Clinical trials: Postsurgical Pain
Cesarean Section, Postoperative Pain
Efficacy of Acetaminophen Alone Versus Combination of Acetaminophen/Ibuprofen After Cesarean Section
The investigators aim to compare the analgesic efficacy of intravenous acetaminophen alone versus combination of acetaminophen/ibuprofen (Maxigesic®IV) in multimodal analgesia after cesarean section.
- Trial name
- NCT06479122
- Testing
- Acetaminophen, Acetaminophen/Ibuprofen
- Where
- South Korea
- Volunteers
- 84 people, healthy volunteers welcome
- Sponsor
- Seoul National University Hospital
Postoperative Pain, Postoperative Nausea and Vomiting
Effect of Steroids on Post-tonsillectomy Morbidities
This study aims to evaluate the effect of postoperative systemic rapid onset and short acting dexamethasone followed by a tapering dose of oral prednisolone on post-tonsillectomy morbidities.
- Trial name
- NCT02401529
- Testing
- IV dexamethasone, Oral prednisolone, Paracetamol
- Volunteers
- 100 people, healthy volunteers welcome
- Sponsor
- King Fahd General Hospital
Postoperative Pain
Hydromorphone and C-section
This study will investigate the dose of hydromorphone which will relieve the pain of women following a cesarean section when delivered directly in the area around the spinal cord (i.e., intrathecal injection).
- Trial name
- NCT01598545
- Testing
- Hydromorphone
- Where
- United States
- Volunteers
- 20 people, healthy volunteers welcome
- Sponsor
- Emory University
Postoperative Pain
Comparison of Post-Operative Pain After Use of Calcium Hydroxide and Bio Ceramic Sealer for Root Canal Treatment.
Background: Root canal therapy is a well documented and established method to eliminate inflamed pulp and reduce pain, but the procedure itself is associated with postoperative discomfort, ranging from 1.2%-82.9% in different…
- Trial name
- NCT05816772
- Testing
- Endosequence Bio ceramic Sealer, Sealapex Calcium hydroxide Based Sealer
- Where
- Pakistan
- Volunteers
- 80 people, healthy volunteers welcome
- Sponsor
- Dow University of Health Sciences
Acupressure, Post Operative Pain
Effect of Acupressure on Postoperative Pain With Gynecologıcal Surgery
In this study, the effect of acupressure on postoperative pain level in women with abdominal gynecologıcal surgery will be studied and it will be conducted as a randomized controlled intervention study to examine the…
- Conditions
- Acupressure, Post Operative Pain, Nurse's Role
- Trial name
- NCT06172439
- Testing
- acupressure
- Where
- Turkey (Türkiye)
- Volunteers
- 102 people, healthy volunteers welcome
- Sponsor
- Saglik Bilimleri Universitesi
Transversalis Fascia Plane Block, Gynecologic Surgical Procedures
Efficacy of US-guided TFPB in Open Gynecologic Surgery
Transversalis fascia plane block (TFPB) has been studied and has shown to be very effective in controlling postoperative pain after caesarean section but has not been studied in open gynecologic surgery with transverse incision.
- Trial name
- NCT06847022
- Testing
- US-guided transversalis fascia plane block
- Where
- Thailand
- Volunteers
- 32 people, healthy volunteers welcome
- Sponsor
- Thammasat University
Pain Management, Analgesia
Post-Operative Pain Management Following Spine Surgery
The primary objective of this pilot study is to assess the feasibility of comparing two standardized approaches to manage post-operative pain following spine surgery: one approach using Patient Controlled Analgesia (PCA) devices…
- Conditions
- Pain Management, Analgesia, Anesthetic
- Trial name
- EXPAREL (NCT03076710)
- Testing
- Opioids delivered through PCA, EXPAREL® infiltration
- Where
- United States
- Volunteers
- healthy volunteers welcome
- Sponsor
- University of Miami
Pain, Postoperative
Application of the ICE-T Postoperative Multimodal Pain Regimen to Laparoscopic Hysterectomy
This is a randomized controlled trial evaluating whether application of ice packs and scheduled ketorolac to the surgical site after laparoscopic hysterectomy reduces need for narcotic medications.
- Trial name
- NCT04137770
- Testing
- Ice pack and ketorolac
- Where
- United States
- Volunteers
- 18 people, healthy volunteers welcome
- Sponsor
- Mercy Research
Postoperative Pain
Effect of Lidocaine Versus Magnesium on Postoperative Pain in Spine Surgery
The goal in this work is to compare the effect of intravenous single-bolus lidocaine infusion versus intravenous single-bolus magnesium sulfate infusion on postoperative pain, emotional status and quality of life in patients…
- Trial name
- NCT04776369
- Testing
- Lidocaine IV, Magnesium Sulfate Injection, IV saline
- Where
- Egypt
- Volunteers
- 60 people, healthy volunteers welcome
- Sponsor
- Haitham Mohammad Ahmad Mohammad
Post Operative Pain, Necrotic Mandibular Molars
Postoperative Pain and Periapical Tissue Healing
The success of endodontic treatment derives from the complete elimination of microorganisms capable of causing an intraradicular or extra radicular infection.
- Trial name
- NCT06771570
- Testing
- Silver Nanoparticles Irrigation
- Where
- Egypt
- Volunteers
- 48 people, healthy volunteers welcome
- Sponsor
- Radwa fath Ahmed
Postoperative Pain
Factors Influencing Postoperative Pain After Gingival Graft Harvesting
This prospective cohort study aims to evaluate patient-related, psychological, and clinical factors influencing postoperative pain following gingival graft harvesting from the palate.
