Clinical trials: Post-Traumatic Stress Disorders
Posttraumatic Stress Disorder
The Effect of Oxytocin on Fear Memory Consolidation Novel Intervention to Prevent Posttraumatic Stress Disorder (PTSD)
The purpose of the study is to learn how differences in learning under mildly-stressful circumstances may be changed by taking oxytocin. Oxytocin is a hormone made naturally in the body.
- Trial name
- NCT01466127
- Testing
- Oxytocin
- Where
- United States
- Volunteers
- 60 people, healthy volunteers welcome
- Sponsor
- Massachusetts General Hospital
PostTraumatic Stress Disorder
Equine Assisted Psychotherapy for PTSD
The purpose of this study is to assess the efficacy of Equine Assisted Psychotherapy on PTSD symptoms in veterans with PTSD as compared with existing care.
- Trial name
- NCT03039361
- Testing
- Equine Assisted Psychotherapy
- Volunteers
- 20 people, healthy volunteers welcome
- Sponsor
- University of New Mexico
Post Traumatic Stress Disorder
Department of Defense PTSD Adaptive Platform Trial - Intervention A - Fluoxetine
This is a Phase 2 randomized, double-blinded, placebo-controlled study that will evaluate multiple potential pharmacotherapeutic interventions for PTSD utilizing an adaptive platform trial design.
- Trial name
- NCT05948553
- Testing
- Intervention A Fluoxetine Hydrochloride (HCl)
- Where
- 9 sites in United States
- Volunteers
- 200 people, healthy volunteers welcome
- Sponsor
- Global Coalition for Adaptive Research
Posttraumatic Stress Disorder
Investigating Cardiac Health of Adults With Trauma
This project examines the impact of a healthy lifestyle intervention, specifically designed for adults with posttraumatic stress and identified cardiovascular risks.
- Trial name
- I - CHAT (NCT05700201)
- Testing
- Lifestyle / Healthy Behavior Intervention, standard care
- Where
- United States
- Volunteers
- 216 people, healthy volunteers welcome
- Sponsor
- Nova Southeastern University
Post-traumatic Stress Disorder
Perception of Stressful Social Stimuli After Trauma Exposure.
Post-traumatic stress disorder is associated with altered processing of sensory stimuli. The clinical phenotype PTSD has predominantly been described for the visual and auditory sensory modalities.
- Trial name
- NCT03421587
- Testing
- Processing of social olfactory and tactile stimuli
- Where
- Germany
- Volunteers
- 100 people, healthy volunteers welcome
- Sponsor
- University Hospital, Bonn
Post Traumatic Stress Disorder PTSD
Effectiveness of Informational and Educational Tools to Improve the Experience of Relatives of ICU Patients. RELIEF, a Platform Trial
The admission of a patient to an intensive care unit (ICU) is associated with high levels of acute stress, anxiety, and depression among relatives, as well as extreme emotions such as fear, guilt, distress, and helplessness.
- Trial name
- RELIEF (NCT06851884)
- Testing
- Standard of Care (SOC), Video capsules, Cartoon
- Volunteers
- 562 people, healthy volunteers welcome
- Sponsor
- Assistance Publique - Hôpitaux de Paris
Post-traumatic Stress Disorder (PTSD), Acute Stress Disorder
EMDR Flash Group Protocol for Earthquake Survivors
This pilot randomized controlled trial evaluated the preliminary effects of the online EMDR Flash Group Protocol among adults affected by the 2023 Kahramanmaraş earthquakes in Türkiye.
- Conditions
- Post-traumatic Stress Disorder (PTSD), Acute Stress Disorder, Anxiety, Depression
- Trial name
- FlashGP-EQ (NCT07672613)
- Testing
- EMDR Flash Group Protocol
- Where
- Turkey (Türkiye)
- Volunteers
- 410 people, healthy volunteers welcome
- Sponsor
- Istanbul Galata University
Posttraumatic Stress Disorder, Somatization
Intervention Through EMDR and CBT With Women Victim of Childhood Sexual Abuse. A Randomized Controlled Trial.
This study evaluates the effectiveness of two types of therapy for the treatment of sexual abuse psychological impact on a sample of Spanish women.
- Conditions
- Posttraumatic Stress Disorder, Somatization, Obsessive-Compulsive Disorder, Depression
- Trial name
- NCT04813224
- Testing
- TRAUMA CENTERED EMDR-BASED TREATMENT and TRAUMA-FOCUSED CBT-BASED TREATMENT
- Where
- Spain
- Volunteers
- 50 people, healthy volunteers welcome
- Sponsor
- Universidad Internacional de Valencia
Trauma and Stressor Related Disorders
The Effect of Cognitive Behavioral Therapy on Post-Traumatic Stress Symptoms in Nursing Students
Objectives: This research was planned to examine the effect of cognitive behavioral therapy on the post-traumatic stress symptoms of nursing students during the COVID-19 pandemic.
- Trial name
- NCT06037005
- Testing
- Cognitive Behavioral Therapy Group
- Where
- 2 sites in Turkey (Türkiye)
- Volunteers
- 60 people, healthy volunteers welcome
- Sponsor
- Necmettin Erbakan University
Posttraumatic Stress Disorder With Attention Defic
Atomoxetine and Executive Function in PTSD
Attention deficits (AD) frequently co-occur with posttraumatic stress disorder (PTSD). The presence of AD is associated with greater PTSD clinical severity and poorer clinical outcomes.
