Clinical trials: Postoperative Gastrointestinal Dysfunction
Postoperative Ileus, Postoperative Complications
Coffee After Pancreatic Surgery
Postoperative ileus is a common complication after major abdominal surgery. A positive effect of coffee to bowel movement has been described after colorectal and gynecologic interventions.
- Conditions
- Postoperative Ileus, Postoperative Complications, Bowel Dysfunction, Pancreatic Diseases
- Trial name
- COPS (NCT04205058)
- Testing
- Standard coffee, Caffeine-free coffee, Drinking water
- Where
- Italy
- Volunteers
- 204 people
- Sponsor
- Azienda Ospedaliera Universitaria Integrata Verona
Rare Disorders, Undiagnosed Disorders
Rare Disease Patient Registry & Natural History Study - Coordination of Rare Diseases at Sanford
The Coordination of Rare Diseases at Sanford (CoRDS) is an international patient registry that serves as a centralized resource for rare disease research.
- Conditions
- Rare Disorders, Undiagnosed Disorders, Disorders of Unknown Prevalence, Cornelia De Lange Syndrome
- Trial name
- CoRDS (NCT01793168)
- Where
- United States
- Volunteers
- 20,000 people
- Sponsor
- Sanford Health
Liver Cancer, Hepatectomy
Effects of Different Anesthetic Techniques on Intraoperative and Postoperative Pain Levels and Cognitive Function in Patients Undergoing Hepatectomy for Liver Cancer
To evaluate the effects of general anesthesia (GA) versus combined general and epidural anesthesia (GEA) on postoperative pain, cognitive dysfunction (POCD), hospital stay, and recovery quality in liver cancer patients undergoing…
- Conditions
- Liver Cancer, Hepatectomy, Anesthesia Techniques, Postoperative Pain
- Trial name
- NCT07097220
- Testing
- General Anesthesia (GA) group, General-Epidural Anesthesia (GEA) group
- Where
- China
- Volunteers
- 106 people
- Sponsor
- Sir Run Run Shaw Hospital, Qingchun Campus, Zhejiang University School of Medicine,
Ileus
Study of Alvimopan for the Management of Opioid-induced Postoperative Bowel Dysfunction/ Postoperative Ileus
Patients undergoing major abdominal surgery are at highest risk for developing postoperative ileus (POI), occurring in nearly all cases.
- Trial name
- NCT00388479
- Testing
- Alvimopan
- Where
- United States
- Volunteers
- 666 people
- Sponsor
- Cubist Pharmaceuticals LLC, a subsidiary of Merck & Co., Inc. (Rahway, New Jersey USA)
Postoperative Gastric Distension, Postoperative Gastrointestinal Dysfunction
Anti-Bloating Patch for Postoperative Gastric Distension After Cardiac Surgery
Postoperative gastric distension is a common gastrointestinal complication after cardiac surgery and may delay recovery, prolong intensive care unit (ICU) stay, and reduce patient comfort.
- Conditions
- Postoperative Gastric Distension, Postoperative Gastrointestinal Dysfunction, Cardiac Surgery
- Trial name
- ABP-CS (NCT07677423)
- Testing
- Anti-Bloating Patch, Standard Perioperative Care
- Where
- China
- Volunteers
- 150 people
- Sponsor
- Southeast University, China
Gastrointestinal Dysfunction
Effects of Intraoperative Stimulation of Acupoints on Postoperative Gastrointestinal Motility Recovery
1. Research name: Effects of intraoperative stimulation of acupoints on postoperative gastrointestinal motility recovery in patients undergoing non-gastrointestinal abdominal surgery. 2. Research center: Multicenter research 3.
- Trial name
- NCT03724656
- Testing
- acupuncture treatment
- Volunteers
- 600 people
- Sponsor
- Tianjin Nankai Hospital
Obesity, Postoperative Gastrointestinal Dysfunction
Effect of TAP Block on GI Function After Sleeve Gastrectomy Using PRO-diGI Scale and Perlas Score
This prospective clinical study aims to evaluate the effect of Transversus Abdominis Plane (TAP) block on postoperative gastrointestinal function in patients undergoing laparoscopic sleeve gastrectomy.
