Clinical trials: Post-Acute Sequelae of SARS-CoV-2 (PASC) Infection
COVID-19 Pneumonia, COVID-19 Respiratory Infection
Phase 2/Phase 3 Study To Evaluate The Efficacy And Safety Of Ramatroban Along With The Standard Of Care In Subjects Hospitalized For COVID Pneumonia
Phase II/Phase III study to evaluate the safety and efficacy of Ramatroban 75 mg tablet against Placebo in subjects hospitalized for pneumonia due to SARS-CoV-2 infection.
- Trial name
- NCT05706454
- Testing
- Ramatroban
- Where
- 7 sites in India
- Volunteers
- 324 people
- Sponsor
- KARE Biosciences
Long COVID, Dysautonomia
Mindfulness in Post Acute Sequelae of SARS-CoV-2 Infection (PASC) Dysautonomia
The current pilot study will recruit participants experiencing new, returning, or ongoing symptoms related to COVID-19 illness for at least four weeks after being first infected with SARS-CoV-2.
- Trial name
- NCT05566379
- Testing
- Mindfulness - Mindful Awareness Practices ( MAPs)
- Where
- United States
- Volunteers
- 20 people
- Sponsor
- University of California, Los Angeles
Post-COVID Condition
Supervised Computerized Active Program for People With Post-COVID Syndrome (SuperCAP Study)
SuperCAP study is a project aimed at designing and implementing an online program for improvement of cognitive, emotional, and functional status in post-COVID condition.
- Trial name
- SuperCAP (NCT06315894)
- Testing
- SuperCAP Program
- Where
- Spain
- Volunteers
- 60 people
- Sponsor
- Fundación FLS de Lucha Contra el Sida, las Enfermedades Infecciosas y la Promoción de la Salud y la Ciencia
COVID-19
Exercise in Adults with Post-Acute Sequelae of SARS-CoV-2 (COVID-19) Infection Study
To examine the efficacy of an 8-week exercise training program on functional, cognitive, and emotional health outcomes compared to a no treatment control condition in adults with PASC.
- Trial name
- PASC (NCT05218174)
- Testing
- Exercise Prescription
- Where
- United States
- Volunteers
- 21 people
- Sponsor
- Baylor Research Institute
COVID-19, SAR
(CBDRA60) to Prevent or Reduce Symptoms of COVID-19 and Prevention of Post-Acute Sequelae of SARS-CoV-2 Infection PASC
Coronavirus disease (COVID-19), caused by the novel severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2), presents a major threat to human health.
- Trial name
- NCT04777981
- Testing
- CBDRA60 supplement
- Where
- United States
- Volunteers
- 60 people, healthy volunteers welcome
- Sponsor
- Anewsha Therapeutics Inc.
PASC Post Acute Sequelae of COVID 19, Long COVID
From Inflammation to Remodelling Towards Personalized Diagnosis in Post-acute Sequelae of COVID-19
Rationale: The diagnosis and pathogenesis of long COVID remains unknown. We have previously shown that [68Ga]FAPI Positron Emission Tomography-Computed Tomography (PET/CT) imaging shows potential for diagnosis and molecular…
- Conditions
- PASC Post Acute Sequelae of COVID 19, Long COVID, Long Covid-19, PASC
- Trial name
- LIBERATE (NCT06911476)
- Volunteers
- 60 people, healthy volunteers welcome
- Sponsor
- University Medical Center Groningen
Long Covid
Long COVID Ultrasound Trial
The research objective is to assess the safety and potential efficacy of spleen ultrasound stimulation as an intervention for Long COVID in a pilot study.
- Trial name
- LOCUS (NCT06189066)
- Testing
- Splenic Ultrasound
- Where
- United States
- Volunteers
- 15 people
- Sponsor
- SecondWave Systems Inc.
