Clinical trials: Pre-Diabetic
Pre Diabetic, Obesity & Overweight
The Impact of Continuous Glucose Monitoring on Glucose Variability and Weight Loss in Individuals With Prediabetes and Obesity
This randomized, crossover interventional study evaluates the effects of real-time (open) versus blinded continuous glucose monitoring (CGM) on glycemic variability, lifestyle behaviors, and metabolic outcomes in adults with…
- Trial name
- CGM (NCT07423065)
- Testing
- Continuous Glucose Monitoring (CGM)
- Where
- 3 sites in Slovenia
- Volunteers
- 34 people
- Sponsor
- University of Primorska
Type 2 Diabetes, Type II Diabetes Mellitus
The GRoceries Aimed at Increasing Nutrition Study
Only 2% of Americans meet the recommended levels of whole grain consumption, despite its association with reduced risk of type 2 diabetes.
- Conditions
- Type 2 Diabetes, Type II Diabetes Mellitus, Type II Diabetes, Pre-diabetes
- Trial name
- GRAINS (NCT07167004)
- Testing
- Marketing Nudges Only, Marketing Nudges + Dynamically Adapted Financial Incentives
- Where
- United States
- Volunteers
- 219 people
- Sponsor
- University of Pennsylvania
Diabetes Mellitus, Type 2, Pre-diabetes
Regular Use of aPDT in the Management and Prevention of Periodontitis Symptoms in Diabetic Patients
This is an investigator-initiated clinical study to establish easy referral and access for diabetic patients from primary health care to oral health care facilities for preventive oral care, periodontal assessment, and treatment…
- Conditions
- Diabetes Mellitus, Type 2, Pre-diabetes, Periodontal Diseases, Periodontitis
- Trial name
- APDT-T2D (NCT06486012)
- Testing
- Lumoral Treatment, Standard oral hygiene
- Where
- Finland
- Volunteers
- 150 people
- Sponsor
- Wellbeing Services County of Pirkanmaa
Pre Diabetic
PASO A PASO: Tailored Diabetes Prevention Program for Spanish-Speaking Communities Feasibility Study
The interdisciplinary and interprofessional community-academic partnership (CAP) has been working with Spanish-speaking H/L Salt Lake City residents and organization leaders to adapt the National Diabetes Prevention Program to…
- Trial name
- NCT07392008
- Testing
- Paso a Paso
- Where
- United States
- Volunteers
- 48 people, healthy volunteers welcome
- Sponsor
- University of Utah
Pre Diabetes, Type 2 Diabetes Mellitus
Personalised Medicine in Pre-diabetes and Early Type 2 Diabetes
Prediabetes is a common condition in overweight individuals affecting approximately 35% of American adults and 30% of Australian adults.
- Trial name
- PREDICT (NCT03558867)
- Testing
- Metformin + Healthy diet, Metformin + Personalized diet
- Where
- Australia
- Volunteers
- 138 people
- Sponsor
- Garvan Institute of Medical Research
Pre Diabetes, Type2 Diabetes Mellitus
A Study to Assess Effect of Glucocil® on Metabolic Health in Individuals With Prediabetes and Type 2 Diabetes Mellitus.
A randomized, double-blind, placebo-controlled study to assess the effect of Glucocil® on metabolic health in individuals with prediabetes and Type 2 Diabetes Mellitus.
- Trial name
- NCT06496893
- Testing
- IP 1200 mg per soft gel capsule
- Where
- 6 sites in India
- Volunteers
- 104 people, healthy volunteers welcome
- Sponsor
- Vedic Lifesciences Pvt. Ltd.
