Clinical trials: Pragmatic Randomized Controlled Trial
Diabetes, Physical Activity
Feasibility of REHIT in NDH Patients
The aim of this feasibility study was to describe and report data relevant to the acceptability of an exercise intervention (reduced-exertion, high-intensity interval training) in non-diabetic hyperglycaemia patients delivered in…
- Trial name
- NCT04011397
- Testing
- Exercise intervention, Usual care
- Volunteers
- 6 people, healthy volunteers welcome
- Sponsor
- University of Huddersfield
Chronic Disease, Sedentary Lifestyle
Evidence-Based Lifestyle Prescription Program: Pilot Study
The HealtheSteps™ (HeS) Program is an evidence-based, community-focused, lifestyle prescription (Rx) program, supported by in-person coaching and innovative health technologies.
- Conditions
- Chronic Disease, Sedentary Lifestyle, Overweight
- Trial name
- HeSP (NCT02413385)
- Testing
- HealtheSteps Program
- Where
- Canada
- Volunteers
- 118 people, healthy volunteers welcome
- Sponsor
- Western University, Canada
Emotional Distress, Quality of Life
At-risk and vulNerable Individuals To Infection With COVID-19 and ProActive inTervention With intEgrated Health and Social Care
This randomized control trial aims to explore a data-driven, proactive approach to identifying patients at greatest risk during the pandemic, and assess the impact of an embedded System Navigator in a primary health care setting.
- Conditions
- Emotional Distress, Quality of Life, Mental Health
- Trial name
- ANTICIPATE (NCT05197608)
- Testing
- System Navigator, Tailored list of resources
- Where
- Canada
- Volunteers
- 180 people, healthy volunteers welcome
- Sponsor
- Unity Health Toronto
Plasmodium Vivax Malaria, Malaria
FocaL Mass Drug Administration for Vivax Malaria Elimination
FLAME is an open-label cluster-randomized controlled trial that aims to determine the effectiveness of focal mass drug administration (fMDA) to reduce the incidence of Plasmodium vivax malaria in the Loreto Department in Peru.
- Trial name
- FLAME (NCT05690841)
- Testing
- Focal Mass Drug Administration (fMDA)
- Where
- Peru
- Volunteers
- 7,530 people, healthy volunteers welcome
- Sponsor
- University of California, San Francisco
Moderate Acute Malnutrition
Comparing Several Strategies to Manage Moderate Acute Malnutrition Among Children From 6 to 24 Months Old
The aim of this open-label randomized controlled trial conducted in four African countries (Madagascar, Niger, Central African Republic and Senegal) is to compare three strategies of renutrition for moderate acute malnutrition…
- Trial name
- MALINEA (NCT03474276)
- Testing
- Azythromycin, Inuline and fructo-oligosaccharides, Albendazole
- Where
- 4 sites in Central African Republic, Madagascar and 2 more
- Volunteers
- 1,357 people, healthy volunteers welcome
- Sponsor
- Institut Pasteur
Opioid-Related Disorders
EA for Protracted Withdrawal of OUD
Opioid use disorder (OUD) the most harmful of all the illicit drugs is a serious substance-related disorder resulting from abuse or misuse of opioids.
- Trial name
- NCT04961294
- Testing
- Electro-Acupuncture
- Where
- China
- Volunteers
- 300 people, healthy volunteers welcome
- Sponsor
- Chengdu University of Traditional Chinese Medicine
Cervical Disc Herniation
Pharmacopuncture Therapy for Cervical Disc Herniation: A Pilot Study
This is pilot study for a 3-arm parallel pragmatic randomized controlled trial that will compare pharmacopuncture therapy, acupunture therapy and physical therapy, medication(prn) for cervical disc herniation.
