Clinical trials: Post-operative Cardiac Surgery
Delirium, Postoperative
Effectiveness of Delirium Care Protocol After Cardiac Surgery
This study was conducted as a quasi-experimental study to determine the effectiveness of the postoperative delirium prevention, diagnosis and intervention protocol in patients monitored in the intensive care unit after cardiac…
- Trial name
- NCT06268119
- Testing
- training nurses and caring for patients to prevent, diagnose, and intervene in postoperative delirium.
- Where
- Turkey (Türkiye)
- Volunteers
- 64 people, healthy volunteers welcome
- Sponsor
- Gonul Kara Soylemez
Acute Kidney Injury (AKI)
The Impact of Blood Pressure Variability During the Induction and Surgical Periods on Postoperative Acute Kidney Injury
The goal of this multicenter retrospective cohort study aimed to explore the effect of BPV during anesthesia induction and surgery on the occurrence of postoperative AKI in non-cardiac surgery patients.
- Trial name
- NCT07602465
- Where
- China
- Volunteers
- 5,000 people
- Sponsor
- Zhongda Hospital
Post-Operative Complications in Cardiac Surgery
Effect of RBT-1 on Reducing the Risk of Post-Operative Complications in Subjects Undergoing Cardiac Surgery
The purpose of this study is to evaluate the effect of RBT-1 on reducing the risk of post-operative complications in subjects undergoing cardiac surgery on cardiopulmonary bypass (CPB).
- Trial name
- NCT06021457
- Testing
- RBT-1
- Where
- 41 sites in United States, Canada
- Volunteers
- 454 people
- Sponsor
- Renibus Therapeutics, Inc.
Atrial Fibrillation
Atorvastatin Using as a Possible Prophylaxis of Postoperative Atrial Fibrillation After Cardiac Surgery
The purpose of this study is to evaluate the effectiveness of atorvastatin therapy (both during preoperative and postoperative period), as prophylaxis against postoperative atrial fibrillation after cardiac surgery, in a valve…
- Trial name
- PROFACE (NCT01570530)
- Testing
- Cardiac surgery
- Where
- Spain
- Volunteers
- 90 people
- Sponsor
- Fundación General Universidad de Valladolid
Congenital Heart Disease in Children
How to Report Postoperative Outcomes After a Paediatric Cardiac Surgery ?
Congenital heart disease is a common abnormality in newborns. The marked improvement in the surgical management of congenital heart disease has led to a reduction in postoperative mortality, historically a quality criterion for…
- Trial name
- Pedia-Card (NCT05546983)
- Where
- France
- Volunteers
- 189 people
- Sponsor
- University Hospital, Strasbourg, France
Opioid Use, Side Effect of Drug
Pharmacokinetics of Morphine and Oxycodone in Frail Elderly Undergoing Cardiac Surgery
Single centre observational cohort study. 20 older patients undergoing cardiac surgery who receive standard of care pain treatment.
- Conditions
- Opioid Use, Side Effect of Drug, Postoperative Pain
- Trial name
- NCT04696445
- Testing
- Morphine & Oxycodone
- Where
- Netherlands
- Volunteers
- 34 people
- Sponsor
- St. Antonius Hospital
Surgical Incision, Surgical Site Infection
Comparison of the Classical Median Sternotomy Skin Incision with the Paramedian Flap Skin Incision
The goal of this observational study is to determine the effects of a flap-shaped paramedian skin incision on protection from mediastinal infections, wound healing, and scar formation in open heart surgery performed through the…
- Conditions
- Surgical Incision, Surgical Site Infection, Keloid Scar Following Surgery
- Trial name
- NCT06725472
- Testing
- Open Heart Surgery
- Where
- Turkey (Türkiye)
- Volunteers
- 90 people
- Sponsor
- Ataturk University
Delirium, Postoperative, Delirium in Old Age
The SCOPE Trial: Sleep, Cognition, and Pain Bundle vs. ERAS-cardiac for Postoperative Delirium
Sleep disturbances, cognitive reserve, and continuing pain and inflammation are other risk factors contributing to delirium (confusion and agitation) and neurocognitive decline (in the long term) following heart surgery.
