Clinical trials: Pre-Gestational Diabetes
Gestational Diabetes, Gestational Hypertension
sFlt-1:PlGF Ratio in Gestational Diabetes: PREDICTION (PREeclampsia in DIabetiC gestaTION) Study
The ratio of soluble fms-like tyrosine kinase 1 (sFlt-1) to placental growth factor (PlGF) is elevated in pregnant women before the clinical onset of preeclampsia and can be used to predict the preeclampsia.
- Conditions
- Gestational Diabetes, Gestational Hypertension, Pre-Eclampsia
- Trial name
- PREDICTION (NCT04877119)
- Where
- Italy
- Volunteers
- 500 people, healthy volunteers welcome
- Sponsor
- Azienda Ospedaliero, Universitaria Pisana
Gestational Diabetes Mellitus in Pregnancy
Acute Metabolic Effects of Pre-meal Consumption of Whey in Women at Risk of Gestational Diabetes Mellitus
The main objective of our study is to investigate the metabolic effects of whey protein (whey protein isolate, WPI, (Lacprodan® ISO.Water.
- Trial name
- NCT04767880
- Testing
- Whey
- Where
- Denmark
- Volunteers
- 24 people, healthy volunteers welcome
- Sponsor
- University of Aarhus
Hypertension in Pregnancy, Diabetes Mellitus in Pregnancy
Insulin Resistance and Hypertensive Disorders in Pregnancy
The purpose of this study is to determine whether insulin resistance might affect the pathogenesis of hypertensive disorders in pregnancy since midtrimester.
- Trial name
- NCT00412230
- Where
- Italy
- Volunteers
- 100 people, healthy volunteers welcome
- Sponsor
- University of Messina
Pregnancy, Pre-eclampsia
Oxfordshire Women and Their Children's Health
The aim of this feasibility study is to test recruitment of participants into Phase 1 of the study and then the re-recruitment and retention of participants in Phase 2 of the study.
- Conditions
- Pregnancy, Pre-eclampsia, Gestational Diabetes, Depression
- Trial name
- OxWATCH (NCT02419898)
- Where
- United Kingdom
- Volunteers
- 250 people, healthy volunteers welcome
- Sponsor
- Oxford University Hospitals NHS Trust
Preeclampsia, Pregnancy Complications
Berlin-Brandenburg Pregnancy Cohort
This study will investigate the interplay of different immune cells and placental cells as well as their potential for the development of pregnancy complications.
- Conditions
- Preeclampsia, Pregnancy Complications, Diabetes Mellitus in Pregnancy
- Trial name
- BBPC (NCT03313024)
- Where
- Germany
- Volunteers
- 1,580 people, healthy volunteers welcome
- Sponsor
- Charite University, Berlin, Germany
Pregnant Women With Singleton Pregnancies
Harvesting Health: Advancing Nutrition and Wellness for Moms and Babies
This is a randomized controlled trial to assess whether a personalized food kit to pregnant women is feasible, improves diet quality, and enhances pregnancy and birth outcomes compared to standard prenatal care.
- Trial name
- HH (NCT07659821)
- Testing
- Food Kit
- Where
- 3 sites in United States
- Volunteers
- 800 people, healthy volunteers welcome
- Sponsor
- Texas A&M University
Polycystic Ovary Syndrome
Effects of Oral Inositol Supplementation on Obstetrics Outcomes in PCOS Women
Polycystic ovarian syndrome (PCOS) is a heterogeneous, multifaceted and complex disorder characterized by insulin resistance (IR), hyperinsulinemia, and hyperandrogenism leading ovarian disfunction and infertility.
- Trial name
- IPOSI-1 (NCT03585738)
- Testing
- Inositol + Folic acid, Folic acid
- Volunteers
- 80 people, healthy volunteers welcome
- Sponsor
- Università degli Studi dell'Insubria
Obstetric Labor, Pregnancy in Diabetics
Intrapartum Glucose and Insulin Compared to Glucose Alone in Diabetic Women
This study aims to examine the effect of intrapartum treatment of diabetic women with combined glucose and constant insulin infusion compared to glucose alone on the incidence of neonatal hypoglycemia.
- Trial name
- NCT03273881
- Testing
- glucose solution and Insulin, glucose solution only
- Where
- Israel
- Volunteers
- 200 people, healthy volunteers welcome
- Sponsor
- HaEmek Medical Center, Israel
Diabetes, Gestational
Insulin Sensitivity and Secretion During Pregnancy and Post Partum in Women With Gestational Diabetes.
Aim of the study: To define insulin requirement during pregnancy and to identify the rapid changes in insulin sensitivity around parturition and the first 6 months post partum.
- Trial name
- NCT02770079
- Where
- Denmark
- Volunteers
- 10 people, healthy volunteers welcome
- Sponsor
- University of Aarhus
Pregestational Diabetes
Intrapartum Maternal Glycemic Control Using Insulin Pump Versus Insulin Drip - Cohort Observational Trial
The purpose of this study is to compare intrapartum glycemic control using insulin pump versus intravenous (IV) insulin administration.
- Trial name
- NCT01158040
- Where
- Israel
- Volunteers
- 88 people, healthy volunteers welcome
- Sponsor
- Sheba Medical Center
Overweight and Obesity, Insulin Resistance
DHA Supplements to Improve Insulin Sensitivity in Obese Pregnant Women (The Omega-3 Pregnancy Study)
Women with excess adiposity while pregnant are more likely to develop gestational diabetes and high blood pressure during pregnancy than women of healthy weights.