- Trial name
- NCT05240586
- Testing
- pharmacopuncture therapy, acupuncture therapy, physical therapy, medication(prn)
- Where
- 7 sites in South Korea
- Volunteers
- 84 people, healthy volunteers welcome
- Sponsor
- Jaseng Medical Foundation
Dermatitis, Atopic
Atopic Dermatitis in Atopy Predisposed Infants
The primary objective of this study is to investigate the effectiveness of a standardized skin care regimen using a milk lotion once daily and a bathing addendum as needed during the first 52 weeks of life on the development of…
- Trial name
- ADAPI (NCT02906475)
- Testing
- standardized skin care regimen
- Where
- Germany
- Volunteers
- 160 people, healthy volunteers welcome
- Sponsor
- HiPP GmbH & Co. Vertrieb KG
Stress, Mental Health
PPI and Mindfulness App for Parents of Children with a NDD
An app based on positive psychology and mindfulness to support the mental well-being of parents of children with a Neurodevelopmental Disorder (NDD) was developed and will be evaluated on effectiveness.
- Conditions
- Stress, Mental Health, Mental Well-being
- Trial name
- Adappt (NCT06248762)
- Testing
- Adappt
- Where
- Netherlands
- Volunteers
- 212 people, healthy volunteers welcome
- Sponsor
- University of Twente
Food Allergy in Infants
Early Allergen System Experience
Multiple clinical trials have demonstrated that early allergen introduction, feeding babies common food allergens before six months, decreases children's risk of developing a food allergy.
- Trial name
- EASE (NCT06262867)
- Testing
- Ready. Set. Food! Stage 1 Mix ins
- Where
- United States
- Volunteers
- 1,110 people, healthy volunteers welcome
- Sponsor
- Prollergy dba Ready Set Food
Healthy
Examining the Real-World Effectiveness of the Movr App
The objective of this 8-week pilot pragmatic randomized controlled trial was to examine the real-world impact of movr on functional movement, flexibility, strength, and cardiovascular fitness.
- Trial name
- NCT04865666
- Testing
- movr mHealth App
- Where
- Canada
- Volunteers
- 48 people, healthy volunteers welcome
- Sponsor
- University of British Columbia
Smokers, Workplace
Evaluation of a Workplace Smoking Cessation Program in Hong Kong (Phase VI)
This study aims to test, by a 2-arm RCT, the effectiveness of an intervention that includes mobile phone-supported simple physical exercise for smoking cessation in workplaces in Hong Kong.
- Conditions
- Smokers, Workplace, Exercise
- Trial name
- NCT05758272
- Testing
- mobile phone-based simple physical exercise reminder to help quit smoking, regular text-based intervention
- Where
- Hong Kong
- Volunteers
- 646 people, healthy volunteers welcome
- Sponsor
- The University of Hong Kong
Health Promotion, Cardiovascular Disease
Effectiveness and Cost-effectiveness of the Check Your Health Preventive Programme
Check your health is a prevention intervention designed to create awareness and action on health condition with focus at physical activity at a population-level to 30-49 years of age.
- Conditions
- Health Promotion, Cardiovascular Disease, Physical Inactivity, Selfreported Quality of Health
- Trial name
- NCT02028195
- Testing
- Health check
- Where
- Denmark
- Volunteers
- 11,000 people, healthy volunteers welcome
- Sponsor
- University of Aarhus
Health Behavior, Quality of Life
Feasibility and Implementation of a Healthy Lifestyles Program
Chronic conditions, such as obesity and diabetes, are increasing worldwide. Lifestyle changes (e.g., physical activity, healthy diet, sufficient sleep, managing stress, smoking cessation) are often recommended to prevent or…
- Conditions
- Health Behavior, Quality of Life, Chronic Disease, Health Promotion
- Trial name
- NCT03258138
- Testing
- Health and wellness learning sessions, Brainstorming group sessions, Individual sessions with a multidisciplinary health team
- Where
- Canada
- Volunteers
- 30 people, healthy volunteers welcome
- Sponsor
- McMaster University
Mental Health, Child Wellbeing
Generation Victoria Cohort 2020s: A Statewide Longitudinal Cohort Study of Victorian Children and Their Parents
Generation Victoria (GenV) is a longitudinal, population-based study of Victorian children and their parents that will bring together data on a wide range of conditions ,exposures and outcomes.
