Clinical trials: Post-ERCP Pancreatitis
Pancreas Disease
A COMBINATION OF RECTAL INDOMETHACIN AND COLD WATER EXPOSURE OF THE AMPULLA AFTER ERCP IS SUPERIOR TO RECTAL INDOMETHACIN ALONE IN REDUCING THE INCIDENCE OF POST-ERCP PANCREATITIS -RCT
Endoscopic retrograde cholangiopancreatography (ERCP) has emerged as the primary modality in the management of biliary and pancreatic disease. The complications occurring from ERCP can range from mild to fatal.
- Trial name
- ERCP (NCT07574970)
- Where
- India
- Volunteers
- 150 people
- Sponsor
- Asian Institute of Gastroenterology, India
Post-ERCP Pancreatitis
Pharmacological Prophylaxis of Post- Endoscopic Retrograde Cholangiopancreatography (ERCP) Pancreatitis
The investigators aimed to perform a comparative study, evaluating the efficacy of three prophylactic approaches aiming to reduce the risk of post-ERCP pancreatitis, using pharmacologic agents with different mechanisms of action…
- Trial name
- NCT03708458
- Testing
- indomethacin suppository, N-acetylcysteine (NAC)
- Where
- Romania
- Volunteers
- 250 people
- Sponsor
- Grigore T. Popa University of Medicine and Pharmacy
Pancreatitis
Topical Pancreatic Duct Lidocaine for Prevention of Post-ERCP Pancreatitis
The purpose of this study is to determine if lidocaine is effective in reducing the incidence of post-ERCP pancreatitis.
- Trial name
- NCT00953199
- Testing
- Lidocaine Hydrochloride, Normal Saline
- Where
- United States
- Volunteers
- 506 people
- Sponsor
- Abraham Mathew MD
Post ERCP Pancreatitis
Ice Cold Water Flushing of the Ampulla After Endoscopic Sphincterotomy to Reduce Post-ERCP Pancreatitis
Endoscopic retrograde cholangiopancreatography (ERCP) is an essential diagnostic and therapeutic tool used to manage diseases of the pancreatic and biliary systems.
- Trial name
- ERCP (NCT07677397)
- Testing
- Ice cold water flushing post ERCP
- Volunteers
- 210 people
- Sponsor
- Oman Ministry of Health
Post-ERCP Pancreatitis
Rectal Indomethacin in the Prevention of Post-endoscopic Retrograde Cholangiopancreatography (ERCP) Pancreatitis in High Risk Patients
Pancreatitis (inflammation of the pancreas) is the most common complication of endoscopic retrograde cholangiopancreatography (ERCP), a procedure for the diagnosis and treatment of disorders of the pancreas and bile duct.
- Trial name
- NCT00820612
- Testing
- Indomethacin
- Where
- 4 sites in United States
- Volunteers
- 602 people
- Sponsor
- University of Michigan
Post-ERCP Acute Pancreatitis, NSAIDs
Prevention of Post-ERCP Pancreatitis by Indomethacin vs Diclofenac
Post-ERCP pancreatitis (PEP) is the most common complication after ERCP, which was associated with occasional mortality, prolonged hospital days and increased health costs.
- Conditions
- Post-ERCP Acute Pancreatitis, NSAIDs, Indomethacin, Diclofenac
- Trial name
- NCT05947461
- Testing
- 100mg diclofenac, 100mg indomethacin
- Where
- 11 sites in China
- Volunteers
- 1,204 people
- Sponsor
- Air Force Military Medical University, China
Acute Pancreatitis
Study of Peripheral Blood Non-coding RNAs as Diagnosis and Prognosis Biomarker for Acute Pancreatitis
It is important to identify patients with acute pancreatitis who are at risk for developing persistent organ failure early in the course of disease.
