Clinical trials: Pre-diabetic State
Obesity & Overweight, Circadian Rhythm Disorders
Effects of Akkermansia Muciniphila and Berberine Supplementation on Insulin Sensitivity in Night-shift Workers
Night shift work is associated with an increased risk of obesity, insulin resistance, and cardiometabolic disorders, largely due to circadian misalignment, disrupted sleep, and altered eating patterns.
- Conditions
- Obesity & Overweight, Circadian Rhythm Disorders, Gut Microbiota Modulation, Prediabetes (Insulin Resistance, Impaired Glucose Tolerance)
- Trial name
- Shift2Health (NCT07440147)
- Testing
- Verum (A)
- Where
- Austria
- Volunteers
- 200 people, healthy volunteers welcome
- Sponsor
- FH Joanneum Gesellschaft mbH
Prediabetes, Overweight
Evaluation of a Lifestyle Intervention for Employees With Prediabetes
The purpose of this study is to evaluate the impact of a worksite lifestyle intervention for diabetes prevention among employees with prediabetes.
- Conditions
- Prediabetes, Overweight, Obese
- Trial name
- NCT01682954
- Testing
- Lifestyle counseling
- Where
- United States
- Volunteers
- 78 people
- Sponsor
- Ohio State University
PreDiabetes
Effect of Green Tea on Obese Pediatrics With Prediabetes
The aim of this research is to evaluate the safety and efficacy of green tea in obese pediatrics with prediabetes versus the metformin therapy alone that is given to these patients.
- Trial name
- NCT06229795
- Testing
- Green Tea Leaf Extract Decaffeinated, Metformin Hydrochloride 500 MG
- Where
- Egypt
- Volunteers
- 90 people, healthy volunteers welcome
- Sponsor
- Ain Shams University
PreDiabetes, Older Adult
Examining the Effects of Vivo on Physical Function and Glycemic Level in Sedentary Older With Prediabetes.
This is a 12-week randomized, controlled trial that seeks to examine the effect of Vivo on 1) change in lower extremity strength defined as number of chair stands done in 30 seconds and 2) change in average glycemic level (HbA1c)…
- Conditions
- PreDiabetes, Older Adult, Muscle Loss, Muscle Weakness
- Trial name
- NCT06458530
- Testing
- Vivo
- Where
- United States
- Volunteers
- 74 people, healthy volunteers welcome
- Sponsor
- Impactiv, Inc.
PreDiabetes
Metformin and Vascular Function in Prediabetes
The goal of this clinical trial is to investigate whether metformin improves vascular function in individuals with prediabetes. The main questions it aims to answer are: 1.
- Trial name
- NCT06526494
- Testing
- Metformin
- Where
- 2 sites in United States
- Sponsor
- Diana Jalal
Obesity, Prediabetic State
Effects of Melatonin Supplementation on Renal Physiology in a Habitual Sleep Restricted Population.
In a 6 week pilot study, 20 individuals with habitual sleep restriction will all be asked to extend their nightly sleep by 1 hour, and will then be randomized 1:1 to nightly controlled-release oral melatonin (2mg) or placebo.
- Trial name
- MAST (NCT02631148)
- Testing
- Melatonin
- Where
- United States
- Volunteers
- 12 people, healthy volunteers welcome
- Sponsor
- Brigham and Women's Hospital
Prediabetes
Effects of Autonomic Nervous System Modulation by Heart Rate Variability Biofeedback Training With Resonant Frequency Breathing on Glucose Metabolism in Individuals With Prediabetes
Approximately 20% of adults have prediabetes in Germany. Prediabetes is defined as a condition with glucose levels outside the normal range but not yet meeting the criteria for type 2 diabetes.
- Trial name
- RwHRVBFinPD (NCT06739993)
- Testing
- Resonance frequency breathing with heart rate variability biofeedback training, Anti-Stress program
- Where
- 2 sites in Germany
- Volunteers
- 60 people
- Sponsor
- Johannes Gutenberg University Mainz
Prediabetes, Healthy (Controls)
Effects of Exogenous Ketones on Cognitive Function in Older Adults With Prediabetes?
