Clinical trials: Postsurgical Pain, Chronic
Cardiac Surgery, Chronic Postsurgical Pain
SPIP vs ESP Block in Cardiac Surgery
This multicentre, randomized, assessor-blinded, non-inferiority trial will compare the analgesic efficacy of bilateral superficial parasternal intercostal plane (SPIP) block with bilateral erector spinae plane (ESP) block in…
- Conditions
- Cardiac Surgery, Chronic Postsurgical Pain, Postoperative Pain
- Trial name
- SPARE (NCT07780773)
- Testing
- Bilateral Superficial Parasternal Intercostal Plane Block, Bilateral Erector Spinae Plane Block, morphine PCA
- Where
- Turkey (Türkiye)
- Volunteers
- 308 people
- Sponsor
- Ondokuz Mayıs University
Endometriosis, Postoperative Pain
Postoperative Pain Trajectories After Endometriosis Surgery
The pain associated with endometriosis reflects a multifactorial pathophysiology combining peripheral nociception, central sensitisation and psychosocial factors.
- Conditions
- Endometriosis, Postoperative Pain, Pain Trajectories, Chronic Postsurgical Pain
- Trial name
- TRACK-ENDO (NCT07882498)
- Testing
- Perioperative quantitative sensory testing, questionnaire
- Where
- France
- Volunteers
- 150 people
- Sponsor
- Centre Hospitalier Universitaire, Amiens
Chronic Postsurgical Pain, Chronic Post-surgical Pain
Prevention of Postsurgical Chronic Pain in Children and Adolescents (PREVENDOL)
Chronic postsurgical pain is a health problem with a great societal impact: approximately 20% of all children and adolescents undergoing surgery will develop chronic pain.
- Conditions
- Chronic Postsurgical Pain, Chronic Post-surgical Pain, Chronic Postoperative Pain, Chronic Post-operative Pain
- Trial name
- NCT06638437
- Testing
- Cognitive-behavioral therapy
- Where
- 3 sites in Spain
- Volunteers
- 125 people
- Sponsor
- University Rovira i Virgili
Postsurgical Pain Management, Postsurgical Pain, Chronic
An Artificial Intelligence Driven Approach to Optimize Patient Selection for a Transitional Pain Service
The goal of this clinical trial is to learn whether a pain-management program called a Transitional Pain Service can help prevent long-term pain and reduce opioid needs after surgery in adult surgical patients who may be at…
- Conditions
- Postsurgical Pain Management, Postsurgical Pain, Chronic, Opioid Use After Surgery
- Trial name
- TPS-Select (NCT07296770)
- Testing
- TPS-Select, Pharmacologic Pain Management, Interventional Pain Procedures
- Where
- United States
- Volunteers
- 474 people
- Sponsor
- University of California, San Francisco
Chronic Postsurgical Pain, Acute Postoperative Pain
Persistent Pain and Its Impact on Daily Life After Lung Surgery
This study will examine how pain changes over the first six months after lung surgery and how it affects daily life. It will include adults scheduled for surgery to remove part or all of a lung.
- Conditions
- Chronic Postsurgical Pain, Acute Postoperative Pain, Pain-Related Functional Interference
- Trial name
- NCT07853456
- Testing
- Longitudinal Assessment of Pain and Pain-Related Functional Interference
- Volunteers
- 350 people
- Sponsor
- Aerospace Center Hospital
Postoperative Pain, Chronic Postsurgical Pain
Effect of Erector Spinae Plane Block on Neuropathic Pain After Abdominal Hysterectomy
This study evaluated whether bilateral erector spinae plane block (ESPB) performed before abdominal hysterectomy could reduce postoperative pain and the development of chronic and neuropathic pain.
- Trial name
- NCT07830706
- Testing
- Bupivacaine, Standard Perioperative Analgesia
- Where
- Turkey (Türkiye)
- Volunteers
- 200 people
- Sponsor
- Necmettin Erbakan University
Postoperative Pain, Chronic Postsurgical Pain
Erector Spinae Plane Block for Chronic Pain After Spinal Surgery
The aim of this study is to evaluate whether the erector spinae plane (ESP) block reduces acute and chronic postoperative pain in patients undergoing spinal surgery.