Pre-Gestational Diabetes, Type2diabetes
A Randomized Controlled Trial of Diabetes Screening Immediately Postpartum (DIP) and Follow Up PP CARE
DIP : To conduct a pragmatic, non-blinded randomized controlled trial (pRCT) of immediate in-patient postpartum OGTT prior to delivery discharge (intervention) versus 4-12 week outpatient postpartum OGTT (current standard care)…
- Conditions
- Pre-Gestational Diabetes, Type2diabetes, Pregnancy in Diabetic, Pregnancy, High Risk
- Trial name
- NCT05909046
- Testing
- Immediate inpatient postpartum OGTT, Standard of care 4-12 week postpartum OGTT
- Where
- United States
- Volunteers
- 104 people
- Sponsor
- Ohio State University
Pre Diabetic, Obesity & Overweight
PREdiabetes GLycemic Impact and Data Evaluation
This prospective, randomized controlled trial evaluates whether real-time continuous glucose monitoring (CGM) improves glycemic control and lifestyle adherence in adults with prediabetes compared to conventional self-monitoring…
- Conditions
- Pre Diabetic, Obesity & Overweight, Insulin Resistance
- Trial name
- PRE-GLIDE (NCT07599072)
- Testing
- CGM Sibionics, On-Call Extra Glucometer
- Where
- 3 sites in Ukraine
- Volunteers
- 80 people
- Sponsor
- Nazarii Kobyliak
Diabetes Mellitus, Type 2, Pre-diabetic
Glucagon-like Peptide-1 Metabolism and Acute Neprilysin Inhibition
Type 2 diabetes is common, increases in prevalence with age, and patients with diabetes have an increased risk of cardiovascular disease.
- Conditions
- Diabetes Mellitus, Type 2, Pre-diabetic, Hypertension, Elevated Blood Pressure
- Trial name
- NCT03508739
- Testing
- Sacubitril/Valsartan 200mg (blinded), Valsartan 160mg (blinded)
- Where
- United States
- Sponsor
- University of Pennsylvania
Obesity, Diabetes Mellitus
Inflammation, Diabetes, Ethnicity and Obesity Cohort
Obesity affects over one third of US adults (>72 million, with BMI ≥30 kg/m2), and the proportion of US adults with BMI ≥40 kg/m2 has doubled in the last 20 years.
- Conditions
- Obesity, Diabetes Mellitus, Pre Diabetes
- Trial name
- IDEO (NCT03022682)
- Where
- United States
- Volunteers
- 350 people, healthy volunteers welcome
- Sponsor
- University of California, San Francisco
Diabetes Mellitus, Type 2, Pre Diabetes
Increasing Uptake of EHR-enabled Population Health Outreach Strategies to Improve Diabetes Screening
The study team's central hypothesis is that the Parkland Diabetes Detection Program (PDDP) screening invitations targeted by race/ethnicity with culturally concordant messaging and tailored by glycemic risk (known PDM vs.
- Trial name
- NCT05730582
- Testing
- Parkland Diabetes Detection Program (PDDP) Screening Invitation
- Where
- United States
- Volunteers
- 500,000 people
- Sponsor
- University of Texas Southwestern Medical Center
Pre-diabetes, Type 2 Diabetes
Mechanisms of Fatigability With Diabetes
Pre-diabetes (Pre-D) is a precursor to type 2 diabetes (T2D) and characterized by increased exercise fatigability of lower limb muscles, that can impede exercise performance.
- Trial name
- NCT04442451
- Testing
- Control Exercise, Blood Flow Restriction Exercise
- Where
- United States
- Volunteers
- 80 people
- Sponsor
- University of Michigan
Pre Diabetic
How Fig Polyphenols Affect Blood Sugar and Insulin Levels After Eating in Adults at Risk for Diabetes
The study purpose is to understand how the body absorbs and metabolizes nutrient-like components in dried figs called polyphenols over 24 hours.