Brief Summary The goal of this clinical trial is to learn whether older adults with prediabetes, but no diagnosed cognitive impairment, show early changes in brain energy use and thinking speed compared to older adults with…
- Trial name
- NCT07546409
- Testing
- Ketone Monoester (KE)
- Where
- 2 sites in United States
- Volunteers
- 20 people, healthy volunteers welcome
- Sponsor
- University of Alabama at Birmingham
PreDiabetes, Body Weight
Effect of Empagliflozin Versus Placebo on Brain Insulin Sensitivity in Patients With Prediabetes
Recently, various sodium glucose cotransporter 2 (SGLT2) inhibitors have been approved for the treatment of type 2 diabetes mellitus. Empagliflozin is a preparation of this class of substances.
- Trial name
- NCT03227484
- Testing
- Empagliflozin 25mg
- Where
- Germany
- Volunteers
- 42 people, healthy volunteers welcome
- Sponsor
- University Hospital Tuebingen
Overweight, PreDiabetes
Medically Intensive Nutrition Therapy Program for Obesity and Diabetes in a Low-income Population
This study is being done to better understand whether meal replacements can be an effective tool for weight loss and treatment of elevated blood sugars in people with obesity/overweight and diabetes/pre-diabetes who have a low…
- Conditions
- Overweight, PreDiabetes, Diabetes Type 2, Obesity
- Trial name
- MINT (NCT05799222)
- Testing
- Bariatrix Meal Replacement Products
- Where
- United States
- Volunteers
- 20 people
- Sponsor
- Massachusetts General Hospital
PreDiabetes, Pre Diabetes
Comparative Effects of High-Intensity Interval Training and Continuous Endurance Training Among Prediabetic Patients
Prediabetics is a condition where blood sugar levels are normal but not yet high enough to be diagnosed as type 2 diabetes. This phase offers a crucial point for timely intervention to delay or prevent type 2 diabetes.
- Conditions
- PreDiabetes, Pre Diabetes, Prediabetic State
- Trial name
- NCT07713030
- Testing
- High-Intensity Interval Training, Continuous Endurance Training
- Where
- Pakistan
- Volunteers
- 80 people, healthy volunteers welcome
- Sponsor
- Riphah International University
PreDiabetes
Effect of BFR Training on Glycemic Control, Functional Activity and Quality of Life in Individuals With Pre-diabetes
The aim of this study is to determine the effects of blood flow restriction training on glycemic control and functional activity in participants with prediabetes.
- Trial name
- NCT05411640
- Testing
- Aerobic exercise with Blood flow restriction, Aerobic exercise without Blood flow restriction, Patient Education and dietary modification
- Where
- Pakistan
- Volunteers
- 60 people
- Sponsor
- Riphah International University
Type2 Diabetes, PreDiabetes
Peer Support To Enhance The Shanghai Integration Model Of Diabetes Care: Dissemination To 12 Communities
This project will disseminate a community-level intervention that integrates peer support from Community Self-Management Groups (CSMGs) and primary care through Community Health Centers (CHC).
