Clinical trials: Post-operative Pain Control
Pain, Postoperative
Preemptive Analgesia With Celecoxib for Acute Dental Pain Management
The purpose of this study is to compare the effect on postoperative pain of a single agent nonsteroidal anti-inflammatory drug (NSAID) [celecoxib plus placebo] to an NSAID combination [celecoxib plus acetaminophen] administered…
- Trial name
- NCT04790812
- Testing
- Celecoxib, Acetaminophen
- Where
- United States
- Volunteers
- 65 people, healthy volunteers welcome
- Sponsor
- The University of Texas Health Science Center, Houston
Pain
Ear Acupuncture for Pain Associated With Ambulatory Arthroscopic Knee Surgery
The investigators propose to complete a randomized controlled trial to compare ear acupuncture at Cingulate gyrus, thalamus, omega 2, shen-men, and point zero on the right and left ear plus standard of care versus standard of…
- Trial name
- BFAKnee (NCT01447329)
- Testing
- Ear Acupuncture, Standard Treatment
- Where
- United States
- Volunteers
- 49 people, healthy volunteers welcome
- Sponsor
- Mike O'Callaghan Military Hospital
Post Operative Analgesia, Non-inferiority Trial
Efficacy of Transversus Abdominis Plane (TAP) Block Techniques: Surgeon vs Anesthesia - Ultrasound Guidance
The transversus abdominis plane (TAP) block is a regional anesthesia technique where local anesthetic is injected into the neurovascular plane between the transversus abdominis and internal oblique muscles.
- Trial name
- NCT03577912
- Testing
- TAP block administered by Surgery, TAP block administered by Anesthesia
- Where
- United States
- Volunteers
- 60 people, healthy volunteers welcome
- Sponsor
- Beth Israel Deaconess Medical Center
Knee Osteoarthritis, Knee Pain Chronic
iPACK Block for Total Knee Arthroplasty
This randomized, double-blinded, placebo-controlled trial seeks to evaluate the efficacy of the rehabilitation process of the Interspace between the Popliteal Artery and Capsule of the Posterior Knee (iPACK) block in total knee…
- Conditions
- Knee Osteoarthritis, Knee Pain Chronic, Knee Disease
- Trial name
- NCT06087562
- Testing
- Ropivacaine 0.5% Injectable Solution 20mL, 0,9% normal saline 20mL
- Where
- Poland
- Volunteers
- 350 people, healthy volunteers welcome
- Sponsor
- Poznan University of Medical Sciences
Pain, Postoperative
Reducing Opioid Use and Misuse After Wisdom Molar Extractions
Reducing opioid prescription related use and misuse is a major focus for countering the national epidemic of opioid overdose and death.
- Trial name
- NCT04414917
- Testing
- Twin block, iPill dispenser
- Where
- United States
- Volunteers
- 133 people, healthy volunteers welcome
- Sponsor
- Rutgers, The State University of New Jersey
Acute Pain, Arthropathy of Knee
NSS-2-BRIDGE Study for Total Knee and Hip Arthroplasties, Bariatric, and Kidney Transplant Surgeries
The current opioid epidemic has led to a renewed interest in exploring non-pharmacological techniques to treat post-operative pain.
- Conditions
- Acute Pain, Arthropathy of Knee, Arthropathy of Hip, Pain, Postoperative
- Trial name
- NCT03834142
- Testing
- NSS-2 Bridge
- Where
- 3 sites in United States
- Volunteers
- 20 people, healthy volunteers welcome
- Sponsor
- Jacques E. Chelly
Postoperative Pain
RCT to Test Regional Anesthesia Effect on Decreased Opiate Use
Examining use of strong pain medication with the use of perioperative anesthetic medications vs no use of the same perioperative medication
- Trial name
- NCT06989866
- Testing
- Bupivacaine
- Where
- United States
- Volunteers
- 50 people, healthy volunteers welcome
- Sponsor
- United States Naval Medical Center, Portsmouth
Post-operative, Analgesia
Erectae Spinae Block Versus Intrathecal Morphine for Postoperative Analgesis in Lumbar Surgeries
The study design will be double blinded retrospective controlled comparative study. The patients will be included in the study shoud be in the following category: American Society of Anesthesiologists (ASA) physical status I, II…
- Trial name
- NCT05123092
- Testing
- Ultrasound guided lumbar erectae spinae block, Intrathecal Morphine injection
- Where
- Egypt
- Volunteers
- 82 people, healthy volunteers welcome
- Sponsor
- Fayoum University Hospital
Post Operative Pain
Effect of Ascorbic Acid Final Flush on Post-operative Pain in Mandibular Molars.
The study is conducted to evaluate the effect of Ascorbic acid as a final flush on post operative pain after single visit root canal treatment in cases with symptomatic irreversible pulpits.
- Trial name
- NCT05478044
- Testing
- Ascorbic acid, saline
- Volunteers
- 30 people, healthy volunteers welcome
- Sponsor
- Cairo University
Cholecystectomy, Laparoscopic, Noise
The Effect of Noise Control During Anesthesia Induction in Laparoscopic Cholecystectomy Surgery
This study aims to determine the effects of active and passive noise control method and headphone usage and noise level during anesthesia induction in laparoscopic cholecystectomy surgery on hemodynamic parameters, pain, nausea…
- Conditions
- Cholecystectomy, Laparoscopic, Noise, Anesthesia Induction
- Trial name
- Anesth-noise (NCT06666686)
- Testing
- Active noise control headphone, Passive noise control headphone
- Where
- 2 sites in Turkey (Türkiye)
- Volunteers
- 105 people, healthy volunteers welcome
- Sponsor
- Namik Kemal University
Symptomatic Irreversible Pulpitis (SIP), Dental Pain
Local Dexamethasone Administration in Symptomatic Irreversible Pulpitis
Symptomatic irreversible pulpitis is associated with a high incidence of inadequate pulpal anesthesia during endodontic treatment, particularly in mandibular molar teeth.
