Clinical trials: Postoperative Cardiovascular Complication
Peripheral Vascular Disease
Lower Extremity Regional Anesthesia and Infrainguinal Bypass Grafting
In this investigation, the investigators will attempt to demonstrate that patients who have received nerve blocks (regional anesthesia) prior to open surgical vascular bypass of the lower extremities (infrainguinal bypass…
- Trial name
- NCT01803165
- Testing
- Single shot femoral and sciatic nerve block
- Sponsor
- University of Nebraska
Congenital Heart Disease (CHD), Ventricular Septal Defects (VSD)
A Multimodal AI Prediction Model for Complications After Transcatheter Closure of Perimembranous VSD in Children
The goal of this observational study is to develop and validate a multimodal artificial intelligence prediction model for treatment-related complications in children with perimembranous ventricular septal defect (pmVSD)…
- Conditions
- Congenital Heart Disease (CHD), Ventricular Septal Defects (VSD), Cardiac Catheterization, Postoperative Complications
- Trial name
- NCT07375602
- Where
- China
- Volunteers
- 5,249 people
- Sponsor
- Xinhua Hospital, Shanghai Jiao Tong University School of Medicine
Acute Ischemic Stroke, Cerebral Infarction
Safely Quenching Complement in Stroke Survivors
This study will include adults (ages 18-80) who have had a stroke caused by a large blood clot blocking blood flow in the brain.
- Trial name
- SUCCESS (NCT07495722)
- Testing
- Pegcetacoplan Injection [Empaveli]
- Volunteers
- 20 people
- Sponsor
- Columbia University
Aortic Dissection Aneurysm, Aortic Dissection Rupture
Effects of Precise Education on Postoperative Discomfort Symptoms in Patients With Aortic Disease Undergoing Endovascular Intervention: a Single-center Randomized Controlled Study
The incidence and severity of post-procedural discomfort were evaluated in patients undergoing endovascular repair for aortic dissection across six symptom-related dimensions: immobilization-related issues, puncture site…
- Conditions
- Aortic Dissection Aneurysm, Aortic Dissection Rupture, Aortic Dissection Involving the Descending Thoracic Aorta
- Trial name
- NCT07362901
- Testing
- postoperative precise education
- Where
- China
- Volunteers
- 132 people
- Sponsor
- First Affiliated Hospital of Zhejiang University
Diabetic Foot, Postoperative Wound Healing
OEOd-Based Wound Dressing in Post-Surgical Diabetic Foot Ulcers
This study is a prospective randomized controlled pilot study evaluating the efficacy and safety of an OEOd-based wound dressing compared with standard wound care in patients with post-surgical diabetic foot ulcers.
- Trial name
- OEOd-DFU-pilot (NCT07368816)
- Testing
- OEOd-based wound dressing, Standard of Care (Investigator Choice)
- Where
- Italy
- Volunteers
- 40 people
- Sponsor
- Ospedale San Donato
Ischemia Reperfusion Injury
YSPSL for Prevention of Ischemic Reperfusion Injury in Patients Undergoing Cadaveric Orthotopic Liver Transplantation
The study is designed to assess the feasibility of evaluating YSPSL for the amelioration of ischemia reperfusion injury following liver transplantation by administering YSPSL into the liver graft directly ex vivo via the portal…
- Trial name
- YSPSL (NCT00876902)
- Testing
- recombinant P-selectin glycoprotein ligand Ig fusion protein, Viaspan® and saline
- Where
- United States
- Volunteers
- 36 people
- Sponsor
- Y's Therapeutics, Inc.
Hemorrhoids, Postoperative Pain
Botulinum Toxin A Before Hemorrhoidectomy to Prevent Postoperative Pain
Hemorrhoidectomy is an effective surgical treatment for advanced hemorrhoidal disease but is often associated with significant postoperative pain, which may delay recovery.