- Trial name
- TAP (NCT07168538)
- Testing
- TAP Block Group, Control Group
- Where
- Turkey (Türkiye)
- Volunteers
- 60 people
- Sponsor
- Elazıg Fethi Sekin Sehir Hastanesi
Liver Dysfunction, Morbidity
Von Willebrand Factor to Predict Postoperative Outcome
vWF is stored in weibel-palade-bodies of endothelial cells as well as alpha-granula of platelets and is released upon their activation.
- Conditions
- Liver Dysfunction, Morbidity, Mortality, Hospitalisation
- Trial name
- NCT02118545
- Where
- 4 sites in Austria, Switzerland
- Volunteers
- 133 people
- Sponsor
- Medical University of Vienna
Low Anterior Resection Syndrome, Radiotherapy
Development and Validation of The Post-RT LARS Prediction Model (PORTLARS)
Bowel dysfunction is common after a restorative rectal cancer resection. Neoadjuvant radiotherapy is an influential factor that impairs bowel function and quality of life.
- Conditions
- Low Anterior Resection Syndrome, Radiotherapy, Rectal Cancer
- Trial name
- PORTLARS (NCT05129215)
- Testing
- Questionnaire
- Where
- China
- Volunteers
- 901 people
- Sponsor
- Sixth Affiliated Hospital, Sun Yat-sen University
Empty Pelvis Syndrome, Pelvic Exenteration
PelvEx - Beating the Empty Pelvis Syndrome
The empty pelvis syndrome is an unsolved and poorly defined problem severely affecting patients that have pelvic exenteration surgery, and also the teams looking after them.
- Conditions
- Empty Pelvis Syndrome, Pelvic Exenteration, Pelvic Neoplasm, Pelvic Cancer
- Trial name
- NCT05683795
- Testing
- Consensus study
- Where
- United Kingdom
- Volunteers
- 150 people, healthy volunteers welcome
- Sponsor
- University of Southampton
Rejection Acute Hepatic, Transplant; Failure, Liver
Single-center Prospective Study of Non-invasive Methods for the Diagnosis of Postoperative Complications in Liver Transplant Recipients
A lot of different early and late complications may occur after liver transplantation. They could be related to surgical procedure, to infectious diseases or immuno-mediated diseases (acute cellular rejection, ACR).
- Conditions
- Rejection Acute Hepatic, Transplant; Failure, Liver, Liver Dysfunction
- Trial name
- ElastOLT (NCT05793203)
- Where
- Italy
- Volunteers
- 100 people
- Sponsor
- Fondazione Policlinico Universitario Agostino Gemelli IRCCS
Rectal Cancer, Low Anterior Resection Syndrome
The Effects of Kegel Exercise Combined With Biofeedback Therapy on Bowel Function Recovery, Emotional Distress, and Quality of Life in Patients Following Low Anterior Resection for Rectal Cancer
This randomized controlled trial aims to evaluate the effects of combining Kegel exercise with a single biofeedback session on bowel function, emotional distress, and quality of life in patients who have undergone low anterior…
- Conditions
- Rectal Cancer, Low Anterior Resection Syndrome, LARS - Low Anterior Resection Syndrome
- Trial name
- BFT in LARS (NCT07253298)
- Testing
- Kegel Exercise with Biofeedback, Kegel Exercise Only
- Where
- Taiwan
- Volunteers
- 66 people
- Sponsor
- National Taiwan University Hospital
Gastrointestinal Dysfunction, Surgery
Postoperative Gastrointestinal Dysfunction After High Risk Surgery
This study aims to find out the role of plasma I-FABP level, SOFA score, fluid balance, and vasopressor dose in predicting gastrointestinal dysfunction in high-risk postoperative patients treated in ICU
- Conditions
- Gastrointestinal Dysfunction, Surgery, Postoperative Complications
- Trial name
- NCT05867043
- Where
- Indonesia
- Volunteers
- 66 people
- Sponsor
- Aldy Heriwardito
Nutritional Deficiency, Ileostomy; Functional Disturbance
Absorption of Peptides, Fluid, and Electrolytes in Patients With an Ileostomy
Clinical trial, active comparator, cross over, randomised. In total, 12 adults with an ileostomy will be randomised to a sequential 4 weeks intervention with different qualities and sources of protein wish 2-week washout periods.