- Trial name
- NCRNAP (NCT02602808)
- Where
- 3 sites in China
- Volunteers
- 1,097 people
- Sponsor
- Changhai Hospital
Post ERCP Pancreatitis, Acute Pancreatitis (AP)
Cold Water Papillary Irrigation Plus Rectal NSAIDs vs Rectal NSAIDs Alone for Post-ERCP Pancreatitis (COLD)
Post-ERCP pancreatitis is the most frequent complication of endoscopic retrograde cholangiopancreatography (ERCP). Rectal non-steroidal anti-inflammatory drugs (NSAIDs) are the current standard prophylaxis.
- Trial name
- COLDHUVN (NCT07885852)
- Testing
- Cold water irrigation of the papilla, Rectal NSAID (diclofenac 100 mg)
- Where
- Spain
- Volunteers
- 250 people
- Sponsor
- University Hospital Virgen de las Nieves
Pancreatitis
Precise Endoscopic Application of Nitroglycerin in Preventing Post-ERCP Pancreatitis
Endoscopic retrograde cholangiopancreatography (ERCP) is a technically demanding procedure combining endoscopy and fluoroscopy to diagnose and treat pancreaticobiliary disorders such as bile duct stones, strictures, and…
- Trial name
- NCT07083063
- Testing
- Nitroglycerin (NTG), Normal Saline (0.9% NaCl)
- Where
- Taiwan
- Volunteers
- 440 people, healthy volunteers welcome
- Sponsor
- National Cheng-Kung University Hospital
Post-ERCP Acute Pancreatitis
Low-acid Contrast Media for Preventing Post ERCP Pancreatitis
Title： Low-acid contrast media for preventing post ERCP pancreatitis: a multicenter, retrospective, cohort study (LAMP-R) . Objective: Main objective: This study aims to determine whether low-acid contrast media can reduce the…
- Trial name
- LAMP-R (NCT07391787)
- Testing
- Ioversol, Iopromide, Iohexol
- Where
- 2 sites in China
- Volunteers
- 3,979 people
- Sponsor
- Shandong University
Pancreatitis, Endoscopic Retrograde Cholangiopancreatography
Effect of Papillary Epinephrine Spraying on Post-ERCP Pancreatitis in Patients Received Rectal Indomethacin
Acute pancreatitis is the most common and feared complication of ERCP, occurring after 1% to 30% of procedures. It accounts for substantial morbidity and represents a substantial cost to health-care systems.
- Trial name
- NCT03057769
- Testing
- Papillary epinephrine spraying, Papillary saline spraying, Indomethacin
- Where
- 10 sites in China
- Volunteers
- 3,300 people
- Sponsor
- Air Force Military Medical University, China
Acute Biliary Pancreatitis
Prophylactic Sphincterotomy in Acute Biliary Pancreatitis Patients Unfit for Surgery
This is a prospective, multicenter, open-label, randomized controlled trial designed to evaluate the efficacy and safety of prophylactic endoscopic sphincterotomy (ES) in frail patients unfit for cholecystectomy following an…
- Trial name
- PROSECCO (NCT07238296)
- Testing
- Prophylactic endoscopic sphincterotomy
- Volunteers
- 92 people
- Sponsor
- Semmelweis University
Pancreatitis
Diclofenac for the Prevention of Post-ERCP Pancreatitis in Higher Risk Patients
Inflammation of the pancreas (pancreatitis) is an uncommon but potentially serious complication of endoscopic retrograde cholangiopancreatography (ERCP), a specialized endoscopic examination of the ducts draining the liver and…
- Trial name
- NCT00428025
- Testing
- diclofenac
- Where
- Canada
- Volunteers
- 23 people
- Sponsor
- Queen's University
Pancreatitis, Acute
Cold and NSAID Trial for Prevention of Post-ERCP Pancreatitis
The standard prophylaxis for post-endoscopic retrograde cholangiopancreatography pancreatitis (PEP) is performed with rectal non-steroidal anti-inflammatory drugs (NSAIDs).