- Trial name
- NCT06573970
- Testing
- Atomoxetine
- Where
- United States
- Volunteers
- 160 people, healthy volunteers welcome
- Sponsor
- VA Office of Research and Development
Posttraumatic Stress Disorder
Testing of a Mobile Web App to Decrease Posttraumatic Stress Symptoms in Women After Sexual Assault
Interventions are available to all adult women sexual assault survivors to reduce the risk of pregnancy and sexually transmitted infection, yet no interventions are provided to reduce posttraumatic stress.
- Trial name
- NCT04334356
- Testing
- Mobile Web App
- Where
- 2 sites in United States
- Volunteers
- 25 people, healthy volunteers welcome
- Sponsor
- University of North Carolina, Chapel Hill
Post-Traumatic Stress Disorders
Mental Health in Veterans and Families After Group Therapies
PTSD (posttraumatic stress disorder) and associated mental health conditions affect both veterans and their family members. This study investigates whether group therapy using EFT (Emotional Freedom Techniques) and CBT (Cognitive…
- Trial name
- NCT01327690
- Testing
- CBT (Cognitive Behavior Therapy), EFT (Emotional Freedom Techniques)
- Where
- United States
- Volunteers
- 100 people, healthy volunteers welcome
- Sponsor
- Soul Medicine Institute
Post-Traumatic Stress Disorder
Resilience and Modification of Brain Control Network Following November 13
This is a multiwave longitudinal neuroimaging study in a cohort of direct survivors of 11/13 Paris terrorist attacks. Both structural and functional brain imaging data will be collected at 8-12 months, 3 years, and 6 years after…
- Trial name
- REMEMBER (NCT02810197)
- Testing
- Psychopathological assessment, Neuropsychological assessment, Functional magnetic resonance imaging (fMRI)
- Where
- France
- Volunteers
- 216 people, healthy volunteers welcome
- Sponsor
- Institut National de la Santé Et de la Recherche Médicale, France
Mindfulness, Educational Support
Adaptation of Mindfulness Training to Treat Moral Injury in Veterans
This project is highly innovative as it will be the first to develop a mindfulness-based treatment as a first-line intervention tailored to target moral injury among combat-wounded veterans.
- Trial name
- NCT05341882
- Testing
- Mindfulness, Educational Support
- Where
- United States
- Volunteers
- 75 people, healthy volunteers welcome
- Sponsor
- Old Dominion University
Posttraumatic Stress Disorder
Targeted Strategies to Accelerate Evidence-Based Psychotherapy (EBP) Implementation in Military Settings
This study will evaluate a program designed to increase military treatment facilities' use of Prolonged Exposure (PE), an evidence-based psychotherapy for PTSD.
- Trial name
- NCT03663452
- Testing
- Targeted Assessment and Context-Tailored Implementation of Change Strategies (TACTICS), Prolonged exposure training
- Where
- 8 sites in United States
- Volunteers
- 8 people, healthy volunteers welcome
- Sponsor
- Palo Alto Veterans Institute for Research
Activity, Motor, Emotion Regulation
Moving Forward Together 2.0: An Activity Intervention
The study will test whether an online physical activity program that includes mindfulness can increase activity in women who have been abused by a relationship partner.
- Trial name
- MFT (NCT06502444)
- Testing
- Moving Forward Together Activity Intervention
- Where
- 2 sites in United States
- Volunteers
- healthy volunteers welcome
- Sponsor
- Rosalind Franklin University of Medicine and Science
Depressive; Episode, Major, Depression, Postpartum
Diagnostic Accuracy of the Stepped Screening Protocol and Its Screening Tools in the Perinatal Period.
It is known that 1 in 5 women experience psychological difficulties during their pregnancy or in the first year after giving birth.
- Conditions
- Depressive; Episode, Major, Depression, Postpartum, Anxiety Disorders, Obsessive-Compulsive Disorder
- Trial name
- DAS (NCT05961306)
- Testing
- SCID 5
- Where
- 2 sites in Belgium
- Volunteers
- 1,800 people, healthy volunteers welcome
- Sponsor
- University Hospital, Ghent
PTSD, Generalized Anxiety Disorder
Feasibility and ML Training Investigation of the Senseye DT for Diagnosis of Adults with PTSD
The aim of this study is to obtain data on the feasibility of the Senseye Diagnostic Tool (DT) to assess the presence and severity of post-traumatic stress disorder (PTSD) symptoms.
- Conditions
- PTSD, Generalized Anxiety Disorder, Major Depressive Disorder
- Trial name
- NCT05717439
- Testing
- CAPS-5-R, Senseye DT
- Where
- 5 sites in United States
- Volunteers
- 338 people, healthy volunteers welcome
- Sponsor
- Senseye, Inc.
PTSD, Post-traumatic Stress Disorder
Network-based Neurofeedback in PTSD
This project will examine the use of real-time fMRI (rt-fMRI) neurofeedback in the regulation of neural networks underlying symptoms experienced by individuals with posttraumatic stress disorder (PTSD).
- Trial name
- NCT04875221
- Testing
- Connectivity-based neurofeedback
- Where
- Canada
- Volunteers
- healthy volunteers welcome
- Sponsor
- London Health Sciences Centre Research Institute OR Lawson Research Institute of St. Joseph's
PTSD
Neural Circuits in Women With Abuse and Posttraumatic Stress Disorder
The purpose of this study was to assess the effects of the medication paroxetine on symptoms of posttraumatic stress disorder (PTSD) and the brain in women with a history of PTSD related to childhood abuse.
- Trial name
- NCT01681849
- Testing
- Paroxetine, Positron Emission Tomography (PET) Imaging
- Where
- United States
- Volunteers
- 91 people, healthy volunteers welcome
- Sponsor
- Emory University