Clinical trials: Posterior Wall Isolation
Atrial Fibrillation
Reduction in Arrhythmia Burden With Left Atrial Posterior Wall Ablation for Persistent AF
RABLAP-AF will compare pulmonary vein isolation (PVI) in combination with posterior wall isolation (PWI) for patients with persistent atrial fibrillation (AF).
- Trial name
- RABLAP-AF (NCT05195268)
- Testing
- Intracardiac Catheter Ablation
- Where
- United Kingdom
- Sponsor
- Liverpool Heart and Chest Hospital NHS Foundation Trust
Atrial Fibrillation (AF)
Comparative Effectiveness of Different Techniques for Repeat Ablation of Atrial Fibrillation
Atrial fibrillation (AF) is the most common type of irregular heartbeat doctors see. People with AF sometimes have a procedure called an ablation to help get their heart back into a normal rhythm.
- Trial name
- REPEAT-AF (NCT06988202)
- Testing
- Pulmonary Vein Isolation (PVI) without Left Atrial Posterior Wall Isolation (PWI), Pulmonary Vein Isolation (PVI) with Left Atrial Posterior Wall Isolation (PWI)
- Where
- United States
- Volunteers
- 630 people
- Sponsor
- University of Rochester
Atrial Fibrillation, Persistent, Atrial Fibrillation Recurrent
A Prospective Study of REPeat Ablation In Patients With Recurrent PERSistent Atrial Fibrillation: Pulmonary Vein Isolation vs. Adjunct Posterior Wall Isolation (REPAIR PERS-AF Study)
This study aims to investigate the best strategy for repeat ablation of recurrent persistent atrial fibrillation (AF) after previous persistent AF ablation involving pulmonary vein isolation (PVI) along.
- Trial name
- REPAIR PERS-AF (NCT06098989)
- Testing
- Radio frequency ablation
- Volunteers
- 150 people
- Sponsor
- Haukeland University Hospital
Atrial Fibrillation, Persistent Atrial Fibrillation
Left Atrial Arrhythmia Substrate Identification After Confirmed durABLE Pulmonary Vein Isolation
Under current practice, patients with persistent atrial fibrillation, can be offered one of two types of ablation treatment. Both of these treatments are aimed at electrically isolating the 4 pulmonary veins (PVs) at the back of…
- Trial name
- LAUDABLE (NCT04111731)
- Testing
- Cryoballoon pulmonary vein isolation, Radiofrequency pulmonary vein isolation, Repeat electrophysiological study
- Where
- 3 sites in United Kingdom
- Volunteers
- 44 people
- Sponsor
- Liverpool Heart and Chest Hospital NHS Foundation Trust
Atrial Fibrillation
Posterior Wall And Left Atrial Appendage Empiric Electrical Isolation for Non-Paroxysmal Atrial Fibrillation
The purpose of this study is to evaluate the safety and effectiveness of empirical posterior wall isolation (PWI), left atrial appendage electrical isolation (LAAEI) and coronary sinus isolation (CSI) when compared to pulmonary…
- Trial name
- PLEA (NCT04216667)
- Testing
- Catheter ablation
- Where
- 16 sites in United States, Argentina and 5 more
- Volunteers
- 124 people
- Sponsor
- Montefiore Medical Center
Recurred Atrial Fibrillation
Comparison of Circumferential Pulmonary Vein Isolation and Complex Pulmonary Vein Isolation Additional Linear Ablation for Recurred Atrial Fibrillation After Previous Catheter Ablation: Prospective Randomized Trial (RILI Trial)
The purpose of this study is to compare the clinical outcomes depending on catheter ablation strategy for repeat ablation procedure among the patients with recurred atrial fibrillation after de novo catheter ablation.
- Trial name
- NCT02747498
- Testing
- Procedure with circumferential pulmonary vein isolation, Procedure with linear ablation in addiction to pulmonary vein isolation
- Where
- South Korea
- Volunteers
- 120 people
- Sponsor
- Yonsei University
Persistent Atrial Fibrillation, Atrial Fibrillation Ablation
Oesophageal Pacing to Check Left Atrial Posterior Wall Isolation
Patients undergoing hybrid AF ablation second stage catheter ablation have the posterior left atrium mapped to see it if is electrically isolated.
- Trial name
- NCT05086861
- Testing
- Oesophageal pacing after left atrial posterior wall isolation
- Where
- United Kingdom
- Volunteers
- 52 people
- Sponsor
- University Hospital Plymouth NHS Trust
Paroxysmal Atrial Fibrillation
Cryoballoon PVI With PWI Versus PVI Alone In Patients With PAF
Cryoballoon ablation has emerged as a safe and effective strategy for treatment of atrial fibrillation (AF) for which it has recently received a 'first-line' therapy indication by the FDA.
