Clinical trials: Pre - Delivery Pregnant Women
Hypertension, Premature Birth
Trial of Exercise to Prevent HypeRtension in Young Adults
TEPHRA investigates the effect of exercise on blood pressure and other cardiovascular factors in young adults with different birth histories.
- Trial name
- TEPHRA (NCT02723552)
- Testing
- Aerobic Exercise
- Where
- United Kingdom
- Volunteers
- 203 people, healthy volunteers welcome
- Sponsor
- University of Oxford
Preeclampsia, Eclampsia
The Preeclampsia Registry
The purpose of The Preeclampsia Registry is to collect and store medical and other information from women who have been medically diagnosed with preeclampsia or a related hypertensive (high blood pressure) disorder of pregnancy…
- Conditions
- Preeclampsia, Eclampsia, HELLP Syndrome, Toxemia
- Trial name
- TPR (NCT06377878)
- Where
- United States
- Volunteers
- 20,000 people, healthy volunteers welcome
- Sponsor
- Preeclampsia Foundation
Preeclampsia
Agouti-related Peptide (AgRP) in Healthy Mothers and Mothers With Preeclampsia and Their Offspring
The study is focused on the investigation of possible associations between plasma/serum levels of agouti related peptide (AgRP) and its genetic background in healthy women with physiological pregnancy (non-preeclamptic) and women…
- Trial name
- NCT01042210
- Where
- Czechia
- Volunteers
- 84 people
- Sponsor
- Masaryk University
Preterm Birth
The Effect Of Risk Factors Considered Together With Preterm Birth History on Development
This thesis was planned to examine the effects of risk factors seen with a history of preterm birth on sensory and motor development in preschool children.
- Trial name
- NCT05087511
- Testing
- motor and sensory development assessment
- Where
- Turkey (Türkiye)
- Volunteers
- 48 people, healthy volunteers welcome
- Sponsor
- Gazi University
Preeclampsia
Proof-of-Concept Trial on Selective Removal of sFlt-1 in Pregnant Women With Preeclampsia Via Apheresis
This clinical investigation is a medical device trial to examine the safety and efficacy of TheraSorb sFlt-1 adsorber treatment of pregnant patients with preeclampsia.
- Trial name
- SAVE (NCT02923206)
- Testing
- TheraSorb sFlt-1 adsorber
- Where
- 4 sites in Germany, United Kingdom
- Volunteers
- 21 people, healthy volunteers welcome
- Sponsor
- Miltenyi Biomedicine GmbH
Pregnancy, Cervical Ripening
Improving the Childbirth Experience for Women Who Have Undergone Cervical Ripening by Involving Them in the Choice of Ripening Technique
This is a prospective, single-centre, quasi-experimental before-and-after study. Women due to give birth at the participating centre will be informed about the study during their 9th-month antenatal appointment.
- Conditions
- Pregnancy, Cervical Ripening, Childbirth
- Trial name
- AVAPAM (NCT07855146)
- Testing
- The patient will be offered the various possible methods of inducing cervical ripening, and the choice of method will be left to her, Standard Care (in control arm)
- Where
- France
- Volunteers
- 204 people
- Sponsor
- Centre Hospitalier Régional Metz-Thionville
Vitamin d Deficiency, Preeclampsia
25- Hydroxyvitamin D Levels in Pregnancy and Effects on Pregnancy Related Disorders
Evaluation of 25- Hydroxyvitamin D levels in pregnant women in Austria and potential related disorders Hypothesis: Austrian pregnant women are Vitamin D deficient Present vitamin D supplementation in pregnancy is insufficient…
- Conditions
- Vitamin d Deficiency, Preeclampsia, Preterm Delivery, Gestational Hypertension
- Trial name
- VIDIS (NCT04637880)
- Where
- Austria
- Volunteers
- 249 people, healthy volunteers welcome
- Sponsor
- Medical University of Vienna
Pre Term Birth
Time to Delivery of Preterm Birth
Preterm birth (babies being born before 34 weeks pregnancy) occurs in approximately 11% of pregnancies; preterm birth can lead to complications for the baby.
- Trial name
- NCT02853656
- Where
- United Kingdom
- Volunteers
- 128 people
- Sponsor
- Mid and South Essex NHS Foundation Trust
Preeclampsia
Removal of Anti-Angiogenic Proteins in Preeclampsia Before Delivery
Preeclampsia is a syndrome that occurs in approximately 3% to 8% of pregnancies and is associated with considerable maternal and neonatal morbidity and mortality.
- Trial name
- RAAPID-II (NCT01404910)
- Testing
- Apheresis using Liposorber LA-15 System
- Where
- 3 sites in United States, Germany
- Volunteers
- 11 people
- Sponsor
- Massachusetts General Hospital
Preeclampsia, Gestational Diabetes
Exercise and Pregnancy: Randomized Clinical Trial
The effects of physical exercise on pregnancy remain to be elucidated. A randomized controlled trial will be conducted to study the impact of exercise on maternal and perinatal outcomes.
- Trial name
- NCT00641550
- Testing
- Physical exercise
- Where
- 2 sites in Brazil
- Volunteers
- 188 people, healthy volunteers welcome
- Sponsor
- Universidade Estadual da Paraiba
Gestational Diabetes Mellitus, Preeclampsia
MYPP-trial: Myo-inositol Supplementation to Prevent Pregnancy Complications in Women With Polycystic Ovary Syndrome.
