Clinical trials: Postmenopausal Disorder
Osteoporosis
The Effects of Inhaled Glucocorticoids on the Postmenopausal Skeleton
There are over 10 million individuals with asthma using inhaled glucocorticoids (IGCs) in the United States. While oral GCs are recognized to have destructive skeletal effects, far less is known about the effects of IGCs.
- Trial name
- NCT02357277
- Testing
- Budesonide
- Volunteers
- healthy volunteers welcome
- Sponsor
- Columbia University
Menopause, Insomnia
The Treatment of Insomnia in Symptomatic Peri- and Postmenopausal Women
To examine the change in sleep patterns and mood symptoms in response to eszopiclone (Lunesta) using a double-blind placebo-controlled cross-over study design in perimenopausal and postmenopausal women who experience insomnia…
- Trial name
- NCT00374192
- Testing
- Eszopiclone
- Where
- United States
- Volunteers
- 67 people, healthy volunteers welcome
- Sponsor
- Massachusetts General Hospital
Postmenopausal Flushing, Cardiovascular Risk Factor
Hot Flash as a Marker of Cardiovascular Risk in Recent Postmenopause: Effects of Non-hormonal Treatments
Hot flashes, vasomotor symptoms that affect many postmenopausal women, are associated with cardiovascular disease and endothelial dysfunction.
- Conditions
- Postmenopausal Flushing, Cardiovascular Risk Factor, Endothelial Dysfunction
- Trial name
- NCT03149419
- Testing
- Paroxetine
- Where
- Brazil
- Volunteers
- 140 people, healthy volunteers welcome
- Sponsor
- Rio de Janeiro State University
Postmenopausal Osteoporoses
Clinical Study on Treatment of Postmenopausal Osteoporosis (Kidney Deficiency and Blood Stasis Syndrome) With Xulin Jiangu Granules
Osteoporosis is a common senile disease with a high incidence. The Chinese medicine differentiation treatment has small side effects and can be taken for a long time, which has certain advantages.
- Trial name
- CSOPOPWXJG (NCT03563235)
- Testing
- Xulin Jiangu granules, Calcitriol capsules
- Where
- China
- Volunteers
- 60 people, healthy volunteers welcome
- Sponsor
- Fujian Academy of Traditional Chinese Medicine
Overactive Bladder, Caffeine
"The Effects of Caffeine on Overactive Bladder Symptoms and Mental Health in Postmenopausal Women"
The purpose of this study is to observe effects of caffeine on overactive bladder symptoms and wellbeing. This study looks at whether caffeine has bad effects on urinary symptoms or if lower doses of caffeine decrease the…
- Conditions
- Overactive Bladder, Caffeine, Menopause
- Trial name
- NCT02180048
- Testing
- 400 mg of caffeine/day (Two 200mg pills/day)
- Where
- United States
- Volunteers
- 55 people, healthy volunteers welcome
- Sponsor
- Loma Linda University
Social Media Addiction
Effect Of Social Media On Body Weight And Eating Behaviour In Housewife Versus Worker Postmenopausal Women
The purpose of this study is to determine the effect of social media on body weight and eating behaviour in housewife versus worker postmenopausal women.
- Trial name
- NCT06612905
- Testing
- Detection of the time spent on social media, Evaluation of body composition and basal metabolic rate, Evaluation of eating behavior among social media users
- Where
- Egypt
- Volunteers
- 148 people, healthy volunteers welcome
- Sponsor
- Cairo University
Osteoporosis
A Phase I Study of AK159 in Healthy Postmenopausal Women
The objective of this study is to investigate the pharmacokinetics, safety, and tolerability of AK159 administered to healthy postmenopausal women.
- Trial name
- NCT01935479
- Testing
- AK159, MN-10-T
- Where
- 3 sites in Japan
- Volunteers
- 170 people, healthy volunteers welcome
- Sponsor
- Asahi Kasei Therapeutics Corporation
Relative Bioavailability
A Relative Bioavailability Study of FOR-6219 in Capsule and Tablet Formulations
This is a phase 1, randomised, open-label, three-way, three-period, crossover relative bioavailability study to assess the single-dose pharmacokinetics of FOR-6219 in capsule and tablet formulations in postmenopausal women.
- Trial name
- NCT04686669
- Testing
- FOR-6219 capsule formulation, FOR-6219 tablet formulation
- Where
- United Kingdom
- Volunteers
- 12 people, healthy volunteers welcome
- Sponsor
- Forendo Pharma Ltd
Osteoporosis
A Study to Evaluate the Effects of SB-751689 or rhPTH(1-34) on Excretion of Calcium and Phosphate in Women
SB-751689 may alter calcium and phosphate handling at the kidney level. This study will examine what happens to calcium and phosphate, and other electrolytes, at the kidney after treatment with SB-751689 for 1 month.
- Trial name
- NCT00532077
- Testing
- rhPTH(1-34), SB-751689 100 mg, SB-751689 400 mg
- Where
- 5 sites in United States
- Volunteers
- 40 people, healthy volunteers welcome
- Sponsor
- GlaxoSmithKline
Healthy, Osteopenia
Resistance Training and Rapamycin to Enhance Bone Formation in Postmenopausal Women
The aim of the present clinical trial is to examine the effects of everolimus, resistance training, or their combination on bone and muscle health formation in elderly women aged 60-75 years.
