Clinical trials: Pre-Menopause
Women in Need of Long Acting Reversibel Cntraception With the Intrauterine Levonorgestrel Releasing System, Mirena
Pretreatment With Mifepristone Prior to Mirena Insertion
Hypothesis: Pretreatment with mifeprsitone prior to Mirena placement will induce amenorrhea and reduce bleeding irrregularities during the initial months of Mirena use.
- Trial name
- MiMi (NCT01931657)
- Testing
- Mifepristone prior to Mirena
- Where
- Sweden
- Volunteers
- 60 people, healthy volunteers welcome
- Sponsor
- Karolinska Institutet
Premenopause, Iron-deficiency
A Clinical Study on Adherence and Efficacy of Different Doses of Active Iron in Treatment Resistant Subjects
A randomized, placebo controlled, parallel group, double blind study to compare the 3-month adherence and efficacy of Active Iron in subjects with or at-risk of iron deficiency and a history of intolerance to oral iron.
- Conditions
- Premenopause, Iron-deficiency, Iron Adverse Reaction, Iron Deficiency Anemia
- Trial name
- NCT04778072
- Testing
- Ferrous sulfate 14mg once daily, Ferrous sulfate 25mg once daily, Ferrous sulfate 25mg twice daily
- Where
- Ireland
- Volunteers
- 60 people, healthy volunteers welcome
- Sponsor
- Solvotrin Innovations Ltd
Depression, Healthy
Bone Loss in Premenopausal Women With Depression
The purpose of this study is to determine whether women with major depression lose bone mass at a faster rate than women without depression.
- Conditions
- Depression, Healthy, Osteopenia, Osteoporosis
- Trial name
- NCT00006180
- Testing
- Alendronate
- Where
- United States
- Volunteers
- 220 people, healthy volunteers welcome
- Sponsor
- National Institute of Mental Health (NIMH)
Menopause, Aging
Role of Menopause in Thermoregulation
The frequency and severity of heat waves has increased in the last decades. Older adults (over 65 years) have impaired responses to heat stress making them at increased risk for adverse events.
- Trial name
- NCT06798571
- Testing
- Elagolix Oral Tablet, Estradiol patch
- Where
- United States
- Volunteers
- 24 people, healthy volunteers welcome
- Sponsor
- Penn State University
Menopause, Cardiovascular Health
Acute Physiological Effects of Greek Traditional Dancing
In Greece, people of different age groups, including young children to older adults, are involved in traditional dance. To date, the well-know benefits of dancing include entertainment, socialization and increased physical…
- Conditions
- Menopause, Cardiovascular Health, Body Composition, Physical Performance
- Trial name
- NCT06260124
- Testing
- Slow tempo, Moderate tempo, Fast tempo
- Where
- Greece
- Volunteers
- 20 people, healthy volunteers welcome
- Sponsor
- University of Thessaly
Estrogen, Premenopause
Disentangling the Effects of Daily Stress, Sleep, and Sex Hormones on Accelerated Vascular Aging in Midlife Women
The purpose of this study is to identify the impact of estradiol (E2) on the associations between (a) responsivity to daily stress or (b) sleep variability with vascular function in midlife premenopausal women.
- Trial name
- V-RISES (NCT06745466)
- Testing
- ganirelix acetate
- Where
- United States
- Volunteers
- 30 people, healthy volunteers welcome
- Sponsor
- University of Delaware
Menopause
Effects of a Seven-day BASIS™ Supplementation on Menopausal Syndromes and Measurements of the Urinary Vitamin B3 and Estradiol Levels in Pre-, Peri- and Post-menopause
The purpose of this study is to determine whether a short supplementation (7days) with BASIS™ increases the natural production of estradiol, measured in urinary waste.
- Trial name
- NCT04841499
- Testing
- BASIS™ (Crystalline Nicotinamide Riboside 250mg and Pterostilbene 50mg)
- Where
- United States
- Volunteers
- 40 people, healthy volunteers welcome
- Sponsor
- University of South Alabama
Breast Cancer
Prevention Strategy for Pre-Menopausal Women at High Risk for Development of Breast Cancer
The investigators will study the effect of 12 months of SDG (Brevail) vs placebo on women at increased risk for development of breast cancer.
- Trial name
- NCT01276704
- Testing
- secoisolariciresinol
- Where
- 7 sites in United States
- Volunteers
- 180 people, healthy volunteers welcome
- Sponsor
- Carol Fabian, MD
Breast Cancer
Acolbifene in Preventing Cancer in Premenopausal Women at High Risk of Breast Cancer
This phase II trial is studying how well acolbifene works in preventing cancer in premenopausal women at high risk of breast cancer. Chemoprevention is the use of certain drugs to keep cancer from forming.
- Trial name
- NCT00853996
- Testing
- acolbifene hydrochloride
- Where
- United States
- Volunteers
- 25 people, healthy volunteers welcome
- Sponsor
- University of Kansas Medical Center
Obesity, Cardiovascular Disease
The WORLD (Weight Optimization: Revamping Lifestyles Using the Dietary Guidelines) Study - Developing, Implementing, and Testing an Education Program
The WORLD study is a single-center, year-long randomized controlled trial in free-living women. Participants were randomly assigned to follow either a lower-fat (LF) diet or a moderate-fat (MF) diet for weight management in a…
- Trial name
- WORLD (NCT00847574)
- Testing
- Moderate-fat, Lower-fat
- Where
- United States
- Volunteers
- 101 people, healthy volunteers welcome
- Sponsor
- Penn State University
Menopause, Depression
Brain Imaging Study in Menopausal Women With and Without Major Depressive Disorder
The purpose this study is to measure cortical gama-aminobutyric acid levels (GABA) levels in menopausal women with major depressive disorder and healthy subjects using nuclear magnetic resonance spectroscopy (MRS).