- Trial name
- FG (NCT07625046)
- Testing
- Fig, Control
- Where
- United States
- Volunteers
- 5 people
- Sponsor
- Clinical Nutrition Research Center, Illinois Institute of Technology
Type 1 Diabetes (T1D), Pre Diabetes
INNODIA Family & Friends Early-Stage T1D Detection Protocol
The purpose of INNODIA DETECT is to identify people who are at increased risk of developing T1D. Investigators are doing this by testing for markers in the blood (autoantibodies) that tell them an individuals risk of getting T1D…
- Trial name
- INNODIA DETECT (NCT07118098)
- Where
- 21 sites in Austria, Belgium and 6 more
- Volunteers
- 30,000 people, healthy volunteers welcome
- Sponsor
- INNODIA iVZW
Pre Diabetic
Effects of Intermittent Fasting Variations on Nutrigenomic Profile, Metabolic Parameters, Inflammation, and Body Composition in Prediabetic Patients
Prediabetes is a metabolic condition associated with increased risk of type 2 diabetes and cardiovascular disease. Intermittent fasting (IF) has emerged as a potential dietary intervention to improve metabolic health, yet…
- Trial name
- NCT07755982
- Testing
- Diet
- Where
- Indonesia
- Volunteers
- 120 people
- Sponsor
- Muhammad Aron Pase
Pre-diabetes, Diabetes
OGTT at Home Using CGM vs at the Clinic
This randomized, crossover study evaluates the feasibility and accuracy of a self-administered oral glucose tolerance test (OGTT) at home using continuous glucose monitoring (CGM) compared to a standard clinic-based OGTT.
- Trial name
- OGTT-CGM (NCT06862128)
- Testing
- OGTT at home using CGM, OGTT at the clinic
- Where
- 3 sites in Sweden
- Volunteers
- 70 people
- Sponsor
- Linkoeping University
Pre Diabetic
Xinqiao High-risk Cohort of Diabetes(NICE)
Objective: 1. To systematically screen the high-risk population of diabetes in Xinqiao area, understand the characteristics of early glucose metabolism changes and pancreatic islet function changes in the high-risk population and…
- Trial name
- NCT07281170
- Where
- 2 sites in China
- Volunteers
- 7,000 people
- Sponsor
- Shanghai General Hospital, China
Type 2 Diabetes, Pre-diabetes
Point-of-care Capillary HbA1c Testing for Type 2 Diabetes Screening Among At-risk Individuals in Rural Dali, China
This project aims to compare Point-of-care capillary HbA1c (POC-cHbA1c) testing and fingerstick random blood glucose (RBG) testing in terms of type 2 diabetes detection rate and cost-effectiveness, in order to optimise current…
- Trial name
- NCT07718867
- Testing
- POC-cHbA1c, Fingerstick RBG
- Where
- China
- Volunteers
- 720 people
- Sponsor
- The University of Hong Kong
Pre-eclampsia, Gestational Diabetes Mellitus (GDM)
Placental Biology in Health and Disease
Pre-eclampsia (PET) is a condition characterised by high blood pressure and damage to other organs, and is a leading cause of maternal and fetal complications such as fetal growth restriction (FGR).
- Conditions
- Pre-eclampsia, Gestational Diabetes Mellitus (GDM), Fetal Growth Restriction (FGR), Pregnancy Induced Hypertension (PIH)
- Trial name
- NCT07470320
- Testing
- There are no interventions for this study
- Where
- United Kingdom
- Volunteers
- 360 people, healthy volunteers welcome
- Sponsor
- University of Oxford
Diabetes Mellitus, Type 2, Pre-diabetes
Skeletal Muscle Diacylglycerol and Sphingolipids - Impact of Localization and Species on Insulin Resistance in Humans
The rationale for the proposed research is that elucidating changes in localized diacylglycerol (DAG) and sphingolipid species that predict insulin sensitivity will reveal specific localized lipids to target in therapeutics for…
- Conditions
- Diabetes Mellitus, Type 2, Pre-diabetes, Obesity
- Trial name
- NCT03077360
- Testing
- Lifestyle
- Where
- United States
- Volunteers
- 62 people, healthy volunteers welcome
- Sponsor
- University of Colorado, Denver