- Conditions
- Healthy, Osteopenia, Osteoporosis Risk
- Trial name
- StrongBone (NCT07191353)
- Testing
- Everolimus, Resistance training
- Where
- 2 sites in Denmark
- Volunteers
- 148 people, healthy volunteers welcome
- Sponsor
- Odense University Hospital
Postmenopausal Symptoms, Cardiovascular Diseases
Estrogen Deficiency on Cardiovascular Risk
To explore how estrogen deficiency impacts the blood pressure (BP) and sympathetic nerve activity (SNA), and how it impacts the production of the key pro-inflammatory mediators such as Tumor necrosis factor α (TNF-α)…
- Trial name
- NCT06369363
- Testing
- Estradiol
- Volunteers
- 20 people, healthy volunteers welcome
- Sponsor
- Milton S. Hershey Medical Center
Cardiovascular Diseases, Cognition
Acute Impact of Whey Protein-enriched Milk Fat Globule Membrane Supplementation on Postprandial Markers of Heart and Brain Health
In a single-blind, randomised, placebo-controlled crossover manner, this study aims to assess the impact of a high-fat mixed meal containing a whey protein (WP)-enriched milk fat globule membrane (MFGM) powdered ingredient on…
- Conditions
- Cardiovascular Diseases, Cognition, Overweight or Obesity, Postmenopausal Women
- Trial name
- NCT06953232
- Testing
- Whey protein-enriched milk fat globule membrane supplement, Whey protein-based supplement
- Where
- United Kingdom
- Volunteers
- 16 people, healthy volunteers welcome
- Sponsor
- Loughborough University
Osteoporosis
Safety and Effectiveness of Soy Phytoestrogens to Prevent Bone Loss
The purpose of this study is to determine whether soy isoflavone supplementation is safe and effective to prevent bone loss in postmenopausal women.
- Trial name
- OPUS (NCT00665860)
- Testing
- Soy isoflavones
- Where
- 3 sites in United States
- Volunteers
- 403 people, healthy volunteers welcome
- Sponsor
- Baylor College of Medicine
Musculoskeletal Diseases
Phase 1 Study of ACE-083 in Healthy Subjects
This study will evaluate the safety and tolerability of single and multiple doses of ACE-083 as a local injection into selected skeletal muscles of healthy subjects.
- Trial name
- NCT02257489
- Testing
- ACE-083
- Where
- United States
- Volunteers
- 58 people, healthy volunteers welcome
- Sponsor
- Acceleron Pharma, Inc., a wholly-owned subsidiary of Merck & Co., Inc., Rahway, NJ USA
Bone Density, Osteopenia
The Influence of Vibration on Bone Mineral Density in Women Who Have Weak Bones After Menopause
This study will examine whether whole-body vibration slows down bone loss in healthy postmenopausal women with osteopenia. Whole-body vibration is a promising novel therapy that involves standing on a platform which produces…
- Conditions
- Bone Density, Osteopenia, Osteoporosis, Post-Menopause
- Trial name
- NCT00420940
- Testing
- Juvent 1000 Dynamic Motion Therapy (DMT) Platform
- Where
- Canada
- Volunteers
- 202 people, healthy volunteers welcome
- Sponsor
- University Health Network, Toronto
Breast Cancer, Endometrial Cancer
Genistein in Preventing Breast or Endometrial Cancer in Healthy Postmenopausal Women
RATIONALE: Chemoprevention therapy is the use of certain drugs to try to prevent the development or recurrence of cancer. The use of genistein may be effective in preventing breast or endometrial cancer.
- Trial name
- NCT00099008
- Testing
- Genistein
- Where
- United States
- Volunteers
- 30 people, healthy volunteers welcome
- Sponsor
- UNC Lineberger Comprehensive Cancer Center
Calcium Deficiency, Vitamin D Deficiency
Human Pharmacology Trial of Calcium-vitamin D3 Tablet in Healthy Participants
The purpose of this study is to demonstrate that the intestinal absorption of calcium from a newly developed calcium carbonate-vitamin D3 chewable tablet formulation increases the amount of calcium excreted in urine and decreases…
- Trial name
- Osteopro (NCT01639222)
- Testing
- Calcium 500 mg and Vitamin D3 800 IU, Low calcium meals
- Where
- Germany
- Volunteers
- 55 people, healthy volunteers welcome
- Sponsor
- Takeda
Sleep, Body Composition
Nutrition, Body Composition, and Sleep
The purpose of the research is to determine if protein and omega-3 fatty acid supplementation improve sleep, improve body composition, and improve markers of metabolic health in postmenopausal women.
- Conditions
- Sleep, Body Composition, Strength, Insulin Sensitivity
- Trial name
- SHAPE (NCT03603041)
- Testing
- Whey protein, Omega-3 fatty acids
- Where
- United States
- Volunteers
- 45 people, healthy volunteers welcome
- Sponsor
- University of Arkansas, Fayetteville
Postmenopausal Osteoporosis
Bone Modeling Effects of Combined Anabolic/Antiresorptive Administration
The purpose of this study is to examine, via iliac crest bone biopsies, the mechanism of combined teriparatide and denosumab on the bone of postmenopausal osteoporotic women after 3 months of treatment.
- Trial name
- NCT04026256
- Testing
- Teriparatide, Denosumab
- Where
- United States
- Volunteers
- 37 people, healthy volunteers welcome
- Sponsor
- Massachusetts General Hospital
Osteoporosis, Postmenopause
The Effect of Mechanical Loading on Bone Material Strength and Microarchitecture in Postmenopausal Women
Osteoporosis is a large public health disease, characterized by low bone mass and micro architectural deterioration of bone tissue, resulting in enhanced bone fragility and consequent increase in fracture risk.
- Trial name
- NCT02339051
- Testing
- Jumping on one leg
- Volunteers
- 20 people, healthy volunteers welcome
- Sponsor
- Mattias Lorentzon