- Conditions
- Overweight and Obesity, Insulin Resistance, Diabetes, Gestational, Hypertension in Pregnancy
- Trial name
- NCT00865683
- Testing
- DHA Supplements
- Where
- United States
- Volunteers
- 90 people, healthy volunteers welcome
- Sponsor
- National Heart, Lung, and Blood Institute (NHLBI)
Postpartum Infection
Trends in Pregnancy Outcomes Beyond Twenty Weeks Gestational Age in Assisted Reproductive Technology Conceived Pregnancies in British Columbia
Examining outcomes beyond 20 weeks gestational age in pregnancies conceived by ART compared to spontaneously conceived pregnancies 1.
- Trial name
- NCT06726603
- Testing
- Assisted Reproductive Technology
- Volunteers
- 1,000 people, healthy volunteers welcome
- Sponsor
- University of British Columbia
Obstructive Sleep Apnea
Targeted CPAP Therapy for Obstructive Sleep Apnea in Pregnancy
Prospective, randomized controlled trial. Pregnant women in early pregnancy will be randomized to either the Sleep Study + CPAP (Continuous Positive Airway Pressure Therapy) group or to a Standard Prenatal Care group.
- Trial name
- NCT02755831
- Testing
- CPAP, Pre-natal care
- Where
- United States
- Volunteers
- 193 people, healthy volunteers welcome
- Sponsor
- United States Naval Medical Center, San Diego
Pregnancy Complications, Placental Insufficiency
PREdelivery Placental Biomarkers- Pregnancy and Delivery Outcome
The PREPPeD study proposes that predelivery placenta-derived maternal circulating biomarkers reflect placental health, capacity and ageing, and can help predict onset and complications of delivery both in complicated pregnancies…
- Trial name
- PREPPeD (NCT03100084)
- Testing
- Blood sampling
- Where
- Norway
- Volunteers
- 1,000 people, healthy volunteers welcome
- Sponsor
- Oslo University Hospital
Gestational Diabetes Mellitus in Pregnancy
Lifestyle Intervention IN Gestational Diabetes (LIVING)
Investigators have taken the learning from various programs to develop a new lifestyle program (LIVING) that has a high probability of being feasible, acceptable and cost-effective in the South Asian context for women with prior…
- Trial name
- LIVING (NCT03305939)
- Testing
- Life style Intervention
- Where
- 20 sites in Bangladesh, India and 1 more
- Volunteers
- 1,612 people, healthy volunteers welcome
- Sponsor
- The George Institute
Pregnancy Complications
Measuring sVAP-1 as a Predictor of Pregnancy Problems
Pre-eclampsia is a common pregnancy disorder defined as high blood pressure and protein in the urine after 20 weeks of pregnancy.
- Trial name
- NCT04891315
- Testing
- Blood test for soluble VAP-1 (sVAP-1).
- Where
- United Kingdom
- Volunteers
- 102 people, healthy volunteers welcome
- Sponsor
- University of Leicester
Diabetes Mellitus, Gestational Diabetes Mellitus (GDM)
A Proof of Concept (PoC), Randomized, Controlled Study to Validate the Algorithm and Evaluate the Accuracy, Safety and Pain Level of the Smartest-AE in Comparison to Self-measure Blood Glucose Levels
The study is conducted in Israel so plain language for the study is exist in Hebrew only
- Conditions
- Diabetes Mellitus, Gestational Diabetes Mellitus (GDM), Pre Diabetes
- Trial name
- NCT06587087
- Testing
- Smartest-AE: The lancet that will be used will be the Vitrex Soft Lite lll 28G.
- Where
- Israel
- Volunteers
- 300 people, healthy volunteers welcome
- Sponsor
- Smartest Technologies
Gestational Diabetes, Pre-Eclampsia
Body Fat Index for Obstetric Risk Stratification
Primary Outcome:- GDM Diagnosis Secondary Outcomes:- Pre-eclampsia diagnosis. Cesarean section delivery due to labor dystocia defined as protracted or arrested progress of labor using labor partogram.
- Conditions
- Gestational Diabetes, Pre-Eclampsia, Labour Dystocia
- Trial name
- BFIors (NCT05533996)
- Testing
- ultrasound
- Volunteers
- 206 people, healthy volunteers welcome
- Sponsor
- Assiut University
Overweight or Obesity
NDPP-NextGen: A Clinical Trial to Reduce Intergenerational Obesity and Diabetes Risks
The goal of this clinical trial is to test an enhanced version of the National Diabetes Prevention Program (NDPP-NextGen) that is tailored to young women in childbearing years.
- Trial name
- NCT05674799
- Testing
- NDPP-NextGen
- Where
- United States
- Volunteers
- 403 people, healthy volunteers welcome
- Sponsor
- Wake Forest University Health Sciences
Periodontal Diseases, Pregnancy Complications
Oral Health and Adverse Pregnancy Complications
Pregnant women are susceptible to develop periodontitis, but these oral health changes related to pregnancy are often neglected.
- Conditions
- Periodontal Diseases, Pregnancy Complications, Pregnancy Preterm, Gestational Diabetes
- Trial name
- NCT06110143
- Testing
- Periodontal treatment
- Where
- 3 sites in Denmark
- Volunteers
- 600 people, healthy volunteers welcome
- Sponsor
- University Hospital Bispebjerg and Frederiksberg