- Trial name
- NCT07738094
- Testing
- NSAID alone, Cryoprevention associated with NSAID
- Where
- Brazil
- Volunteers
- 583 people
- Sponsor
- Instituto do Cancer do Estado de São Paulo
Post ERCP Acute Pancreatitis
Indomethacin Decreases Post-ERCP Pancreatitis
Endoscopic retrograde cholangiopancreatography (ERCP) is now a widely accepted therapy for treating benign and malignant diseases of the pancreatobiliary tree.
- Trial name
- Indomethacin (NCT02110810)
- Testing
- Indomethacin, 2.6-g suppository of glycerin
- Where
- Mexico
- Volunteers
- 160 people
- Sponsor
- Instituto Mexicano del Seguro Social
Post ERCP Pancreatitis
Comparative Clinical Study to Evaluate the Possible Efficacy and Safety of Oral N-Acetyl Cysteine Versus Rectal Diclofenac in the Prevention of Post Endoscopic Retrograde Cholangiopancreatography Pancreatitis
The aim of the current study is to compare the efficacy and safety of oral NAC and rectal diclofenac in preventing Post Endoscopic retrograde cholangiopancreatography Pancreatitis. .
- Trial name
- NCT06252441
- Testing
- Rectal Diclofenac, Oral N-acetyl cysteine
- Where
- Egypt
- Volunteers
- 46 people
- Sponsor
- Tanta University
Post-ERCP Acute Pancreatitis
Randomized Controlled Trial of Rectal Indomethacin Versus Combined Pancreatic Stent Placement and Rectal Indomethacin for Preventing Post-ERCP Pancreatitis
The goal of this clinical trial is to compare rectal indomethacin alone versus combined pancreatic duct stenting and rectal indomethacin in prevention of post ERCP pancreatitis.
- Trial name
- NCT05857514
- Testing
- Rectal Indomethacin, Prophylactic Pancreatic duct stenting
- Where
- 2 sites in India
- Volunteers
- 384 people
- Sponsor
- Moti Lal Nehru Medical College
Common Bile Duct Stone, Malignant Hepatobiliary Neoplasm
Primary Needle Knife Fistulotomy Versus Conventional Cannulation Method
The aim of this study are to evaluate the feasibility of needle knife fistulotomy (NKF) as an initial procedure for biliary access in patients with biliary disease who are at increased risk for post-endoscopic retrograde…
- Conditions
- Common Bile Duct Stone, Malignant Hepatobiliary Neoplasm, Biliary Stricture, Pancreatic Diseases
- Trial name
- NCT02916199
- Testing
- cannulation of ampulla of Vater
- Where
- 7 sites in South Korea
- Volunteers
- 207 people
- Sponsor
- Gangnam Severance Hospital
Cholangiopancreatography, Endoscopic Retrograde, Biliary Tract Diseases
Fistulotomy as the Primary Cannulation Technique for All Patients Undergoing ERCP: A Randomized, Controlled Trial
Participants in this study will be undergoing a procedure called an endoscopic retrograde cholangiopancreatography (ERCP). This procedure is most commonly performed to help treat conditions affecting specific areas of the…
- Trial name
- NCT04559867
- Testing
- Needle knife fistulotomy, Sphincterotomy
- Where
- Canada
- Volunteers
- 538 people
- Sponsor
- Lawrence Charles Hookey
Pancreatitis, Acute
Prophylaxis of Post-ERCP Acute Pancreatitis
This study aims to compare indomethacin and the combination of indomethacin and aggressive lactated Ringer infusion in terms of efficacy in preventing post-ERCP acute pancreatitis (PEP).
- Trial name
- PEPPER (NCT05381428)
- Testing
- Indomethacin suppository, Indomethacin suppository and high-flow lactated ringer infusion combination
- Where
- 10 sites in Italy
- Volunteers
- 184 people
- Sponsor
- Azienda USL Reggio Emilia - IRCCS