Clinical trials: Post-operative Cardiac Surgery
Coronary Artery Bypass Graft Surgery
Development of an Arterial Pressure Monitoring Set Fixation Apparatus
This study aims to develop an arterial pressure monitoring set fixation device and evaluate its effectiveness in clinical settings.
- Trial name
- NCT07035756
- Testing
- Arterial Pressure Monitoring Set Fixation Device
- Where
- Turkey (Türkiye)
- Volunteers
- 60 people
- Sponsor
- Yuzuncu Yil University
Atrial Fibrillation, Post-cardiac Surgery
Vernakalant Versus Amiodarone for Post-operative Atrial Fibrillation in Cardiac Surgery Patients
Post-operative atrial fibrillation is a common problem post cardiac surgery with rates exceeding 30%. Atrial fibrillation has multiple adverse effects on cardiac hemodynamics and can lead to hypotension, diminished end organ…
- Trial name
- NCT04748991
- Testing
- Vernakalant, Amiodarone
- Volunteers
- 50 people
- Sponsor
- University of Calgary
Chylothorax
Chylothorax Following Heart Surgery
The purpose of this study is to determine at risk populations for certain congenital heart defects or certain operative procedures and to define the associated morbidity secondary to chylothorax - prolonged chest tube drainage…
- Trial name
- NCT00215098
- Where
- United States
- Volunteers
- 70 people
- Sponsor
- Children's Healthcare of Atlanta
Immunosuppression
Improvement of Postoperative Immunosuppression in Patients Receiving Coronary Artery Bypass Grafting by TEAS
The coronary artery bypass grafting (CABG) is a surgery to relieve angina and reduce mortality of coronary heart disease. However, the patient is more prone to have immunosuppression after the surgery, causing secondary…
- Trial name
- NCT02933996
- Testing
- TEAS+GA group
- Where
- China
- Volunteers
- 88 people
- Sponsor
- ShuGuang Hospital
Postoperative Cognitive Complications, Open Heart Surgery
Effect of a Cooling Helmet on Postoperative Cognitive Dysfunction in Adults Undergoing Open-Heart Surgery
Postoperative cognitive dysfunction, or POCD, is a decline in thinking, memory, attention, or executive function that may occur after surgery and anesthesia.
- Trial name
- HELMET-POCD (NCT07689500)
- Testing
- Cooling Helmet With Cold Water Circulation, Cooling Helmet With Room-Temperature Water Circulation
- Where
- Indonesia
- Volunteers
- 153 people
- Sponsor
- Universitas Indonesia
Delirium, Cognitive Decline
Dexmedetomidine Use in ICU Sedation and Postoperative Recovery in Elderly Patients and Post-cardiac Surgery
Increasing numbers of elderly patients are undergoing cardiac surgery. Elderly patients may have prolonged recovery following cardiac surgery when compared to other groups of patients, and are at higher risk of postoperative…
- Conditions
- Delirium, Cognitive Decline, Post-operative Quality of Recovery
- Trial name
- DIRECT (NCT02699801)
- Testing
- propofol, Dexmedetomidine
- Where
- Canada
- Volunteers
- 70 people
- Sponsor
- University of British Columbia
Myocardial Reperfusion Injury, Cardiac Output, Low
Metabolic Support With Perhexiline to Protect Myocardium Undergoing Coronary Artery Surgery
Open-heart surgery causes injury of the heart muscle. Although this is usually mild, temporary and reversible, if it is severe it can endanger life and require additional high cost care.
- Trial name
- CASPER (NCT00845364)
- Testing
- Perhexiline
- Where
- 2 sites in United Kingdom
- Volunteers
- 290 people
- Sponsor
- University Hospital Birmingham
Delirium, Postoperative
Liraglutide in Preventing Delirium in Diabetic Elderly After Cardiac Surgery
This study aims to clarify the preventive effect of perioperative liraglutide application on postoperative delirium in elderly patients with Type 2 diabetes undergoing cardiac surgery.
- Trial name
- NCT06361238
- Testing
- Liraglutide injection
- Where
- China
- Volunteers
- 260 people
- Sponsor
- The Affiliated Nanjing Drum Tower Hospital of Nanjing University Medical School
Postoperative Delirium
Factors Affecting the Incidence of Postoperative Delirium in Frail Elderly
Postoperative delirium has been found to be associated with increased risk of future neurocognitive decline and mortality especially in elderly patients.
- Trial name
- NCT02227225
- Where
- Singapore
- Volunteers
- 50 people
- Sponsor
- Singapore General Hospital
Myocardial Injury
Effects of Remimazolam on Postoperative Myocardial Injury
This study is designed as a prospective, double-blind, randomized controlled trial to investigate the effect of remimazolam on intraoperative cardiac output (CO) in elderly patients undergoing general anesthesia, and to evaluate…
- Trial name
- NCT07725185
- Testing
- Remimazolam, Propofol
- Where
- China
- Volunteers
- 80 people
- Sponsor
- Affiliated Hospital of Jiaxing University
Acute Kidney Injury
Postoperative Acute Kidney Injury in Children Undergoing Major Non-cardiac Surgery
This project aims to conduct an international, prospective, multicentre, observational study to determine the incidence of Postoperative Acute Kidney Injury (PO-AKI) in hospitalized children after noncardiac surgery.
