Clinical trials: Postoperative Ileus.
Postoperative Ileus
Lidocaine Infusion in Radical Cystectomy
Radical cystectomy (RC) remains the gold standard for treatment of patients with muscle invasive bladder cancer, or recurrent high grade non-muscle invasive bladder cancer.
- Trial name
- NCT03047057
- Testing
- Lidocaine, IV normal saline
- Where
- Egypt
- Volunteers
- 57 people
- Sponsor
- Assiut University
Postoperative Ileus
The Effect of Coffee Consumption in Enhancing Recovery of Bowel Function Following Colorectal Surgery.
The effects of coffee have been shown to act as a colonic stimulant. Caffeinated coffee stimulates colonic activity, most notably in the transverse/descending colon, in magnitude similar to a meal, 60% stronger than water, and…
- Trial name
- NCT02639728
- Testing
- Regular Coffee, Decaffeinated coffee, Warm water
- Where
- United States
- Volunteers
- 90 people
- Sponsor
- Cedars-Sinai Medical Center
Perforated Duodenal Ulcer
Early Oral Feeding vs Traditional Post-operative Care In Emergency Abdominal Surgeries
ABSTRACT BACKGROUND: Enhanced recovery after surgery (ERAS) protocols have been widely studied in elective abdominal surgeries and have shown better outcomes.
- Trial name
- NCT04431037
- Testing
- Early oral feeding/Enhanced recovery after surgery protocols
- Where
- Pakistan
- Volunteers
- 36 people, healthy volunteers welcome
- Sponsor
- College of Physicians and Surgeons Pakistan
Pain, Postoperative, Anesthesia Complication
Laparoscopic Cholecystectomy: General Anesthesia With Opioid Versus General Opioid Free Anesthesia
The use of opioid during surgery can cause side effects and may delay hospital discharge. Some studies have shown balanced sparing opioid anesthesia can optimize the side effects and and the time of discharge.
- Conditions
- Pain, Postoperative, Anesthesia Complication, Nausea, Vomiting
- Trial name
- GALOFF (NCT02953210)
- Testing
- dexter ketamine, Lidocaine Hydrochloride, Fentanyl Hydrochloride
- Where
- 2 sites in Brazil
- Volunteers
- 40 people
- Sponsor
- Federal University of São Paulo
Prevention of Post Operative Ileus
Perioperative Use of a Selective COX2 Inhibitor in Patients Undergoing Elective Colorectal Surgery: the Effect on Post-operative Bowel Motility and Post-operative Pain
Perioperative Celecoxib to promote bowel movement and to reduce post-operative pain after elective colonic resection.
- Trial name
- NCT02790203
- Testing
- Celecoxib
- Volunteers
- 100 people
- Sponsor
- Sheba Medical Center
Postoperative Ileus
Dexamethasone in the Prevention of Post-spinal Paralytic Ileus After Cesarean Section
Postoperative ileus is a perplexing problem for clinical surgeons. It occurs not only after abdominal surgery but also after any surgery that requires general anesthesia.
- Trial name
- NCT05654649
- Testing
- 0.9%sodium chloride, Dexamethasone
- Where
- Egypt
- Volunteers
- 90 people
- Sponsor
- Assiut University
Post-operative Ileus
Post-operative Ileus and Gut Microbiota
Postoperative ileus (POI) is a common clinical condition after abdominal surgical procedure, leading to increased patient morbidity and prolonged hospitalisation.The mechanism of POI is not very clear until now.
- Trial name
- NCT04009954
- Testing
- Fecal and blood samples collection for analysis
- Where
- China
- Volunteers
- 40 people
- Sponsor
- First Affiliated Hospital of Harbin Medical University
Ileus Postoperative
Effect of Lollipop on Postoperative Gastrointestinal Recovery in Children
Postoperative ileus is common in children. There are various method to prevent postoperative ileus. In this study, the investigators will explore the role of sucking lollipop after operation on the recovery of gastrointestinal…
- Trial name
- NCT06108011
- Testing
- Lollipop
- Where
- Hong Kong
- Volunteers
- 50 people
- Sponsor
- The University of Hong Kong
Postoperative Ileus (Post Cardiac Surgery Constipation)
Effect of Naloxegol on Postoperative Ileus in Patients Undergoing Cardiac Surgery
Postoperative ileus, defined as the transient postoperative functional inhibition of propulsive bowel activity, commonly occurs in patients after cardiac surgery and contributes to postoperative morbidity.
