Clinical trials: Post-stroke Dementia
Rare Disorders, Undiagnosed Disorders
Rare Disease Patient Registry & Natural History Study - Coordination of Rare Diseases at Sanford
The Coordination of Rare Diseases at Sanford (CoRDS) is an international patient registry that serves as a centralized resource for rare disease research.
- Conditions
- Rare Disorders, Undiagnosed Disorders, Disorders of Unknown Prevalence, Cornelia De Lange Syndrome
- Trial name
- CoRDS (NCT01793168)
- Where
- United States
- Volunteers
- 20,000 people
- Sponsor
- Sanford Health
Haemorrhagic Stroke, Ischaemic Stroke
Digital Application for Stroke Health
Stroke is a leading cause of death and long-term disability worldwide. Despite substantial advances in acute stroke care, there remains a lack of evidence-based digital solutions to support patients after hospital discharge.
- Conditions
- Haemorrhagic Stroke, Ischaemic Stroke, Transient Ischemic Attack (TIA)
- Trial name
- DASH (NCT07511868)
- Testing
- StrokeApp, Standard care
- Where
- 7 sites in Austria
- Volunteers
- 500 people
- Sponsor
- VASCage GmbH
Stroke
Protecting the Brain From Post-Stroke Cognitive Impairment and Dementia With Multimodal Exercise Training
The rates of cognitive decline and dementia after stroke are disproportionately high. Strategies that can protect the brain early after the stroke event could reduce the future risk of cognitive decline and dementia in these…
- Trial name
- PROTECT (NCT07445841)
- Testing
- Multimodal Training, Balance, Toning and Stretching
- Where
- 2 sites in Canada
- Volunteers
- 120 people
- Sponsor
- McGill University
Post-stroke Dementia
Acupuncture Combined With Nimodipine for Prevention of Post-stroke Dementia
To observe the clinical efficacy of TCM acupuncture combined with western medicine nimodipine for prevention of post-stroke dementia by comparing with clinical conventional treatment methods.
- Trial name
- NCT06007573
- Testing
- The control group received oral nimodipine tablets
- Where
- China
- Volunteers
- 40 people
- Sponsor
- Yuzhen Pan
Dementia, Mild Cognitive Impairment
Norwegian COgnitive Impairment After STroke (NorCOAST) Study
A prospective observational multicenter study aiming to describe incidence, and identify predictors for development of poststroke dementia (PSD) and mild cognitive impairment (MCI) after stroke
- Conditions
- Dementia, Mild Cognitive Impairment, Stroke
- Trial name
- Nor-Coast (NCT02650531)
- Where
- Norway
- Volunteers
- 816 people
- Sponsor
- Norwegian University of Science and Technology
Stroke, Cognitive Disorders
Post-stroke Cognitive Impairment and Dementia
Projections from epidemiological studies suggest that, among the Western adult population, one in three will present a cerebrovascular accident (stroke), severe cognitive disorders, or both.
- Conditions
- Stroke, Cognitive Disorders, Behavioral Disorders
- Trial name
- GRECogVASC (NCT01339195)
- Testing
- French adaptation of NINDS-Canadian Stroke Network battery
- Where
- 7 sites in France
- Volunteers
- 1,635 people, healthy volunteers welcome
- Sponsor
- Centre Hospitalier Universitaire, Amiens
Cognitive Impairment, Stroke
The Efficacy of Gliatiline® on Post-stroke Patients With Vascular Cognitive Impairment no Dementia
To date, there are no approved treatments for vascular cognitive impairment (VCI) and the main therapeutic efforts are aimed at controlling vascular risk factors for countering VCI development or progression.
- Trial name
- GLITTER (NCT01363648)
- Testing
- choline alfoscerate
- Where
- South Korea
- Volunteers
- 222 people
- Sponsor
- Seoul National University Hospital
Carotid Artery Diseases, Carotid Artery Stenosis
A Lithium-Based Medication to Improve Neurological Outcomes After Surgical Carotid Reconstruction
There are 10.3 million cases of stroke registered in the world every year; 63% of them lead to death. According to World Health Organization, stroke is one of the most important risk factors of death and early disability.
- Trial name
- NCT05126238
- Testing
- Lithium Carbonate
- Where
- Russia
- Volunteers
- 107 people
- Sponsor
- Negovsky Reanimatology Research Institute
Vascular Cognitive Impairment, Post-stroke Depression
Cognition and Affect After Stroke: a Prospective Evaluation of Risks
Stroke is a leading cause of disability, affecting about 34,000 to 41,000 individuals in the Netherlands of middle and old age every year.
