Clinical trials: Post-Operative Condition
Postoperative Cognitive Dysfunction
Effects of Amantadine on Postoperative Cognitive Dysfunction
Post-operative cognitive dysfunction (POCD) is a fairly well-documented clinical phenomenon. Investigators will determine whether amantadine can reduce the occurrence of POCD in elderly patients with major abdominal surgery.
- Trial name
- NCT03527134
- Testing
- Amantadine
- Where
- China
- Volunteers
- 390 people, healthy volunteers welcome
- Sponsor
- Zhiyi Zuo
Disorder; Heart, Functional, Postoperative, Cardiac Surgery
Functional Recovery After Cardiac Surgery : Does Delirium and Calorie Intake Matter?
The aims of the cohort study is to describe the rates of 30-day surgical complication, functional decline, frailty and one-year mortality for patients experienced cardiac surgery and to delineate the trajectory of functional…
- Trial name
- NCT02212509
- Where
- Taiwan
- Volunteers
- 300 people
- Sponsor
- National Taiwan University Hospital
Pain
Mechanism-based Choice of Therapy for Neuropathic Pain
Mechanism-based choice of therapy for neuropathic pain: Can treatments success in neuropathic post-operative pain be coupled to psychophysical pain modulation profile?
- Trial name
- NCT01359514
- Testing
- Pregabalin, Duloxetine
- Where
- Israel
- Volunteers
- 32 people
- Sponsor
- Rambam Health Care Campus
Flumazenil Adverse Reaction, Ambulatory Surgery
Reversal of Remimazolam by a Single Dose of Flumazenil
Remimazolam, a brand-new sedative which has benzodiazepine property. It is an ultra-short acting sedative and regarded as a proper drug for procedural sedation.
- Conditions
- Flumazenil Adverse Reaction, Ambulatory Surgery, Postoperative Nausea, Remimazolam
- Trial name
- NCT05382806
- Testing
- Flumazenil
- Where
- South Korea
- Volunteers
- 224 people, healthy volunteers welcome
- Sponsor
- Konkuk University Medical Center
Pain, Postoperative, Acute Pain
EFFECT - EFFectiveness of ESPB (Erector Spinae Plane Block) in Laparoscopic Cοlectomies Trial
The aim of the trial is to study the efficacy of continuous bilateral Erector Spinae Plane Block (ESPB) in managing perioperative pain in patients who undergo elective laparoscopic colectomy.
- Conditions
- Pain, Postoperative, Acute Pain, Postoperative Complications, Pain
- Trial name
- EFFECT (NCT04879004)
- Testing
- Ropivacaine injection
- Where
- Greece
- Volunteers
- 40 people
- Sponsor
- Democritus University of Thrace
Pain, Post Operative Pain
Phase II Study of Inhaled AeroLEF for Analgesia After ACL Knee Surgery
To evaluate the safety and efficacy of self-titration to effective analgesia with inhaled AeroLEF in patients with moderate/severe acute pain in the post-surgical setting.
- Trial name
- Pain (NCT00791804)
- Testing
- AeroLEF
- Where
- 2 sites in Canada
- Volunteers
- 19 people
- Sponsor
- YM BioSciences
Morbid Obesity
Bougie Sleeve Trial
Staple-line leak is the most frequent and incapacitating complication after laparoscopic sleeve gastrectomy (LSG). The aim of this prospective randomized trial is to compare the staple-line leak rate after LSG according to the…
- Trial name
- BOUST (NCT02937649)
- Testing
- Laparoscopic sleeve gastrectomy using 48-Fr bougie, Laparoscopic sleeve gastrectomy using standard care bougie
- Where
- 12 sites in France
- Volunteers
- 1,658 people
- Sponsor
- Assistance Publique - Hôpitaux de Paris
Orthognathic Surgical Site Infection
Antibiotics for Prevention of Infection Following Orthognathic Surgery
Orthognathic surgery describes a group of procedures aimed at correcting developmental or acquired deformities of the jaws and facial skeleton.
- Trial name
- NCT05852158
- Testing
- Cefazolin 2 GM Injection, Cefazolin Injection
- Where
- Canada
- Volunteers
- 400 people
- Sponsor
- Abdul El-Rabbany
Postoperative Ileus, Postoperative Complications
Coffee After Pancreatic Surgery
Postoperative ileus is a common complication after major abdominal surgery. A positive effect of coffee to bowel movement has been described after colorectal and gynecologic interventions.
- Conditions
- Postoperative Ileus, Postoperative Complications, Bowel Dysfunction, Pancreatic Diseases
- Trial name
- COPS (NCT04205058)
- Testing
- Standard coffee, Caffeine-free coffee, Drinking water
- Where
- Italy
- Volunteers
- 204 people
- Sponsor
- Azienda Ospedaliera Universitaria Integrata Verona
Postoperative Pain, Acute, Postoperative Complications
Minimally Invasive Esophagectomy Pain Control Trial
A pilot randomized controlled trial comparing intercostal nerve blocks, cryo-ablation plus intercostal nerve blocks, and serratus plane catheter plus intercostal nerve blocks in patients undergoing esophagectomies with minimally…
- Trial name
- NCT05906134
- Testing
- Local intercostal nerve block, Cryo-analgesia and intercostal nerve block, Serratus plane catheter blocks and intercostal nerve blocks
- Where
- United States
- Volunteers
- 30 people
- Sponsor
- Swedish Medical Center
Surgical Site Infection
One Stage Versus Two Stage For Periprosthetic Hip And Knee Infection
The purpose of this study is to compare the outcomes of two different treatment options commonly used to manage periprosthetic joint infection (PJI), an infection around the artificial knee or hip.
