Clinical trials: Postpartum Endometritis
Meconium Stained, Azithromycin
Efficacy of Azithromycin in MSAF Cases to Improve Maternal and Neonatal Outcomes
Meconium stained amniotic fluid increases the risk of maternal complications (e.g., dystocia, operative delivery, and postpartum endometritis) and neonatal complications (e.g., sepsis, admission to the neonatal intensive care…
- Conditions
- Meconium Stained, Azithromycin, Postpartum Endometritis
- Trial name
- NCT05118984
- Testing
- Azithromycin capsule (Zithromax, Pfizer) (250 mg)
- Where
- 2 sites in Egypt
- Volunteers
- 324 people, healthy volunteers welcome
- Sponsor
- Cairo University
Obstetric Complication, Postpartum Hemorrhage
Antibiotics During Intrauterine Balloon Tamponade Placement
The goal of this study is to identify whether antibiotics given at the time of placement of an intrauterine balloon tamponade (IBT) will result in reduction of the risk of endometritis.
- Conditions
- Obstetric Complication, Postpartum Hemorrhage, Postpartum Endometritis
- Trial name
- NCT03478163
- Testing
- CeFAZolin 1000 MG, Clindamycin 900 MG in 6 ML Injection
- Where
- United States
- Volunteers
- 11 people
- Sponsor
- Cedars-Sinai Medical Center
Postoperative Infection
RCT of Postoperative Infections Following Caesarean Section Infections Following Caesarean Section
Background Women undergoing Caesarean Section (CS) have an increased risk of postpartum infections compared to women undergoing vaginal delivery. In Denmark the incidence of post-CS infections is 7-10%.
- Trial name
- APIPICS (NCT02009098)
- Testing
- Cefuroxime
- Where
- 3 sites in Denmark
- Sponsor
- Odense University Hospital
Postpartum Endometritis
Does Preoperative Vaginal Preparation With Povidone-iodine Before Cesarean Delivery Reduce the Risk of Endometritis?
Cesarean delivery rates are increasing in Turkey and a major component of this increase is cesarean on demand. Although data on the rate of cesarean delivery in Turkey is limited, a national study reported a rate of 23.8%.
- Trial name
- NCT01437228
- Testing
- povidone- iodine solution.
- Where
- Turkey (Türkiye)
- Volunteers
- 668 people, healthy volunteers welcome
- Sponsor
- Erzincan Military Hospital
Chorioamnionitis, Intrauterine Infection
Effect of Sterile Versus Clean Gloves Intrapartum and Postpartum Infections at Term
This prospective randomized controlled study examines whether the type of glove used (sterile vs clean) for cervical examination to assess progression in labor impacts the rates of intrapartum and/or postpartum infection in…
- Conditions
- Chorioamnionitis, Intrauterine Infection, Postpartum Endometritis, Puerperal Infection
- Trial name
- NCT05603624
- Testing
- Cervical examination to assess labor
- Where
- United States
- Volunteers
- 163 people, healthy volunteers welcome
- Sponsor
- Eastern Virginia Medical School
Postpartum Sepsis, Postpartum Endometritis
Antibiotic Prophlaxis for High-risk Laboring Women in Low Income Countries
This study, performed over a course of 3 years in 5 collaborating hospitals in Cameroon, Africa, will randomize 750 women in labor with prolonged rupture of membranes ≥ 8 hours or prolonged labor ≥ 18 hours to identical oral…
- Conditions
- Postpartum Sepsis, Postpartum Endometritis, Postpartum Fever
- Trial name
- NCT03248297
- Testing
- Azithromycin, Azithromycin and amoxicillin
- Where
- Cameroon
- Volunteers
- 756 people, healthy volunteers welcome
- Sponsor
- University of Alabama at Birmingham
The Primary Outcome of This Study Will be the Rate of Endometritis
Treatment Utility of Postpartum Antibiotics in Chorioamnionitis
To determine if prophylactic postpartum antibiotics are required post-cesarean delivery for pregnancies with treated chorioamnionitis.
- Trial name
- TUPAC (NCT01585129)
- Testing
- Postpartum Antibiotics, No postpartum antibiotics
- Where
- 2 sites in United States
- Volunteers
- 80 people, healthy volunteers welcome
- Sponsor
- Washington University School of Medicine
Cesarean Section Complications
Association of Placenta Removal Method and Postpartum Leucocytosis
Cesarean delivery is one of the most common major abdominal operation in women worldwide. The incidence of postpartum infection has been estimated to be 1-4% after vaginal delivery and 10-20% after Cesarean delivery.
