Clinical trials: Postoperative Cognitive Function
Osteoarthritis, Femoral Head Necrosis
Donepezil Attenuate Postoperative Cognitive Dysfunction
Postoperative cognitive dysfunction (POCD) occurs mainly in aged patients. POCD may increase the mortality and morbidity. However, the mechanism of POCD is not clear yet and no effective therapy method was proved.
- Conditions
- Osteoarthritis, Femoral Head Necrosis, Rheumatoid Arthritis
- Trial name
- DAPOCD (NCT02927522)
- Testing
- Donepezil
- Where
- China
- Volunteers
- 550 people, healthy volunteers welcome
- Sponsor
- RenJi Hospital
Alzheimer Disease
Differential Effects of Various Anesthetic Agents on Cognitive Function in Patients With Alzheimer's Disease
The objective of the study is to determine the effects of different anesthetic agents on cognitive function in patients with Alzheimer's disease (AD).
- Trial name
- NCT01870453
- Where
- United States
- Volunteers
- healthy volunteers welcome
- Sponsor
- Massachusetts General Hospital
Postoperative Cognitive Dysfunction, Postoperative Delirium
Study of Depressive Symptoms Predicting Postoperative Cognitive Dysfunction
Postoperative cognitive dysfunction (POCD) describes a condition where cognitive functions such as attention, perception, concentration, learning, abstract thinking and problem solving are impaired postoperatively.
- Conditions
- Postoperative Cognitive Dysfunction, Postoperative Delirium, Depressive Symptoms
- Trial name
- DeprPOCD (NCT02210312)
- Where
- Germany
- Volunteers
- 300 people, healthy volunteers welcome
- Sponsor
- Universitätsklinikum Hamburg-Eppendorf
Melatonin, Cognitive Dysfunction
Use of Melatonin for Preventing POCD in Transurethral Prostate Resection Under Spinal Anesthesia
This study aims to evaluate the possible effect of melatonin on prevention of cognitive dysfunction in the postoperative period of elderly patients undergoing transurethral resection of the prostate (TURP) under spinal anesthesia
- Conditions
- Melatonin, Cognitive Dysfunction, Postoperative Complications, Prostate Hyperplasia
- Trial name
- NCT03966950
- Testing
- melatonin
- Where
- Brazil
- Volunteers
- 104 people, healthy volunteers welcome
- Sponsor
- University of Sao Paulo
Postoperative Cognitive Dysfunction
Effects of Thoracic Paravertebral Block Combined With S-ketamine on Postoperative Pain and Cognitive Function After Thoracoscopic Surgery
To investigate the effect of ultrasound-guided thoracic paravertebral nerve block combined with intraoperative infusion of s-ketamine on postoperative acute pain and cognitive function in patients with thoracoscopic surgery
- Trial name
- NCT05341375
- Testing
- Thoracic paravertebral block, Esketamine, Measurement of cognitive function
- Where
- China
- Volunteers
- 110 people, healthy volunteers welcome
- Sponsor
- The First Hospital of Qinhuangdao
Elective Surgery, Postoperative Cognitive Dysfunction
Effect Of Aspirin Preoperative on Postoperative Cognitive Dysfunction In Elderly Patients Undergoing Knee Arthroplasty
Studies have shown that the lifetime risk of developing symptomatic knee osteoarthritis is 40% in men and 47% in women; and the risk can be increased to 60% when the patient's BMI reaches 30 kg/m2.
- Conditions
- Elective Surgery, Postoperative Cognitive Dysfunction, Knee Arthroplasty
- Trial name
- NCT04225702
- Where
- China
- Volunteers
- 220 people, healthy volunteers welcome
- Sponsor
- Xuzhou Medical University
Delirium, Cognitive Impairment
Stanford ICU Delirium PIPRA Study
The purpose of this study is to determine the accuracy of the Pre-Interventional Preventive Risk Assessment (PIPRA) tool in predicting clinical cases of Intensive Care Units (ICU)-delirium, in a population at high risk of…
- Conditions
- Delirium, Cognitive Impairment, Delirium, Postoperative
- Trial name
- SIDPVS (NCT06519890)
- Where
- United States
- Volunteers
- 199 people, healthy volunteers welcome
- Sponsor
- Stanford University
Post-Operative Delirium, Postoperative Cognitive Dysfunction
Role of Absolute Cerebral Oximetry to Prevent Neurocognitive Injury in Elderly Patients Undergoing Cardiac Surgery
The purpose of this study is to determine whether brain oxygenation measured by cerebral oximeter has an impact on neurocognitive dysfunction.
- Trial name
- NCT00991328
- Testing
- SctO2 < 60 %.
- Where
- United States
- Volunteers
- 15 people, healthy volunteers welcome
- Sponsor
- Icahn School of Medicine at Mount Sinai
Cognitive and Behavioral Impairment
Incidence of Postoperative Cognitive Decline in Patients With Preexisting Cognitive Impairment
This study aims to find out how often memory and thinking problems happen after surgery in people who already have memory issues before their operation. These memory problems are called postoperative cognitive decline (POCD).
- Trial name
- NCT07135336
- Testing
- surgery, norma
- Where
- China
- Volunteers
- 340 people, healthy volunteers welcome
- Sponsor
- Peking University Shenzhen Hospital
Cognitive Dysfunction
Ketamine vs Midazolam on Cognitive Function in Elderly in Elective Surgery Three-Months Postoperatively (ketaminvsMDZ)
Deterioration of posoperative cognitive function (DCPO) is an intermediate state between normal cognitive aging and dementia, defined as a cognitive alteration greater than expected for the patient's age and educational level…
- Trial name
- ketaminvsMDZ (NCT04134052)
- Testing
- ketamine sedation versus midazolam sedation
- Where
- Mexico
- Volunteers
- 68 people, healthy volunteers welcome
- Sponsor
- Universidad de Colima
Postoperative Cognitive Dysfunction
Normative Data for the Qmci-TW in a Taiwanese Sample
Many perioperative factors have been pointed out as the risk factors for postoperative cognitive dysfunction, which may occur immediately after the surgery, days after the surgery, or months after the surgery.
- Trial name
- NCT04598178
- Where
- Taiwan
- Volunteers
- 30 people, healthy volunteers welcome
- Sponsor
- National Taiwan University Hospital