- Trial name
- NCT02734134
- Testing
- One-stage exchange joint replacement surgery, Two-stage exchange joint replacement surgery
- Where
- 5 sites in United States
- Volunteers
- 343 people
- Sponsor
- OrthoCarolina Research Institute, Inc.
Colon Tumor, Malignant, Rectum Tumor
Use of VIrtual REAlity to Reduce Postoperative Anxiety and Pain After Surgery for Colorectal Cancer
In patients operated for colorectal cancer, pain, anxiety and depression are important factors in postoperative rehabilitation. The use of new technologies, as virtual reality immersion, could further improve their postoperative…
- Conditions
- Colon Tumor, Malignant, Rectum Tumor, Pain, Postoperative
- Trial name
- VIREA (NCT05653934)
- Testing
- Pre-operative use of virtual reality headset, Standard surgery, Post-operative use of virtual reality headset
- Where
- France
- Volunteers
- 124 people
- Sponsor
- Assistance Publique - Hôpitaux de Paris
Postoperative Pain
Peripheral Nerve Block Anaesthesia for Ankle Fracture Surgery - an Exploratory Study: Is Rebound Pain a Problem?
The purpose of this exploratory study is to characterize the postoperative pain profile of patients undergoing operation with internal fixation of an ankle fracture under nerve block anaesthesia.
- Trial name
- NCT02100098
- Where
- Denmark
- Volunteers
- 21 people
- Sponsor
- Herlev Hospital
Pain, Postoperative
Analgesic Effect of Three-point Transversus Abdominis Plane Block Compared With Continuous Epidural Infusion for Post-laparoscopic Nephrectomy
This study aimed to compare the efficacy three-point Transversus Abdominis Plane (TAP) blocks with continuous epidural infusion for alleviating pain post-laparoscopic nephrectomy
- Trial name
- NCT03154463
- Testing
- TAP Blocks, continuous epidural infusion
- Where
- Indonesia
- Volunteers
- 50 people, healthy volunteers welcome
- Sponsor
- Universitas Indonesia
Chronic Post Operative Pain
Prevalence and Risk Factors for Postsurgical Pain After the Open Reduction and Internal Fixation of Lower Limbs.
The objective of this study is to specify the demographic and medical factors that most likely constitute a risk of developing CPSP in the patients with lower limb.
- Trial name
- NCT06136663
- Where
- China
- Volunteers
- 1,000 people, healthy volunteers welcome
- Sponsor
- Xuzhou Central Hospital
Lumbar Disc Herniation
QLB vs mTLIP for Lumbar Spinal Surgery
Ultrasound-guided quadratus lumborum block (QLB) is a fascial plane block where local anesthetic is injected adjacent to the quadratus lumborum muscle with the goal of anesthetizing the thoracolumbar nerves.
- Trial name
- NCT05217121
- Testing
- Quadratus Lumborum Block, Modified-thoracolumbar interfascial plane block
- Where
- Turkey (Türkiye)
- Volunteers
- 60 people
- Sponsor
- Medipol University
Cognitive Impairment (CI)
Post-operative Functional Disability in Unrecognized Cognitive Impairment (POF) Study
This is a prospective multicenter cohort study, which will determine the prevalence of preoperative cognitive impairment (CI) using the Modified Telephone Interview for Cognitive Status (TICS-M), Eight-items interview to…
- Trial name
- NCT04850833
- Where
- 2 sites in Canada
- Volunteers
- 390 people
- Sponsor
- University Health Network, Toronto
Colon Adenocarcinoma, Microsatellite Stable Colon Carcinoma
Testing the Use of BRAF-Targeted Therapy After Surgery and Usual Chemotherapy for BRAF-Mutated Colon Cancer
This phase II/III trial compares the effect of the combination of encorafenib and cetuximab to usual care (patient observation) for reducing the chance of cancer recurrence after standard surgery and chemotherapy in patients with…
- Conditions
- Colon Adenocarcinoma, Microsatellite Stable Colon Carcinoma, Stage IIB Colon Cancer AJCC v8, Stage IIC Colon Cancer AJCC v8
- Trial name
- NCT05710406
- Testing
- Encorafenib, Cetuximab, Biospecimen Collection
- Where
- 202 sites in United States
- Volunteers
- 1 people
- Sponsor
- Alliance for Clinical Trials in Oncology
Hypersensitivity Dentin
Post-operative Hyper-sensitivity Assessment After Immediate Versus Delayed Dentine Sealing in Teeth for Indirect Tooth Colored Restorations
PICOT elements:P: Teeth restored with indirect tooth colored restoration I: Immediate dentin sealing using universal adhesive C: Delayed dentin sealing O: Post-operative Hypersensitivity T: -Hypersensitivity assessment one week…
- Trial name
- NCT03562858
- Testing
- Immediate dentin sealing protocol, Delayed dentin sealing protocol
- Where
- Egypt
- Volunteers
- 54 people, healthy volunteers welcome
- Sponsor
- Cairo University
Breast Cancer, Pain
Chronic Pain in Women Who Have Undergone Surgery for Stage I, Stage II, or Stage III Breast Cancer
RATIONALE: Learning about chronic pain in women who have undergone surgery for breast cancer may help improve the quality of life for these patients and may help doctors plan the best treatment.
- Conditions
- Breast Cancer, Pain, Perioperative/Postoperative Complications
- Trial name
- NCT00971919
- Testing
- questionnaire administration, assessment of therapy complications, psychosocial assessment and care
- Where
- United Kingdom
- Volunteers
- 284 people
- Sponsor
- Aberdeen Royal Infirmary