Clinical trials: Post-traumatic Stress Disorders
Moral Injury
A Novel Posttraumatic Stress Disorder Treatment for Veterans With Moral Injury
The objective of this project is to test the efficacy of an individual treatment for post-traumatic stress disorder (PTSD) stemming from moral injury called Impact of Killing (IOK), compared to a present-centered therapy (PCT)…
- Trial name
- IOK (NCT03764033)
- Testing
- Impact of Killing (IOK), Present Centered Therapy
- Where
- 3 sites in United States
- Volunteers
- 100 people
- Sponsor
- VA Office of Research and Development
Single-ventricle, Posttraumatic Stress Disorder
The PaTHS Descriptive Correlational Longitudinal Study
The primary objective of this study is to measure parent's post-traumatic stress before and after their infant's second palliative heart surgery for single ventricle congenital heart disease.
- Conditions
- Single-ventricle, Posttraumatic Stress Disorder, Psychosocial Impairment
- Trial name
- PaTHS (NCT04785482)
- Where
- United States
- Volunteers
- 22 people
- Sponsor
- Children's Mercy Hospital Kansas City
Posttraumatic Stress Disorder
MGH Trauma-related Nightmares SDI Study
Interested individuals will first complete a telephone screening followed by a series of structured clinical interviews to diagnose PTSD and comorbid psychiatric disorders, confirm initial inclusion criteria, rule out exclusion…
- Trial name
- NM (NCT05195684)
- Testing
- imaginal probe
- Where
- United States
- Volunteers
- 30 people
- Sponsor
- Massachusetts General Hospital
Drug Use, Drug Abuse
Acute Intervention to Reduce Distress Following Sexual Assault
The purpose of this study was to evaluate whether a brief intervention in video format delivered in the post assault medical exam setting and including education about assault reactions and instruction in and modeling of…
- Conditions
- Drug Use, Drug Abuse, Posttraumatic Stress Disorder
- Trial name
- NCT01622855
- Testing
- PPRS
- Where
- United States
- Volunteers
- 442 people
- Sponsor
- Medical University of South Carolina
Stress Disorders, Post-Traumatic; Mental Disorders
PTSD Treatment for Veterans With Serious Mental Illness to Improve Functional Outcomes
PTSD is common among Veterans with serious mental illness (SMI). Co-occurring PTSD and SMI lead to poorer mental health and physical functioning than either diagnosis alone.
- Trial name
- NCT05674617
- Testing
- Written Exposure Therapy, PTSD Education
- Where
- United States
- Volunteers
- 48 people
- Sponsor
- VA Office of Research and Development
Insomnia Chronic, Posttraumatic Stress Disorder
Pimavanserin for Insomnia in Veterans With Posttraumatic Stress Disorder: Proof of Concept
This is a proof-of-concept, open-label trial of pimavanserin 34mg at bedtime for 6 weeks in Veterans with insomnia and Posttraumatic Stress Disorder.
- Trial name
- NCT04809116
- Testing
- Pimavanserin
- Where
- United States
- Sponsor
- Baylor College of Medicine
Depression, Stress Disorders, Post-Traumatic
Self-Help Intervention for Post 9/11 Veterans With Depression or PTSD Symptoms
It is important to provide support and resources for the many post-9/11 Veterans with mental health symptoms and poor psychosocial functioning who do not engage in psychotherapy.
- Trial name
- NCT07202325
- Testing
- Resilience Training for Veterans (REST-V), Usual resources
- Where
- 2 sites in United States
- Volunteers
- 200 people
- Sponsor
- VA Office of Research and Development
Posttraumatic Stress Disorder, Depression
Loving-Kindness Meditation for PTSD
This randomized controlled trial will assess whether a novel complementary and alternative medicines (CAM) intervention, Loving-kindness Meditation (LKM), is not meaningfully inferior to another group-based PTSD treatment …
- Trial name
- NCT01962714
- Testing
- Loving-Kindness Meditation, Cognitive Processing Therapy
- Where
- United States
- Volunteers
- 184 people
- Sponsor
- VA Office of Research and Development
Stress Disorders, Post-Traumatic, Myocardial Infarction
Myocardial Infarction - Stress Prevention Intervention
Posttraumatic Stress Disorder (PTSD) is a mental disorder that may occur after someone experiences a traumatic event. Between 10-20% of patients may develop PTSD in response to the traumatic experience of myocardial infarction…
- Trial name
- MI-SPRINT (NCT01781247)
- Testing
- Minimal behavioral intervention, Control intervention
- Where
- Switzerland
- Volunteers
- 190 people
- Sponsor
- Insel Gruppe AG, University Hospital Bern
Traumatic Brain Injury
Neurofeedback Technology (GZNT) for Persistent Post-Concussive Symptoms in Soldiers
A new technology called Global Z-Score Neurofeedback Technology (GZNT) has been identified that can overcome an existing barrier to the use of neurofeedback as a treatment technique in a military setting.
- Trial name
- GZNT (NCT02509689)
- Testing
- Global Z-Score Neurofeedback Training
- Where
- United States
- Volunteers
- 172 people
- Sponsor
- The Defense and Veterans Brain Injury Center
Mechanical Ventilation Complication
Reduce Pediatric Sedation to Reduce Mechanical Ventilation Complication in ICU
Mechanical ventilation is a common procedure used in pediatric intensive care units (ICU). Its use requires almost always the establishment of a sedation.
