Clinical trials: Post-extubation Respiratory Failure
Respiratory Failure
Extubation Readiness and Neuroventilatory Efficiency After Acute Respiratory Failure
The aim of this study was to compare the indices of rapid shallow breathing, neuromechanical efficiency (NME), and neuroventilatory efficiency (NVE) between patients being successfully extubated and those who failed weaning.
- Trial name
- NCT01065428
- Where
- China
- Volunteers
- 52 people
- Sponsor
- Southeast University, China
Acute Respiratory Failure, Non-invasive Ventilation
Tissue Doppler Ultrasound During Spontaneous Breathing and Non-invasive Ventilation in the Post-extubation Period.
The aim of the present investigation will be to evaluate diaphragmatic excursion velocity during non-invasive ventilation and spontaneous breathing at both inspiration and expiration.
- Trial name
- TDIpostext (NCT03978221)
- Testing
- Post-extubation TDI
- Where
- Italy
- Volunteers
- 20 people
- Sponsor
- Azienda Ospedaliero Universitaria Maggiore della Carita
Respiratory Distress Syndrome, Bronchopulmonary Dysplasia
Post-extubation Pressures in Preterm Neonates: A CER Study
The optimal post-extubation pressure level on non-invasive respiratory support modes - irrespective of the choice of the specific non-invasive mode - that optimizes extubation success and improves clinical outcomes remains…
- Conditions
- Respiratory Distress Syndrome, Bronchopulmonary Dysplasia, Preterm Birth
- Trial name
- NCT06552455
- Volunteers
- 1,050 people
- Sponsor
- McMaster Children's Hospital
Respiratory Failure
Extubation Failure Prevention in High Risk Patients by High-flow Conditioned Oxygen Therapy vs. Standard Oxygen Therapy
Failure of extubation after mechanical ventilation is a frequent and deleterious issue. Main reasons for failure are hypoxemia, secretions retention, lung collapse and excessive work of breathing.
- Trial name
- NCT01820507
- Testing
- Optiflow (Fisher&Paykel), Nasal cannulae or controlled oxygen concentration mask
- Where
- Spain
- Volunteers
- 155 people
- Sponsor
- Althaia Xarxa Assistencial Universitària de Manresa
Extubation, Respiratory Depression
Effect of Percutaneous Electrical Acupoint Stimulation on the Improvement of Incidence of Adverse Respiratory Events
The goal of this study is to investigate the effect of combined acupoint electrical stimulation at Taiyuan (LU9) and Hegu (LI4) on improving the incidence of respiratory adverse events after extubation in patients during the…
- Conditions
- Extubation, Respiratory Depression, Acupuncture Points, Hypoxia
- Trial name
- NCT06772961
- Testing
- Transcutaneous electrical acupoint stimulation, Conventional care plan
- Where
- 2 sites in China
- Volunteers
- 236 people, healthy volunteers welcome
- Sponsor
- Nanjing First Hospital, Nanjing Medical University
Respiratory Failure
Non-invasive Neurally Adjusted Ventilatory Assist
Neurally adjusted ventilatory assist (NAVA) is a new concept of mechanical ventilation. NAVA delivers assistance to spontaneous breathing based on the detection of the electrical activity of the diaphragm.
- Trial name
- NCT01280383
- Testing
- non-invasive neurally adjusted ventilatory assist
- Sponsor
- Insel Gruppe AG, University Hospital Bern
Post Extubation Respiratory Failure
Non-Invasive Ventilation Versus High-flow Nasal Oxygen in Intensive Care Units
In intensive care units (ICUs), around 20% of patients experience respiratory failure after planned extubation. Nearly 40-50% of them eventually require reintubation with subsequently high mortality rates reaching 30-40%.
- Trial name
- VENTILO (NCT05686850)
- Testing
- High-Flow Oxygen, Non invasive ventilation
- Where
- 47 sites in Belgium, France and 3 more
- Volunteers
- 670 people
- Sponsor
- Poitiers University Hospital
Prematurity, Respiratory Failure
Non-invasive Neurally Adjusted Ventilatory Assist Versus Nasal Intermittent Positive Pressure Ventilation for Preterm Infants After Extubation
Non-invasive respiratory support has been emerging in the management of respiratory distress syndrome (RDS) in preterm infants to minimise the risk of lung injury.
- Conditions
- Prematurity, Respiratory Failure, Ventilator Lung; Newborn
- Trial name
- NCT03388437
- Testing
- NI-NAVA, NIPPV
- Where
- Saudi Arabia
- Volunteers
- 36 people
- Sponsor
- King Fahad Armed Forces Hospital
Airway Obstruction
Dexamethasone and the Prevention of Post-Extubation Airway Obstruction in Adults
Laryngotracheal injury related to intubation may cause narrowing of the airway due to edema of the glottis. Post-extubation airway frequently necessitating re-intubation and resulting in the prolongation of intensive care.
- Trial name
- NCT00452062
- Testing
- Dexamethasone
- Where
- Taiwan
- Volunteers
- 70 people
- Sponsor
- Mackay Memorial Hospital
Respiratory Failure
Non-Invasive Ventilation After Extubation in Hypercapnic Patients
The purpose of this study is to assess the efficacy of noninvasive ventilation in the prevention of extubation failure and mortality in patients with chronic respiratory disorders and hypercapnic respiratory failure during…
- Trial name
- NCT00539708
- Testing
- Non-invasive ventilation
- Where
- Spain
- Volunteers
- 106 people
- Sponsor
- Hospital Clinic of Barcelona
Type II Respiratory Failure, Hypercapnic Respiratory Failure
Post-Extubation High-Flow Nasal Cannula Versus Non-Invasive Ventilation in Type II Respiratory Failure
Acute hypercapnic respiratory failure is characterized by elevated arterial carbon dioxide levels and commonly occurs in patients with chronic respiratory diseases.
