Clinical trials: Post-operative Delirium
Delirium - Postoperative
The Effect of Remimazolam Tosylate on the Incidence of Postoperative Delirium in Older Patients Undergoing Cardiac Surgery: A Prospective Randomized Controlled Trial
This study aims to compare the efficacy and safety of remimazolam tosylate and propofol for postoperative sedation in patients aged 65 years or older undergoing cardiac surgery with cardiopulmonary bypass.
- Trial name
- NCT07908121
- Testing
- Remimazolam Tosylate, Propofol
- Where
- China
- Volunteers
- 600 people, healthy volunteers welcome
- Sponsor
- Nanjing First Hospital, Nanjing Medical University
Delayed Emergence From Anesthesia, Postoperative Delirium
Trajectory of Recovery in the Elderly
The purpose of this study is to understand how elderly individuals regain their cognitive skills following general anesthesia. The investigators will compare an age stratified group of volunteers who will be evaluated with a…
- Conditions
- Delayed Emergence From Anesthesia, Postoperative Delirium, Postoperative Cognitive Dysfunction
- Trial name
- TORIE (NCT02275026)
- Testing
- Functional magnetic resonance imaging
- Where
- United States
- Volunteers
- 104 people, healthy volunteers welcome
- Sponsor
- Icahn School of Medicine at Mount Sinai
Preoperative Anxiety, Emergence Delirium in Pediatric Anesthesia
Ride-On Toy Car Use During Operating Room Transfer in Preschool Children
The goal of this clinical trial is to determine whether the method of transfer to the operating room can reduce preoperative anxiety and postoperative emergence delirium in male children aged 3 to 7 years undergoing elective…
- Trial name
- NCT07403747
- Testing
- Toy car, Standard Transfer
- Where
- Turkey (Türkiye)
- Volunteers
- 96 people, healthy volunteers welcome
- Sponsor
- Ankara City Hospital Bilkent
Osteoarthritis, Femoral Head Necrosis
Donepezil Attenuate Postoperative Cognitive Dysfunction
Postoperative cognitive dysfunction (POCD) occurs mainly in aged patients. POCD may increase the mortality and morbidity. However, the mechanism of POCD is not clear yet and no effective therapy method was proved.
- Conditions
- Osteoarthritis, Femoral Head Necrosis, Rheumatoid Arthritis
- Trial name
- DAPOCD (NCT02927522)
- Testing
- Donepezil
- Where
- China
- Volunteers
- 550 people, healthy volunteers welcome
- Sponsor
- RenJi Hospital
Delirium
Perioperative Cognitive Protection - Cognitive Exercise and Cognitive Reserve (The Neurobics Trial)
Many individuals experience an acute change in thinking and reasoning skills after surgery. This is called post-operative delirium (PD). PD symptoms typically start 1-3 days after surgery.
- Trial name
- NCT02230605
- Testing
- Mini-Mental State Examination, Self-Administered Gerocognitive Examination, Geriatric Depression Scale
- Where
- United States
- Volunteers
- 322 people, healthy volunteers welcome
- Sponsor
- Ohio State University
Failed Moderate Sedation During Procedure
Effects of Dexmedetomidine on the Postoperative Experience in Children
Background: The study aim was to compare the efficacy of dexmedetomidine versus midazolam for sedation during the early postoperative period in children who underwent scoliosis surgery.
- Trial name
- NCT01748630
- Testing
- dexmedetomidine, Midazolam, fentanyl
- Where
- Turkey (Türkiye)
- Volunteers
- 42 people, healthy volunteers welcome
- Sponsor
- Inonu University
Postoperative Complications, Delirium
Donepezil in Preventing Delirium in Hospitalized Elderly
The purpose of this study is to explore the efficacy of a perioperative daily dose of Donepezil (a cholinergic enhancer) in reducing the incidence and severity of delirium.
- Trial name
- NCT00182884
- Testing
- Donepezil
- Where
- United States
- Volunteers
- 30 people, healthy volunteers welcome
- Sponsor
- Indiana University Health
Postoperative Delirium, Postoperative Pain, Acute
Postoperative Delirium and Analgesia in Elderly Patients
This study aims to evaluate the effects of different postoperative analgesic approaches on postoperative delirium in elderly patients undergoing total knee arthroplasty.