- Conditions
- Nutritional Deficiency, Ileostomy; Functional Disturbance, Short Bowel Syndrome, Absorption; Disorder, Protein
- Trial name
- ABSOLYT (NCT04141826)
- Testing
- Hydrolysed whey, Intact whey, Caseinate
- Where
- Denmark
- Volunteers
- 14 people, healthy volunteers welcome
- Sponsor
- Christian Hvas
Gastrointestinal Dysfunction, Anxiety
Does Acupressure Affect Gastrointestinal Function, Pain and Anxiety?
The aim of this randomised, placebo-controlled, 3-way blinded study was to determine the effect on GIS symptoms, pain and anxiety of acupressure applied for a total of 12 mins, as 3 mins at each of the ST25, CV12, TH6 and HT7…
- Conditions
- Gastrointestinal Dysfunction, Anxiety, Pain, Postoperative
- Trial name
- NCT04606485
- Testing
- Acupressure
- Where
- Turkey (Türkiye)
- Volunteers
- 53 people, healthy volunteers welcome
- Sponsor
- Kahramanmaras Sutcu Imam University
Oesophageal Atresia, Dumping Syndrome
Dumping Syndrome and Esophageal Atresia
Dumping syndrome (DS) is frequent in oesophageal atresia (29%). In causing hypoglycaemia, it can be dangerous for neonates. Mechanisms of DS are actually partialy understood.
- Trial name
- DUMTORING (NCT04522193)
- Testing
- Glycemic Holter, gastric emptying scintigraphy, Holter ECG
- Where
- 2 sites in France
- Volunteers
- 15 people
- Sponsor
- University Hospital, Lille
Postoperative Complications, Postoperative Gastrointestinal Dysfunction (POGD)
Abdominal Acupuncture for Gastrointestinal Function Recovery After Gynecologic Laparoscopic Surgery
Current research on the role of abdominal acupuncture in promoting postoperative gastrointestinal recovery remains limited, characterized by a lack of large-scale, standardized clinical trials, particularly with respect to…
- Conditions
- Postoperative Complications, Postoperative Gastrointestinal Dysfunction (POGD), Postoperative Ileus
- Trial name
- NCT07293026
- Testing
- Abdominal acupuncture, Standard postoperative management protocol
- Where
- China
- Volunteers
- 80 people
- Sponsor
- Mengyao Han
Low Anterior Resection Syndrome
Translation of the International Consensus Definition of LARS Into a Bowl Dysfunction Severity Scoring Tool (New LARS Score)
The purpose of this study is to develop a new severity scoring tool for Low Anterior Resection Syndrome (LARS) drawing on the international consensus criteria for LARS as well as opinions of patients with lived-experience of LARS.
- Trial name
- NCT05605600
- Where
- United Kingdom
- Volunteers
- 8 people
- Sponsor
- Cardiff and Vale University Health Board
Cholestasis, Short Bowel Syndrome
Compassionate Use of Omegaven for Pediatric Patients With Parenteral Nutrition Associated Liver Disease
A compassionate use protocol to provide Omegaven to pediatric patients with parenteral nutrition (PN) dependence and parenteral nutrition associated liver disease (PNALD).
- Trial name
- Omegaven (NCT01297933)
- Testing
- Omegaven
- Where
- United States
- Sponsor
- Children's Hospital of Philadelphia
Postoperative Gastrointestinal Dysfunction
A Phase Ⅱ Study of Mosapride Citrate Injection in the Treatment of Postoperative Gastrointestinal Dysfunction
This study is a multicenter, randomized, double-blind, parallel, placebo-controlled phase II clinical study.
- Trial name
- NCT06782594
- Testing
- Mosapride Citrate Injection(high), Mosapride Citrate Injection(low)
- Where
- 2 sites in China
- Volunteers
- 150 people
- Sponsor
- Shandong New Time Pharmaceutical Co., LTD