Clinical trials: Postsurgical Pain Management
Pain, Postoperative, Opioid Use
Management Of Pain After Cesarean Trial
This is a double blinded randomized controlled trial to test the efficacy of a combination of acetaminophen and ibuprofen administered to patients on schedule compared to ibuprofen alone on the patient's reported pain score on…
- Trial name
- MOPAC (NCT03929640)
- Testing
- Acetaminophen, Ibuprofen
- Where
- United States
- Volunteers
- 49 people
- Sponsor
- Milton S. Hershey Medical Center
Total Knee Arthroplasty
Femoral Triangle and Adductor Canal Blocks Versus Femoral Nerve Block for Total Knee Arthroplasty
This prospective, double-blinded, randomized controlled study evaluates effects of femoral triangle and adductor canal blocks in comparison with femoral nerve block for primary total knee arthroplasty.
- Trial name
- NCT03645954
- Testing
- Femoral Nerve Block, Femoral Triangle & Adductor Canal Blocks
- Where
- Lithuania
- Volunteers
- 80 people
- Sponsor
- Lithuanian University of Health Sciences
Pain, Postoperative
Multimodal Pain Management After Robotic-Assisted Total Laparoscopic Hysterectomy
Hysterectomy is the most common major gynecologic surgery performed in the US and is performed for a variety of indications including malignancy, pelvic mass, endometriosis, leiomyoma, and pelvic organ prolapse.
- Trial name
- RA-TLH (NCT04429022)
- Testing
- Gabapentin, Acetaminophen, Celecoxib
- Where
- United States
- Volunteers
- 68 people, healthy volunteers welcome
- Sponsor
- State University of New York at Buffalo
Traumatic Amputation
Strength, Pain and Function in Operation Iraqi Freedom/Operation Enduring Freedom Amputees: A Nurse-Managed Program
The purpose of this randomized control study is to determine if administering neuromuscular electrical stimulation (NMES) to the thigh muscles of a below the knee amputee is more effective than the current standard of care in…
- Trial name
- NCT00942890
- Testing
- NMES (EMPI 300PV stimulator) plus standard of care, TMARP standard of care
- Where
- 3 sites in United States
- Volunteers
- 44 people
- Sponsor
- University of Tennessee
Pain, Postoperative, Urethral Stricture
Efficacy of Opioid-limiting Pain Management Protocol in Men Undergoing Urethroplasty
The investigator's study aims to see if an enhanced recovery regimen of pain medications before and during surgery will decrease the use and risk of opioid pain medications as well as improve pain control in anterior…
- Trial name
- NCT03859024
- Testing
- Oxycodone, Acetaminophen, Gabapentin
- Where
- United States
- Volunteers
- 48 people
- Sponsor
- University of Alabama at Birmingham
Abdominoplasty
Evaluate the Safety and Pharmacokinetic Profile of CPL-01 in the Management of Acute Postoperative Pain
Evaluate the Safety and Pharmacokinetic Profile of CPL-01 in patients after mini-abdominoplasty
- Trial name
- NCT04182880
- Testing
- CPL-01
- Where
- United States
- Volunteers
- 20 people, healthy volunteers welcome
- Sponsor
- Cali Pharmaceuticals LLC
Lower Extremity Surgery, Bunion
Study to Evaluate the Efficacy, Safety, and Pharmacokinetics of EXPAREL, EXPAREL Admixed With Bupivacaine HCl vs. Bupivacaine HCl Administered as Combined Sciatic and Saphenous Nerve Blocks for Postsurgical Analgesia in Subjects Undergoing Lower Extremity Surgeries
This is a Phase 3, multicenter, randomized, double blinded, active controlled study in approximately 120 subjects undergoing lower extremity surgeries.
- Conditions
- Lower Extremity Surgery, Bunion, Metatarsophalangeal Fushion, Midfoot Fusion
- Trial name
- STRIDE (NCT04518462)
- Testing
- Exparel, Bupivacaine Hydrochloride
- Where
- 5 sites in United States
- Volunteers
- 121 people
- Sponsor
- Pacira Pharmaceuticals, Inc
Pain Management
A Non-invasive Intervention (BreEStim) for Management of Phantom Limb Pain (PLP) After Limb Amputation (Experiment 1)
The purpose of this study is to compare the effectiveness of innovative intervention of breathing controlled electrical stimulation (BreEStim) and conventional electrical stimulation (EStim) in management of neuropathic phantom…
- Trial name
- NCT04750525
- Testing
- BreEStim, EStim
- Where
- United States
- Volunteers
- 15 people
- Sponsor
- The University of Texas Health Science Center, Houston
Laminectomy
Esmolol Infusion During Laminectomy: Effect on Quality of Recovery
The purpose of this study is to evaluate the effects of esmolol, a drug which is commonly administered during surgery to help control blood pressure and heart rate, on postoperative pain levels and requirements for pain…
- Trial name
- NCT01179113
- Testing
- Esmolol, Saline
- Where
- United States
- Volunteers
- 33 people
- Sponsor
- Cedars-Sinai Medical Center
Elbow Fracture
The Post-Operative Pain Management of Pediatric Supracondylar Elbow Fractures
The goal of this study is to compare different ways of treating pain after surgery. This research study involves subjects who have a supracondylar elbow fracture and need surgery.