- Trial name
- NCT03958838
- Testing
- Peer Support Integrated with Primary Care
- Where
- 16 sites in China
- Volunteers
- 2,160 people
- Sponsor
- Shanghai 6th People's Hospital
Prediabetes, Health Communication
Study EHR Risk Stratification Tools
This study evaluates whether adding machine learning-based risk information to electronic health record (EHR) lab result messages helps older adults better understand their risk of developing diabetes and influences their…
- Conditions
- Prediabetes, Health Communication, Patient Comprehension
- Trial name
- NCT06995378
- Testing
- Hemoglobin A1c Lab Result Communication Tool
- Where
- United States
- Volunteers
- 1,200 people
- Sponsor
- University of California, Los Angeles
PreDiabetes, Obesity
Effect of Nutritional Supplements on Clinical Outcomes in Patients With Prediabetes and Obesity
This study aims to improve blood glucose and weight in patients with prediabetes and obesity through health education, nutritional supplement interventions, clinical evaluation, and close clinical follow-up.100 patients with…
- Trial name
- NCT05273840
- Testing
- Ivital Control, lifestyle intervention
- Where
- China
- Volunteers
- 100 people
- Sponsor
- Ningbo No. 1 Hospital
Safety Issues, Pharmacokinetic
Evaluation of Safety and Pharmacokinetics of Oral Controlled-ileal-release Nicotinic Acid (CIR-NA) Compared to Immediate-release Nicotinic Acid and Placebo in Healthy Subjects and Subjects With Prediabetes
A double-blind, randomised, placebo-controlled, single-ascending and multiple-ascending dose trial to evaluate the safety and pharmacokinetics of oral controlled-ileal-release nicotinic acid (CIR-NA) compared to immediate-release…
- Trial name
- NCT06378125
- Testing
- controlled-ileal-release nicotinic acid (SAD/ MAD/MD) single- and multiple-ascending dose (SAD/MAD) or multiple dose (MD), immediate-release nicotinic acid (SAD)
- Where
- Germany
- Volunteers
- 60 people, healthy volunteers welcome
- Sponsor
- University Hospital Schleswig-Holstein
Left Ventricular Hypertrophy, Insulin Resistance
MetfoRmin and Its Effects on Left Ventricular Hypertrophy in Normotensive Patients With Coronary Artery Disease
Thickening of the heart muscle (left ventricle) known medically as Left Ventricular Hypertrophy (LVH) is very common in patients with heart disease. This increases risk of cerebrovascular/cardiovascular event.
- Conditions
- Left Ventricular Hypertrophy, Insulin Resistance, Coronary Artery Disease, PreDiabetes
- Trial name
- MET-REMODEL (NCT02226510)
- Testing
- Metformin XL
- Where
- United Kingdom
- Volunteers
- 68 people
- Sponsor
- University of Dundee
Pre Diabetes, Diabetes (DM)
Preventing Diabetes: Impact of an EMR-Based Intervention for Enhanced Pre-Diabetes Management in Primary Care
The goal of this study is to find out if adding electronic medical record (EMR) prompts helps prevent people with pre-diabetes from developing diabetes. It will also look at how these prompts affect doctor and patient behaviors.
- Trial name
- NCT07252700
- Testing
- Electronic Medical Record-Based Clinical Decision Support
- Where
- Singapore
- Volunteers
- 6,000 people
- Sponsor
- Lynette Goh
PreDiabetes
Effects of Almonds on Insulin Sensitivity in Prediabetes
The goal of this clinical trial is to evaluate the effects of consuming 1.5 oz almonds twice daily on insulin sensitivity and markers of cardiometabolic health in men and women with prediabetes.
- Trial name
- NCT03126981
- Testing
- 1.5 oz of whole, natural almonds, Low-fat, high refined starches/sugars
- Where
- 2 sites in United States
- Volunteers
- 54 people
- Sponsor
- Midwest Center for Metabolic and Cardiovascular Research
Elevated Blood Pressure, Hypertension
WeArable teChnology daTa driVen digitAl healTh cOachINg (ACTIVATION)- A Mixed-methods Study
Public health priorities have shifted towards disease prevention, emphasising health promotion and lifestyle interventions to reduce disease burden.
- Conditions
- Elevated Blood Pressure, Hypertension, Overweight/Obesity, Type 2 Diabetes Mellitus (T2DM)
- Trial name
- NCT06752772
- Testing
- Smart watch, Dashboard with nudging system, Digital Health Coach (DHC)
- Where
- Singapore
- Volunteers
- 1,700 people
- Sponsor
- Alexandra Hospital