- Trial name
- PEDIASED (NCT02040168)
- Where
- France
- Volunteers
- 106 people
- Sponsor
- Nantes University Hospital
Post-traumatic Stress Disorder (PTSD)
rTMS in the Treatment of PTSD
The purpose of this study is to assess the effects of repetitive transcranial magnetic stimulation (rTMS) in civilian patients with a confirmed diagnosis of post-traumatic stress disorder (PTSD).
- Trial name
- NCT01806168
- Testing
- rTMS
- Where
- Canada
- Volunteers
- 31 people
- Sponsor
- University of British Columbia
Post Traumatic Stress Disorder
Biochemical and Physiological Response to Stressogenic Stimuli
Post-traumatic stress disorder (PTSD) is characterized by physiological changes, some of which are thought to be chronic, while others are observed in response to stressogenic stimuli.
- Trial name
- NCT04076215
- Testing
- Stressogenic stimulus, Biobeat smart watch and adhesive biosensor patches.
- Volunteers
- 50 people, healthy volunteers welcome
- Sponsor
- Nadav Goldental
Post-traumatic Stress Disorder, Generalized Anxiety Disorder
Primary Care Intervention Strategy for Anxiety Disorders
This study will compare the effectiveness of an intervention strategy for the treatment of people with post traumatic stress disorder, generalized anxiety disorder, panic disorder, and social anxiety disorder in the primary care…
- Conditions
- Post-traumatic Stress Disorder, Generalized Anxiety Disorder, Panic Disorder, Social Anxiety Disorder
- Trial name
- NCT00347269
- Testing
- Cognitive-behavioral therapy, Psychotropic medication optimization, Treatment as Usual
- Where
- 4 sites in United States
- Volunteers
- 1,004 people
- Sponsor
- University of Washington
Posttraumatic Stress Disorder
Prolonged Exposure for Swedish Immigrants
The goal of this clinical trial is to compare therapist-guided internet delivered prolonged exposure (I-PE) in simple english to a waiting list condition for immigrants in Sweden diagnosed with post-traumatic stress disorder…
- Trial name
- NCT06193161
- Testing
- Therapist-supported internet delivered prolonged exposure
- Where
- Sweden
- Volunteers
- 100 people
- Sponsor
- Karolinska Institutet
Violence, Non-accidental, Posttraumatic Stress Disorder
Addressing Traumatic Stress Symptoms in Children
The objective of this study is to evaluate the effectiveness of the Child and Family Traumatic Stress Intervention (CFTSI), provided soon after a violent traumatic event, in producing significant and sustained reduction in PTSS…
- Conditions
- Violence, Non-accidental, Posttraumatic Stress Disorder, Parent-Child Relations, Assault
- Trial name
- NCT03334942
- Testing
- Child and Family Traumatic Stress Intervention
- Where
- United States
- Volunteers
- 132 people
- Sponsor
- Children's Hospital of Philadelphia
Alcohol Dependence, Post Traumatic Stress Disorder
The Use of Anticonvulsants for Treatment of Patients With Alcohol Dependence and Post Traumatic Stress Disorder
The objective of this study is to evaluate the efficacy of topiramate (250mg) or lamotrigine (250mg) versus placebo in reducing alcohol consumption and decreasing symptoms of PTSD in patients with comorbid AD and PTSD.
- Trial name
- NCT00571246
- Testing
- Topiramate, lamotrigine
- Where
- United States
- Sponsor
- Yale University
Stress Disorders, Post-Traumatic
An Integrated Online Program Using Psychoeducation and Expressive Writing for People With Probable Post-traumatic Stress Disorder and Coexisting Dissociative Symptoms
Objectives: To evaluate the feasibility, acceptability, safety, and preliminary effects of an integrated online program with psychoeducation and expressive writing components for people with probable post-traumatic stress…
- Trial name
- NCT06523023
- Testing
- An integrated online program
- Where
- Hong Kong
- Volunteers
- 72 people
- Sponsor
- Chinese University of Hong Kong
Stress Disorders, Post-Traumatic, Alcohol Abuse
Combined Treatment for Alcohol-Dependent Individuals With PTSD
This treatment intervention trial is designed for men and women with either alcohol misuse (e.g. hazardous or binge drinking) or alcohol use disorders (alcohol abuse or dependence) and comorbid PTSD.
- Conditions
- Stress Disorders, Post-Traumatic, Alcohol Abuse, Substance-Related Disorders
- Trial name
- NCT00262223
- Testing
- Seeking Safety, Sertraline
- Where
- United States
- Volunteers
- 69 people
- Sponsor
- New York State Psychiatric Institute
Suicide, Attempted
Pilot Trial of Inpatient Cognitive Therapy for the Prevention of Suicide in Military Personnel
The broad objective of this research is to effectively utilize a unique window of opportunity during the hospitalization period following a recent suicide attempt to deliver a brief and targeted intervention for traumatized…
- Trial name
- CDMRP (NCT01356186)
- Testing
- Post Admission Cognitive Therapy (PACT)
- Where
- 2 sites in United States
- Volunteers
- 36 people
- Sponsor
- Henry M. Jackson Foundation for the Advancement of Military Medicine
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