Clinical trials: Post-Concussive Symptom
Brain Concussion, Post-Concussion Syndrome
Investigating the Physiological, Cognitive, and Psychological Effects of a Cognitive-Based Intervention
The primary purpose of this study is to investigate the effectiveness of a brief mindfulness-based intervention for targeting chronic physiological underarousal and post-concussive symptoms following a mild head injury (MHI), as…
- Trial name
- IPCPE-Mind (NCT02906449)
- Testing
- Meditation Technique
- Volunteers
- 70 people, healthy volunteers welcome
- Sponsor
- Brock University
Brain Concussion
Examination of Balance, Vestibular, and Ocular Functions and Activity Following Concussion
Previous research and position statements have outlined the necessity of balance and gait testing in the post-concussion evaluation of athletes.
- Trial name
- NCT02317107
- Where
- United States
- Volunteers
- 110 people, healthy volunteers welcome
- Sponsor
- Boston Children's Hospital
Occipital Neuralgia, Headache
Ultrasound Guided Platelet Rich Plasma Injections for Post Traumatic Greater Occipital Neuralgia
This study is a randomized controlled trial, assessing the effect of a single platelet rich plasma (PRP) injection in post traumatic (concussive) greater occipital neuralgia.
- Trial name
- NCT04051203
- Testing
- Autologous Platelet Rich Plasma Injection, Depo-Medrol and lidocaine, Normal Saline
- Where
- Canada
- Volunteers
- 35 people, healthy volunteers welcome
- Sponsor
- University of Calgary
Concussion Post Syndrome
Auditory Slow Wave Enhancement After Concussion
The prevalence of a traumatic brain injury (TBI) in children and adolescents is around 30% with 70-90% being classified as mild (concussion).
- Trial name
- NCT04770116
- Testing
- Auditory Stimulation
- Where
- Switzerland
- Volunteers
- 120 people, healthy volunteers welcome
- Sponsor
- University Children's Hospital, Zurich
Chronic Traumatic Encephalopathy
Post-Concussion Syndrome in Professional Athletes: A Multidisciplinary Study
to examine the relationship between repeated concussions and late decline of brain function. In addition, all participants agreeing to participate in the study will be asked to will their brains to The Krembil Neuroscience Centre…
- Trial name
- NCT03218332
- Testing
- Biomarkers for detecting possible CTE invivo
- Where
- Canada
- Volunteers
- 150 people, healthy volunteers welcome
- Sponsor
- University Health Network, Toronto
Cerebral Concussion, Brain Injuries
The Effects of Head Trauma on Collegiate Athletes
Recently, researchers and clinicians have examined many different forms of concussion testing aimed to assess if a brain injury has occurred and to what degree it affects the individual being tested.
- Trial name
- NCT02354469
- Where
- United States
- Volunteers
- 437 people, healthy volunteers welcome
- Sponsor
- Boston Children's Hospital
TBI (Traumatic Brain Injury)
Evaluation of Military Service and Family Members for Post Concussive and Posttraumatic Stress Symptoms
This protocol is designed to facilitate the recruitment, screening and registry of Military Service Members (SMs) and individuals eligible for care in the Department of Defense (DoD) healthcare system.
- Trial name
- MRP (NCT03191357)
- Testing
- n/a observational
- Where
- United States
- Volunteers
- 424 people, healthy volunteers welcome
- Sponsor
- Uniformed Services University of the Health Sciences
Post-Concussion Syndrome, Post-Traumatic Headache
Aerobic Exercise and Cognitive Training Effects on Postconcussive Symptomology
The purpose of this study is to compare a 4-week, moderately intensive, lab and home-based aerobic exercise program versus exercise plus cognitive training.
- Conditions
- Post-Concussion Syndrome, Post-Traumatic Headache, Post-Concussive Syndrome, Chronic, Head Injury
- Trial name
- NCT03674398
- Testing
- Exercise+CT, Exercise only
- Where
- United States
- Volunteers
- 34 people, healthy volunteers welcome
- Sponsor
- University of Illinois at Urbana-Champaign
Mild Concussion, Post Concussion Syndrome
Clinical Evaluation of a Novel Balance, Vestibular and Oculomotor Assessment Tool
The iDETECT (Integrated Display Enhanced Testing for Concussion and mild traumatic brain injury) system is a novel portable, open access platform that enables immediate and rapid assessment of multimodal neurologic function.
- Conditions
- Mild Concussion, Post Concussion Syndrome, Vestibular Neuritis
- Trial name
- NCT02171312
- Testing
- iDETECT Assessment, Routine Balance and Vestibular Testing
- Where
- United States
- Volunteers
- 126 people, healthy volunteers welcome
- Sponsor
- Emory University
Traumatic Brain Injury, Post-Concussion Syndrome
"Interactive Metronome Technology for Blast-Related Traumatic Brain Injury"
The purpose of this research is to see whether adding a new therapy helps people with brain injury focus better and think more clearly.
