Clinical trials: Pre-diabetic State
Diabetes Mellitus, Type 2, PreDiabetes
Exercise and Time of Day in Type 2 Diabetes
The overall purpose of the study is to test the effect exercise time of day in adults with type 2 diabetes or prediabetes. The overarching hypothesis is that afternoon exercise in the afternoon may promote better changes in…
- Trial name
- NCT05108987
- Testing
- Morning Exercise, Afternoon Exercise
- Where
- 3 sites in United States
- Volunteers
- 36 people
- Sponsor
- Rutgers, The State University of New Jersey
Diabetes, Prediabetes
The CArdiovasCulAr Diabetes & Ethanol (CASCADE) Trial
Moderate alcohol may be beneficial for diabetics
- Trial name
- CASCADE (NCT00784433)
- Testing
- alcohol
- Volunteers
- 224 people
- Sponsor
- Ben-Gurion University of the Negev
Prediabetes, Hypercholesterolemia
Effect of Simvastatin and Ezetimibe on Lipid and Inflammation
Ezetimibe specifically blocks the absorption of dietary and biliary cholesterol and plant sterols. Synergism of ezetimibe-statin therapy on LDL-cholesterol has been demonstrated, but data concerning the pleiotropic effects of…
- Conditions
- Prediabetes, Hypercholesterolemia, Inflammation, Cardiovascular Risk
- Trial name
- NCT01103648
- Testing
- Simvastatin, Ezetimibe, Combination Simvastatin plus Ezetimibe
- Where
- Brazil
- Volunteers
- 50 people
- Sponsor
- Federal University of São Paulo
Impaired Glucose Tolerance
Prevention of Type 2 Diabetes in Children With a Family-based Healthy Lifestyle Program
The purpose of this study is to determine if the Bright Bodies (BB) Healthy Lifestyle Program can help reverse early abnormalities in glucose metabolism and prevent the progression to type 2 diabetes (T2DM) in high-risk, obese…
- Trial name
- NCT01030978
- Testing
- Bright Bodies Healthy Lifestyle Program, Control
- Where
- United States
- Volunteers
- 72 people
- Sponsor
- Yale University
PreDiabetes, Metabolic Management Center
Prediabetes Management
Systematically screen the high-risk population of diabetes in Xinqiao district to understand the characteristics of early glucose metabolism changes and pancreatic islet function changes in patients with pre diabetes.
- Conditions
- PreDiabetes, Metabolic Management Center, Continuous Glucose Monitoring
- Trial name
- NCT05531838
- Testing
- Fu Lishan instant sense hospital dynamic glucose monitoring system
- Volunteers
- 190 people, healthy volunteers welcome
- Sponsor
- Shanghai General Hospital, Shanghai Jiao Tong University School of Medicine
Overweight, Obesity
Meta-analyses of Total and Individual Fructose-containing Sugars and Incident Cardiometabolic Disease
Since uncontrolled observational studies first linked fructose to the epidemic of obesity almost a decade ago, it has become a focus of intense concern regarding its role in the obesity epidemic and increasing burden of…
- Conditions
- Overweight, Obesity, Dyslipidemia, Hyperlipidemia
- Trial name
- NCT01608620
- Where
- Canada
- Volunteers
- 1 people
- Sponsor
- John Sievenpiper
Type 1 Diabetes (T1D), Autoantibodies
Standardized Italian netwoRk Enrolling iNdividuals With Islet-Autoantibodies
This project characterizes the longitudinal progression of children and adults who have tested positive for one or more islet cell autoantibodies across the early stages of type 1 diabetes (T1D).
- Conditions
- Type 1 Diabetes (T1D), Autoantibodies, Hyperglycemia, Impaired Glucose Tolerance (Prediabetes)
- Trial name
- SIRENA (NCT07503366)
- Where
- 24 sites in Italy
- Volunteers
- 300 people
- Sponsor
- Società Italiana di Endocrinologia e Diabetologia Pediatrica
PreDiabetes, Obesity, Morbid
Metabolic Effects of a Low Carbohydrate Versus a Standard Diet in Morbidly Obese With Prediabetes
To investigate the metabolic effects of a low carbohydrate versus energy-matched standard diet in morbidly obese individuals with prediabetes awaiting bariatric surgery.
- Conditions
- PreDiabetes, Obesity, Morbid, Bariatric Surgery Candidate
- Trial name
- CaPrO (NCT03880162)
- Testing
- Low carbohydrate diet, Energy-matched standard diet
- Where
- Switzerland
- Volunteers
- 20 people
- Sponsor
- Insel Gruppe AG, University Hospital Bern
Diabetes, Prediabetes
Effect of Whole Grain Diet on Insulin Sensitivity, Advanced Glycation End Products and Inflammatory Markers in Pre-diabetes
Food products derived from cereal grains constitute a major part of the daily diet of many Americans . For example, a typical Chinese American eats rice about 9.5 times a week on an average.