- Conditions
- Mental Health, Child Wellbeing, Infant Health, Child Health
- Trial name
- GenV (NCT05394363)
- Where
- Australia
- Volunteers
- 150,000 people, healthy volunteers welcome
- Sponsor
- Murdoch Childrens Research Institute
Labor Onset and Length Abnormalities
Goal-directed Labor Epidural Analgesia Maintenance
The GLEAM trial is a multicenter, pragmatic, cluster-randomized trial to assess the effects of programmed intermittent epidural bolus versus continuous epidural infusion on the rate of spontaneous vaginal delivery and several…
- Trial name
- GLEAM (NCT05255263)
- Testing
- PIEB, CEI
- Where
- United States
- Volunteers
- healthy volunteers welcome
- Sponsor
- University of California, San Francisco
Nasal Obstruction, Septal Defect
Does Batten Grafting Improve Nasal Outcomes in Septoplasty and Turbinate Reduction?
The objective of this study is to compare the effectiveness of batten grafts plus septoplasty and turbinate reduction (intervention arm) compared to septoplasty and turbinate reduction alone (control arm), both in terms of…
- Conditions
- Nasal Obstruction, Septal Defect, Allergic Rhinitis, Nasal Polyps
- Trial name
- NCT05287841
- Testing
- Batten batten graft, Septoplasty, Inferior Turbinate Reduction
- Where
- 3 sites in United States
- Volunteers
- 13 people, healthy volunteers welcome
- Sponsor
- Northwell Health
Nurse-Patient Relations, Psychology, Social
Meaning-Centered Psychotherapy at Home
The purpose of this study is to train nurses from the VNS Health Visiting Nurse Service to deliver Meaning-Centered Psychotherapy for Palliative Care Patients (MCP-PC) to homebound people, and to evaluate how effective MCP-PC is…
- Trial name
- NCT05495737
- Testing
- Meaning-Centered Psychotherapy/MCP-PC Training, Meaning-Centered Psychotherapy/MCP-PC, Treatment As Usual/TAU
- Where
- 2 sites in United States
- Volunteers
- 81 people, healthy volunteers welcome
- Sponsor
- Memorial Sloan Kettering Cancer Center
Organ Donation, Registration for Deceased Organ Donation
Promoting Organ Donor Registration in Family Physician Offices
This study evaluates the effects of using reception staff to prompt patients by providing a pamphlet and an opportunity to register in the waiting room via a mobile tablet on deceased organ donor registration rates.
- Trial name
- NCT03213171
- Testing
- Reception staff providing handout., Mobile Tablet (e.g. iPad)
- Where
- 2 sites in Canada
- Volunteers
- 6 people, healthy volunteers welcome
- Sponsor
- London Health Sciences Centre Research Institute OR Lawson Research Institute of St. Joseph's
Hepatocellular Carcinoma (HCC), Intrahepatic Cholangiocarcinoma (Icc)
Pragmatic RCT of AI-Assisted Reading for Malignant Hepatic Lesions on CE-CT
The purpose of this multicenter pragmatic randomized controlled trial is to determine whether AI-assisted interpretation of multiphasic liver contrast-enhanced computed tomography (CE-CT) is non-inferior to standard radiology…
- Conditions
- Hepatocellular Carcinoma (HCC), Intrahepatic Cholangiocarcinoma (Icc), Hepatic Metastasis, Hepatic Hemangioma
- Trial name
- NCT07768085
- Testing
- AI-assisted abdominal CE-CT reporting, Standard abdominal CE-CT reporting without AI assistance
- Where
- China
- Volunteers
- 40,000 people, healthy volunteers welcome
- Sponsor
- Shengjing Hospital