- Trial name
- SCOPE (NCT06721819)
- Testing
- Sleep Hygiene, Brain Game, and IV Acetaminophen Intervention, Control
- Where
- 3 sites in United States
- Volunteers
- 406 people
- Sponsor
- Beth Israel Deaconess Medical Center
Hemorrhage, Surgical, Blood Loss, Surgical
Safe and Timely Antithrombotic Removal - Ticagrelor (STAR-T)
Prospective, multi-center, double-blind, randomized pivotal trial to evaluate the safety and effectiveness of the DrugSorb-Antithrombotic Removal (ATR) system for intraoperative removal of ticagrelor in patients undergoing urgent…
- Conditions
- Hemorrhage, Surgical, Blood Loss, Surgical, Blood Loss, Postoperative, Hemorrhage Postoperative
- Trial name
- STAR-T (NCT04976530)
- Testing
- DrugSorb-ATR system
- Where
- 29 sites in United States, Canada
- Volunteers
- 140 people
- Sponsor
- CytoSorbents, Inc
Systemic Inflammatory Response Syndrome
Perioperative Sitagliptin Medication for Reduction of the Inflammatory Response Associated With Cardiopulmonary Bypass
Sitagliptin is an inhibitor of the enzyme dipeptidylpeptidase-4 (DPP-4) and represents an established drug in type 2 diabetes mellitus treatment. However, Sitagliptin may also have several antiinflammatory properties.
- Trial name
- SiCa-Flam (NCT05725798)
- Testing
- Sitagliptin
- Where
- Germany
- Volunteers
- 20 people
- Sponsor
- University Hospital Muenster
Breast Cancer, Gynecologic Cancer
Management of Perioperative Anxiety by the Cardiac Coherence Technique Coupled With a Hypnosis Session
the investigator proposes to use the cardiac coherence technique coupled with a hypnosis session to improve post-operative recovery.
- Trial name
- COHEC (NCT03981731)
- Testing
- Cardiac coherence
- Where
- France
- Volunteers
- 53 people
- Sponsor
- Institut du Cancer de Montpellier - Val d'Aurelle
Heart; Dysfunction Postoperative, Cardiac Surgery, Right Heart Failure
Femoral Venous Pulsatility and Right Heart Dysfunction in Heart Surgery: An Observational Study
Right heart failure during cardiac surgery is associated with increased perioperative morbidity and mortality. In this context, it is imperative to develop simple diagnostic tools to detect right heart failure.
- Conditions
- Heart; Dysfunction Postoperative, Cardiac Surgery, Right Heart Failure, Right Ventricular Dysfunction
- Trial name
- FemousTechno6 (NCT05038267)
- Where
- Canada
- Volunteers
- 150 people
- Sponsor
- Montreal Heart Institute
Delirium, Postoperative, Cardiac Disease
Optic Nerve Sheath Diameter is Associated With Postoperative Delirium in Patients Undergoing Open Heart Surgery
Although the incidence of delirium after cardiac surgery is high, it is not sufficiently recognized. The long-term effects of delirium are likely to be underestimated.
- Conditions
- Delirium, Postoperative, Cardiac Disease, Cardiac Valve Disease
- Trial name
- NCT05942183
- Testing
- ONSD
- Where
- Turkey (Türkiye)
- Volunteers
- 90 people
- Sponsor
- Samsun University
New Onset Atrial Fibrillation, Complications; Cardiac, Postoperative
Nifekalant Versus Amiodarone in New-Onset Atrial Fibrillation After Cardiac Surgery
Postoperative atrial fibrillation is a major complication of cardiac surgery, which could lead to high morbidity and mortality, increase duration of hospital stay and increase the cost of treatment.