- Trial name
- NCT01328782
- Testing
- Oxycodone with Acetaminophen, Bupivacaine 0.25%, Ropivacaine 0.20%
- Where
- United States
- Volunteers
- 124 people
- Sponsor
- University of Colorado, Denver
Myofacial Pain, Pain, Neck
Trigger Point Injections in Anterior Cervical Surgery
To achieve appropriate exposure for an anterior neck surgery (for example an Anterior Cervical Discectomy and Fusion or ACDF), patients are positioned supine with their neck extended.
- Conditions
- Myofacial Pain, Pain, Neck, Pain, Back, Cervical Fusion
- Trial name
- NCT04640896
- Testing
- Trigger point injection with bupivacaine, Trigger point injection with normal saline, Lidocaine skin wheal
- Where
- United States
- Volunteers
- 60 people
- Sponsor
- George Washington University
Fracture of Shoulder and Upper Arm
Exparel for Postoperative Pain Management in Shoulder Surgery
The purpose of this study is to compare the effect of liposomal Bupivacaine infiltration into the shoulder to continues nerve block with Bupivacaine on postoperative pain control and functional outcomes.
- Trial name
- NCT02472314
- Testing
- 1.3% Liposomal Bupivacaine, 0.125% Bupivacaine
- Where
- United States
- Volunteers
- 70 people
- Sponsor
- Wayne State University
Supracondylar Humerus Fracture
NSAIDs vs Opioids for Post-op Pain in Supracondylar Humerus Fractures
The purpose of this study is to determine if using the combination of acetaminophen (also known as Tylenol) and ibuprofen (also known as Motrin or Advil) will provide equal or better pain control as compared to…
- Trial name
- NCT04905563
- Testing
- Acetaminophen-Hydrocodone, Acetaminophen and Ibuprofen
- Where
- United States
- Volunteers
- 30 people
- Sponsor
- Le Bonheur Children's Hospital
Post-operative Pain, Gynecological Surgery
Acupuncture for Post-Operative Pain Control for Patients Undergoing Gynecological Surgery
This study investigates the role of acupuncture in controlling post-operative pain in patients who have undergone gynecological surgery.
- Conditions
- Post-operative Pain, Gynecological Surgery, Acupuncture
- Trial name
- NCT02855567
- Testing
- Acupuncture needles
- Where
- United States
- Volunteers
- 110 people, healthy volunteers welcome
- Sponsor
- Icahn School of Medicine at Mount Sinai
Pain Management
A Non-invasive Intervention (BreEStim) for Management of Phantom Limb Pain (PLP) After Limb Amputation (Experiment 2)
The purpose of this study is to compare the effectiveness of innovative intervention of breathing controlled electrical stimulation (BreEStim) and conventional electrical stimulation (EStim) in management of neuropathic phantom…
- Trial name
- NCT04750538
- Testing
- BreEStim 120, BreEStim 240
- Where
- United States
- Volunteers
- 17 people
- Sponsor
- The University of Texas Health Science Center, Houston
Knee Osteoarthritis, Pain Management
Phase 3 Adductor Canal Block With EXPAREL in Subjects Undergoing Primary Unilateral Total Knee Arthroplasty
The purpose of the study is to compare magnitude of postsurgical analgesic effect in different groups following a single dose of study drug when administered via adductor canal block in subjects undergoing primary unilateral…
- Trial name
- NCT05139030
- Testing
- bupivacaine liposome injectable suspension, Bupivacaine Hydrochloride
- Where
- 6 sites in United States
- Volunteers
- 167 people
- Sponsor
- Pacira Pharmaceuticals, Inc
Pain Management
A Non-invasive Intervention (BreEStim) for Management of Phantom Limb Pain (PLP) After Limb Amputation (Experiment 3)
The purpose of this study is to compare the effectiveness of innovative intervention of breathing controlled electrical stimulation (BreEStim) and conventional electrical stimulation (EStim) in management of neuropathic phantom…
- Trial name
- NCT04751526
- Testing
- BreEStim 240, EStim 240
- Where
- United States
- Volunteers
- 18 people
- Sponsor
- The University of Texas Health Science Center, Houston
Post-operative Pain
Efficacy of IV Acetaminophen for Pain Management
The investigators' goal in this planned prospective, randomized, patient blinded study is to compare our standard of care as the control group to an experimental group in which patients receive preemptive IV acetaminophen dosing…
- Trial name
- NCT02028715
- Testing
- IV acetaminophen
- Where
- United States
- Volunteers
- 68 people
- Sponsor
- Aultman Health Foundation
Postoperative Pain
Ultrasound-guided Fascia Iliaca Compartment Block Versus Periarticular Infiltration
This randomized, controlled, observer-blinded study clinical trial was designed to evaluate ultrasound-guided fascia iliaca compartment block with ropivacaine and periarticular infiltration with ropivacaine for postoperative pain…
- Trial name
- NCT02658240
- Testing
- Ropivacaine, Epinephrine
- Where
- United States
- Volunteers
- 60 people
- Sponsor
- University of Texas Southwestern Medical Center
Coronary Artery Disease, Pain, Postoperative
Parasternal Nerve Block in Cardiac Patients
Exparel is a new local analgesic (numbing medication) that is intended to be longer acting than currently available local analgesics.
- Trial name
- NCT01826851
- Testing
- Exparel
- Where
- United States
- Volunteers
- 79 people
- Sponsor
- Peter A Knight