- Trial name
- POAKIDS (NCT07351149)
- Where
- 16 sites in Australia, Brazil and 8 more
- Volunteers
- 2,000 people
- Sponsor
- Uppsala University
Postoperative Pain, Cardiac Surgery
ASPB-PIPB Combination in Cardiac Surgery
Cardiopulmonary bypass surgery is associated with significant postoperative pain, which may adversely affect respiratory function, delay mobilization, prolong hospital stay, and increase postoperative complications.
- Conditions
- Postoperative Pain, Cardiac Surgery, Cardiopulmonary Bypass, Median Sternotomy
- Trial name
- NCT07716943
- Testing
- Combined ASPB and PIPB, Anterior Serratus Plane Block
- Where
- Turkey (Türkiye)
- Volunteers
- 60 people
- Sponsor
- Sisli Hamidiye Etfal Training and Research Hospital
Postoperative Wound Infection
Effects of Triclosan-coated Sutures in Cardiac Surgery
The purpose of this study is to assess if triclosan-coated sutures reduces wound infections after saphenous vein harvesting in CABG patients.
- Trial name
- NCT01212315
- Testing
- Triclosan coated sutures
- Where
- Sweden
- Volunteers
- 392 people
- Sponsor
- Sahlgrenska University Hospital
Myocardial Reperfusion Injury, Hypoxia
Effects of Hypoxic-hyperoxic Preconditioning in Cardio-surgical Patients
Coronary artery bypass grafting (CABG) with cardiopulmonary bypass is a common surgical therapy for patients suffering from coronary artery diseases.
- Conditions
- Myocardial Reperfusion Injury, Hypoxia, Hyperoxia, Coronary Artery Disease
- Trial name
- NCT05354648
- Testing
- Hypoxic-hyperoxic preconditioning
- Volunteers
- 120 people
- Sponsor
- Alexander Averyanov
Atrial Fibrillation (AF), Cardiac Events
Prevention of Atrial Fibrillation After Cardiac Surgery by Pericardiotomy
PRINCE-CH is a multicentre, randomized controlled trial which evaluates the effectiveness and safety of posterior pericardiotomy in preventing POAF after cardiac surgery in Chinese population.
- Conditions
- Atrial Fibrillation (AF), Cardiac Events, Pericardial Effusion
- Trial name
- PRINCE-CH (NCT06728826)
- Testing
- Posterior pericardiotomy
- Where
- China
- Volunteers
- 650 people
- Sponsor
- Changhai Hospital
Postoperative Delirium (POD), Diabetes
Impact of Sevoflurane Versus Propofol on Postoperative Delirium in Elderly Diabetic Patients Undergoing Non-Cardiac Surgery: a Multicenter, Randomized Controlled Trial
The present study is a multicenter， randomized controlled clinical trial, which plans to enroll 450 diabetic patients aged more than 60 years.
- Trial name
- NCT06788743
- Testing
- TIVA ( anesthesia with propofol and remifentanil), VA（anesthesia with sevoflurane and remifentanil）
- Where
- China
- Volunteers
- 450 people
- Sponsor
- Xijing Hospital
Bleeding, Surgical Blood Loss
Decreasing Postoperative Blood Loss by Topical vs. Intravenous Tranexamic Acid in Open Cardiac Surgery
The aim is to conduct a double-blinded single-centre randomized controlled clinical trial of application of topical dose of tranexamic acid (TA) versus the usual intravenous TA in patients undergoing cardiac surgery at the…
- Trial name
- DEPOSITION (NCT03376061)
- Testing
- Tranexamic Acid
- Where
- Canada
- Volunteers
- 97 people
- Sponsor
- Population Health Research Institute
Ventilator-Induced Diaphragm Dysfunction
Study of TransAeris® System for Enhanced Recovery After Surgery in France
This study will be conducted as a randomized trial of the TransAeris system for the prevention and treatment of ventilator-induced diaphragm dysfunction (VIDD) in patients identified prior to surgery to be at greater risk of…
- Trial name
- ERAS (NCT05404477)
- Testing
- TransAeris System
- Where
- France
- Volunteers
- 30 people, healthy volunteers welcome
- Sponsor
- Synapse Biomedical
Death, Stroke
Postoperative Atrial Fibrillation and Long-term Survival
The aim of the investigators trial was to evaluate association between new onset postoperative atrial fibrillation (POAF) and late cardiovascular morbidity and mortality.
- Conditions
- Death, Stroke, Myocardial Infarction
- Trial name
- POAF (NCT02349269)
- Volunteers
- 519 people, healthy volunteers welcome
- Sponsor
- Kuopio University Hospital
Respiratory Failure
Comparison of Non-invasive Methods of Lung Ventilation in Patients With Respiratory Failure After Cardiac Surgery
Comparison of the effectiveness of three methods of non-invasive ventilation in patients with mild and moderate respiratory failure in the early postoperative period after cardiac surgery
- Trial name
- NCT04787666
- Testing
- Using of non-invasive mask ventilation, high-flow oxygen therapy through a nasal cannula (high-flow nasal oxygenation) and non-invasive ventilation with a helmet
- Where
- Russia
- Volunteers
- 90 people, healthy volunteers welcome
- Sponsor
- Petrovsky National Research Centre of Surgery
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