COVID-19, SARS CoV-2 Infection
COVID-19 Vaccination Status and The Clinical Outcomes of Long COVID-19 Patients
Long COVID is defined by the persistence or emergence of symptoms for more than 4 weeks beyond the acute phase of Severe Acute Respiratory Syndrome-Corona Virus-2 (SARS-CoV-2) infection.
- Trial name
- SURVIVOR (NCT05587868)
- Testing
- COVID-19 Vaccine
- Where
- Indonesia
- Volunteers
- 250 people
- Sponsor
- Universitas Indonesia
Long COVID, Post Acute Sequelae of COVID-19
PET Imaging of Cyclooxygenase-1 in Participants With Neurological Manifestations of Post-Acute Sequelae of SARS-CoV-2 Infection (PASC)
Background: SARS-CoV-2 is the virus that causes COVID-19. Some people who recover from COVID-19 have long-term symptoms that affect the brain.
- Trial name
- NCT06920628
- Testing
- 11C-PS13
- Where
- United States
- Volunteers
- 60 people, healthy volunteers welcome
- Sponsor
- National Institute of Mental Health (NIMH)
LONG-COVID, Post-acute Sequelae of COVID-19
Skeletal Muscle in PASC and ME/CFS Patients
Rationale: A common feature in patients with Post-Acute Sequelae of SARS-CoV-2 Infection (PASC) and Myalgic encephalomyelitis/chronic fatigue syndrome (ME/CFS) are skeletal muscle-related symptoms, such as muscle pain, weakness…
- Conditions
- LONG-COVID, Post-acute Sequelae of COVID-19, ME/CFS
- Trial name
- NCT05225688
- Testing
- Bike exertion test
- Where
- Netherlands
- Volunteers
- 81 people, healthy volunteers welcome
- Sponsor
- Academisch Medisch Centrum - Universiteit van Amsterdam (AMC-UvA)
Long COVID, Long Covid19
RECOVER-VITAL: Platform Protocol to Measure the Effects of Antiviral Therapies on Long COVID Symptoms
This study is a platform protocol designed to be flexible so that it is suitable for a wide range of settings within health care systems and in community settings where it can be integrated into COVID-19 programs and subsequent…
- Trial name
- RECOVER-VITAL (NCT05595369)
- Testing
- Experimental: Paxlovid 25 day dosing, Experimental: Paxlovid 15 day dosing
- Where
- 69 sites in United States, Puerto Rico
- Volunteers
- 963 people
- Sponsor
- Kanecia Obie Zimmerman
Post-acute Sequelae SARS-CoV-2 Infection (PASC)
TDCS-potentiated Generalization of Cognitive Training in the Rehabilitation of Long COVID Symptoms
The overarching goals of this study are to employ cognitive testing to understand how transcranial direct current stimulation (tDCS), when used concurrently with cognitive training tasks, can affect cognitive impairment symptoms…
- Trial name
- NCT05589272
- Testing
- Active tDCS
- Where
- United States
- Sponsor
- University of Minnesota
Long COVID, PASC Post Acute Sequelae of COVID 19
Brain Stimulation in Long COVID
Cognitive problems and severe fatigue are two frequently occurring symptoms in long COVID, also known as Post-Covid Condition or Post-Acute Sequelae of COVID-19 (PASC), and their causes are currently unknown.
- Conditions
- Long COVID, PASC Post Acute Sequelae of COVID 19, Post COVID-19 Condition (PCC)
- Trial name
- MALIBU (NCT07278206)
- Testing
- Repetitive Transcranial Magnetic Stimulation
- Where
- Netherlands
- Volunteers
- 66 people
- Sponsor
- Amsterdam UMC, location VUmc
Long COVID-19, Long COVID
RECOVER-VITAL: Platform Protocol, Appendix to Measure the Effects of Paxlovid on Long COVID Symptoms
This is an appendix of master protocol (NCT05595369) designed to be flexible so that it is suitable for a wide range of settings within health care systems and in community settings where it can be integrated into COVID-19…
- Trial name
- RECOVER-VITAL (NCT05965726)
- Testing
- Paxlovid, Ritonavir
- Where
- United States
- Volunteers
- 964 people
- Sponsor
- Kanecia Obie Zimmerman
Post-acute Sequelae of SARS-CoV-2 Infection, Long COVID
Paxlovid for Treatment of Long Covid
The purpose of this study is to compare whether being treated with nirmatrelvir plus ritonavir for 15 days works better than being treated with placebo plus ritonavir to reduce severe symptoms of Long Covid.
