Clinical trials: Postsurgical Pain Management
Pain, Postoperative, Pharmacokinetics
Liposomal Bupivacaine Versus Plain Bupivacaine After Intercostal Injections For Pain Management After Thoracoscopy
The purpose of this study is to assess pharmacokinetics of liposomal bupivacaine (Exparel) after multilevel intercostal injections of this local anesthetic for pain control during and after thoracoscopic surgeries.
- Trial name
- NCT03737292
- Testing
- Exparel, Bupivacaine
- Where
- United States
- Volunteers
- 40 people
- Sponsor
- Milton S. Hershey Medical Center
Lung Diseases
Continuous Erector Spinae Plane Block or Thoracic Epidural Analgesia Following Video Assisted Thoracic Surgery
Video assisted thoracic surgery (VATS) has recently been evaluated as the standard surgical procedure for lung surgery. Although VATS is less painful than thoracotomy, patients may feel severe pain during the first hours at…
- Trial name
- NCT03960736
- Testing
- ESP block (Group A), TEA group (Group B)
- Where
- Turkey (Türkiye)
- Volunteers
- 50 people
- Sponsor
- Medipol University
Pain, Postoperative
Selective Block of the Axillary Nerve in Postoperative Pain Management
In this study the investigators wish to compare the effect of a selective axillary nerve block to placebo in patients undergoing arthroscopic shoulder surgery.
- Trial name
- NCT01463865
- Testing
- ropivacaine, Sodium chloride
- Where
- Denmark
- Volunteers
- 60 people
- Sponsor
- Hillerod Hospital, Denmark
Spinal Anesthesia, Postoperative Pain Management
Intravenous Dexamethasone for Prolonging Sensory Block in Spinal Anesthesia
The goal of this clinical trial is to learn if intravenous dexamethasone can help prolong the effect of spinal anesthesia in adults having elective pelvic, urologic, or proctologic surgery.
- Conditions
- Spinal Anesthesia, Postoperative Pain Management, Dexamethasone, Pelvic Surgery
- Trial name
- NCT07088432
- Testing
- Dexamethasone
- Where
- Tunisia
- Volunteers
- 120 people
- Sponsor
- Tunis University
Shoulder Syndrome
Ultrasound-Guided Erector Spinae Plane Block or Interscalen Brachial Plexus Block Following Arthroscopic Shoulder Surgery
Postoperative pain is important following arthroscopic shoulder surgery. Postoperative effective pain treatment provides early mobilization and shorter hospital stay.Ultrasound (US)-guided brachial plexus blocks such as…
- Trial name
- NCT04083287
- Testing
- Erector spinae plane block (Group E), Interscalen brachial plexus block (Group I)
- Where
- Turkey (Türkiye)
- Volunteers
- 60 people
- Sponsor
- Medipol University
Osteoarthritis, Knee
Management of Postoperative Pain Following Total Knee Arthroplasty by Using Acupuncture-moxibustion Therapy
Orthopedic surgery is reportedly among the most painful surgical procedures. Surgical damage following major orthopedic surgery often involves a large, deep incision with considerable tissue dissection and muscle, bone, and…
- Trial name
- NCT01047384
- Testing
- acupuncture-moxibustion therapy, Regular therapy
- Where
- Taiwan
- Volunteers
- 100 people, healthy volunteers welcome
- Sponsor
- Chang Gung Memorial Hospital
Pain, Postoperative
An Efficacy and Safety Study to Compare Fentanyl Ionsys and Routine Care With Intravenous (IV) Morphine Patient-controlled Analgesia (PCA) in Participants Who Have Undergone Elective Major Abdominal or Orthopedic Surgery
The purpose of this study is to evaluate the mobilization characteristics, clinical use, safety and Ease of Care (EOC) of a fentanyl Iontophoretic Transdermal Patient Controlled Analgesia (PCA) system (Ionsys) and morphine…
- Trial name
- NCT00766506
- Testing
- Fentanyl IONSYS, Morphine IV PCA
- Where
- 7 sites in United Kingdom
- Volunteers
- 108 people
- Sponsor
- Janssen-Cilag Ltd.
Cesarean Section, Postoperative Pain After Cesarean Section
Nociception Level Index Monitoring During Cesarean Section
This prospective randomized controlled trial evaluated the effect of nociception level (NOL) index-guided intraoperative analgesia on postoperative pain management in patients undergoing elective cesarean section under general…
- Conditions
- Cesarean Section, Postoperative Pain After Cesarean Section, Pain Management
- Trial name
- NOL-CS (NCT07720440)
- Testing
- Nociception Level Index Monitoring, Standard Intraoperative Monitoring
- Where
- Turkey (Türkiye)
- Volunteers
- 60 people
- Sponsor
- Istinye University
Anxiety, Postoperative Pain
Sublingual Melatonin for Anxiety and Pain in Elective Gynecologic Surgery
This prospective randomized controlled study aims to evaluate the anxiolytic effect of preoperative sublingual melatonin and its impact on postoperative pain scores when administered in two different doses to female patients…
- Conditions
- Anxiety, Postoperative Pain, Anesthesia
- Trial name
- NCT06997263
- Testing
- Melatonin 3 mg Sublingual, Melatonin 6 mg Sublingual
- Where
- Egypt
- Volunteers
- 96 people, healthy volunteers welcome
- Sponsor
- Benha University
Total Ankle Arthroplasty, Postsurgical Analgesia
Efficacy of EXPAREL vs. Bupivacaine
The goal of this clinical study is to learn about pain management strategies in subjects undergoing total ankle replacement. arthroplasty surgery The primary objective is to compare the magnitude of the analgesic effect following…
- Trial name
- NCT07212114
- Testing
- EXPAREL, 0.25% bupivacaine (HCl): 50 ml, 0.25% bupivacaine (HCl): 30 ml
- Where
- United States
- Volunteers
- 104 people
- Sponsor
- Emory University
Arthritis Knee, Knee Osteoarthritis
The Effect of a Methylprednisolone Taper on Outcomes Following Total Knee Arthroplasty
Pain control and early range of motion following total knee arthroplasty are essential for patient satisfaction. Intraoperative steroids (dexamethasone) have been shown to have a significant effect in controlling acute pain…
- Conditions
- Arthritis Knee, Knee Osteoarthritis, Pain, Postoperative
- Trial name
- NCT06489626
- Testing
- Methylprednisolone 4 milligram Tab, Dexamethasone injection
- Where
- 2 sites in United States
- Sponsor
- F. Johannes Plate
Total Hip Arthroplasty (THA), Postoperative Pain Management
Iliopsoas (IPB) and Pericapsular Nerve Group (PENG) Blocks Comparison on Analgesia and Recovery After Total Hip Arthroplasty
Background: In recent years, regional anesthesia has become more popular because it can reduce pain and the need for strong pain medications like morphine. For hip surgery, the PENG block is already known to be effective.
