Clinical trials: Post-operative Fistula
Post-COVID-19 Condition, Ulcerative Colitis
Emerging Indications for Hyperbaric Oxygen Treatment
This study will evaluate the effectiveness of hyperbaric oxygen therapy (HBOT) on treating emerging indications (i.e., conditions that have shown to potentially benefit from HBOT) using the Multicenter Registry for Hyperbaric…
- Conditions
- Post-COVID-19 Condition, Ulcerative Colitis, Crohn Disease, Calciphylaxis
- Trial name
- NCT07240649
- Testing
- Hyperbaric oxygen treatment (HBOT), 100% Oxygen
- Volunteers
- 100 people
- Sponsor
- Jay C. Buckey Jr.
Pancreatic Fistula, Pancreatic Neoplasms
Treatment of the Pancreatic Stump With Neoprene®-Based Glue After High-risk Pancreatoduodenectomy
The study evaluates the safety and efficacy of Neoprene-based glue in the management of pancreatic stump after pancreatoduodenectomy (PD) in patients at high risk for pancreatic fistula and early neoplastic recurrence, compared…
- Conditions
- Pancreatic Fistula, Pancreatic Neoplasms, Postoperative Complications
- Trial name
- NCT03738787
- Testing
- Pancreatic duct occlusion with Neoprene, Pancreato-Jejunal anastomosis
- Where
- Italy
- Volunteers
- 40 people
- Sponsor
- Fondazione IRCCS Istituto Nazionale dei Tumori, Milano
Pancreatic Fistula
Study of Pancreatic Enzymes in the Drains as Early Biomarkers of Post-operative Pancreatic Fistula and Its Clinical Repercussions
Surgery is the principal treatment for benign and malignant pancreatic tumours. This surgery can be accompanied by complications among which the main one is pancreatic fistula, which leads to the flow of pancreatic juices into…
- Trial name
- LIPA-DRAIN (NCT02784990)
- Testing
- Lipase, amylase and CRP (C-reactive protein) dosages
- Where
- 10 sites in France
- Volunteers
- 770 people
- Sponsor
- Centre Hospitalier Universitaire Dijon
Rare Disorders, Undiagnosed Disorders
Rare Disease Patient Registry & Natural History Study - Coordination of Rare Diseases at Sanford
The Coordination of Rare Diseases at Sanford (CoRDS) is an international patient registry that serves as a centralized resource for rare disease research.
- Conditions
- Rare Disorders, Undiagnosed Disorders, Disorders of Unknown Prevalence, Cornelia De Lange Syndrome
- Trial name
- CoRDS (NCT01793168)
- Where
- United States
- Volunteers
- 20,000 people
- Sponsor
- Sanford Health
Postoperative Complications
Perioperative Fluid Therapy in Patients Undergoing Pancreaticoduodenectomy
Postoperative complication rates in patients undergoing pancreaticoduodenectomy remain high although the operation techniques have developed a lot in recent years.
- Trial name
- NCT04687826
- Testing
- Goal directed fluid therapy, Liberal fluid therapy
- Volunteers
- 168 people
- Sponsor
- Helsinki University Central Hospital
Postoperative Pancreatic Fistula, Delayed Gastric Emptying
Pancreaticoduodenectomy With or Without Braun Enteroenterostomy: Comparison of Postoperative Pancreatic Fistula and Delayed Gastric Emptying
The investigators plan to perform a prospective randomized, head-to-head trial to test the hypothesis that the addition of Braun enteroenterostomy to standard pancreaticoduodenectomy (PD) reconstruction can decrease the rates of…
- Trial name
- NCT01481753
- Testing
- pancreaticoduodenectomy without Braun enteroenterostomy, Braun enteroenterostomy
- Where
- United States
- Volunteers
- 341 people
- Sponsor
- Johns Hopkins University
Hepatectomy
Postoperative Biliary Fistula Prevention After Hepatectomy
Aim : Effect of external biliary duct stent after hepatectomy on the occurence of postoperative biliary fistula. Methods : French prospective multicenter randomized trial.
- Trial name
- VPI (NCT01469442)
- Testing
- External Biliary duct stent in the bile duct by cystic way
- Where
- 12 sites in France
- Volunteers
- 304 people
- Sponsor
- University Hospital, Toulouse
Pancreatic Cancer
A Study in Postoperative Pancreatic Fistula
The International Study Group of Pancreatic Surgery (ISGPS) issued the definition and classification system of postoperative pancreatic fistula (POPF), and received widespread recognition.
- Trial name
- NCT03129607
- Where
- China
- Volunteers
- 300 people
- Sponsor
- Second Affiliated Hospital, Zhejiang University, School of Medicine
Hemorrhoids, Fissure in Ano
Multi-Drug Analgesia vs. Standard Solution for Anal Surgery
The primary aim is to test the magnitude and duration of analgesia provided by single dose multi-drug analgesia administered for perianal block, and compare with standard solution (Marcaine \& Lidocaine in 1:1 mixture - Total 60…
- Conditions
- Hemorrhoids, Fissure in Ano, Fistula;Rectal
- Trial name
- NCT03105674
- Testing
- Multi-drug local anesthetics (Combination), Standard local anesthetics (Combination)
- Volunteers
- healthy volunteers welcome
- Sponsor
- Columbia University
Anal Fissure, Anal Fistula
Ultrasound Guided Caudal Block for Benign Anal Surgery
Interventional study that evaluate analgesia and side effects of Ultrasound guided Caudal block preoperatively in benign canal anal surgery
- Conditions
- Anal Fissure, Anal Fistula, Hemorrhoids, Pain, Postoperative
- Trial name
- NCT03345511
- Testing
- Ultrasound Guided Caudal Block
- Where
- Colombia
- Volunteers
- 23 people
- Sponsor
- Universidad de Antioquia
Cleft Palate, Plasma Rich in Growth Factors
Role of Plasma Rich Growth Factor in Repair Primary Cleft Palate
Does the plasma-rich growth factor (PRGF) with primary cleft palate repair accelerate wound healing and prevent post-operative oronasal fistula occurrence?