- Trial name
- NCT05296824
- Testing
- Cryoballoon ablation for the treatment of atrial fibrillation
- Where
- 4 sites in United States
- Volunteers
- 320 people, healthy volunteers welcome
- Sponsor
- Sacramento EP Research
Atrial Fibrillation
Strategies in Patients Undergoing Repeat AF Ablation
The aim of the proposed research project is to compare the efficacy of three different ablation strategies in patients with atrial fibrillation (AF) who are undergoing their first repeat catheter ablation for recurrent AF.
- Trial name
- TRAP-AF (NCT05185310)
- Testing
- Ablation
- Where
- United States
- Volunteers
- 8 people
- Sponsor
- University of Pennsylvania
Atrial Fibrillation
Safety and Effectiveness of Pulmonary Vein isOLation And posterioR Wall Ablation wIth pulSed Field Energy in Patients With Paroxysmal and Persistent AF
The primary objective of this clinical investigation is to demonstrate the safety and 12-month effectiveness of pulmonary vein isolation (PVI) and posterior LA wall isolation in the treatment of subjects with symptomatic…
- Trial name
- POLARIS (NCT06099730)
- Testing
- Pulsed Field Ablation (PFA)
- Where
- 6 sites in United States
- Volunteers
- 442 people
- Sponsor
- Massachusetts General Hospital
Persistent Atrial Fibrillation, Atrial Fibrillation (AF)
Atrial Remodeling After PFA Substrate Modification for Persistent AF (PeAF)
Atrial fibrillation (AF) is associated with both electrical and structural remodeling of the left atrium. While successful catheter ablation has been shown to reverse some aspects of atrial remodeling, the impact of pulsed-field…
- Conditions
- Persistent Atrial Fibrillation, Atrial Fibrillation (AF), Atrial Remodeling, Pulsed Field Ablation
- Trial name
- NCT07675395
- Testing
- Pulsed-Field Ablation with FARAWAVE Catheter System
- Where
- Taiwan
- Volunteers
- 30 people
- Sponsor
- Taipei Veterans General Hospital, Taiwan
Atrial Fibrillation (AF), Persistent Atrial Fibrillation (PersAF)
A Global Randomized Trial Evaluating the FARAFLEX™ Mapping and Pulsed Field Ablation System With Electrographic Flow Mapping in Patients Undergoing Repeat Ablation for Atrial Fibrillation
The goal of the ReDEFINE-AF Clinical Study is to evaluate the safety and effectiveness of the FARAFLEX™ Mapping and Pulsed Field Ablation System with electrographic flow mapping in subjects undergoing repeat ablation for atrial…
- Conditions
- Atrial Fibrillation (AF), Persistent Atrial Fibrillation (PersAF), Paroxysmal Atrial Fibrillation (PAF)
- Trial name
- ReDEFINE-AF (NCT07820930)
- Testing
- FARAFLEX Mapping and Pulsed Field Ablation System
- Volunteers
- 650 people
- Sponsor
- Boston Scientific Corporation
Persistent Atrial Fibrillation
PVI Alone Versus PVI Plus PWI and SVCI With PFA
Catheter based ablation of atrial fibrillation (AF) is an established treatment modality for rhythm control of AF, with pulmonary vein isolation (PVI) being the cornerstone of this technique.
- Trial name
- PVI-PLUS (NCT07405359)
- Testing
- AF Ablation: PVI + PWI + SVCI, PFA, Implantable loop recorder
- Where
- United States
- Volunteers
- 220 people
- Sponsor
- Edward Gerstenfeld, MD
Atrial Fibrillation Paroxysmal
Posterior Wall Substrate Modification Using Irreversible Electroporation for Paroxysmal Atrial Fibrillation
The purpose of this study is to compare the efficacy and safety between pulmonary vein isolation (PVI) alone versus PVI with left atrial (LA) posterior wall isolation (PWI) using pulsed-field ablation (PFA) in the treatment of…
- Trial name
- (SMILE-AF) (NCT06364215)
- Testing
- Farapulse PFA, Pulmonary Vein Isolation alone, Farapulse PFA, Pulmonary Vein Isolation and Left atrial Posterior Wall Isolation
- Where
- 18 sites in United States
- Volunteers
- 198 people
- Sponsor
- Jorge Romero
Persistent Atrial Fibrillation
Optimized Posterior Left Atrial Wall Ablation Strategy for PeAF
This is an open-label, multicenter, randomized parallel-controlled clinical trial. The study aims to investigate the optimal ablation method for the posterior left atrial wall in patients with persistent atrial fibrillation…
- Trial name
- NCT06633523
- Testing
- PVI + Posterior Wall Isolation (PWI) + Electrogram Ablation (EGM), PVI + Posterior Wall Isolation (PWI), Pulmonary Vein Isolation (PVI) alone
- Volunteers
- 384 people
- Sponsor
- Shanghai Chest Hospital