- Conditions
- Total Hip Arthroplasty (THA), Postoperative Pain Management, Peripheral Nerve Blocks, PENG Block
- Trial name
- NCT06964282
- Testing
- PENG Block, Iliopsoas nerve block
- Where
- Belgium
- Volunteers
- 118 people
- Sponsor
- University of Liege
Postoperative Opioid Requirements in Patients With Traumatic Fracture Hip
Fascia Iliaca Versus Quadratus Lumborum Block for Pain Management in Total Hip Replacement.
Postoperative analgesia is essential for early ambulation of patients with hip arthroplasties as well as decreasing hospital stay time.
- Trial name
- NCT05504525
- Testing
- Fascia Iliaca block, Quadratus lumborum block
- Where
- Egypt
- Volunteers
- 68 people
- Sponsor
- Ain Shams University
Post Operative Analgesia
Erector Spinae Plane Versus Quadratus Lumborum Blocks for Pain Management After Total Abdominal Hysterectomy
TAH, being a large scale gynaecological operation, is a construction bound to cause serious postoperative pain to the patient in that the procedure will inevitably entail massive tissue dissection.
- Trial name
- NCT07480499
- Testing
- Erector Spinae Plane Block, Quadratus Lumborum Block (QLB)
- Where
- Pakistan
- Volunteers
- 60 people
- Sponsor
- Sheikh Khalifa Bin Zayed Al Nahyan Combined Military Hospital Muzaffarabad
Coronary Artery Bypass Graft Surgery(CABG), Postoperative Pain Management
VR During Chest Tube Removal After CABG
The purpose of this randomized controlled clinical trial was to investigate whether virtual reality (VR) could reduce pain and anxiety during chest tube removal in adult patients who underwent coronary artery bypass graft (CABG)…
- Trial name
- VR-CABG (NCT07891299)
- Testing
- VR Shinecon G04EA Virtual Reality Headset
- Where
- Turkey (Türkiye)
- Volunteers
- 82 people
- Sponsor
- Maltepe University
Lung Diseases, Lung Cancers
Optimizing Post-Thoracotomy Pain Management: Comparing Erector Spinae vs. Paravertebral Block in Thoracotomy Patients
This prospective, observational study included ASA class II-III patients aged 18-70 years who underwent elective unilateral lobectomy via a thoracotomy.
- Trial name
- NCT06964698
- Where
- Turkey (Türkiye)
- Volunteers
- 60 people
- Sponsor
- Başakşehir Çam & Sakura City Hospital
Pain
Lidocaine For Treatment of Post-operative Pain From Donor Sites Following Burn Injury.
Burn pain is known to be one the most severe forms of acute pain often requiring large amounts of narcotics in addition to other adjuvants.
- Trial name
- LidocaineBurn (NCT02229578)
- Testing
- Lidocaine
- Where
- 2 sites in United States
- Volunteers
- 34 people, healthy volunteers welcome
- Sponsor
- University of Florida
Post Operative Pain, Knee Osteoarthritis
Cryoneurolysis Prior to Total Knee Arthroplasty
Knee osteoarthritis is a major issue worldwide with limited treatment options. Many patients receive knee joint replacement surgery which is considered effective and safe.
- Conditions
- Post Operative Pain, Knee Osteoarthritis, Opioid-Related Disorders
- Trial name
- NCT05840276
- Testing
- Cryoneurolysis
- Where
- Denmark
- Volunteers
- 100 people
- Sponsor
- Esbjerg Hospital - University Hospital of Southern Denmark
Breast Cancer
PECI/SPB vs Intercostal Nerve Block for the Management of Postoperative Pain in Latissimus Dorsi Flap Reconstruction
Regional Anesthesia is a procedure in which numbing medication is injected around nerves that transmit pain from areas involved in a surgery. The objective is to block the nerves so a patient does not feel pain after surgery.
- Trial name
- NCT02821676
- Volunteers
- 42 people
- Sponsor
- Ottawa Hospital Research Institute
Post-operative Pain
Dexmedetomidine Added to Bupivacaine for ESP Block in Children Undergoing Lower Abdominal Surgeries
This study aims to evaluate the effect of adding dexmedetomidine to bupivacaine in erector spinae plane (ESP) blocks on the duration of postoperative analgesia in pediatric patients undergoing lower abdominal surgery.
- Trial name
- NCT07023991
- Testing
- Bupivacaine, Dexmedetomidine
- Where
- Egypt
- Volunteers
- 30 people, healthy volunteers welcome
- Sponsor
- Ain Shams University
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