Polycystic Ovary Syndrome (PCOS) is the most common endocrine disorder in women of reproductive age. PCOS is a heterogeneous condition, characterised by metabolic disturbances, insulin resistance and hyperandrogenism.
- Conditions
- Gestational Diabetes Mellitus, Preeclampsia, Preterm Birth, Polycystic Ovary Syndrome
- Trial name
- MYPP (NCT05524259)
- Testing
- Myo-inositol and routinely recommended folic acid, Routinely recommended folic acid
- Where
- Netherlands
- Volunteers
- 464 people
- Sponsor
- Erasmus Medical Center
Pregnancy Related, Diet Modification
Effects of Diet on Pregnancy Outcome and Child Obesity
The purpose of the study is to compare 3 different diets in pregnancy, equal in calories, and fats, different in refined grains compared to whole grains as a source of carbohydrates, and in calories from carbohydrate, compared to…
- Conditions
- Pregnancy Related, Diet Modification, Obesity, Hypertension
- Trial name
- NCT03232762
- Testing
- Refined Grains, Whole Grains
- Where
- United States
- Volunteers
- 303 people, healthy volunteers welcome
- Sponsor
- NYU Langone Health
Pre-term Birth, HIV-1-infection
Improving Pregnancy Outcomes With Progesterone
This is a phase III, double-masked, placebo-controlled, randomized controlled trial taking place in Zambia.
- Trial name
- IPOP (NCT03297216)
- Testing
- 17P
- Where
- 2 sites in Zambia
- Volunteers
- 800 people
- Sponsor
- University of North Carolina, Chapel Hill
Preeclampsia
Mild Preeclampsia Near Term: Deliver or Deliberate?
Preeclampsia with new-onset hypertension and proteinuria is a pregnancy-specific disease that affects 5-7% of gestations usually after the 20th week.
- Trial name
- NCT00789919
- Testing
- Delivery of infant
- Where
- United States
- Volunteers
- 185 people
- Sponsor
- University of Mississippi Medical Center
Postpartum Depression, Preterm Infant
The Impact of a Newborn Behavioral Intervention on the Mental Health of Mothers With Late Pre-Term Infants
Preterm birth is a serious public health issue, affecting 10% of all births in the US alone. Three quarters of these infants are born between 34 0/7 and 36 6⁄7 weeks' gestation or late-preterm (LP).
- Conditions
- Postpartum Depression, Preterm Infant, Infant Development
- Trial name
- BabyAMOR (NCT03836430)
- Testing
- Newborn Behavioral Observation-Family Wellness (NBO-FW)
- Where
- United States
- Volunteers
- 208 people
- Sponsor
- Brigham and Women's Hospital
Ophthalmic Artery, Labor and Delivery
The Ophthalmic Artery Doppler Evaluation Prior to Labor Induction and Adverse Intrapartum Fetal Outcomes
The ophthalmic artery Doppler has been recently proposed as a potential "soft marker" for placental insufficiency in retrospective and observational studies, with similar clinical significance with respect to Uterine Artery (UA)…
- Conditions
- Ophthalmic Artery, Labor and Delivery, Induction of Labor, Intrapartum Fetal Distress
- Trial name
- OPHELIA (NCT07846137)
- Testing
- Ophthalmic Artery Doppler
- Volunteers
- 1,477 people
- Sponsor
- Fondazione Policlinico Universitario Agostino Gemelli IRCCS
Preterm Birth
Cervical Cerclage for Preventing Spontaneous Preterm Birth in Singleton Pregnancies Without Prior Spontaneous Preterm Birth and With Short Transvaginal Ultrasound Cervical Length
Spontaneous preterm birth (SPTB) remains the number one cause of perinatal mortality in many countries, including the United States.
- Trial name
- NCT02746900
- Testing
- Cervical cerclage
- Where
- Italy
- Volunteers
- 587 people
- Sponsor
- Federico II University
Premature Birth
HeartLight Pulse Study: Evaluation of Heart Rate Using an Electronic Stethoscope and Pre Placed ECG in the Delivery Room
This study will evaluate the accuracy of both an electronic stethoscope and electrocardiogram (ECG) to evaluate heart rate in neonatal patients in the delivery suite.
- Trial name
- HLPulseS (NCT02747069)
- Testing
- NICU electronic stethoscope, Newborns <32 weeks and ECG
- Where
- United Kingdom
- Volunteers
- 50 people
- Sponsor
- University of Nottingham
Preeclampsia, Preterm Birth
The Effect of Prematurity and Hypertensive Disorders of Pregnancy on Offspring Cardiovascular Health
The purpose of this study is to investigate whether exposure to hypertensive disorders of pregnancy and/or a preterm birth results in alterations in the cardiovascular system during infancy.
- Trial name
- EPOCH (NCT01888770)
- Where
- United Kingdom
- Volunteers
- 300 people
- Sponsor
- University of Oxford
Pre-Eclampsia, Premature Birth
PREPARE, Prematurity Reduction by Pre-eclampsia Care
Investigators will test a novel system of integrated care, to promote the use of the WORLD HEALTH ORGANIZATION Guidelines for the management of pre-eclampsia and initiate the use of a structured risk assessment strategy to reduce…
- Trial name
- PREPARE (NCT03073317)
- Testing
- FullPIERS and sFlit/PLGF (Soluble fms-Like Tyrosine Kinase-1-to-Placental Growth Factor Ratio)
- Where
- 8 sites in Brazil
- Volunteers
- 1,250 people, healthy volunteers welcome
- Sponsor
- Instituto Fernandes Figueira