- Trial name
- PRGF (NCT06889181)
- Testing
- Plasma Rich in Growth Factors (PRGF)
- Where
- Egypt
- Volunteers
- 36 people, healthy volunteers welcome
- Sponsor
- Cairo University
Pancreaticoduodenectomy, Distal Pancreatectomy
Randomized Controlled Trial Comparing Closed-suction Drain Versus Passive Gravity Drain Following Pancreatic Resection
Pancreatic resection is the only potentially curative modality of treatment for pancreatic neoplasm. The mortality associated with this procedure decreased rapidly in the past decades.
- Trial name
- DRAPA (NCT01988519)
- Testing
- Closed gravity drain, closed suction drain
- Where
- 2 sites in Czechia
- Volunteers
- 223 people
- Sponsor
- University Hospital Hradec Kralove
Postoperative Bile Leak, Focal Liver Lesions
Prevention of Bile Leakage After Liver Resection in Children
Bile leakage is a clinically important complication after liver resection in children and may require prolonged drainage, additional radiological or endoscopic procedures, or repeat surgery.
- Trial name
- NCT07867522
- Testing
- prophylactic extrahepatic biliary drainage during liver resection
- Where
- Russia
- Volunteers
- 12 people
- Sponsor
- Federal Research Institute of Pediatric Hematology, Oncology and Immunology
FISTULA IN ANO
Comparison Between Laser and Open Fistula Surgeries in the Management of Fistula - In - Ano
This prospective randomized controlled trial compared the outcomes of laser versus open surgical techniques in the management of fistula-in-ano among 100 patients at a tertiary care center.
- Trial name
- NCT07083778
- Testing
- Laser Fistula Surgery (FiLaC - Fistula-tract Laser Closure), Open Fistula Surgery (Fistulotomy, Fistulectomy, or LIFT Procedure)
- Where
- India
- Volunteers
- 100 people
- Sponsor
- GSVM Medical College
Pancreatic Fistula, Pancreas Cancer
Preoperative Inflammatory Biomarkers and Postoperative Day 1 Drain Amylase Value Predict Pancreatic Fistula After Pancreaticoduodenectomy
Particularly, pancreatic fistula is the most common and serious complication after pancreaticoduodenectomy (PD) and is reported in up to 40% of cases.
- Conditions
- Pancreatic Fistula, Pancreas Cancer, Inflammatory Response
- Trial name
- NCT04361682
- Testing
- Surgical Drain Management
- Volunteers
- 227 people
- Sponsor
- Campus Bio-Medico University
Pancreatic Tumor
Effect of Thrombin-containing Collagen-based Hemostatic Matrix
Under the hypothesis that collagen-based hemostatic agents improve the suppression of leakage of hemostatic pancreatic fluid at the surgical site during surgery, thrombin-containing collagen-based hemostatic agents are applied in…
- Trial name
- TCM (NCT04357483)
- Testing
- flowable thrombin containing collagen hemostat matrix, thrombin coated L-dopa contained collagen patch
- Where
- South Korea
- Volunteers
- 60 people, healthy volunteers welcome
- Sponsor
- Asan Medical Center
Pancreatic Fistula
Evaluation of a Novel Pancreaticojejunostomy Technique for Pancreaticoduodenectomy
Pancreaticoduodenectomy is a surgical procedure for removing cancer in the pancreas, the bile system or the duodenum that is associated with a high rate of complications.
- Trial name
- NCT01696903
- Testing
- Pancreaticojejunostomy technique
- Where
- 2 sites in Sweden
- Volunteers
- 123 people
- Sponsor
- Karolinska Institutet
Hemorrhoid, Anal Fistulas
Effect of Listening to Standardized Music Sequences on Preventing Postoperative Pain in Proctologic Surgery
The study, "Effect of Listening to Standardized Music Sequences on Preventing Postoperative Pain in Proctologic Surgery," aims to evaluate the impact of preoperative listening to standardized music sequences on postoperative pain…
- Conditions
- Hemorrhoid, Anal Fistulas, MUSICAL THERAPY, Anal Fissure and Fistula
- Trial name
- MUSICOPROCTO (NCT06798155)
- Testing
- Standardized Music Listening Therapy
- Where
- 2 sites in Reunion
- Volunteers
- 550 people
- Sponsor
- Clinique Saint-Vincent
Nasal Polyps
Mometasone Furoate Nasal Spray for Treatment of Nasal Polyposis After Surgery (Study P03218)
This study was conducted to evaluate the effectiveness of mometasone nasal spray in preventing polyp relapse/symptom worsening in patients after surgical treatment of nasal polyps.
- Trial name
- NCT00731185
- Testing
- Mometasone Furoate Nasal Spray
- Volunteers
- 162 people
- Sponsor
- Organon and Co
Wound Healing, Fistulectomy
Comparison of Wound Healing in Fistulectomy and Fistulectomy With Marsupialization
The study was done at Central Park Medical College Lahore during January to September, 2024. Low fistula-in-ano patients were randomized into 2 groups i.e. Group A (SUR 1 fistulectomy) and Group B (170 patients in each group).
- Conditions
- Wound Healing, Fistulectomy, Fistulectomy With Marsupialization, Fistula in Ano
- Trial name
- NCT07080424
- Testing
- Fistulectomy with Marsupialization, Fistulectomy
- Where
- Pakistan
- Volunteers
- 340 people
- Sponsor
- Central Park Medical College