- Trial name
- SIPDEX (NCT07672873)
- Testing
- Saline (0.9%, sterile, for infusion), Dexamethasone
- Where
- Turkey (Türkiye)
- Volunteers
- 84 people, healthy volunteers welcome
- Sponsor
- Marmara University
Post-operative Analgesia
Bilateral Ultrasound Guided ESP Block Versus TAP Block on Post-operative Analgesia After Total Abdominal Hysterectomy
Abdominal hysterectomy is an open surgical procedure associated with considerable post-operative pain. Narcotics are often required during patient recovery but can result in adverse side effects.
- Trial name
- NCT03965156
- Testing
- 1) Ultrasound guided Erector spinae block, Ultrasound guided transversus abdominis plane block
- Where
- Egypt
- Volunteers
- 48 people, healthy volunteers welcome
- Sponsor
- Zagazig University
Cesarean Section
Sharp Versus Blunt Fascial Incision at Caesarean Section
The purpose of this study is to compare sharp and blunt fascial entry during caesarean section on the same patient. The study is performed on woman having cesarean section for the first time and who have not previously had lower…
- Trial name
- NCT01297725
- Testing
- Blunt right, sharp left, Blunt left, sharp right
- Where
- 2 sites in Denmark
- Volunteers
- 30 people, healthy volunteers welcome
- Sponsor
- Holbaek Sygehus
Hip Dysplasia
Can PLIA Reduce Early Post-operative Pain After PAO Surgery?
The goal of this clinical trial is to compare different peri-incisional local infiltrative anesthesia (PLIA) methods in patients ages 13 to 50 undergoing a periacetabular osteotomy (PAO). The main questions to answer here are: 1.
- Trial name
- PILA PAO (NCT06519955)
- Testing
- Ropivacaine, Epinephrine, Ketorolac, NaCl (Saline)
- Where
- United States
- Volunteers
- 121 people, healthy volunteers welcome
- Sponsor
- Michael C Willey
Postoperative Pain
Evaluation of the Efficacy and Safety of HTX-011 for Postoperative Analgesia Following Abdominoplasty Surgery
A Phase 2, Randomized, Controlled Evaluation of the Efficacy and Safety of HTX-011 or HTX-002 for Post-Operative Analgesia Following Abdominoplasty Surgery
- Trial name
- NCT02689258
- Testing
- HTX-011B, HTX-011A, HTX-002
- Where
- 8 sites in United States
- Volunteers
- 277 people, healthy volunteers welcome
- Sponsor
- Heron Therapeutics
Post-operative Pain
Effectiveness of Pre-emptive Analgesics on Post-Operative Pain After Stainless Steel Crown Placement On Primary Molars
The aim of this study is to evaluate the effectiveness of pre-emptive analgesia using ibuprofen and paracetamol on reducing post-operative pain following the placement of stainless steel crowns on primary molars compared to…
- Trial name
- NCT05602064
- Testing
- Ibuprofen, Paracetamol
- Where
- Egypt
- Volunteers
- 66 people, healthy volunteers welcome
- Sponsor
- Alexandria University
Postoperative Pain
Total Knee Replacement TIVA With Robotic Arm Assisted
Total knee replacement (TKR) is a commonly performed surgical procedure, and is associated with moderate to severe acute postoperative pain.
- Trial name
- NCT04002271
- Testing
- Propofol, Sevoflurane, Spinal anaesthesia
- Where
- 2 sites in Hong Kong
- Volunteers
- healthy volunteers welcome
- Sponsor
- The University of Hong Kong
Postoperative Pain, Cesarean Section
Liposomal Bupivacaine + Bupivacaine vs. Bupivacaine Alone on Opioid Use After Elective c/Section
The purpose of this study is to compare the effectiveness of local wound infiltration of EXPAREL® (liposomal bupivacaine) with bupivacaine HCl compared to active control with bupivacaine HCl alone following elective primary or…
- Trial name
- NCT04232306
- Testing
- Liposomal bupivacaine, Bupivacaine HCl
- Where
- United States
- Volunteers
- healthy volunteers welcome
- Sponsor
- Wake Forest University Health Sciences
Post Operative Pain, Cesarean Section
The Effect of Intravenous Infusion of Tramadol-ondansetron on Recovery After Caesarean Section.
It will be a prospective observational cohort study. The investigators will compare post-cesarean section recovery in patients receiving intravenous infusion of tramadol-ondansetron versus epidural catheter with infusion of local…
- Conditions
- Post Operative Pain, Cesarean Section, Tramadol, Postoperative Recovery
- Trial name
- TRON (NCT05879536)
- Testing
- Tramadol-ondansetron continuous infusion, Ropivacaine via epidural catheter
- Where
- Spain
- Volunteers
- 312 people, healthy volunteers welcome
- Sponsor
- Hospital Universitario La Fe
Morphine
Epidural Low Dose Morphine in Postoperative Pain After Posterior Lumbar Spinal Surgery
The effect of epidural low-dose morphine-soaked microfibrillar collagen sponge in postoperative pain control after posterior lumbar spinal surgery: a randomized, double-blind, placebo-controlled study
- Trial name
- NCT02067338
- Testing
- 1 mg morphine soak in epidural oxidized cellulose, normal saline
- Where
- Thailand
- Volunteers
- 19 people, healthy volunteers welcome
- Sponsor
- Mahidol University