- Trial name
- NCT07849517
- Testing
- adductor canal block and biFes block including bupivacain, Periarticular infiltration
- Where
- Turkey (Türkiye)
- Volunteers
- 300 people, healthy volunteers welcome
- Sponsor
- Ankara City Hospital Bilkent
Postoperative Delirium
Effects of Nutritional Support on Postoperative Delirium
This study is a prospective, single-center, randomized controlled trial to compare whether applying nutritional supplementation therapy before and after surgery in elderly patients aged 65 years or older undergoing non-cardiac…
- Trial name
- NCT06467552
- Testing
- control group, Nucare Curact group
- Where
- South Korea
- Volunteers
- 314 people, healthy volunteers welcome
- Sponsor
- Yonsei University
Emergence Agitation
Effect of Extubation Under Deep Anesthesia on Emergence Agitation of Nasal Surgery
This study analyzed the relationship between extubation timing and Emergence agitation in 18-60 years old adults undergoing nasal surgery, such as nasal septum correction, endoscopic sinus surgery, and nasal bone fracture…
- Trial name
- NCT04844333
- Testing
- Extubation under deep anesthesia
- Where
- 3 sites in China
- Volunteers
- 202 people, healthy volunteers welcome
- Sponsor
- Shanghai Ninth People's Hospital Affiliated to Shanghai Jiao Tong University
Dementia, Mild Cognitive Impairment
Evaluation of the Effect of Cataract Surgery on Cognitive Function in Very Elderly Patients
The study intends to measure the evolution over time of the cognitive capacity of patients undergoing cataract surgery in relation to the opaque lens removal surgery (cataract) in a population considered to be at risk of…
- Conditions
- Dementia, Mild Cognitive Impairment, Cataract Senile, Cataract
- Trial name
- NCT04047485
- Testing
- Visual Acuity, CAM (Confusion Assesment Method), CATQUEST 9-SF
- Where
- Italy
- Volunteers
- 100 people, healthy volunteers welcome
- Sponsor
- University of Modena and Reggio Emilia
Frailty, Cognitive Impairment
Orthopedic Procedures and Postoperative Delirium in Older Adults in the Czech Republic
This multicenter, prospective, non-interventional observational study (ORTOPODCZ) investigates the association between preoperative cognitive impairment and postoperative delirium (POD) in older adults undergoing elective total…
- Conditions
- Frailty, Cognitive Impairment, Older Adults, Hip Arthroplasty
- Trial name
- ORTOPODCZ (NCT07432009)
- Where
- 7 sites in Czechia
- Volunteers
- 400 people, healthy volunteers welcome
- Sponsor
- Tomas Bata Hospital, Czech Republic
Emergence Agitation
Efficacy of Remifentanil in Preventing Emergence Agitation
The primary aim of the study was to test the hypothesis that remifentanil administered for analgesia prevents emergence agitation more effectively than fentanyl and N2O in patients undergoing rhinoplasty who received desflurane…
- Trial name
- agitation (NCT06539013)
- Testing
- Remifentanil, N2O, Fentanyl
- Where
- Turkey (Türkiye)
- Volunteers
- 99 people, healthy volunteers welcome
- Sponsor
- Saglik Bilimleri Universitesi Gazi Yasargil Training and Research Hospital
Procedural Sedation, Emergence Delirium
Positive Imagery Therapy and the Incidence of Emergence Reactions With the Use of Ketamine
The purpose of this study is to determine if positive imagery therapy while using ketamine in procedural sedation reduces the number of emergence reactions and impacts pre and post-procedural anxiety.
- Trial name
- NCT04746079
- Testing
- Positive Imagery Therapy
- Where
- United States
- Volunteers
- 180 people, healthy volunteers welcome
- Sponsor
- Mercy Health Ohio
Postoperative Cognitive Dysfunction, Cerebrovascular Accident
Neurological Outcome After Minimal Invasive Coronary Artery Bypass Graft
Primary objectives: Assessment of the incidence of postoperative cognitive dysfunction (POCD), cerebrovascular accident (CVA), and delirium after minimal invasive coronary artery bypass grafting (Endo-CABG).
- Conditions
- Postoperative Cognitive Dysfunction, Cerebrovascular Accident, Delirium
- Trial name
- NOMICS (NCT02979782)
- Testing
- Endo-CABG, PCI
- Where
- 2 sites in Belgium
- Volunteers
- 180 people, healthy volunteers welcome
- Sponsor
- Jessa Hospital