- Trial name
- NCT07377370
- Testing
- Gingival graft harvesting from the palate
- Where
- Spain
- Volunteers
- 93 people, healthy volunteers welcome
- Sponsor
- Universitat Internacional de Catalunya
Postoperative Pain
Assessment of Postoperative Pain After Using Various Intracanal Medication in Patients With Necrotic Pulp
To assess the Postoperative Pain after using Silver Nanoparticles with and without Calcium Hydroxide as an Intracanal Medication in Patients with necrotic pulp (RCT)
- Trial name
- NCT03692286
- Testing
- Silver nanoparticle/Calcium hydroxide, Silver Nanoparticles in gel form, Calcium Hydroxide Intracanal medication
- Where
- Egypt
- Volunteers
- 30 people, healthy volunteers welcome
- Sponsor
- Cairo University
Pain, Postoperative, Gingival Diseases
Effect of Using Placental Membranes on Healing and Post-op Pain After Gum Surgery
When harvesting autogenous free grafts to treat periodontal conditions (e.g., lack of attached keratinized tissue, ridge defects, and other mucogingival deformities), the hard palate is the preferred donor site.
- Trial name
- NCT04957342
- Testing
- amnion-chorion membrane, Sutures
- Where
- United States
- Volunteers
- 10 people, healthy volunteers welcome
- Sponsor
- Harvard Medical School (HMS and HSDM)
Free Gingival Graft, Survey and Questionnaire
Free Gingival Graft Patients' Treatment Perception and Experience
Free gingival graft (FGG) is a common and effective periodontal procedure used to improve gum health; however, it can involve challenges such as postoperative pain and discomfort due to the requirement of a secondary donor site.
- Conditions
- Free Gingival Graft, Survey and Questionnaire, Postoperative Pain
- Trial name
- NCT07568327
- Testing
- Free Gingival Graft
- Where
- Turkey (Türkiye)
- Volunteers
- 77 people, healthy volunteers welcome
- Sponsor
- Istanbul Aydın University
Total Knee Arthroplasty
Treatment With Iovera° for Total Knee Arthroplasty (TKA) Post-Operative Pain
This study is designed to investigate whether iovera° treatment prior to TKA decreases cumulative participant opioid use over the course of 6 weeks following TKA while maintaining similar levels of pain relief.
- Trial name
- NCT03327220
- Testing
- iovera°
- Where
- United States
- Volunteers
- 124 people, healthy volunteers welcome
- Sponsor
- Pacira Pharmaceuticals, Inc
Opioid Use, Surgical Recovery
Paracervical Injection and Opioid Use After Vaginal Hysterectomy for Prolapse
The goal of the study to see if giving a numbing medicine around the cervix (called a paracervical block) during vaginal hysterectomy with prolapse repair helps people feel less pain and need fewer strong pain medicines…
- Conditions
- Opioid Use, Surgical Recovery, Vaginal Hysterectomy, Prolapse Pelvic
- Trial name
- NCT07213635
- Testing
- Bupivacaine-epinephrine, Normal saline
- Where
- United States
- Volunteers
- 50 people, healthy volunteers welcome
- Sponsor
- University of North Carolina, Chapel Hill
Pain, Chronic Post-Surgical
PERIoperative Holistic RIsk Factor SCreening in the Prevention of Persistent Pain
Assessment and management for improved wellbeing after elective surgery (PERISCOP³E-Care) Diagnostic assessment tool evaluation and cut-off determination for participation in a transmural perioperative care program
- Trial name
- PERISCOPEcare (NCT05526976)
- Testing
- PERISCOPE-care
- Where
- 2 sites in Belgium
- Volunteers
- 660 people, healthy volunteers welcome
- Sponsor
- University Hospital, Antwerp
Outpatient Surgery, Pain, Postoperative
Patient Narcotic Requirements After Outpatient Otolaryngology Procedures
Patient's pain level and narcotic requirements will be evaluated after routine outpatient Otolaryngology procedures. This will be done by having study participants record their pain level and medication usage from home.
- Trial name
- NCT03404518
- Testing
- Norco, Ibuprofen
- Where
- 2 sites in United States
- Volunteers
- 185 people, healthy volunteers welcome
- Sponsor
- Loma Linda University
Knee Osteoarthritis
Effect of Foot Massage on Pain and Analgesic Consumption in Total Knee Prosthesis
This randomized controlled trial aims to examine the effects of foot massage combined with cold application on postoperative pain, patient satisfaction, and analgesic consumption in individuals undergoing Total Knee Arthroplasty…
- Trial name
- NCT07126340
- Testing
- Foot Massage and Cold Application, Cold Application
- Where
- Turkey (Türkiye)
- Volunteers
- 60 people, healthy volunteers welcome
- Sponsor
- Alev Keskin
Postoperative Pain, Analgesia
Evaluation of Dexketoprofen in Total Knee Arthroplasty
Pain is a global public health issue and represents the most common reason for both physician consultation and hospital admissions. Dexketoprofen is a new NSAID treating acute postoperative pain.
- Trial name
- NCT04161690
- Testing
- Dexketoprofen Trometamol, Ropivacaine Hydrochloride 7.5 MG/ML
- Where
- Greece
- Volunteers
- 120 people, healthy volunteers welcome
- Sponsor
- KAT General Hospital
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