- Trial name
- NCT04323241
- Testing
- Controlled cord traction
- Where
- Turkey (Türkiye)
- Volunteers
- 300 people, healthy volunteers welcome
- Sponsor
- Haydarpasa Numune Training and Research Hospital
Endometritis
Pharmacokinetics and Safety of Ertapenem in the Postpartum Period
The investigators are doing this study to learn more about the dosing and safety of ertapenem in women with suspected serious infections less than 42 days from the delivery of their infant.
- Trial name
- NCT01587495
- Testing
- Ertapenem
- Where
- United States
- Volunteers
- 3 people
- Sponsor
- Daniel Benjamin
Endometritis Postpartum, Endometritis
Antibiotic Prophylaxis in Ragged Placental Membranes
In some centres, women are routinely given a course of antibiotics postnatally if ragged placental membranes were present at delivery. The investigators examined the necessity such an intervention.
- Conditions
- Endometritis Postpartum, Endometritis, Membranes; Retained
- Trial name
- NCT03459599
- Testing
- Prophylactic antibiotics, No prophylaxis (Amox-clav withheld)
- Volunteers
- 716 people, healthy volunteers welcome
- Sponsor
- Sarawak General Hospital
Surgical Site Infection, Cesarean Section; Complications, Wound, Infection (Following Delivery)
The Use of Steri3X for Prevention of Post-operative Wound Infections in Cesarean Sections
Postpartum infection if a major cause of maternal morbidity and mortality and surgical site infections are some of the common complications following cesarean section.
- Conditions
- Surgical Site Infection, Cesarean Section; Complications, Wound, Infection (Following Delivery), Postpartum Complication
- Trial name
- NCT05392400
- Testing
- Steri3X, Control
- Where
- United States
- Volunteers
- 1,000 people, healthy volunteers welcome
- Sponsor
- University of Tennessee
Chorioamnionitis, Puerperal Endometritis
Antibiotic Prophylaxis in Prelabor Rupture of Membranes at Term
The aims of this study are to determine whether antibiotics administered routinely in women presenting with premature rupture of membranes later than the 37+0 weeks of gestation can alter the rate of maternal and neonatal…
- Conditions
- Chorioamnionitis, Puerperal Endometritis, Neonatal Early Onset Sepsis, Neonatal Meningitis
- Trial name
- NCT01633294
- Testing
- Ampicillin + gentamicin
- Where
- Portugal
- Volunteers
- 161 people
- Sponsor
- Hospital de Santa Maria, Portugal
Postpartum Hemorrhage, Maternal Morbidity
Secondary Postpartum Hemorrhage
Postpartum hemorrhage (PPH) remains one of the leading causes of maternal mortality and morbidity worldwide, including in France, where it accounts for approximately 20% of maternal mortality.
- Conditions
- Postpartum Hemorrhage, Maternal Morbidity, Retained Placenta, Postpartum Endometritis
- Trial name
- SPPH (NCT03840889)
- Testing
- Data collection
- Where
- 10 sites in France
- Volunteers
- 80 people
- Sponsor
- University Hospital, Clermont-Ferrand
Endometritis
Uterine Flora During Elective and Urgent Cesarean Sections
Hypothesis: The bacterial flora of the uterus during elective Cesarean sections differs from the uterine flora during non-elective Cesarean sections.
- Trial name
- NCT00500019
- Where
- Israel
- Volunteers
- 600 people, healthy volunteers welcome
- Sponsor
- Western Galilee Hospital-Nahariya
Postpartum Endometritis, Wound Infection
Chlorhexidine Vaginal Preparation for Reduction of Post-cesarean Endometritis and Sepsis
The study aims to assess the beneficial value of vaginal preparation with chlorhexidine gluconate 0.05% before cesarean delivery of cases in labor in reduction of postoperative endometritis, fever and wound complications compared…
- Conditions
- Postpartum Endometritis, Wound Infection, Chlorhexidine Adverse Reaction, Postoperative Fever
- Trial name
- NCT04385680
- Testing
- Chlorhexidine Gluconate vaginal solution 0.05%
- Where
- Saudi Arabia
- Volunteers
- 840 people
- Sponsor
- Zagazig University