- Trial name
- BoTo-HEM (NCT07399860)
- Testing
- Botulinum toxin type A, Saline (0.9% NaCl)
- Where
- Russia
- Volunteers
- 292 people
- Sponsor
- Lomonosov Moscow State University Medical Research and Educational Center
Scheduled Cardiac Surgery With Extracorporeal Circulation, Vasoplegic Syndrome
Evaluation of the Superiority of VAsopressin Versus NOradrenaline in the Management of Patients at Risk of Kidney Failure Undergoing Cardiac Surgery With Extracorporeal Circulation
This is a randomized, double blind, multicenter study following surgery with extracorporeal circulation to compare blood pressure optimization with vasopressin versus noradrenaline.
- Trial name
- NOVACC (NCT05568160)
- Testing
- Vasopressin, Norepinephrine, Collection of clinical data
- Where
- France
- Volunteers
- 840 people
- Sponsor
- Centre Hospitalier Universitaire Dijon
Congenital Heart Disease, Perioperative/Postoperative Complications
Central Venous to Arterial CO2 Difference and Low Cardiac Output Syndrome Related Outcomes in Children After Cardiac Surgery
The goal of this clinical trial is to compare the capability of 3 different bedside surrogates in children who underwent cardiac surgery and were admitted in intensive care unit.
- Conditions
- Congenital Heart Disease, Perioperative/Postoperative Complications, Lactate Blood Increase
- Trial name
- VACO2 (NCT06292910)
- Testing
- arterial and central venous blood gas analysis, lactate
- Where
- Thailand
- Volunteers
- 136 people
- Sponsor
- Prince of Songkla University
Ischemia-Reperfusion Injury, Atherosclerosis
Does a Seven Day Treatment With Dipyridamole Induce Protection Against Ischemia-Reperfusion Injury?
This study is performed to determine whether a seven day treatment with dipyridamole (slow release, 200mg twice daily) can induce a protective effect against ischemia-reperfusion injury, after ischemic exercise of the…
- Trial name
- NCT00457405
- Testing
- dipyridamole
- Where
- Netherlands
- Volunteers
- 10 people, healthy volunteers welcome
- Sponsor
- Radboud University Medical Center
Analgesia, Inguinal Surgery
"Comparison of USG-Guided Caudal Versus Ilioinguinal/Iliohypogastric Nerve Block for Pediatric Inguinal Surgeries"
This study is designed to compare the analgesic effectiveness of caudal analgesia to ilioinguinal regional analgesia techniques in children undergoing inguinal surgeries.
- Conditions
- Analgesia, Inguinal Surgery, Undescended Testes, Hydrocele
- Trial name
- CAUCIN (NCT05558748)
- Testing
- USG-guided Caudal block, USG-guided Ilioinguinal/Iliohypogastric block
- Where
- Oman
- Volunteers
- 128 people
- Sponsor
- Sultan Qaboos University
Perioperative Cardiovascular Risk, Postoperative Complications (Cardiopulmonary)
AI-ECG for Preoperative Cardiovascular Risk Stratification Before General Surgery
This randomized controlled trial evaluates whether an artificial intelligence-enhanced electrocardiography (AI-ECG)-based strategy for preoperative cardiovascular risk stratification is noninferior to usual care in patients…
- Conditions
- Perioperative Cardiovascular Risk, Postoperative Complications (Cardiopulmonary), Preoperative Care
- Trial name
- NCT07774689
- Testing
- AI-ECG-based preoperative risk stratification (ECG Buddy)
- Where
- South Korea
- Volunteers
- 3,200 people
- Sponsor
- Seoul National University Bundang Hospital
Diabetic Retinopathy, Postoperative Recurrent Vitreous Hemorrhage
A Prospective Study of Ranibizumab in the Treatment of Postoperative Recurrent Vitreous Haemorrhage of Diabetic Retinopathy
Diabetic retinopathy (DR) is one of the main complications in diabetes, the proliferative diabetic retinopathy (PDR) is the most important one of the reasons leading to decreased vision, PDR is the stage of clinical intervention.
