Mobile App to Support Academic Success for Student Veterans
Compared to civilian students in higher education, student Veterans have high rates of mental health disorders (e.g., Depression: 24% vs 12.1%).
- Conditions
- Mental Health, Depression, Post-Traumatic Stress Disorder, Anxiety
- Trial name
- NCT05344092
- Testing
- VetEd Mobile Application
- Where
- United States
- Volunteers
- 13 people, healthy volunteers welcome
- Sponsor
- VA Office of Research and Development
Chronic Musculoskeletal Pain, Posttraumatic Stress Disorder (PTSD)
Neurobiological and Psychological Benefits of Exercise in Chronic Pain and PTSD
The wars in Iraq and Afghanistan are creating a new generation of Veterans, including an increasing number of women Veterans, who present with comorbid PTSD and chronic pain conditions from recent deployment-related physical…
- Conditions
- Chronic Musculoskeletal Pain, Posttraumatic Stress Disorder (PTSD), Mild or Moderate Traumatic Brain Injury
- Trial name
- EXCPPTSD (NCT03283163)
- Testing
- Exercise Testing and Training
- Where
- United States
- Volunteers
- 23 people, healthy volunteers welcome
- Sponsor
- VA Office of Research and Development