- Trial name
- NCT01248286
- Testing
- Whole grain rice, Refined grain rice
- Where
- United States
- Volunteers
- 100 people
- Sponsor
- Icahn School of Medicine at Mount Sinai
Diabetes, Prediabetes
Reducing Type 2 Diabetes Diagnostic Delays Using Decision Support
This study will focus on the cohort of 20,000 established patients cared for by 31 attending physicians in the outpatient, adult primary care practices at UT Southwestern (two general internal medicine one family medicine and one…
- Trial name
- NCT02199769
- Testing
- Clinical Decision Support
- Where
- United States
- Volunteers
- 747 people
- Sponsor
- University of Texas Southwestern Medical Center
Spinal Cord Injuries (SCI), Prediabetes / Type 2 Diabetes
Neuromodulation for Metabolic Dysfunction
This study evaluates the use of noninvasive transcutaneous spinal cord stimulation (tSCS) to improve glucose regulation and metabolic function in individuals with and without spinal cord injury (SCI) across a spectrum of…
- Trial name
- NCT07597161
- Testing
- Transcutaneous Spinal Cord Stimulation (tSCS)
- Where
- United States
- Volunteers
- 120 people, healthy volunteers welcome
- Sponsor
- Rahul Sachdeva
Prediabetes / Type 2 Diabetes, Diabetes Mellitus, Type 2
Pilot RCT of PIPE-AI for Prediabetes and Diabetes Self-Management
This pilot randomized controlled trial evaluates the feasibility, effectiveness, and acceptance of the Personalized Interactive Patient Empowerment Artificial Intelligence Platform (PIPE-AI) enhanced by DiabetesGPT among adults…
- Conditions
- Prediabetes / Type 2 Diabetes, Diabetes Mellitus, Type 2, Prediabetes
- Trial name
- PIPE-AI (NCT07787403)
- Testing
- PIPE-AI digital patient empowerment intervention, Waitlist usual care control
- Volunteers
- 50 people
- Sponsor
- The Hong Kong Polytechnic University
Diabetes Mellitus, Prediabetes
Effects of an Exercise and Lifestyle Education Program for People With Diabetes and Prediabetes
The purpose of this trial is to pragmatically investigate whether participation of people with diabetes and prediabetes in an Exercise and Lifestyle Education Program (i.e., exercise and education classes) results in better…
- Trial name
- NCT03914924
- Testing
- Exercise Program, Lifestyle Education Program
- Where
- 2 sites in Brazil
- Volunteers
- 240 people
- Sponsor
- Federal University of Juiz de Fora
Type 2 Diabetes, PreDiabetes
Bialystok Exercise Study in Diabetes
The "Bialystok Exercise Study in Diabetes" (BESD), is an exercise intervention study, conducted by the Department of Endocrinology, Diabetology and Internal Medicine and Clinical Research Centre of the Medical University of…
- Conditions
- Type 2 Diabetes, PreDiabetes, Overweight, Obesity
- Trial name
- BESD (NCT04634890)
- Testing
- Exercise intervention
- Where
- Poland
- Volunteers
- 300 people, healthy volunteers welcome
- Sponsor
- Medical University of Bialystok
Pre-diabetes
Continuous Glucose Monitoring in Prediabetes
The objective of this project is to develop a behavioral intervention that combines wearable continuous glucose monitoring (CGM) with smartphone feedback and educational video clips generated by artificial intelligence (AI)…
- Trial name
- G1 (NCT06472297)
- Testing
- The continuous glucose monitoring system
- Where
- United States
- Volunteers
- 23 people, healthy volunteers welcome
- Sponsor
- University of Southern California
Diabetes Mellitus, Type 2, PreDiabetes
18F-FDOPA PET/CT Imaging in Patients Undergoing Metabolic Surgery
The aim of the study is to compare the endocrine function of pancreas between pre and post metabolic surgery in patients with type 2 diabetes or prediabetes.
- Conditions
- Diabetes Mellitus, Type 2, PreDiabetes, Obesity
- Trial name
- NCT03821961
- Testing
- Metabolic Surgery
- Where
- South Korea
- Volunteers
- 30 people, healthy volunteers welcome
- Sponsor
- Korea University Anam Hospital
Type 2 Diabetes, Obesity
Energy Flux and Fat Oxidation Using Low and High Glycaemic Index Foods
Purpose: This study is carried out to determine the effect of GI on 24 hour blood glucose profiles and energy regulation in Asians when fed a normal diet modulated with sweeteners.
- Conditions
- Type 2 Diabetes, Obesity, PreDiabetes
- Trial name
- NCT03031886
- Testing
- low glycaemic index intervention, high glycaemic index intervention
- Where
- Singapore
- Volunteers
- 20 people, healthy volunteers welcome
- Sponsor
- Singapore Institute of Food and Biotechnology Innovation
Prediabetes
Development of Smart Food /Nutraceutical Solutions Dedicated to Cardiometabolic Disorders in Ageing
Describe the anthropometric measurements and informations relating to body composition, blood chemistry tests, blood glucose monitoring, and dietary habits of the volunteers participating in the study before and after taking…
- Trial name
- NutriAge (NCT07817290)
- Testing
- Probiotic
- Where
- Italy
- Volunteers
- 15 people, healthy volunteers welcome
- Sponsor
- Azienda Ospedaliero Universitaria Maggiore della Carita
PreDiabetes, Neuropathy
Heat Shock Therapy to Improve Mitochondrial Function in Neuropathy
Sensory dysfunction as a result of peripheral nerve damage is a significant problem that leads to reduced quality of life for patients.
- Trial name
- HOTFUN (NCT05070741)
- Testing
- Heat Therapy
- Where
- United States
- Volunteers
- 3 people
- Sponsor
- University of Kansas Medical Center
PreDiabetes, Dysbiosis
Assessing Gut Microbiota Mediated Health Outcomes of Whole Wheat and Its Major Bioactive Components
This study will investigate the gut microbiota-mediated effects of whole wheat consumption on human health in adults with pre-diabetes.
- Conditions
- PreDiabetes, Dysbiosis, Endotoxemia, Inflammation
- Trial name
- NCT05318183
- Testing
- Whole Wheat Bread, White Bread (control)
- Where
- United States
- Volunteers
- 65 people
- Sponsor
- Ohio State University