- Trial name
- NCT05169866
- Testing
- Nifekalant, Amiodarone
- Where
- China
- Volunteers
- 274 people
- Sponsor
- Beijing Anzhen Hospital
Acute Kidney Injury
Effect of Cholesterol Level on Postoperative Acute Kidney Injury of Non-cardiac Surgeries
Preoperative serum cholesterol level may influence occurrence of postoperative acute kidney injury of cardiac surgeries. However, the effect of Preoperative serum cholesterol level for non cardiac surgery remains unknown.
- Trial name
- NCT03954353
- Where
- China
- Volunteers
- 78,888 people
- Sponsor
- Peking University First Hospital
Cardiac Surgery
Interest of the Not Invasive Ventilation Used in Meadow and Post-operative of Cardiac Surgery
After cardiac surgery, many complications can arise, in particular at the cardiac and lung level and it is true especially as the patient is with comorbidity.
- Trial name
- CAPVNI (NCT02302300)
- Testing
- Manufacturer STELLAR 150
- Where
- France
- Volunteers
- 216 people
- Sponsor
- University Hospital, Brest
Severe Mitral Regurgitation, Preserved Ventricular Ejection Fraction
Use of Pre-operative Global Longitudinal Strain to Predict Post-operative Left Ventricular Dysfunction in Mitral Regurgitation Surgery
Primary mitral regurgitation (MR) is the second most frequent valve disease requiring surgery and it is important to identify patients whose outcome could be improved with surgery by considering the risks and benefits.
- Trial name
- DysPO IM (NCT03968601)
- Testing
- Mitral regurgitation surgery such as mitral valve replacement or repair
- Where
- France
- Volunteers
- 79 people
- Sponsor
- University Hospital, Clermont-Ferrand
ERAS, Cardiac Surgery
Impact of a Technology Platform Based on Enhanced Recovery After(ERAS) Surgery on Length of Stay After Coronary Artery Bypass Grafting: Timely Project
Cardiovascular diseases continue to be the leading cause of death worldwide. Among them, coronary artery disease has the greatest impact, being characterized as one of the main causes of death in Brazil over the last decade.
- Conditions
- ERAS, Cardiac Surgery, Cardiac Surgery-CABG, Digital Health
- Trial name
- REPLICCARIII (NCT06786819)
- Testing
- ERACS with Digital Platform
- Where
- 2 sites in Brazil
- Volunteers
- 480 people
- Sponsor
- University of Sao Paulo General Hospital
Pain, Postoperative, Anxiety
The Effect of Acupressure on Procedural Pain, Anxiety and Hemodynamic Variables During Chest Tube Removal
When the literature was reviewed, many studies were found in which various non-pharmacologic interventions such as reflexology, music therapy, slow and deep breathing exercises, relaxation exercises and cold application were…
- Conditions
- Pain, Postoperative, Anxiety, Hemodynamic Instability
- Trial name
- NCT05875337
- Testing
- Acupressure
- Where
- Turkey (Türkiye)
- Volunteers
- 68 people, healthy volunteers welcome
- Sponsor
- Mersin University
Ischemic Heart Disease, Bone Marrow Cells
Autologous Bone Marrow Mononuclear Cells in the Combined Treatment of Coronary Heart Disease
The purpose of this study evaluate the effect of the method of administration of autologous bone marrow mononuclear cells for the duration of of functioning aorto-coronary bypass grafts in the surgical treatment of coronary heart…
- Conditions
- Ischemic Heart Disease, Bone Marrow Cells, Coronary Artery Bypass Grafting (CABG), Heart Failure, Diastolic
- Trial name
- TAMIS (NCT02059512)
- Testing
- Group 1, Group 0, Group 2
- Where
- Russia
- Volunteers
- 117 people
- Sponsor
- St. Petersburg State Pavlov Medical University
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