- Conditions
- Postoperative Pain, Chronic Postsurgical Pain, Spinal Surgery
- Trial name
- NCT07834502
- Testing
- NRS SCORE, Total tramadol consumption, Post Operative Pain Relievers
- Where
- Turkey (Türkiye)
- Volunteers
- 80 people
- Sponsor
- Aydin Adnan Menderes University
Chronic Postsurgical Pain
Effect of Oliceridine Patient-Controlled Intravenous Analgesia on Postoperative Chronic Pain After Video-Assisted Thoracoscopic Lung Resection
The primary objective is to evaluate the impact of oliceridine versus sufentanil for perioperative analgesia on the incidence of chronic postsurgical pain (CPSP) with functional impact in patients undergoing video-assisted…
- Trial name
- NCT07018375
- Testing
- Oliceridine, Sufentanil
- Where
- 7 sites in China
- Volunteers
- 320 people
- Sponsor
- Tianjin Medical University General Hospital
Lumbar Spine Surgery, Chronic Low-back Pain
Telehealth Mindfulness After Spine Surgery
The goal of this pilot clinical trial is to compare two behavioral interventions for patients who are recovering from lumbar spinal surgery for a degenerative spine condition. The study aims to answer the following questions: 1.
- Conditions
- Lumbar Spine Surgery, Chronic Low-back Pain, Postsurgical Pain
- Trial name
- NCT05698914
- Testing
- Telehealth mindfulness-based intervention (MBI), Telehealth Education
- Where
- United States
- Volunteers
- 67 people
- Sponsor
- Vanderbilt University Medical Center
Chronic Postsurgical Pain, Chronic Opioid Users
Prevention of Chronic Postsurgical Pain in Chronic Opioid Users:
Chronic opioid users undergoing surgery are at increased risk of CPSP, contributing to long-term disability, decreased quality of life, and prolonged opioid exposure.
- Conditions
- Chronic Postsurgical Pain, Chronic Opioid Users, Transitional Pain Service, Postoperative Pain
- Trial name
- PRE-OPIOID (NCT07717151)
- Testing
- standard institutional perioperative management, specialized teleconsultation
- Where
- France
- Volunteers
- 354 people
- Sponsor
- Centre Hospitalier Universitaire, Amiens
Postoperative Pain, Chronic Postsurgical Pain
Perioperative Quantitative Sensory Testing and Incision Pain Mapping in Thoracic Surgery
Postoperative pain remains a common and clinically important burden after thoracic surgery and may progress to chronic postsurgical pain.
- Conditions
- Postoperative Pain, Chronic Postsurgical Pain, Thoracic Surgery, Lung Resection
- Trial name
- NCT07653932
- Testing
- Perioperative QST and incision pain mapping assessment
- Where
- China
- Volunteers
- 46 people
- Sponsor
- Tongji Hospital
Chronic Postsurgical Pain
Optimizing the Use of Ketamine to Reduce Chronic Postsurgical Pain
The study utilizes a 3-arm placebo-controlled RCT to study the effectiveness of ketamine in reducing chronic post-mastectomy pain.
- Trial name
- KALPAS (NCT05037123)
- Testing
- Continuous ketamine infusion, Ketamine + Saline
- Where
- 14 sites in United States
- Volunteers
- 765 people
- Sponsor
- NYU Langone Health
Neuropathic Pain, Chronic Postsurgical Pain
Efficacy of an Intraoperative Periradicular Application of Platelet Rich Fibrin (PRF) on the Intensity of Residual Post-surgical Neuropathic Pain After a Surgery for Disc Herniation
The prevalence of post-surgical lumbar neuropathic radiculopathy is approximately 30%. Poor response to the treatments recommended for neuropathic pain, namely antidepressants and/or gabapentinoids, requires the development of…
- Trial name
- NeuroPRF (NCT05196503)
- Testing
- Treatment
- Where
- France
- Volunteers
- 60 people
- Sponsor
- University Hospital, Strasbourg, France
Scoliosis Correction, Esketamine
Different Dose Esketamine and Dexmedetomidine Combination for Supplemental Analgesia After Scoliosis Correction Surgery
Scoliosis correction surgery is associated with severe pain. Patients after scoliosis correction surgery usually require high dose opioids and long duration analgesia, which may increase side effects and drug tolerance.
