Clinical trials: Pre-Menopause
Overweight, Obesity
"Improving Diet, Exercise And Lifestyle (IDEAL) for Women" Study
Diets all share the same principle: eat less energy than you need. This results in weight loss. However, the weight loss is usually a combination of a loss of body fat and muscle mass.
- Trial name
- NCT00710398
- Testing
- Exercise - Aerobic and Resistance, Dietary - Caloric Restriction
- Where
- Canada
- Volunteers
- 90 people, healthy volunteers welcome
- Sponsor
- McMaster University
Elevated Blood Pressure, Endothelial Dysfunction
Effectiveness of Vitamin D Supplementation
This pilot study will examine the effectiveness of vitamin D supplementation on reducing blood pressure and improving endothelial function. Premenopausal African American women will be recruited.
- Trial name
- NCT02513823
- Testing
- 2,000 International Units (IU)of vitamin D3
- Where
- United States
- Volunteers
- 27 people, healthy volunteers welcome
- Sponsor
- Texas Woman's University
Menopause, Aging
Role of Menopause in Thermoregulation
The frequency and severity of heat waves has increased in the last decades. Older adults (over 65 years) have impaired responses to heat stress making them at increased risk for adverse events.
- Trial name
- NCT06798571
- Testing
- Elagolix Oral Tablet, Estradiol patch
- Where
- United States
- Volunteers
- 24 people, healthy volunteers welcome
- Sponsor
- Penn State University
Menopause
Effects of a Seven-day BASIS™ Supplementation on Menopausal Syndromes and Measurements of the Urinary Vitamin B3 and Estradiol Levels in Pre-, Peri- and Post-menopause
The purpose of this study is to determine whether a short supplementation (7days) with BASIS™ increases the natural production of estradiol, measured in urinary waste.
- Trial name
- NCT04841499
- Testing
- BASIS™ (Crystalline Nicotinamide Riboside 250mg and Pterostilbene 50mg)
- Where
- United States
- Volunteers
- 40 people, healthy volunteers welcome
- Sponsor
- University of South Alabama
Menopause, Insulin Resistance
Effects of Physical Training on Adipose Tissue Metabolism and Insulin Sensitivity in the Menopausal Transition Phase
The purpose of this study is to determine if physical exercise reduces the adverse changes in adipose tissue metabolism and insulin sensitivity that occurs in women during the menopausal transition.
- Conditions
- Menopause, Insulin Resistance, Body Composition, Beneficial
- Trial name
- NCT02076932
- Testing
- Spinning
- Where
- Denmark
- Volunteers
- 43 people, healthy volunteers welcome
- Sponsor
- University of Copenhagen
Breast Cancer
Prevention Strategy for Pre-Menopausal Women at High Risk for Development of Breast Cancer
The investigators will study the effect of 12 months of SDG (Brevail) vs placebo on women at increased risk for development of breast cancer.
- Trial name
- NCT01276704
- Testing
- secoisolariciresinol
- Where
- 7 sites in United States
- Volunteers
- 180 people, healthy volunteers welcome
- Sponsor
- Carol Fabian, MD
Obesity, Cardiovascular Disease
The WORLD (Weight Optimization: Revamping Lifestyles Using the Dietary Guidelines) Study - Developing, Implementing, and Testing an Education Program
The WORLD study is a single-center, year-long randomized controlled trial in free-living women. Participants were randomly assigned to follow either a lower-fat (LF) diet or a moderate-fat (MF) diet for weight management in a…
- Trial name
- WORLD (NCT00847574)
- Testing
- Moderate-fat, Lower-fat
- Where
- United States
- Volunteers
- 101 people, healthy volunteers welcome
- Sponsor
- Penn State University
Contraception
To Investigate the Pharmacological Effects, Drug Blood Levels and Safety of an Intrauterine System Releasing the Study Drug BAY1007626 in Comparison to Mirena and Jaydess in Healthy Young Women Treated for 90 Days to Determine the Drug Dose for Further Development
Investigation of pharmacological effects, drug blood levels and safety of an intrauterine system releasing the study drug BAY1007626 in comparison to Mirena and Jaydess in healthy young women treated for 90 days to determine the…
- Trial name
- NCT02490774
- Testing
- BAY1007626, Jaydess, Mirena
- Where
- 7 sites in Germany, Netherlands and 1 more
- Volunteers
- 174 people, healthy volunteers welcome
- Sponsor
- Bayer
Premenopause
Clinical Pharmacological Study of GnRH Antagonist, Cetrorelix for Healthy Female Volunteer
GnRH analogs are globally used for assisted reproduction in infertile patients. To date, in healthy female volunteers the pharmacokinetic and pharmacodynamic profiles of cetrorelix when administered in a single dose have been…
- Trial name
- NCT00628121
- Testing
- Cetrorelix
- Where
- Japan
- Volunteers
- 31 people, healthy volunteers welcome
- Sponsor
- Nippon Kayaku Co., Ltd.
Estrogen Deficiency, Cardiovascular Disease (CVD)
Atherosclerosis, Immune Mediated Inflammation and Hypoestrogenemia in Young Women
The purpose of this study is to determine whether young women with functional hypothalamic amenorrhea (premenopausal HypoE) is associated with risk factors for pre-clinical cardiovascular disease (CVD).
