Clinical trials: Post-Anoxic Coma
Cardiac Arrest, Post-Anoxic Coma
Evaluation of the "Pupillary Pain Index" in Neurological Prognosis After Cardiac Arrest
Two-thirds of patients admitted to the Intensive Care Unit after a cardiac arrest die in the context of treatment withdrawal after a multimodal evaluation that determines an unfavorable neurological outcome.
- Conditions
- Cardiac Arrest, Post-Anoxic Coma, Anoxic Brain Injury
- Trial name
- CAPPI (NCT04336930)
- Testing
- Pupillary pain index (PPI)
- Volunteers
- 60 people
- Sponsor
- Central Hospital, Nancy, France
Coma
Improving Awakening Prognostication After Non Anoxic Coma Using PET-MRI in Intensive Care Unit
In last decades, several advances in the neuro-intensive management have lead to decrease mortality in Intensive Care Units. A significant morbidity remains as patients survive after a traumatic coma with uncertain quality of…
- Trial name
- ETIC (NCT02798588)
- Testing
- PET-MRI
- Where
- France
- Volunteers
- 38 people
- Sponsor
- Hospices Civils de Lyon
Anoxic-Ischemic Encephalopathy
Study for the Improvement of Long-Term Outcome Prediction in Patients in Coma After Cardiac Arrest
The primary objective of HOPE is to improve the accuracy of outcome prediction in anoxic-ischemic encephalopathy following cardiac arrest by bringing under close scrutiny some of the existing methods used for this purpose (e.g.
- Trial name
- HOPE (NCT02231060)
- Where
- 16 sites in Germany
- Volunteers
- 150 people
- Sponsor
- Ludwig-Maximilians - University of Munich
Post-Anoxic Coma
Ultrasonic Measurement of the Optic Nerve Sheath Diameter Predicting Outcome After Cardiac Arrest
Rationale: An important proportion of patients with return of spontaneous circulation (ROSC) after cardiac arrest remain comatose as a result of post anoxic encephalopathy (PAE).
- Trial name
- ONSD (NCT04084054)
- Testing
- Ultrasound
- Where
- Netherlands
- Volunteers
- 160 people
- Sponsor
- Rijnstate Hospital
Cardiac Arrest
Early DiaGnosis of Anoxic Brain Injury for Resuscitated Patients
Sudden cardiac arrest (CA) in adults remains a major public health issue in industrialized countries, leading to a mortality rate greater than 90%.
- Trial name
- EDGAR (NCT03806660)
- Where
- France
- Volunteers
- 500 people
- Sponsor
- Centre Hospitalier Régional Metz-Thionville
Status Epilepticus, Electrographic, Coma
VIGABatrin in Post-anoxic STATus Epilepticus - Phase IIa
This is a pilot trial of a single loading dose of vigabatrin in post-anoxic status epilepticus.
- Trial name
- VIGAB-STAT (NCT04772547)
- Testing
- Vigabatrin Only Product
- Where
- United States
- Volunteers
- 6 people
- Sponsor
- University of Florida
Post-Anoxic Coma, Postanoxic Enchephalopathie
Cracking Coma: Towards EEG and MRI Based Precision Medicine After Cardiac Arrest
Rationale: 30-70% of comatose patients admitted to the intensive care unit (ICU) after cardiac arrest never regain consciousness as a result of post anoxic encephalopathy (PAE).
- Trial name
- NCT03308305
- Where
- 3 sites in Netherlands
- Volunteers
- 94 people
- Sponsor
- Rijnstate Hospital
Cardiac Arrest, Post-Anoxic Coma
QUality Of Life and surviVAl in carDIac arreSt Patients
QUO VADIS is a national observational study with the aim to describe clinical intervention and utilization of neuroprognostication tools in the management of patients admitted to ICU following cardiac arrest
- Conditions
- Cardiac Arrest, Post-Anoxic Coma, Central Nervous System Diseases
- Trial name
- QUOVADIS (NCT04129073)
- Testing
- Intensive care treatment
- Volunteers
- 1,600 people
- Sponsor
- Gruppo Italiano per la Valutazione degli Interventi in Terapia Intensiva
Comatose Survivors of Cardiac Arrest
High Dose of Erythropoietin Analogue After Cardiac Arrest
The investigators hypothesised that the neuroprotective effects of erythropoietin and its analogues could lead to an improve outcome after cardiac arrest.
- Trial name
- Epo-ACR-02 (NCT00999583)
- Testing
- EPOETINE ALPHA, Control arm
- Where
- France
- Volunteers
- 500 people
- Sponsor
- Assistance Publique - Hôpitaux de Paris
Post Anoxic Coma
Comparison Between High-density Electroencephalography and Conventional Electroencephalography for Comatose Patients
The purpose of this study is to measure whether high-density electroencephalography can improve the detection of electrophysiological signs of awareness compared to conventional electroencephalography in post-anoxic comatose…
- Trial name
- COMETIQUE (NCT02588482)
- Testing
- high-density electroencephalography, Conventional electroencephalography
- Where
- France
- Volunteers
- 50 people
- Sponsor
- Centre Hospitalier Universitaire de Besancon
Traumatic Coma
Brain Network Disruptions Related to Traumatic Coma
To provide a fine-grained description of the brain network dysfunctions induced by severe traumatic brain injury (TBI) or anoxic encephalopathy, that are responsible for the acute state of unarousable unawareness, named coma…
- Trial name
- Coma3D (NCT03482115)
- Testing
- PET examination with radiopharmaceutical drug [18F] DPA-714, MRI examination, Blood samples
- Where
- France
- Volunteers
- 59 people, healthy volunteers welcome
- Sponsor
- University Hospital, Toulouse
Cardiac Arrest (CA), Anoxic Brain Injury
Early WAKE-up Predictors After Out-of-Hospital Cardiac Arrest
WAKE-OHCA is a prospective observational substudy of the Danish Out-of-Hospital Cardiac Arrest (DANOHCA) trial, identifier NCT05895838.
- Conditions
- Cardiac Arrest (CA), Anoxic Brain Injury, Comatose Survivors of Cardiac Arrest, EEG
- Trial name
- WAKE-OHCA (NCT06979700)
- Testing
- Automated Pupillometry, Transcranial Doppler Ultrasound, Optic Nerve Sheath Diameter
- Where
- 2 sites in Denmark
- Volunteers
- 250 people
- Sponsor
- University of Aarhus