- Conditions
- Scoliosis Correction, Esketamine, Dexmedetomidine, Postoperative Analgesia
- Trial name
- NCT06062550
- Testing
- Esketamine
- Where
- China
- Volunteers
- 312 people
- Sponsor
- Peking University First Hospital
Chronic Postsurgical Pain
Intertransverse Process Block to Improve Quality of Recovery and Pain Management in Adult Cardiac Surgical Patients
The goal of this clinical trial is to evaluate the efficacy of intertransverse process block (ITPB) in improving quality of recovery and potentially preventing chronic postsurgical pain (CPSP) in adult patients undergoing…
- Trial name
- NCT06946290
- Testing
- Intertransverse process block
- Where
- Hong Kong
- Volunteers
- 96 people
- Sponsor
- Chinese University of Hong Kong
Chronic Postsurgical Pain, Acute Pain
Acute Preoperative Pain and Chronic Post-surgical Pain in Emergency Surgery
Studies evaluating postoperative pain as a risk factor for CPSP are almost exclusively carried out in the context of scheduled surgery.
- Conditions
- Chronic Postsurgical Pain, Acute Pain, Emergency Surgery, Opioid
- Trial name
- POCSE (NCT06555107)
- Testing
- questionnaire, phone call
- Where
- France
- Volunteers
- 693 people
- Sponsor
- Centre Hospitalier Universitaire, Amiens
Osteoarthritis, Knee, Total Knee Arthroplasty
Reducing Perioperative Oxidative Stress to Prevent Postoperative Chronic Pain Following Total Knee Arthroplasty
This is a prospective randomized controlled trial that will assess preoperative, perioperative, and long-term oxidative stress (OS); pain; and functional outcomes over a 12 month period and test the hypothesis that a potent…
- Conditions
- Osteoarthritis, Knee, Total Knee Arthroplasty, Chronic Postsurgical Pain
- Trial name
- NCT06083480
- Testing
- GlyNAC (combination of glycine and n-acetylcysteine)
- Where
- United States
- Volunteers
- 148 people
- Sponsor
- Vanderbilt University Medical Center
Chronic Postsurgical Pain, Chronic Pain
Intraoperative Sufentanil and Chronic Postsurgical Pain in Non-major Scheduled Abdominal Surgery
Several risk factors for chronic postoperative pain have been identified. A series of studies have shown that administrating intraoperatively a high dose of Remifentanil is associated with an increased incidence of CPSP.
- Conditions
- Chronic Postsurgical Pain, Chronic Pain, Abdominal Surgery, Sufentanil
- Trial name
- ISPAIN (NCT06374849)
- Testing
- phone interview
- Where
- France
- Volunteers
- 855 people
- Sponsor
- Centre Hospitalier Universitaire, Amiens
Scoliosis Correction, Postoperative Analgesia
Mini-dose Esketamine-dexmedetomidine Supplemented Analgesia and Long-term Outcomes
Chronic postsurgical pain (CPSP) refers to pain that occurs or increases after surgery and lasts longer than 3 months. Severe postoperative acute pain is one of the major risk factors of CPSP.
- Conditions
- Scoliosis Correction, Postoperative Analgesia, Esketamine, Dexmedetomidine
- Trial name
- NCT05718544
- Testing
- Esketamine, Dexmedetomidine, Sufentanil
- Where
- China
- Volunteers
- 199 people
- Sponsor
- Peking University First Hospital
Scoliosis Correction, Postoperative Analgesia
Different Dose Esketamine and Dexmedetomidine for Supplemental Analgesia and Longterm Outcomes
Chronic postsurgical pain (CPSP) refers to pain that occurs or increases after surgery and lasts longer than 3 months. Severe acute postoperative pain is one of the major risk factors of CPSP.
- Conditions
- Scoliosis Correction, Postoperative Analgesia, Esketamine, Dexmedetomidine
- Trial name
- NCT06087510
- Testing
- Esketamine
- Where
- China
- Volunteers
- 312 people
- Sponsor
- Peking University First Hospital