- Trial name
- NCT06918288
- Testing
- High-Flow Nasal Cannula (HFNC), Non-Invasive Ventilation (NIV)
- Where
- Egypt
- Volunteers
- 200 people
- Sponsor
- Benha University
Airway Extubation
Analysis of the Magnetic Tape Bandage on Respiratory Functional Effects.
Invasive mechanical ventilation (IMV) is the mainstay of supportive care in acute respiratory failure. However, maintaining ventilatory support beyond what is necessary may increase the risk of nosocomial infections, favour…
- Trial name
- NCT05356299
- Testing
- Magnetictape bandage application
- Where
- Spain
- Volunteers
- 31 people
- Sponsor
- Hospital Universitario Doctor Peset
Hypoxemia
'Optiflow + Duet' Interface' vs 'Standard' High Flow Nasal Cannula
High-flow nasal cannula (HFNC) therapy is increasingly used in the management of acute respiratory failure. Its clinical application has been largely investigated in chronic obstructive pulmonary disease (COPD) patients but only…
- Trial name
- OPTIMARF (NCT05838326)
- Testing
- Symmetrical high flow nasal cannula (HFNO), Asymmetrical high flow nasal cannula (DUET HFNO)
- Where
- Italy
- Volunteers
- 20 people
- Sponsor
- University of Padova
Respiratory Failure, Post Extubation Acute Respiratory Failure Requiring Reintubation
Effect of HFNO Therapy on Respiratory Effort After Extubation
Rationale: Despite the lack of clear clinical protocols, High Flow Nasal Oxygen (HFNO) is used as post-extubation respiratory support.
- Trial name
- T-REX (NCT05652699)
- Testing
- High Flow Nasal Oxygen, Conventional Oxygen Therapy
- Where
- 2 sites in Netherlands
- Volunteers
- 42 people
- Sponsor
- Henrik Endeman
Mechanical Ventilation Complication, Weaning Failure
NIV Versus HFO Versus Standard Therapy Immediately After Weaning From Mechanical Ventilation in ARDS Patients
The weaning failure is a paramount challenge when aggressive discontinuation of respiratory support in ARDS. The aim of the study is to improve weaning safety and efficacy by a transient postextubation non-invasive respiratory…
- Conditions
- Mechanical Ventilation Complication, Weaning Failure, Acute Respiratory Distress Syndrome, High-flow Oxygenation
- Trial name
- NCT06332768
- Testing
- Respiratory support
- Where
- Russia
- Volunteers
- 60 people
- Sponsor
- Northern State Medical University
Respiratory Failure
Noninvasive Ventilation After Extubation in Hypercapnic Patients
The purpose of this study is to assess the efficacy of noninvasive ventilation (NIV) in the prevention of extubation failure and mortality in patients with either chronic respiratory disorders or hypercapnic respiratory failure…
- Trial name
- VHYPER (NCT01047852)
- Testing
- Noninvasive ventilation
- Where
- 6 sites in France
- Volunteers
- 144 people
- Sponsor
- University Hospital, Bordeaux
Mechanical Ventilation Complication, Acute Respiratory Failure
Protocolized Post-Extubation Respiratory Support Study
Invasive mechanical ventilation is common in the medical intensive care unit, and the period of time following extubation remains high risk as 11 to 15% of patients require reintubation after their first extubation.
- Conditions
- Mechanical Ventilation Complication, Acute Respiratory Failure, Intubation Complication
- Trial name
- PROPER (NCT03288311)
- Testing
- Protocolized post-extubation respiratory support, Usual Care
- Where
- United States
- Volunteers
- 751 people
- Sponsor
- Vanderbilt University Medical Center
Respiratory Insufficiency
Physiological Response to Heliox21 and Air O2
This is a non-commercial study to explore the use of Heliox21 in a new patient cohort. The fundamental aim is to assess the therapeutic benefits of Heliox21 and practicalities of gas delivery in patients who require non-invasive…
- Trial name
- NCT01498432
- Testing
- Heliox21, Air O2
- Where
- United Kingdom
- Volunteers
- 38 people
- Sponsor
- University College, London
Post Extubation Respiratory Failure
The Effectiveness of High-flow Nasal Cannula After Extubation in Patients
Observe the current status of prolonged mechanical ventilation (PMV) patients using high-flow nasal cannula oxygen therapy (experimental group) or traditional oxygen therapy (control group) after extubation, and compare the…
- Trial name
- NCT06746363
- Where
- Taiwan
- Volunteers
- 110 people
- Sponsor
- Chang Gung Memorial Hospital
Acute Respiratory Insufficiency, Respiratory Failure
Mechanical Insufflation-Exsufflation in Preventing Post Extubation Respiratory Failure in Patient With Critical Care Neuromyopathy
Respiratory failure after extubation is a relevant consequence of poor airway clearance due to respiratory muscle weakness and respiratory failure after extubation and reintubation is associated with increased morbidity and…
- Trial name
- NEUROMIE (NCT01931228)
- Testing
- MI-E plus manually assisted coughing, manually assisted coughing
- Where
- France
- Volunteers
- 123 people
- Sponsor
- University Hospital, Bordeaux