- Trial name
- STOP-PASC (NCT05576662)
- Testing
- Nirmatrelvir, Ritonavir
- Where
- United States
- Volunteers
- 168 people
- Sponsor
- Stanford University
Long COVID, Long COVID-19
RECOVER-SLEEP: Platform Protocol, Appendix_B (CPSD)
The platform protocol is designed to be flexible so that it is suitable for a range of study settings and intervention types. Therefore, the platform protocol provides a general protocol structure that can be shared by multiple…
- Conditions
- Long COVID, Long COVID-19, Sleep Disturbance
- Trial name
- NCT06404112
- Testing
- Melatonin, Tailored lighting (TL) Active
- Where
- United States
- Volunteers
- 469 people
- Sponsor
- Duke University
SARS-CoV-2 Infection, COVID-19
Index Individuals in SARS-CoV-2 Prevention Research Studies (COVID-19 Index Individuals Companion Study)
Clinical trials of prevention modalities for Severe Acute Respiratory Syndrome Coronavirus 2 (SARS-CoV-2) infection and coronavirus disease (COVID-19) and pneumonia are underway under separate protocol(s) for close contacts…
- Conditions
- SARS-CoV-2 Infection, COVID-19, Coronavirus Infection, SARS (Severe Acute Respiratory Syndrome)
- Trial name
- IICov19PRS (NCT05074719)
- Where
- United States
- Volunteers
- 155 people
- Sponsor
- University of Washington
Post-acute Sequelae of COVID-19, Depressive Symptoms
Glutamatergic Modulation as a Treatment for Depressive Symptoms Among Patients With Post-acute Sequelae of COVID (PASC): A Pilot Trial
Post-acute sequelae of SARS-CoV2 (PASC), colloquially known as "long-COVID," is thought to affect between 10-30% of all COVID-19 survivors.
- Conditions
- Post-acute Sequelae of COVID-19, Depressive Symptoms, Cognitive Dysfunction
- Trial name
- NCT05690503
- Testing
- CI-581a, CI-581b
- Where
- United States
- Volunteers
- 12 people
- Sponsor
- New York State Psychiatric Institute
Cognitive Impairment, Post-Acute Sequelae of SARS-CoV-2 Infection
Treatment of COVID-19 Post-acute Cognitive Impairment Sequelae With tDCS
After almost 2 years of pandemic, the consequences of the post-COVID syndrome, or PASC (Post Acute-Sequelae of Sars-CoV-2), have become a major challenge in the management of affected patients, generating costs for health…
- Conditions
- Cognitive Impairment, Post-Acute Sequelae of SARS-CoV-2 Infection, COVID-19
- Trial name
- PASC (NCT05389592)
- Testing
- Active tDCS and cognitive training
- Where
- Brazil
- Volunteers
- 60 people
- Sponsor
- University of Sao Paulo
Post-Acute COVID-19 Syndrome, Cognitive Dysfunction
Humanity Neurotech Device Clinical Trial in Adults With Long COVID Cognitive Dysfunction
The purpose of this study is to assess the feasibility of an at-home MMT treatment in patients with cognitive dysfunction related to PASC, and to collect data on safety and efficacy to inform the design of larger clinical…
- Trial name
- NCT06739668
- Testing
- Pascal device
- Where
- United States
- Volunteers
- 30 people
- Sponsor
- Icahn School of Medicine at Mount Sinai