- Conditions
- Estrogen Deficiency, Cardiovascular Disease (CVD), Functional Hypothalamic Amenorrhea, Endothelial Dysfunction
- Trial name
- NCT03018366
- Testing
- 17beta Estradiol, Progesterone
- Where
- United States
- Volunteers
- 29 people, healthy volunteers welcome
- Sponsor
- Cedars-Sinai Medical Center
Aging, Anxiety
The Relationship Between Leisure Activities and Aging Anxiety in Women
The goal of this observational study is to learn about the effect of leisure activities on aging anxiety of middle-aged (45-59) women.
- Conditions
- Aging, Anxiety, Premenopause, Womans Health
- Trial name
- NCT06206057
- Where
- Turkey (Türkiye)
- Volunteers
- 400 people, healthy volunteers welcome
- Sponsor
- Marmara University Pendik Training and Research Hospital
Menopause, Pre-menopause
Following Lipectomy to Understand Adipose Tissue Re-accumulation
The typical female pattern of accumulating fat in the hips and thighs has long been thought to confer less risk for disease than the typical male abdominal fat pattern.
- Trial name
- FLARE (NCT00995631)
- Testing
- Femoral lipectomy
- Where
- United States
- Volunteers
- 53 people, healthy volunteers welcome
- Sponsor
- University of Colorado, Denver
Pharmacokinetics of ASP1707, Pharmacodynamics of ASP1707
A Study to Assess the Safety, Tolerability and Effects of Single and Multiple Ascending Doses of ASP1707 in Healthy Male and Pre-menopausal Female Subjects, Including a Comparison of the Effects Under Fasted and Fed Conditions in Healthy Young Male Subjects
This study consists of four parts: Part 1 is a randomized, double-blind, placebo-controlled, single ascending dose study in healthy young male subjects to evaluate the safety, tolerability pharmacokinetics (PK) and effect on…
- Trial name
- NCT02368912
- Testing
- ASP1707 single dose of dose levels 1 -7, ASP1707 single dose fasted, ASP1707 single dose fed
- Where
- France
- Volunteers
- 176 people, healthy volunteers welcome
- Sponsor
- Astellas Pharma Europe B.V.
Pre-Diabetic
Effect of 1,25-dihydroxyvitamin D3, Treatment on Insulin Secretion and Muscle Strength in Pre-diabetic Persons
The purpose of this research is to study the effects of 1,25(OH)2 D3 (a prescription form of active Vitamin D) on muscle strength and insulin secretion by the pancreas and glucose utilization by skeletal muscle.
- Trial name
- NCT04286529
- Testing
- Calcitriol capsules
- Where
- United States
- Volunteers
- 17 people, healthy volunteers welcome
- Sponsor
- Mayo Clinic
Cardiovascular Diseases, Vascular Disease
Effect of Diet on Vascular Disease in Pre-Menopausal Women
African Americans have a higher prevalence of vascular disease than Caucasians. Vascular disease can lead to heart attacks, strokes and even amputations.
- Conditions
- Cardiovascular Diseases, Vascular Disease, Inflammation, Insulin
- Trial name
- NCT00484861
- Where
- United States
- Volunteers
- 47 people, healthy volunteers welcome
- Sponsor
- National Institute of Diabetes and Digestive and Kidney Diseases (NIDDK)
Osteoporosis, Metabolic Syndrome
Body Composition and Risk for Development of Pre-diabetes in Post-menopausal Chinese Women in Singapore
This project aims to ascertain that novel imaging and metabolic markers can be used to identify as well as to validate and improve the detection of Singapore-Chinese women at increased risk of diabetes.
- Trial name
- NCT03503552
- Where
- Singapore
- Volunteers
- 97 people, healthy volunteers welcome
- Sponsor
- JeyaKumar Henry
Blood Pressure
Pumpkin Seed Oil Supplementation in Premenopausal Women
The purpose of this study is to determine whether or not there is an effect of pumpkin seed oil supplementation, 2 grams per day, on blood pressure (systolic and diastolic) in premenopausal women.
- Trial name
- NCT02119429
- Testing
- Pumpkin Seed Oil, Wheat Germ Oil
- Where
- United States
- Volunteers
- 50 people, healthy volunteers welcome
- Sponsor
- Texas Woman's University
Overweight and Obesity
Betaine Supplementation and Lipid Metabolism in Overweight and Obese Pre-menopausal Women
Obesity represents a serious global health issue with significant consequences, including an increased risk of chronic diseases.
- Trial name
- NCT06344377
- Testing
- Betaine
- Where
- Poland
- Volunteers
- 54 people, healthy volunteers welcome
- Sponsor
- Poznan University of Life Sciences
Iron Deficiency Anaemia Due to Dietary Causes
Measuring Iron Bioavailability From Oral Iron Supplements in Healthy Pre-menopausal Women Using Stable Isotopes
In this study the investigators will compare iron absorption from 3 doses of iron (5, 10, 15 mg, given as either Spatone™ or ferrous sulphate).
- Trial name
- BOIs (NCT07563686)
- Testing
- 5mg Spatone, 10mg Spatone, 15mg Spatone
- Where
- United Kingdom
- Volunteers
- 14 people, healthy volunteers welcome
- Sponsor
- King's College London
Weight Loss, Appetitive Behavior
Investigating the Early Markers of Weight Loss
The study will include 30 women randomized in two distinct groups: G1: Slow weight loss and G2: Rapid weight loss . The total duration of the program will be different for each group, being over 20 and 10 weeks for G1 and G2…
- Conditions
- Weight Loss, Appetitive Behavior, Obesity
- Trial name
- NCT04866875
- Testing
- dieting
- Volunteers
- 30 people, healthy volunteers welcome
- Sponsor
- University of Ottawa