- Conditions
- Vascular Cognitive Impairment, Post-stroke Depression, Post-stroke Apathy, Post-stroke Dementia
- Trial name
- CASPER (NCT02585349)
- Where
- Netherlands
- Volunteers
- 250 people
- Sponsor
- Maastricht University Medical Center
Stroke, Dementia
Taiwan Post-Stroke Disability Study
Stroke remains a major health issue in Taiwan, being the fourth leading cause of death and the top cause of disability. While past research has focused on functional outcomes at three months post-stroke, stroke can cause a range…
- Conditions
- Stroke, Dementia, Epilepsy, Depression
- Trial name
- T-PODS (NCT06772194)
- Where
- Taiwan
- Volunteers
- 2,000 people
- Sponsor
- National Taiwan University Hospital
First-ever Ischemic Stroke, Cognitive Performance
Post-stroke Cognitive Impairment
Present study aims to track the post-stroke cognitive trajectories and to investigate its inter-individual variability.
- Trial name
- CogStroke (NCT05653141)
- Where
- Switzerland
- Volunteers
- 600 people
- Sponsor
- Roza Umarova
Ischemic Stroke, Hemorrhagic Stroke
Observational Study on Determinants of Dementia After Stroke
The primary aim of the DEDEMAS (Determinants of Dementia After Stroke) study is to identify predictors of post stroke dementia (PSD).
- Trial name
- DEDEMAS (NCT01334749)
- Where
- 5 sites in Germany
- Volunteers
- 736 people
- Sponsor
- Ludwig-Maximilians - University of Munich
Post-stroke Cognitive Impairment, Neuroinflammation
The Influence of [18F]PMPBB3 and [18F]THK5351 PET Distribution Patterns on Post-stroke Cognitive Impairment
Background and objects： Neuroinflammation is an active process detectable in the earliest stages of the neurodegeneration pathway.
- Trial name
- NCT04318626
- Testing
- PMPBB3, THK5351
- Where
- Taiwan
- Volunteers
- 80 people, healthy volunteers welcome
- Sponsor
- Chang Gung Memorial Hospital
Post-stroke Dementia, Vascular Mild Cognitive Impairment
The Aging Brain and Cognition: Contribution of Vascular Injury, Amyloid Plaque and Tau Protein to Cognitive Dysfunction After Stroke
Stroke can lead to signficiant neurological deficits, and about one-third of stroke patients will be diagnosed of vascular mild cognitive impairment or post-stroke dementia.
- Trial name
- NCT04588649
- Testing
- THK-5351, AV-45
- Where
- Taiwan
- Volunteers
- 181 people, healthy volunteers welcome
- Sponsor
- Chang Gung Memorial Hospital
Stroke
Development of a Genomics-based Multimodal Prediction Model for Post-stroke Vascular Dementia
To collect large-scale multimodal data, including genomic information, neuroimaging, neurophysiological measures, cognitive assessments, and clinical characteristics from stroke survivors and healthy controls.
- Trial name
- NCT07660263
- Where
- South Korea
- Volunteers
- 300 people, healthy volunteers welcome
- Sponsor
- Seyoung Shin
Asthma, Atrial Fibrillation
The Living With a Long-Term Condition Study
Psychological distress (anxiety and depression) is common in and experienced differently by people living with long-term health conditions (LTCs).
- Conditions
- Asthma, Atrial Fibrillation, Cancer, Cerebrovascular Disorders
- Trial name
- LTC (NCT06072287)
- Testing
- Living with LTC Questionnaire
- Where
- United Kingdom
- Volunteers
- 600 people
- Sponsor
- King's College London
Cerebrovascular Disorders, Dementia
Study of Factors Influencing Post-stroke Dementia
If the risk of dementia occurrence after stroke is well known, few data exist about the factors influencing positively or negatively the developement of cognitive disorders or dementia.
- Trial name
- strokdem (NCT01330160)
- Where
- 4 sites in France
- Volunteers
- 229 people
- Sponsor
- University Hospital, Lille
Healthy, Neurodegenerative Disease
Brain Health Registry: An Online Registry to Identify and Assess Subjects for Brain Research
The overall goal of this project is to identify, assess and longitudinally monitor subjects who are interested in participating in brain research.
- Trial name
- BHR (NCT02402426)
- Where
- United States
- Volunteers
- 200,000 people, healthy volunteers welcome
- Sponsor
- University of California, San Francisco
Ischemic Stroke
Global Blood-Brain Barrier Disruption and Post-Stroke Cognitive Decline
The goal of this study is to gain a better understanding of why some individuals who have suffered a stroke experience post-stroke cognitive decline.
- Trial name
- NCT05556395
- Where
- United States
- Volunteers
- 150 people
- Sponsor
- Johns Hopkins University
Stroke, Cognitive Impairment
Cognitive and Emotional Impairment After Stroke
Cognitive and emotional symptoms are often seen in the acute phase of a stroke. The prevalence of such symptoms later and the mechanisms explaining the symptoms are not fully known.
- Conditions
- Stroke, Cognitive Impairment, Vascular Dementia
- Trial name
- NCT00506818
- Testing
- Multifactorial vascular-risk-factor-intervention
- Where
- Norway
- Volunteers
- 250 people
- Sponsor
- Sykehuset Asker og Baerum