- Trial name
- TRANSIT (NCT04433390)
- Testing
- Naloxegol, inert tablet
- Where
- France
- Volunteers
- 305 people
- Sponsor
- CMC Ambroise Paré
Stoma Ileostomy, Stoma Colostomy
Conventional Hand Sewn End-To-End Anastomosis Versus Side-To-Side Anastomosis for Stoma Reversal: A Prospective Study
The goal of this clinical trial is to compare approaches to enterostomy reversal by hand-sewn end-to-end anastomosis versus side-to-side anastomosis (sub-divided into hand-sewn side-to-side anastomosis and stapled side-to-side…
- Conditions
- Stoma Ileostomy, Stoma Colostomy, Anastomosis, Ileus
- Trial name
- NCT05753709
- Testing
- Hand sewn end-to-end anastomosis, Hand sewn side-to-side anastomosis, Stapled side-to-side anastomosis
- Where
- India
- Volunteers
- 38 people
- Sponsor
- Sawai Mansingh Medical College
Ileus
Subcutaneous Electrical Stimulation in the Prevention of Postoperative Ileus
Assess whether the application of electrical stimulation in patients undergoing subcutaneous colon cancer in a Multimodal Rehabilitation Program (Fast track) decreases the incidence of postoperative ileus, improving the results…
- Trial name
- SESPI (NCT02399605)
- Testing
- Stimulation
- Where
- 2 sites in Spain
- Volunteers
- 500 people
- Sponsor
- Hospital General Universitario Elche
Ileus
Prevention of Ileus After Gynecologic Surgery Using Chewing Gum
This study will attempt to determine if the use of chewing gum can cause the early return of bowel function after gynecologic surgery.
- Trial name
- NCT00831246
- Testing
- chewing gum - Extra Winterfresh, Standard Post-Op Care
- Where
- United States
- Volunteers
- 400 people
- Sponsor
- Aultman Health Foundation
Post Operative Ileus
Predictive Validity of Acoustic Gastrointestinal Surveillance (AGIS) in Post-Operative Feeding
This study will measure the accuracy of a disposable, non-invasive device for the continuous monitoring of abdominal sounds, called the AGIS sensor (Acoustic Gastro-Intestinal Surveillance) in predicting patients' intolerance to…
- Trial name
- AGIS (NCT02065583)
- Where
- United States
- Volunteers
- 100 people
- Sponsor
- VA Greater Los Angeles Healthcare System
Delay in GI Recovery/Postoperative Ileus (POI)
TU-100 for Accelerating GI Recovery After Major Abdominopelvic Surgery (RC & CAWR)
This Phase 2, multicenter, randomized, double-blind, placebo-controlled master protocol study will evaluate the safety and efficacy of TU-100, adjunctive to an Enhanced Recovery After Surgery (ERAS) pathway, for accelerating…
- Trial name
- NCT07765589
- Testing
- TU-100
- Volunteers
- 240 people
- Sponsor
- Tsumura USA
Colorectal Cancer
Acupressure on Postoperative Ileus in Patients With Colorectal Cancer Surgery
The goal of this clinical trial is to learn about acupressure in patients with colorectal cancer surgery. The main questions it aims to answer are: whether acupressure can improve the motility of vagus nerve in patients after…
- Trial name
- NCT06118060
- Testing
- Acupressure
- Volunteers
- 104 people
- Sponsor
- Qilu Hospital of Shandong University
Postoperative Ileus
Study to Evaluate the Safety of Post-Operative TZP-101 (IV Ulimorelin) After Partial Bowel Resection
A study to evaluate the safety of TZP-101 in comparison with placebo when administered post-operatively in patients who have undergone partial bowel resection.
- Trial name
- NCT01710982
- Testing
- TZP-101
- Volunteers
- 27 people
- Sponsor
- Norgine
Ileus Postoperative
Preventing Gastrointestinal Disturbance in Patients After Longitudinal Laparotomy.
This is a multi-center, randomized, double blind, placebo-controlled, phase 2 pilot efficacy study.
- Trial name
- ORE001PIIPOI (NCT05923086)
- Testing
- ORE001
- Where
- 3 sites in Germany
- Volunteers
- 126 people
- Sponsor
- Orexa BV
Hysterectomy, Gastrointestinal Motility Disorder
Coffee Consumption After Laparoscopic Hysterectomy
Postoperative ileus and delayed bowel recovery remain common concerns following laparoscopic hysterectomy despite enhanced recovery protocols.
- Conditions
- Hysterectomy, Gastrointestinal Motility Disorder, Postoperative Ileus
- Trial name
- COFFEE-LH (NCT07686510)
- Testing
- Postoperative Coffee Consumption
- Where
- Turkey (Türkiye)
- Volunteers
- 50 people
- Sponsor
- Istanbul Medipol University Hospital
Bladder Cancer, Cystostomy; Complications
Evaluation of Naloxegol in the Prevention of POI After Cystectomy
Postoperative ileus (POI) is defined as a transient reduction of bowel motility that prevents effective transit of bowel content and tolerance of oral intake following surgical interventions, especially after radical cystectomy.
- Trial name
- ANTAGOCYST (NCT04219046)
- Testing
- Naloxégol oxalate
- Sponsor
- Institut Paoli-Calmettes
Post-Operative Ileus (POI)
Study of Intravenous (IV) Methylnaltrexone Bromide (MNTX) in the Treatment of Post-Operative Ileus (POI)
To evaluate the safety and efficacy of MNTX in participants who have undergone segmental colectomy and to assess if the time between the end of surgery and the first bowel movement is significantly shorter in the MNTX regimen…
- Trial name
- NCT00401375
- Testing
- Methylnaltrexone
- Where
- United States
- Volunteers
- 524 people
- Sponsor
- Bausch Health Americas, Inc.