- Trial name
- NCT01248390
- Testing
- Interactive metronome
- Where
- United States
- Volunteers
- 48 people, healthy volunteers welcome
- Sponsor
- The Defense and Veterans Brain Injury Center
Post-Concussion Syndrome
Cerebellar TDCS for SRPCS Treatment
This study is investigating the immediate and long-term effects of bilateral cerebellar transcranial direct current stimulation on cognition, balance, and symptom severity in people with sports-related post-concussion syndrome.
- Trial name
- NCT04760899
- Testing
- Transcranial Direct Current Stimulation
- Where
- United States
- Volunteers
- 31 people, healthy volunteers welcome
- Sponsor
- University of Iowa
Growth Hormone Deficiency, Traumatic Brain Injury
Charactertizing Growth Hormone Deficiency in Traumatic Brain Injury
The goal of this observational study is to characterize the impact of growth hormone deficiency (GHD) on quality of life, symptom burden, and sleep in adults with traumatic brain injury (TBI), and to evaluate whether these…
- Trial name
- NCT07795736
- Testing
- Not applicable (observational study)
- Where
- 2 sites in Canada
- Volunteers
- 200 people, healthy volunteers welcome
- Sponsor
- University of Calgary
Brain Concussion, Post-Concussion Syndrome
Cerebral Blood Flow Regulation and Concussions
The purpose of this study is to understand how biochemical markers in blood, balance disturbances, and cognitive performance are related to brain blood flow changes after a concussion.
- Trial name
- NCT02754206
- Where
- United States
- Volunteers
- 79 people, healthy volunteers welcome
- Sponsor
- Southern Methodist University
Vascular System Injuries, Concussion, Brain
Sildenafil Treatment for Mild TBI
About 300,000 people are hospitalized for traumatic brain injury (TBI) each year. After TBI, secondary brain injury escalates due in part to heightened levels of oxidant injury, inflammation, and vascular injury.
- Conditions
- Vascular System Injuries, Concussion, Brain, Post-Concussion Syndrome
- Trial name
- NCT03598140
- Testing
- Sildenafil Citrate
- Where
- United States
- Volunteers
- 22 people, healthy volunteers welcome
- Sponsor
- University of Texas Southwestern Medical Center
Traumatic Brain Injury, Post-concussive Symptoms
MEG and DTI of Neural Function and Connectivity in Traumatic Brain Injury
The overall hypothesis is that the long-term cognitive and behavioral sequelae of traumatic brain injury (TBI) are due to selective disruption of the long association white matter tracts of the cerebral hemispheres, with…
- Trial name
- Dana-REAC (NCT01298557)
- Where
- United States
- Volunteers
- 69 people, healthy volunteers welcome
- Sponsor
- University of California, San Francisco
Brain Concussion, Reflex, Pupillary
Utility of Pupillary Metrics in Diagnosis and Management of Concussion in Children
The purpose of this study is to gather information and compare the potential use of pupillometry to identify concussions and post concussive syndrome with standard age appropriate assessments.
- Conditions
- Brain Concussion, Reflex, Pupillary, Post-Concussion Syndrome, Brain Injuries, Traumatic
- Trial name
- NCT04540445
- Testing
- Pupillary Assessment
- Where
- United States
- Volunteers
- 130 people, healthy volunteers welcome
- Sponsor
- Children's Hospital of Orange County
Post-Concussion Syndrome
Craniosacral Therapy for Concussion Symptoms
This study investigated the utilization of CranioSacral Therapy (CST) in patients with Post-Concussion Syndrome (PCS) and capture patient-reported perceptions of their lived experiences of treatment effect upon their symptoms.
- Trial name
- NCT04820192
- Testing
- Craniosacral Therapy
- Where
- United States
- Volunteers
- 67 people, healthy volunteers welcome
- Sponsor
- Special Therapies, Inc.
Traumatic Brain Injury, Post-concussion Syndrome
Measure of Cerebrovascular Dysfunction After TBI With fNIRS
The goal of this project is to determine if it is possible to assess Cerebrovascular Reactivity (CVR) to hypercapnia with functional Near Infrared Spectroscopy (fNIRS).
- Trial name
- NCT01789164
- Where
- United States
- Volunteers
- 100 people, healthy volunteers welcome
- Sponsor
- Uniformed Services University of the Health Sciences
Post Concussion Syndrome, Head Injury
Evaluation of Two Treatments for Chronic Post Concussion Syndrome
This study is designed to investigate factors that are associated with prolonged recovery from mild head injury. The investigators are particularly interested in defining the impact of anxiety related variables, such as health…
- Trial name
- NCT00871884
- Testing
- Psychoeducation, Relaxation Training, Interoceptive Exposure
- Where
- Canada
- Volunteers
- 10 people, healthy volunteers welcome
- Sponsor
- Simon Fraser University
Traumatic Brain Injury, Post-concussive Syndrome
Sildenafil for Cerebrovascular Dysfunction in Chronic Traumatic Brain Injury.
The purpose of this study is to determine whether sildenafil (Viagra®) is effective in improving cerebral blood flow and cerebrovascular reactivity inpatients who have persistent symptoms at least 6 months after a traumatic brain…
- Trial name
- NCT01762475
- Testing
- Sildenafil
- Where
- United States
- Volunteers
- 59 people, healthy volunteers welcome
- Sponsor
- Uniformed Services University of the Health Sciences