- Trial name
- NCT00626340
- Testing
- MDD diagnosis and Estrogen treatment, MDD diagnosis and Fluoxetine treatment, MDD diagnosis with both Estrogen and Fluoxetine treatment
- Where
- United States
- Volunteers
- 18 people, healthy volunteers welcome
- Sponsor
- University of Pennsylvania
Heathy Women, Pre Menopausal Age
Estimation of Minimum Efficacy Daily Dose of Jarlsberg Cheese
Aim: To estimate an oral administered recommended minimum efficacy daily dose (MED) of Jarlsberg cheese in order to obtain the needed increased level of Osteocalcin defined as the ratio [Carboxylated / Under Carboxylated]…
- Conditions
- Heathy Women, Pre Menopausal Age, Exlution Criteria: Gastrointestinal Disorder, Liver Disease
- Trial name
- NCT04185454
- Testing
- Jarlsberg cheese
- Where
- Norway
- Volunteers
- 20 people, healthy volunteers welcome
- Sponsor
- Prof Stig Larsen
Cardiovascular Diseases, Vascular Disease
Effect of Diet on Vascular Disease in Pre-Menopausal Women
African Americans have a higher prevalence of vascular disease than Caucasians. Vascular disease can lead to heart attacks, strokes and even amputations.
- Conditions
- Cardiovascular Diseases, Vascular Disease, Inflammation, Insulin
- Trial name
- NCT00484861
- Where
- United States
- Volunteers
- 47 people, healthy volunteers welcome
- Sponsor
- National Institute of Diabetes and Digestive and Kidney Diseases (NIDDK)
Menopause, Pre-menopause
Following Lipectomy to Understand Adipose Tissue Re-accumulation
The typical female pattern of accumulating fat in the hips and thighs has long been thought to confer less risk for disease than the typical male abdominal fat pattern.
- Trial name
- FLARE (NCT00995631)
- Testing
- Femoral lipectomy
- Where
- United States
- Volunteers
- 53 people, healthy volunteers welcome
- Sponsor
- University of Colorado, Denver
Premenopause, Healthy
Effect of Race on Gonadotropin Responses
The purpose of this study is to attempt to determine why estrogen levels are increased in African-American women as compared to Caucasian women by evaluating estrogen feedback on the brain.
- Trial name
- NCT00455962
- Testing
- Estradiol steroid infusion, Progesterone steroid infusion
- Where
- United States
- Volunteers
- 23 people, healthy volunteers welcome
- Sponsor
- Massachusetts General Hospital
Endometriosis
A Study to Investigate the Safety, Tolerability, Food Effect, Pharmacokinetics and Pharmacodynamics of FOR-6219
This is a randomised, double-blind, placebo-controlled, Phase I/Ib study which will assess the safety, tolerability, food effect, pharmacokinetics and pharmacodynamics of FOR-6219, a hydroxysteroid (17B) dehydrogenase (HSD17B1)…
- Trial name
- NCT03709420
- Testing
- FOR-6219
- Where
- United Kingdom
- Volunteers
- 87 people, healthy volunteers welcome
- Sponsor
- Forendo Pharma Ltd
Contraception
A Study to Compare 3 Doses of a Hormonal Intra-uterine Device Containing Levonorgestrel and Indomethacin With a Hormonal Intra-uterine Device Containing Only Levonorgestrel to Assess the Effect and Safety of the Combined Components
This study is the first study investigating the combined intrauterine administration of LNG (levonorgestrel) and IND (indomethacin). It is a combined proof-of-concept (PoC) and dose finding (DF) study in pre-menopausal women.
- Trial name
- INDessa (NCT03562624)
- Testing
- BAY98-7443, Levonogestrel (Skyla, BAY86-5028)
- Where
- 7 sites in Germany, United Kingdom
- Volunteers
- 177 people, healthy volunteers welcome
- Sponsor
- Bayer
Blood Pressure
Pumpkin Seed Oil Supplementation in Premenopausal Women
The purpose of this study is to determine whether or not there is an effect of pumpkin seed oil supplementation, 2 grams per day, on blood pressure (systolic and diastolic) in premenopausal women.
- Trial name
- NCT02119429
- Testing
- Pumpkin Seed Oil, Wheat Germ Oil
- Where
- United States
- Volunteers
- 50 people, healthy volunteers welcome
- Sponsor
- Texas Woman's University
Healthy
Scalp Hair Estradiol and Progesterone Level Determination in Women (Proof of Concept Study)
The investigators hypothesis is that we can determine estrogen and progesterone levels in the hair by using the immune method and we can show a significant difference in the levels of these hormones in both groups of women: pre…
- Trial name
- NCT02755038
- Where
- Israel
- Volunteers
- 40 people, healthy volunteers welcome
- Sponsor
- Bnai Zion Medical Center
Alcohol Drinking, Weight Loss
The Effects of Alcohol Consumption on Central Adiposity
The objective of the proposed study is to enroll women with obesity that will undergo a controlled, energy restricted feeding intervention to test the effects of chronic ethanol consumption on adipose distribution and circulating…
- Conditions
- Alcohol Drinking, Weight Loss, Adiposity, Obesity
- Trial name
- CONSUME (NCT03521817)
- Testing
- Alcohol, No Alcohol
- Where
- United States
- Volunteers
- 12 people, healthy volunteers welcome
- Sponsor
- Pennington Biomedical Research Center