- Conditions
- Diabetic Retinopathy, Postoperative Recurrent Vitreous Hemorrhage, Pars Plana Vitrectomy, Ranibizumab
- Trial name
- NCT05248334
- Testing
- Ranibizumab Injection, PPV
- Where
- China
- Volunteers
- 120 people
- Sponsor
- Tianjin Medical University Eye Hospital
Surgical Site Infections, Venous Thromboembolism
Tumescent Antibiotic Delivery for Prevention of Surgical Site Infection
The principal aim of the present research is to compare two methods of antibiotic delivery: concomitant tumescent antibiotic delivery (TAD) and intravenous antibiotic delivery (IVAD) versus IVAD alone, (TAD+IVAD vs IVAD), with…
- Trial name
- NCT02503904
- Testing
- Concomitant Tumescent Antibiotic Delivery & IV Delivery, Subcutaneous Tumescent Infiltration, cecefazolin and metronidazole (in a dilute solution of tumescent lidocaine, epinephrin and sodium bicarbonate in 0.9% physiologic saline)
- Volunteers
- 400 people
- Sponsor
- Klein, Jeffrey A., M.D.
Post-operative Pain, Post-cardiac Surgery
Paravertebral Block for Improvement of Quality of Recovery Following Cardiac Surgery
This study aims to evaluate the efficacy of bilateral, paravertebral blockade (intervention) against sham blocks (control) placed prior to sternotomy in improving quality of recovery following cardiac surgery.
- Conditions
- Post-operative Pain, Post-cardiac Surgery, Cardiac Disease
- Trial name
- NCT06008821
- Testing
- Bilateral paravertebral block with 0.25% ropivicaine with 1:400,000 epinephrine
- Where
- Canada
- Volunteers
- 224 people
- Sponsor
- University of British Columbia
Incisional Hernia, Venous Thromboembolism
Risk Factors of Venous Thromboembolism After Incisional Ventral Hernia Repair.
Aim of our study is to find frequency and risk factors for venous thromboembolism development in patients who underwent surgery for incisional ventral hernia.
- Trial name
- NCT05439187
- Testing
- hernia repair
- Where
- Russia
- Volunteers
- 240 people
- Sponsor
- Pirogov Russian National Research Medical University
Hemorrhoid
Study of Pain Control in Hemorrhoidectomy
Patients will get an injection of either SKY0402 or placebo during hemorrhoid surgery, and their pain and pain medicine use will be monitored.
- Trial name
- NCT00890721
- Testing
- SKY0402
- Where
- Poland
- Volunteers
- 189 people
- Sponsor
- Pacira Pharmaceuticals, Inc
Reperfusion Injuries, Myocardial
The Role of Mitochondrial Respiration in the Cardioprotective Capacity of IPC in Diabetic and Non-diabetic Patients
The overall aim of this study is to examine the role of mitochondrial respiration in human diabetic tissue before and after ischemia.
- Trial name
- NCT02993484
- Testing
- Dimethyl Malonate, Ischemic preconditioning, Ischemia reperfusion
- Volunteers
- 39 people
- Sponsor
- University of Aarhus
Mitral Regurgitation, Pain, Postoperative
Cryoablation of Intercostal Nerves for Pain Management in Early Postoperative Period in Patients With Minimally Invasive Mitral Valve Surgery
A single-center, pilot, prospective, randomized clinical trial with a 1:1 allocation ratio. The aim of our trial is to determine whether cryoablation of intercostal nerves provides a clinically significant analgesic effect, which…
- Trial name
- BLOCK (NCT06443931)
- Testing
- cryoablation of intercostal nerves
- Where
- Russia
- Volunteers
- 30 people
- Sponsor
- Meshalkin Research Institute of Pathology of Circulation
No Reflow Phenomenon, Reperfusion Injuries, Myocardial
Evaluating SGLT2 Inhibitors for the Reduction of No-Reflow Phenomenon in Patients Undergoing PCI
Study Background \& Purpose: The no-reflow phenomenon is a significant complication occurring in patients with acute myocardial infarction who undergo percutaneous coronary intervention (PCI).
- Conditions
- No Reflow Phenomenon, Reperfusion Injuries, Myocardial, Myocardial Infarction, STEMI - ST Elevation Myocardial Infarction
- Trial name
- NCT07898709
- Testing
- Empagliflozin (SGLT2i), dapagliflozin, Standard medical treatment
- Where
- 4 sites in Egypt
- Volunteers
- 100 people
- Sponsor
- Al-Azhar University